CD11a Monoclonal Antibody (MEM-25) | Invitrogen MA1-19003 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD11a Monoclonal Antibody (MEM-25)

catalog :

MA1-19003

quantity :

100 µg

price :

US 321.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

MEM-25

reactivity :

human

application :

immunoprecipitation, flow cytometry, blocking or activating experiments

more info or order :

Invitrogen product webpage

citations: 18

Published Application/Species/Sample/Dilution	Reference
blocking or activating experiments; human	Kondo N, Melikyan G. Intercellular adhesion molecule 1 promotes HIV-1 attachment but not fusion to target cells. PLoS ONE. 2012;7:e44827 pubmed publisher
flow cytometry; human; 8 ug/ml	Eksteen B, Mora J, Haughton E, Henderson N, Lee Turner L, Villablanca E, et al. Gut homing receptors on CD8 T cells are retinoic acid dependent and not maintained by liver dendritic or stellate cells. Gastroenterology. 2009;137:320-9 pubmed publisher
flow cytometry; human; fig 3	Zhang F, Marcus W, Goyal N, Selvaraj P, Springer T, Zhu C. Two-dimensional kinetics regulation of alphaLbeta2-ICAM-1 interaction by conformational changes of the alphaL-inserted domain. J Biol Chem. 2005;280:42207-18 pubmed
flow cytometry; human	Suskind D, Muench M. Searching for common stem cells of the hepatic and hematopoietic systems in the human fetal liver: CD34+ cytokeratin 7/8+ cells express markers for stellate cells. J Hepatol. 2004;40:261-8 pubmed
flow cytometry; human	Mathison R, Befus A, Davison J, Woodman R. Modulation of neutrophil function by the tripeptide feG. BMC Immunol. 2003;4:3 pubmed
flow cytometry; human	Hajishengallis G, Martin M, Sojar H, Sharma A, Schifferle R, DeNardin E, et al. Dependence of bacterial protein adhesins on toll-like receptors for proinflammatory cytokine induction. Clin Diagn Lab Immunol. 2002;9:403-11 pubmed
flow cytometry; human	Semnani R, Sabzevari H, Iyer R, Nutman T. Filarial antigens impair the function of human dendritic cells during differentiation. Infect Immun. 2001;69:5813-22 pubmed
flow cytometry; human; fig 3	Schiff D, Rae J, Martin T, Davis B, Curnutte J. Increased phagocyte Fc gammaRI expression and improved Fc gamma-receptor-mediated phagocytosis after in vivo recombinant human interferon-gamma treatment of normal human subjects. Blood. 1997;90:3187-94 pubmed
	Ramírez Jarquín U, Sharma M, Shahani N, Li Y, Boregowda S, Subramaniam S. Rhes protein transits from neuron to neuron and facilitates mutant huntingtin spreading in the brain. Sci Adv. 2022;8:eabm3877 pubmed publisher
	Tsai M, Cheng H, Nian F, Liu C, Chao N, Chiang K, et al. Impairment in dynein-mediated nuclear translocation by BICD2 C-terminal truncation leads to neuronal migration defect and human brain malformation. Acta Neuropathol Commun. 2020;8:106 pubmed publisher
	Genschmer K, Russell D, Lal C, Szul T, Bratcher P, Noerager B, et al. Activated PMN Exosomes: Pathogenic Entities Causing Matrix Destruction and Disease in the Lung. Cell. 2019;176:113-126.e15 pubmed publisher
	Chen Y, Lu I, Tsai J. Contactin-1/F3 Regulates Neuronal Migration and Morphogenesis Through Modulating RhoA Activity. Front Mol Neurosci. 2018;11:422 pubmed publisher
	Meseke M, Neumüller F, Brunne B, Li X, Anstötz M, Pohlkamp T, et al. Distal Dendritic Enrichment of HCN1 Channels in Hippocampal CA1 Is Promoted by Estrogen, but Does Not Require Reelin. Eneuro. 2018;5: pubmed publisher
	Yang Y, Chen J, Guo Z, Deng S, Du X, Zhu S, et al. Endophilin A1 Promotes Actin Polymerization in Dendritic Spines Required for Synaptic Potentiation. Front Mol Neurosci. 2018;11:177 pubmed publisher
	Chen J, Chang C, Tsai J. Gli2 Rescues Delays in Brain Development Induced by Kif3a Dysfunction. Cereb Cortex. 2018;: pubmed publisher
	Raimondo J, Tomes H, Irkle A, Kay L, Kellaway L, Markram H, et al. Tight Coupling of Astrocyte pH Dynamics to Epileptiform Activity Revealed by Genetically Encoded pH Sensors. J Neurosci. 2016;36:7002-13 pubmed publisher
	Baffet A, Hu D, Vallee R. Cdk1 Activates Pre-mitotic Nuclear Envelope Dynein Recruitment and Apical Nuclear Migration in Neural Stem Cells. Dev Cell. 2015;33:703-16 pubmed publisher
	Whitlock B, Gardai S, Fadok V, Bratton D, Henson P. Differential roles for alpha(M)beta(2) integrin clustering or activation in the control of apoptosis via regulation of akt and ERK survival mechanisms. J Cell Biol. 2000;151:1305-20 pubmed

