Caspase 3 Monoclonal Antibody (CPP32 4-1-18) | Invitrogen MA1-16843 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Caspase 3 Monoclonal Antibody (CPP32 4-1-18)

catalog :

MA1-16843

quantity :

200 µL

price :

US 496.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

CPP32 4-1-18

reactivity :

bees , human, mouse, rat, domestic rabbit

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 16

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; rat; 1:500; loading ...; fig 4a	Fodor R, Georgescu A, Grigorescu B, Cioc A, Veres M, Cotoi O, et al. Caspase 3 expression and plasma level of Fas ligand as apoptosis biomarkers in inflammatory endotoxemic lung injury. Rom J Morphol Embryol. 2016;57:951-957 pubmed
immunohistochemistry - paraffin section; rat; 1:500; loading ...; fig 3g	Nooh H, Nour Eldien N. The dual anti-inflammatory and antioxidant activities of natural honey promote cell proliferation and neural regeneration in a rat model of colitis. Acta Histochem. 2016;118:588-595 pubmed publisher
western blot; human; 1:250; fig 2	Soto Nuñez M, Díaz Morales K, Cuautle Rodríguez P, Torres Flores V, Lopez Gonzalez J, Mandoki Weitzner J, et al. Single-cell microinjection assay indicates that 7-hydroxycoumarin induces rapid activation of caspase-3 in A549 cancer cells. Exp Ther Med. 2015;10:1789-1795 pubmed
immunohistochemistry - paraffin section; bees	Higes M, Juarranz A, Dias Almeida J, Lucena S, Botías C, Meana A, et al. Apoptosis in the pathogenesis of Nosema ceranae (Microsporidia: Nosematidae) in honey bees (Apis mellifera). Environ Microbiol Rep. 2013;5:530-6 pubmed publisher
immunohistochemistry; mouse; 1:50	Gezginci Oktayoglu S, Sacan O, Yanardag R, Karatug A, Bolkent S. Exendin-4 improves hepatocyte injury by decreasing proliferation through blocking NGF/TrkA in diabetic mice. Peptides. 2011;32:223-31 pubmed publisher
immunohistochemistry; rat; 1:100	Tunçdemir M, Demirkesen O, Ozturk M, Atukeren P, Gumustas M, Turan T. Antiapoptotic effect of angiotensin-II type-1 receptor blockade in renal tubular cells of hyperoxaluric rats. Urol Res. 2010;38:71-80 pubmed publisher
immunohistochemistry; domestic rabbit; 1:100	Mor F, Ozmen O. Effect of vitamin C in reducing the toxicity of endosulfan in liver in rabbits. Exp Toxicol Pathol. 2010;62:75-80 pubmed publisher
immunohistochemistry; human	Chu P, Jung S, Yeh C, Wu H, Shiu T, She H, et al. Expression of caspase-3-dependent apoptosis in mural thrombi leukocytes. APMIS. 2008;116:995-9 pubmed publisher
western blot; mouse; 1:50	Gezginci Oktayoglu S, Tunali S, Yanardag R, Bolkent S. Effects of Z-FA.FMK on D-galactosamine/tumor necrosis factor-alpha-induced kidney injury and oxidative stress in mice : effects of Z-FA.FMK on TNF-alpha-mediated kidney injury. Mol Cell Biochem. 2008;309:9-20 pubmed
immunohistochemistry; rat; fig 5	Damron T, Horton J, Naqvi A, Margulies B, Strauss J, Grant W, et al. Decreased proliferation precedes growth factor changes after physeal irradiation. Clin Orthop Relat Res. 2004;:233-42 pubmed
	Ye Y, Chang Z, Wang P, Wang Y, Liang J, Chen C, et al. Infarct-preconditioning exosomes of umbilical cord mesenchymal stem cells promoted vascular remodeling and neurological recovery after stroke in rats. Stem Cell Res Ther. 2022;13:378 pubmed publisher
	Long X, Wu H, Zhou Y, Wan Y, Kan X, Gong J, et al. Preventive Effect of Limosilactobacillus fermentum SCHY34 on Lead Acetate-Induced Neurological Damage in SD Rats. Front Nutr. 2022;9:852012 pubmed publisher
	Abo Elsoud R, Ahmed Mohamed Abdelaziz S, Attia Abd Eldaim M, Hazzaa S. Moringa oleifera alcoholic extract protected stomach from bisphenol A-induced gastric ulcer in rats via its anti-oxidant and anti-inflammatory activities. Environ Sci Pollut Res Int. 2022;29:68830-68841 pubmed publisher
	Xie S, Zhao C, Chen W, Li G, Xiong Z, Tang X, et al. Recombinant human bone morphogenetic protein 2 and 7 inhibit the degeneration of intervertebral discs by blocking the Puma-dependent apoptotic signaling. Int J Biol Sci. 2021;17:2367-2379 pubmed publisher
	Bellone M, Muñoz Camero C, Chini M, Dal Piaz F, Hernandez V, Bifulco G, et al. Limonoids from Guarea guidonia and Cedrela odorata: Heat Shock Protein 90 (Hsp90) Modulator Properties of Chisomicine D. J Nat Prod. 2021;84:724-737 pubmed publisher
	Malcok U, Aras A, Şehitoğlu M, Akman T, Yüksel Y. Therapeutic effects of syringaldehyde on spinal cord ischemia in rabbits. Saudi Med J. 2020;41:341-350 pubmed publisher

image

image 1 :

Western blot detection of Caspase (19 and 35 kDa) from HEK293 cell extract using MA1-16843. Lanes 1 and 2 contain inactive and active Caspase, respectively.

product information

Product Type :

Antibody

Product Name :

Caspase 3 Monoclonal Antibody (CPP32 4-1-18)

Catalog # :

MA1-16843

Quantity :

200 µL

Price :

US 496.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human, Mouse, Rat

Applications :

Immunocytochemistry: 2 µg/mL, Immunohistochemistry (Frozen): Assay-Dependent, Immunohistochemistry (Paraffin): 1:10-1:500, Immunoprecipitation: 2 µg/ mg lysate, Western Blot: 1:500-1:1,000

Species :

Human, Mouse, Rat

Clone :

CPP32 4-1-18

Isotype :

IgG2a, kappa

Storage :

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Description :

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.

Immunogen :

Full-length recombinant human Caspase 3 protein

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 2 µg/mL, Immunohistochemistry (Frozen): Assay-Dependent, Immunohistochemistry (Paraffin): 1:10-1:500, Immunoprecipitation: 2 µg/ mg lysate, Western Blot: 1:500-1:1,000

Aliases :

A830040C14Rik; AC-3; Apopain; Apopain precursor; Casp3; CASP-3; caspase 3; Caspase 3 apoptosis related cysteine protease (ICE-like cysteine protease); caspase 3, apoptosis related cysteine protease; Caspase 3, apoptosis related cysteine protease (ICE-like cysteine protease); caspase 3, apoptosis-related cysteine peptidase; caspase 3, apoptosis-related cysteine protease; Caspase3; caspase-3; Caspase-3 subunit p12; Caspase-3 subunit p17; Caspase-3-like protein; CC3; Cpp32; CPP-32; CPP32B; CPP32beta; cysteine protease CPP32; cysteine protease; CPP32; apopain; ICE3; IRP; LICE; mldy; PARP cleavage protease; procaspase3; protein Yama; SCA-1; SREBP cleavage activity 1; Yama; yama protein

more info or order :

Invitrogen product webpage