Troponin I Monoclonal Antibody (12F10) | Invitrogen MA1-16706 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Troponin I Monoclonal Antibody (12F10)

catalog :

MA1-16706

quantity :

100 µg

price :

US 375.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

12F10

reactivity :

human

application :

western blot, ELISA

citations: 2

Reference
Martinez Valbuena I, Valenti Azcarate R, Amat Villegas I, Marcilla I, Martí Andrés G, Caballero M, et al. Mixed pathologies in pancreatic β cells from subjects with neurodegenerative diseases and their interaction with prion protein. Acta Neuropathol Commun. 2021;9:64 pubmed publisher
Loo T, Ye X, Chai R, Ito M, Bonne G, Ferguson Smith A, et al. The mammalian LINC complex component SUN1 regulates muscle regeneration by modulating drosha activity. elife. 2019;8: pubmed publisher

product information

Product Type :

Antibody

Product Name :

Troponin I Monoclonal Antibody (12F10)

Catalog # :

MA1-16706

Quantity :

100 µg

Price :

US 375.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human

Applications :

ELISA: 1:100-1:2,000, Western Blot: 1:100-1:2,000

Species :

Human

Clone :

12F10

Isotype :

IgG2b

Storage :

4° C, do not freeze

Description :

Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes.

Immunogen :

Full length native protein (purified) (Human).

Format :

Liquid

Applications w/Dilutions :

ELISA: 1:100-1:2,000, Western Blot: 1:100-1:2,000

Aliases :

2700018B22Rik; AI747285; Cardiac troponin I; cardiomyopathy, dilated 2A (autosomal recessive); CMD1FF; CMD2A; CMH7; cTNI; DKFZp451O223; RCM1; slow skeletal troponin I isoform; ssTnI; Tn1; TnI; TNN1; TNNC1; TNNI1; TNNI3; Tpn1; troponin 1, type 3; troponin I type 1 (skeletal, slow); troponin I type 3 (cardiac); troponin I, cardiac 3; troponin I, cardiac muscle; troponin I, skeletal, slow; troponin I, skeletal, slow 1; Troponin I, slow isoform; troponin I, slow skeletal; troponin I, slow skeletal muscle; Troponin I, slow-twitch isoform; troponin I1, slow skeletal type; troponin I3, cardiac type