BACE1 Monoclonal Antibody (3C1C3) | Invitrogen MA1-177 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

BACE1 Monoclonal Antibody (3C1C3)

catalog :

MA1-177

quantity :

100 ug

price :

US 491.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3C1C3

reactivity :

human, mouse, rat, dogs

application :

western blot, immunocytochemistry

more info or order :

Invitrogen product webpage

citations: 4

Published Application/Species/Sample/Dilution	Reference
western blot; rat; loading ...; fig 2b	Bazzari F, Abdallah D, El Abhar H. Chenodeoxycholic Acid Ameliorates AlCl3-Induced Alzheimer's Disease Neurotoxicity and Cognitive Deterioration via Enhanced Insulin Signaling in Rats. Molecules. 2019;24: pubmed publisher
immunocytochemistry; human; loading ...; fig 6a	Hui L, Soliman M, Geiger N, Miller N, Afghah Z, Lakpa K, et al. Acidifying Endolysosomes Prevented Low-Density Lipoprotein-Induced Amyloidogenesis. J Alzheimers Dis. 2019;67:393-410 pubmed publisher
	Chen P, Guo Z, Lei J, Wang Y. Pomegranate polyphenol punicalin ameliorates lipopolysaccharide-induced memory impairment, behavioral disorders, oxidative stress, and neuroinflammation via inhibition of TLR4-NF-кB pathway. Phytother Res. 2024;38:3489-3508 pubmed publisher
	Dursun E, Gezen Ak D. Vitamin D receptor is present on the neuronal plasma membrane and is co-localized with amyloid precursor protein, ADAM10 or Nicastrin. PLoS ONE. 2017;12:e0188605 pubmed publisher

product information

Product Type :

Antibody

Product Name :

BACE1 Monoclonal Antibody (3C1C3)

Catalog # :

MA1-177

Quantity :

100 ug

Price :

US 491.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Canine, Human, Mouse, Non-human primate, Rat

Applications :

Immunocytochemistry: 1:100, Western Blot: 1:1,000-1:2,000

Species :

Canine, Human, Mouse, Non-human primate, Rat

Clone :

3C1C3

Isotype :

IgG1

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

BACE1 (beta-secretase) is a key enzyme involved in the production of amyloid beta-peptides (Abeta) found in extracellular amyloid plaques of Alzheimer's disease (AD). In some cases early onset familial AD can be attributed to a Swedish mutation in the amyloid precursor protein (APP), which dramatically enhances the cleavage of this protein by BACE1. This and other genetic and pathological evidence has led to therapeutic approaches that have focused on the inhibition of BACE1 and other APP-cleaving enzymes, such as gamma-secretase stuff. APP is first cleaved by b-secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for g-secretase to generate the 4 kDa amyloid-b peptide, which is deposited in the brains of all sufferers of Alzheimer's disease. The long-sought b-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2). bACE/Asp2 is a novel transmembrane aspartic protease and colocalizes with APP.

Immunogen :

Purified recombinant fragment of Human BACE1 (AA: 112-324) expressed in E. Coli

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:100, Western Blot: 1:1,000-1:2,000

Aliases :

APP beta-secretase; asp 2; ASP2; Aspartyl protease 2; BACE; BACE 1; BACE1; BACE-1D; BACE-I-432; Beta secretase; Beta-secretase 1; beta-secretase 1 precursor variant 1; beta-site amyloid beta A4 precursor protein-cleaving enzyme; beta-site amyloid precursor protein cleaving enzyme 1; Beta-site APP cleaving enzyme 1; beta-site APP-cleaving enzyme 1; C76936; HSPC104; hypothetical protein LOC403005; KIAA1149; Memapsin; Memapsin2; Memapsin-2; membrane-associated aspartic protease 2; protease; transmembrane aspartic proteinase Asp2; zgc:77409

more info or order :

Invitrogen product webpage