DR4 Monoclonal Antibody (DR-4-02) | Invitrogen MA1-19025 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

DR4 Monoclonal Antibody (DR-4-02)

catalog :

MA1-19025

quantity :

100 µg

price :

US 485.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

DR-4-02

reactivity :

human

application :

immunocytochemistry, immunoprecipitation, flow cytometry

more info or order :

Invitrogen product webpage

citations: 4

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; human; 15 ug/ml	Vondálová Blanárová O, Jelínková I, Szöor A, Skender B, Soucek K, Horváth V, et al. Cisplatin and a potent platinum(IV) complex-mediated enhancement of TRAIL-induced cancer cells killing is associated with modulation of upstream events in the extrinsic apoptotic pathway. Carcinogenesis. 2011;32:42-51 pubmed publisher
	Staniek J, Lorenzetti R, Heller B, Janowska I, Schneider P, Unger S, et al. TRAIL-R1 and TRAIL-R2 Mediate TRAIL-Dependent Apoptosis in Activated Primary Human B Lymphocytes. Front Immunol. 2019;10:951 pubmed publisher
	Peskova L, Vinarsky V, Bárta T, Hampl A. Human Embryonic Stem Cells Acquire Responsiveness to TRAIL upon Exposure to Cisplatin. Stem Cells Int. 2019;2019:4279481 pubmed publisher
	McGough I, Steinberg F, Gallon M, Yatsu A, Ohbayashi N, Heesom K, et al. Identification of molecular heterogeneity in SNX27-retromer-mediated endosome-to-plasma-membrane recycling. J Cell Sci. 2014;127:4940-53 pubmed publisher

product information

Product Type :

Antibody

Product Name :

DR4 Monoclonal Antibody (DR-4-02)

Catalog # :

MA1-19025

Quantity :

100 µg

Price :

US 485.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 2-4 µg/mL, Functional Assay: 2-3 µg/mL, Immunocytochemistry: Assay-dependent, Immunoprecipitation: Assay-dependent

Species :

Human

Clone :

DR-4-02

Isotype :

IgG1

Storage :

4° C, do not freeze

Description :

TRAIL-R1 (CD261, DR4) is a type I transmembrane protein, also called TRAIL receptor 1. The ligand for this DR4 death receptor has been identified and termed TRAIL, which is a member of the TNF family. DR4, as many other receptors (Fas, TNFR1, etc.), mediates apoptosis and NF kappaB activation in many cells and tissues. Apoptosis, a programmed cell death, is a operating process in normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by coupled of certain cytokines (TNF family - TNF, Fas ligand) and their death domain containing receptors (TNFR1, Fas receptor).

Immunogen :

Fusion protein containing the extracellular part of TRAIL-R1 and the constant part of the heavy chain of the human IgG1.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 2-4 µg/mL, Functional Assay: 2-3 µg/mL, Immunocytochemistry: Assay-dependent, Immunoprecipitation: Assay-dependent

Aliases :

APO2; CD261; cytotoxic TRAIL receptor; death receptor 4; DR4; MGC9365; sCD261; soluble CD261; soluble TRAIL; sTRAIL; TNF receptor superfamily member 10a; TNF-related apoptosis-inducing ligand receptor 1; TNFRSF10A; TRAIL R1; TRAIL receptor 1; TRAILR1; TRAIL-R1; TRAILR-1; tumor necrosis factor receptor superfamily member 10A; tumor necrosis factor receptor superfamily member 10a variant 2; tumor necrosis factor receptor superfamily, member 10a

more info or order :

Invitrogen product webpage