This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
p19ARF Monoclonal Antibody (5-C3-1)
catalog :
MA1-16665
quantity :
100 uL
price :
US 480.00
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
5-C3-1

The same clone is also sold as:
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
citations: 1
Reference
Takeuchi A, Asano N, Imatani A, Saito M, Jin X, Saito M, et al. Suppressed Cellular Senescence Mediated by T-box3 in Aged Gastric Epithelial Cells may Contribute to Aging-related Carcinogenesis. Cancer Res Commun. 2022;2:772-783 pubmed publisher
product information
Product Type :
Antibody
Product Name :
p19ARF Monoclonal Antibody (5-C3-1)
Catalog # :
MA1-16665
Quantity :
100 uL
Price :
US 480.00
Clonality :
Monoclonal
Purity :
protein A
Host :
Rat
Reactivity :
Human, Mouse, Rat
Applications :
Flow Cytometry: 1 ug/mL, Immunocytochemistry: 1:500-1:1,000, Immunohistochemistry (Frozen): 5 ug/mL, Immunohistochemistry (Paraffin): 5 u/gmL, Immunoprecipitation: 1:10-1:500, Western Blot: 1:500-1:1,000
Species :
Human, Mouse, Rat
Clone :
5-C3-1
Isotype :
IgG2b
Storage :
Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.
Description :
In humans, the multiple tumor suppressor 1 locus (MTS1) encodes two unrelated genes, p16INK4a and p19ARF. Although both act as cell proliferation inhibitors, their mechanisms of action are different. p19ARF works as part of a p53-dependent pathway to counter uncontrolled proliferation and oncogenic signals. Mice lacking the p19ARF gene rapidly develop a broad spectrum of tumors. This result indicates that p19ARF is an important tumor suppressor. In addition, p19ARF helps prevent transforming signals from various onocoproteins via the p53 regulatory loop. These studies and others display the importance of p19ARF in cell cycle control and tumor suppression.
Immunogen :
Synthetic peptide containing amino acids 54-75 of the murine p19ARF.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1 ug/mL, Immunocytochemistry: 1:500-1:1,000, Immunohistochemistry (Frozen): 5 ug/mL, Immunohistochemistry (Paraffin): 5 u/gmL, Immunoprecipitation: 1:10-1:500, Western Blot: 1:500-1:1,000
Aliases :
Alternative reading frame; Arf; ARF-INK4a; CDK4 inhibitor p16-INK4; CDK4I; CDKN2; CDKN2A; cdkn2a {ECO:0000312; cell cycle inhibitor; cell cycle negative regulator beta; cell cycle regulator; CMM2; cyclin dependent kinase inhibitor 2A; Cyclin dependent kinase inhibitor 2A (p16, inhibits CDK4); cyclin-dependent kinase 4 inhibitor A; Cyclin-dependent kinase inhibitor 2A; cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4); cyclin-dependent kinase inhibitor 2A (p16, inhibits CDK4); cyclin-dependent kinase inhibitor 2a p16Ink4a; cyclin-dependent kinase inhibitor 2a p19Arf; cyclin-dependent kinase inhibitor 2A, isoform 1; cyclin-dependent kinase inhibitor 2A, isoform 2; cyclin-dependent kinase inhibitor 2A, isoform 3; cyclin-dependent kinase inhibitor 2A, isoforms 1/2; cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3-like; cyclin-dependent kinase inhibitor protein; EMBL:AAL76336.1, ECO:0000312; EMBL:AAL76338.1, ECO:0000312; INK4; INK4A; Ink4a/Arf; INK4a-ARF; LOC100764983; mitochondrial smARF; MLM; MTS1; MTS-1; Multiple tumor suppressor 1; P14; P14ARF; p16; p16(INK4a); p16Cdkn2a; P16INK4; p16-INK4; P16INK4A; p16-INK4a; P19; p19 ; p19ARF; Pctr1; RGD:2323}; TP16; Tumor suppressor ARF
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA