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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
p21 Monoclonal Antibody (WA-1)
catalog :
MA1-19271
quantity :
100 µg
price :
US 409
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
WA-1
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section
more info or order :
Invitrogen product webpage
citations: 1
Published Application/Species/Sample/DilutionReference
  • western blot; human
Coppock H, Gilham D, Howell A, Clarke R. Cyclin-dependent kinase inhibitors and basement membrane interact to regulate breast epithelial cell differentiation and acinar morphogenesis. Cell Prolif. 2007;40:721-40 pubmed
product information
Product Type :
Antibody
Product Name :
p21 Monoclonal Antibody (WA-1)
Catalog # :
MA1-19271
Quantity :
100 µg
Price :
US 409
Clonality :
Monoclonal
Purity :
protein A
Host :
Mouse
Reactivity :
Human, Non-human primate
Applications :
ELISA: Assay Dependent, Immunocytochemistry: Assay dependent, Immunohistochemistry (Paraffin): Assay Dependent, Western Blot: Assay Dependent
Species :
Human, Non-human primate
Clone :
WA-1
Isotype :
IgG1
Storage :
4° C, do not freeze
Description :
Protein p21 is a tumor suppressor protein which is an inhibitor of Cyclin-dependent kinases (CDK) and is transcriptionally activated by p53. P21 is important in the response of cells to genotoxic stress and a major transcriptional target of p53 protein. The occurrence of p21 in the nucleus executes binding and inhibition activity of cyclin dependent kinases Cdk1 and Cdk2, and blocks the transition from G1 phase into S phase or from G2 phase into mitosis after DNA damage, which enables the repair of damaged DNA. In the cytoplasm, p21 protein has an anti-apoptotic effect. P21 is able to bind to and inhibit caspase 3, as well as the apoptotic kinases ASK1 and JNK. P21 exhibits a dual function in carcinogenesis, and acts as a tumor suppressor, prevents apoptosis, and acts as an oncogene.
Immunogen :
Human p21 protein.
Format :
Liquid
Applications w/Dilutions :
ELISA: Assay Dependent, Immunocytochemistry: Assay dependent, Immunohistochemistry (Paraffin): Assay Dependent, Western Blot: Assay Dependent
Aliases :
CAP20; cdk inhibitor CIP1 (p21); CDKI; CDK-interacting protein 1; CDK-interaction protein 1; Cdkn1; CDKN1A; CDNK1A; CIP1; cyclin dependent kinase inhibitor 1A; cyclin-dependent kinase inhibitor 1; cyclin-dependent kinase inhibitor 1A; cyclin-dependent kinase inhibitor 1A (P21); cyclin-dependent kinase inhibitor 1A (p21, Cip1); cyclin-dependent kinase inhibitor 1A variant 1; cyclin-dependent kinase inhibitor 1A variant 2; DNA synthesis inhibitor; MDA6; MDA-6; melanoma differentiation associated protein 6; melanoma differentiation-associated protein; Melanoma differentiation-associated protein 6; OTTHUMP00000016298; p21; p21 ; p21CIP1; p21Cip1/Waf1; p21WAF; PIC1; SDI1; UV96; WAF1; wild-type p53-activated fragment 1
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA