CD63 Monoclonal Antibody (MEM-259) | Invitrogen MA1-19281 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD63 Monoclonal Antibody (MEM-259)

catalog :

MA1-19281

quantity :

100 µg

price :

US 496

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

MEM-259

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 8

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; human; 1:100; loading ...; fig 4d western blot; human; loading ...; fig s3b	Ferreira K, de Almeida B, Dos Anjos L, Baiocchi G, Soares F, Rocha R, et al. Assessment of TSPAN Expression Profile and Their Role in the VSCC Prognosis. Int J Mol Sci. 2021;22: pubmed publisher
immunocytochemistry; human; loading ...; fig 9a	Guo J, Jayaprakash P, Dan J, Wise P, Jang G, Liang C, et al. PRAS40 Connects Microenvironmental Stress Signaling to Exosome-Mediated Secretion. Mol Cell Biol. 2017;37: pubmed publisher
	Ye Y, Chang Z, Wang P, Wang Y, Liang J, Chen C, et al. Infarct-preconditioning exosomes of umbilical cord mesenchymal stem cells promoted vascular remodeling and neurological recovery after stroke in rats. Stem Cell Res Ther. 2022;13:378 pubmed publisher
	Miao N, Cai W, Ding S, Liu Y, Chen W, Sun T. Characterization of plasma exosomal microRNAs in responding to radiotherapy of human esophageal squamous cell carcinoma. Mol Med Rep. 2022;26: pubmed publisher
	Breyne K, Ughetto S, Rufino Ramos D, Mahjoum S, Grandell E, de Almeida L, et al. Exogenous loading of extracellular vesicles, virus-like particles, and lentiviral vectors with supercharged proteins. Commun Biol. 2022;5:485 pubmed publisher
	de Rus Jacquet A, Tancredi J, Lemire A, DeSantis M, Li W, O Shea E. The LRRK2 G2019S mutation alters astrocyte-to-neuron communication via extracellular vesicles and induces neuron atrophy in a human iPSC-derived model of Parkinson's disease. elife. 2021;10: pubmed publisher
	Tognoli M, Vlahov N, Steenbeek S, Grawenda A, Eyres M, Cano Rodriguez D, et al. RASSF1C oncogene elicits amoeboid invasion, cancer stemness, and extracellular vesicle release via a SRC/Rho axis. EMBO J. 2021;40:e107680 pubmed publisher
	Machala M, Slav xed k J, Kov xe1 x10d O, Proch xe1 zkov xe1 J, P x11b n x10d xed kov xe1 K, Pa x159 enicov xe1 M, et al. Changes in Sphingolipid Profile of Benzo[a]pyrene-Transformed Human Bronchial Epithelial Cells Are Reflected in the Altered Composition of Sphingolipids in Their Exosomes. Int J Mol Sci. 2021;22: pubmed publisher

image

image 1 :

product information

Product Type :

Antibody

Product Name :

CD63 Monoclonal Antibody (MEM-259)

Catalog # :

MA1-19281

Quantity :

100 µg

Price :

US 496

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 2 µg/mL, Immunocytochemistry: 5 µg/mL, Immunofluorescence: 5 µg/mL, Immunohistochemistry (Paraffin): 10 µg/mL, Immunoprecipitation: Assay Dependent

Species :

Human

Clone :

MEM-259

Isotype :

IgG1

Storage :

4° C, do not freeze

Description :

CD63 (LAMP-3, lysosome-associated membrane protein-3), a glycoprotein of tetraspanin family, is present in late endosomes, lysosomes and secretory vesicles of various cell types. CD63 is also present in the plasma membrane, usually following cell activation. Hence, CD63 has become a widely used basophil activation marker. In mast cells, however, CD63 exposition does not need their activation. CD63 interacts with integrins and affects phagocytosis and cell migration, it is also involved in H/K-ATPase trafficking regulation of ROMK1 channels. CD63 also serves as a T-cell costimulation molecule. Expression of CD63 can be used for predicting the prognosis in earlier stages of carcinomas. CD63 is expressed on activated platelets, and is a lysosomal membrane glycoprotein that is translocated to plasma membrane after platelet activation. CD63 is also present in monocytes and macrophages and is weakly expressed on granulocytes, B, and T cells. CD63 is identical to the melanoma-associated antigen which is ME491 and to the platelet antigen PTLGP40. Diseases associated with CD63 dysfunction include melanoma and Hermansky-Pudlak Syndrome.

Immunogen :

T cell line HPB-ALL.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 2 µg/mL, Immunocytochemistry: 5 µg/mL, Immunofluorescence: 5 µg/mL, Immunohistochemistry (Paraffin): 10 µg/mL, Immunoprecipitation: Assay Dependent

Aliases :

C75951; CD 63; CD63; CD63 antigen; CD63 antigen (melanoma 1 antigen); Cd63 molecule; CD63 protein; granulophysin; LAMP-3; Lysosomal-associated membrane protein 3; lysosome-associated membrane glycoprotein 3; mast cell antigen AD1; ME491; melanoma 1 antigen; melanoma-associated antigen ME491; melanoma-associated antigen MLA1; MLA1; Ocular melanoma-associated antigen; OMA81H; tetraspanin-30; TSPAN30; Tspan-30

more info or order :

Invitrogen product webpage