DIABLO Monoclonal Antibody (78-1-118) | Invitrogen MA1-16846 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

DIABLO Monoclonal Antibody (78-1-118)

catalog :

MA1-16846

quantity :

200 uL

price :

US 592.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

78-1-118

The same clone is also sold as:

Novus Biologicals: NB500-213
OriGene: TA309625

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry, immunoprecipitation

product information

Product Type :

Antibody

Product Name :

DIABLO Monoclonal Antibody (78-1-118)

Catalog # :

MA1-16846

Quantity :

200 uL

Price :

US 592.00

Clonality :

Monoclonal

Host :

Mouse

Reactivity :

Human, Mouse, Rat

Applications :

Immunocytochemistry: 5 ug/mL, Immunoprecipitation: 1:10-1:500, Western Blot: 1:500

Species :

Human, Mouse, Rat

Clone :

78-1-118

Isotype :

IgG1/IgG3

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

DIABLO (smac), a mitochondrial protein, activates various forms of apoptosis. This activation may be due to the neutralization of one or more members of the IAP family of apoptosis inhibitory proteins. Smac exits the mitochondria and enter the cytosol during certain apoptosis triggered events. Mitochondrial-mediated apoptosis is important in animal development and tissue homeostasis, with alterations resulting in a range of malignant disorders. Upon apoptotic stimuli, the mitochondrial proteins cytochrome c and Smac/DIABLO are released into the cytosol. The release of these proteins, however, occurs via different mechanisms. Smac/DIABLO has also been found to play a key role in regulating the sensitization of cancer cells to apoptosis (both immune and drug-induced).

Immunogen :

Recombinant mature human Smac/DIABLO (lacks amino acids 1-55 present in Smac/DIABLO precursor)

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 5 ug/mL, Immunoprecipitation: 1:10-1:500, Western Blot: 1:500

Aliases :

0610041G12Rik; 1700006L01Rik; AU040403; DFNA64; DIABLO; diablo homolog (Drosophila); diablo homolog, mitochondrial; diablo IAP-binding mitochondrial protein; diablo, IAP-binding mitochondrial protein; diablo-like protein; DIABLO-S; direct IAP binding protein with low PI; direct IAP-binding protein with low pI; FLJ10537; FLJ25049; hCG_1782202; Second mitochondria-derived activator of caspase; Smac; Smac protein; SMAC3