This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD43 Monoclonal Antibody (MEM-59)
catalog :
MA1-19009
quantity :
100 ug
price :
US 434.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
MEM-59

The same clone is also sold as:
reactivity :
human
application :
western blot, immunohistochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section
citations: 2
Reference
Wisnovsky S, Möckl L, Malaker S, Pedram K, Hess G, Riley N, et al. Genome-wide CRISPR screens reveal a specific ligand for the glycan-binding immune checkpoint receptor Siglec-7. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher
Mazurov D, Ilinskaya A, Heidecker G, Filatov A. Role of O-glycosylation and expression of CD43 and CD45 on the surfaces of effector T cells in human T cell leukemia virus type 1 cell-to-cell infection. J Virol. 2012;86:2447-58 pubmed publisher
product information
Product Type :
Antibody
Product Name :
CD43 Monoclonal Antibody (MEM-59)
Catalog # :
MA1-19009
Quantity :
100 ug
Price :
US 434.00
Clonality :
Monoclonal
Purity :
protein A
Host :
Mouse
Reactivity :
Human
Applications :
Flow Cytometry: 1-5 ug/mL, Functional Assay: Assay-Dependent, Immunohistochemistry (Paraffin): 10 ug/mL, Immunoprecipitation: Assay-dependent, Western Blot: Assay-dependent
Species :
Human
Clone :
MEM-59
Isotype :
IgG1
Storage :
4 C, do not freeze
Description :
CD43 (leukosialin, sialophorin) is a transmembrane mucin-like protein with high negative charge, expressed on the surface of most hematopoietic cells. CD43 contributes to a repulsive barrier that interferes with cellular adhesion, however, in certain cases also promotes leukocyte aggregation. By interaction with actin-binding proteins ezrin and moesin CD43 plays a regulatory role in remodeling T-cell morphology and regulates cell-cell interactions during lymphocyte traffic. CD43 signaling both enhances LFA-1 adhesiveness and counteracts LFA-1 induction via other receptors. Expression of CD43 causes induction of functionally active tumor suppressor p53 protein, but in case of p53 and ARF deficiency CD43 promotes tumor proliferation and viability. CD43 appears to be an important modulator of leukocyte functions. Diseases associated with CD43 dysfunction include Wiscott-Aldrich Syndrome and Adenoid Basal Cell Carcinoma.
Immunogen :
Human T lymphocytes.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1-5 ug/mL, Functional Assay: Assay-Dependent, Immunohistochemistry (Paraffin): 10 ug/mL, Immunoprecipitation: Assay-dependent, Western Blot: Assay-dependent
Aliases :
3E8 antigen; A630014B01Rik; B-cell differentiation antigen LP-3; CD43; CD43 cytoplasmic tail; CD43-ct; Galactoglycoprotein; GALGP; gpL115; Leukocyte sialoglycoprotein; leukosialin; leukosianin; LOC101120462; LOW QUALITY PROTEIN: leukosialin; Lsn; Lsn1; Ly48; Ly-48; Lymphocyte antigen 48; sialophorin; sialophorin (gpL115, leukosialin, CD43); sialophorin gpL115; SPN; W3/13 antigen
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA