TCR V beta 5 Monoclonal Antibody (MEM-262) | Invitrogen MA1-19020 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TCR V beta 5 Monoclonal Antibody (MEM-262)

catalog :

MA1-19020

quantity :

100 ug

price :

US 414.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

MEM-262

reactivity :

human

application :

western blot, immunoprecipitation, flow cytometry

product information

Product Type :

Antibody

Product Name :

TCR V beta 5 Monoclonal Antibody (MEM-262)

Catalog # :

MA1-19020

Quantity :

100 ug

Price :

US 414.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 1-4 ug/mL, Functional Assay: Assay-Dependent, Immunoprecipitation: Assay-dependent, Western Blot: Assay-dependent

Species :

Human

Clone :

MEM-262

Isotype :

IgG2a

Storage :

4 C, do not freeze

Description :

The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease. Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.

Immunogen :

Human thymoma cell line HPB-ALL.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1-4 ug/mL, Functional Assay: Assay-Dependent, Immunoprecipitation: Assay-dependent, Western Blot: Assay-dependent

Aliases :

T cell receptor beta locus; TCR V beta5; TCRB; TCRV b5; TCRV beta 5; TRB; TRB@; Vb5; Vbeta5