Progranulin Monoclonal Antibody (2D4-2F1) | Invitrogen MA1-187 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Progranulin Monoclonal Antibody (2D4-2F1)

catalog :

MA1-187

quantity :

200 uL

price :

US 491.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2D4-2F1

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunohistochemistry - paraffin section

citations: 1

Reference
Tran M, T xfc shaus J, Kim Y, Ramazanov B, Devireddy S, Lichtenthaler S, et al. Cab45 deficiency leads to the mistargeting of progranulin and prosaposin and aberrant lysosomal positioning. Traffic. 2023;24:4-19 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Progranulin Monoclonal Antibody (2D4-2F1)

Catalog # :

MA1-187

Quantity :

200 uL

Price :

US 491.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human

Applications :

ELISA: 25-500 ng/mL, Immunohistochemistry (Paraffin): 1:20, Western Blot: 1:250-1:1,000

Species :

Human

Clone :

2D4-2F1

Isotype :

IgG1

Storage :

-20 C

Description :

Progranulin is the precursor protein of Granulin also called as Proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature Granulin. Both Granulin and smaller cleavage product of Granulin regulates cell growth. Progranulin stimulates proliferation of many epithelial cells, promotes their anchorage-independent growth and, when overexpressed, confers epithelial tumorigenicity. Progranulin/epithelin gene is multifunctional, with important constitutive roles in epithelial homeostasis, reproductive, immunological, and neuronal function. Progranulin constitutively expressed in a number of epithelia, particularly in the skin, GI tract, and reproductive system. Progranulin is expressed in immune cells in vivo and in specific neurons in the brain.

Immunogen :

Recombinant human Progranulin

Format :

Liquid

Applications w/Dilutions :

ELISA: 25-500 ng/mL, Immunohistochemistry (Paraffin): 1:20, Western Blot: 1:250-1:1,000

Aliases :

Acrogranin; acrogranulin; CLN11; epithelin; Epithelin precursor; Epithelin/granulin precursor; Epithelin-1; Epithelin-2; GEP; Glycoprotein of 88 Kda; GP88; granulin; Granulin A; Granulin B; Granulin C; Granulin D; Granulin E; Granulin F; Granulin G; Granulin precursor; Granulin-1; Granulin-2; Granulin-3; Granulin-4; Granulin-5; Granulin-6; Granulin-7; granulin-epithelin; granulins; GRN; Paragranulin; PC cell-derived growth factor; PCDGF; PEPI; Pgrn; Proepithelin; progranulin