image

image 1 :

product information

Product Type :

Antibody

Product Name :

CD11a Monoclonal Antibody (MEM-25)

Catalog # :

MA1-19003

Quantity :

100 µg

Price :

US 321.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 2 µg/mL, Functional Assay: Assay-Dependent, Immunoprecipitation: Assay-dependent

Species :

Human

Clone :

MEM-25

Isotype :

IgG1

Storage :

4° C, do not freeze

Description :

CD11a (LFA-1 alpha, ITGAL) together with CD18 constitute leukocyte function-associated antigen 1 (LFA-1), the alphaLbeta2 integrin. CD11a is implicated in activation of LFA-1 complex. CD11a plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. CD11a is expressed on the plasma membrane of leukocytes in a low-affinity conformation. Cell stimulation by chemokines or other signals leads to induction the high-affinity conformation, which supports tight binding of CD11a to its ligands, the intercellular adhesion molecules ICAM-1, -2, -3. CD11a is thus involved in interaction of various immune cells and in their tissue-specific settlement, but participates also in control of cell differentiation and proliferation and of T-cell effector functions. Blocking of CD11a function by specific antibodies or small molecules has become an important therapeutic approach in treatment of multiple inflammatory diseases. For example, humanized anti- CD11a antibody Efalizumab (Raptiva) is being used to interfere with T cell migration to sites of inflammation, binding of cholesterol-lowering drug simvastatin to CD11a allosteric site leads to immunomodulation and increase in lymphocytic cholinergic activity. Two transcript variants encoding different isoforms of CD11a have been found. Diseases associated with CD11a dysfunction include benign cephalic histiocytosis and leukocyte adhesion deficiency.

Immunogen :

Leucocytes from a patient suffering from a LGL type leukaemia.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 2 µg/mL, Functional Assay: Assay-Dependent, Immunoprecipitation: Assay-dependent

Aliases :

(p180); alpha L integrin; antigen CD11A (p180); antigen CD11A (p180), lymphocyte function-associated antigen 1, alpha polypeptide; antigen CD11A p180; CD11 antigen-like family member A; CD11a; integrin alpha L; integrin alphaL; integrin alpha-L; integrin alpha-L precursor; integrin gene promoter; integrin subunit alpha L; integrin surface receptor; integrin, alpha L; integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide); ITGAL; Leukocyte adhesion glycoprotein LFA-1 alpha chain; leukocyte function-associated molecule 1 alpha chain; LFA-1; LFA-1 alpha; LFA1A; LFA-1A; Ly-15; Ly-21; lymphocyte antigen 15; lymphocyte function associated antigen 1, alpha polypeptide; lymphocyte function-associated antigen 1; lymphocyte function-associated antigen 1, alpha polypeptide; lymphocyte function-associated antigen-1

more info or order :

Invitrogen product webpage