This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
c-Myc Monoclonal Antibody (9E11)
catalog :
MA1-16637
quantity :
100 uL
price :
US 469.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
9.00E+11

The same clone is also sold as:
reactivity :
human, mouse, rat, chicken
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, chromatin immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
citations: 31
Reference
Song Y, Hou G, Diep J, Ooi Y, Akopyants N, Beverley S, et al. Inhibitor of growth protein 3 epigenetically silences endogenous retroviral elements and prevents innate immune activation. Nucleic Acids Res. 2021;49:12706-12715 pubmed publisher
Ghiselli F, Rossi B, Felici M, Parigi M, Tosi G, Fiorentini L, et al. Isolation, culture, and characterization of chicken intestinal epithelial cells. BMC Mol Cell Biol. 2021;22:12 pubmed publisher
Yao Y, Yu D, Xu L, Gu T, Li Y, Zheng X, et al. Tupaia OASL1 Promotes Cellular Antiviral Immune Responses by Recruiting MDA5 to MAVS. J Immunol. 2020;205:3419-3428 pubmed publisher
Xu L, Yu D, Fan Y, Peng L, Wu Y, Yao Y. Loss of RIG-I leads to a functional replacement with MDA5 in the Chinese tree shrew. Proc Natl Acad Sci U S A. 2016;113:10950-5 pubmed publisher
Yokdang N, Hatakeyama J, Wald J, Simion C, Tellez J, Chang D, et al. LRIG1 opposes epithelial-to-mesenchymal transition and inhibits invasion of basal-like breast cancer cells. Oncogene. 2016;35:2932-47 pubmed publisher
Yeheskely Hayon D, Kotler A, Stark M, Hashimshony T, Sagee S, Kassir Y. The roles of the catalytic and noncatalytic activities of Rpd3L and Rpd3S in the regulation of gene transcription in yeast. PLoS ONE. 2013;8:e85088 pubmed publisher
Du W, Josephrajan A, Adhikary S, Bowles T, Bielinsky A, Eichman B. Mcm10 self-association is mediated by an N-terminal coiled-coil domain. PLoS ONE. 2013;8:e70518 pubmed publisher
Inoue M, Yasuda K, Uemura H, Yasaka N, Schnaufer A, Yano M, et al. Trypanosoma brucei 14-3-3I and II proteins predominantly form a heterodimer structure that acts as a potent cell cycle regulator in vivo. J Biochem. 2013;153:431-9 pubmed publisher
Milliman E, Hu Z, Yu M. Genomic insights of protein arginine methyltransferase Hmt1 binding reveals novel regulatory functions. BMC Genomics. 2012;13:728 pubmed publisher
Cattoretti G. MYC expression and distribution in normal mature lymphoid cells. J Pathol. 2013;229:430-40 pubmed publisher
Milliman E, Yadav N, Chen Y, Muddukrishna B, Karunanithi S, Yu M. Recruitment of Rpd3 to the telomere depends on the protein arginine methyltransferase Hmt1. PLoS ONE. 2012;7:e44656 pubmed publisher
Kulemzina I, Schumacher M, Verma V, Reiter J, Metzler J, Failla A, et al. Cohesin rings devoid of Scc3 and Pds5 maintain their stable association with the DNA. PLoS Genet. 2012;8:e1002856 pubmed publisher
Kanke M, Kodama Y, Takahashi T, Nakagawa T, Masukata H. Mcm10 plays an essential role in origin DNA unwinding after loading of the CMG components. EMBO J. 2012;31:2182-94 pubmed publisher
Casolari J, Thompson M, Salzman J, Champion L, Moerner W, Brown P. Widespread mRNA association with cytoskeletal motor proteins and identification and dynamics of myosin-associated mRNAs in S. cerevisiae. PLoS ONE. 2012;7:e31912 pubmed publisher
Li M, Shandilya S, Carpenter M, Rathore A, Brown W, Perkins A, et al. First-in-class small molecule inhibitors of the single-strand DNA cytosine deaminase APOBEC3G. ACS Chem Biol. 2012;7:506-17 pubmed publisher
Sarkar T, Sharan S, Wang J, Pawar S, Cantwell C, Johnson P, et al. Identification of a Src tyrosine kinase/SIAH2 E3 ubiquitin ligase pathway that regulates C/EBPδ expression and contributes to transformation of breast tumor cells. Mol Cell Biol. 2012;32:320-32 pubmed publisher
Fukuura M, Nagao K, Obuse C, Takahashi T, Nakagawa T, Masukata H. CDK promotes interactions of Sld3 and Drc1 with Cut5 for initiation of DNA replication in fission yeast. Mol Biol Cell. 2011;22:2620-33 pubmed publisher
Kanke M, Nishimura K, Kanemaki M, Kakimoto T, Takahashi T, Nakagawa T, et al. Auxin-inducible protein depletion system in fission yeast. BMC Cell Biol. 2011;12:8 pubmed publisher
Weider M, Schroder A, Klebl F, Sauer N. A novel mechanism for target gene-specific SWI/SNF recruitment via the Snf2p N-terminus. Nucleic Acids Res. 2011;39:4088-98 pubmed publisher
Demorest Z, MacDuff D, Brown W, Morham S, Parise L, Harris R. The interaction between AID and CIB1 is nonessential for antibody gene diversification by gene conversion or class switch recombination. PLoS ONE. 2010;5:e11660 pubmed publisher
Das Bradoo S, Nguyen H, Wood J, Ricke R, Haworth J, Bielinsky A. Defects in DNA ligase I trigger PCNA ubiquitylation at Lys 107. Nat Cell Biol. 2010;12:74-9; sup pp 1-20 pubmed publisher
Sollier J, Driscoll R, Castellucci F, Foiani M, Jackson S, Branzei D. The Saccharomyces cerevisiae Esc2 and Smc5-6 proteins promote sister chromatid junction-mediated intra-S repair. Mol Biol Cell. 2009;20:1671-82 pubmed publisher
Warren E, Vaithiyalingam S, Haworth J, Greer B, Bielinsky A, Chazin W, et al. Structural basis for DNA binding by replication initiator Mcm10. Structure. 2008;16:1892-901 pubmed publisher
Kitagawa M. A Sveinsson's chorioretinal atrophy-associated missense mutation in mouse Tead1 affects its interaction with the co-factors YAP and TAZ. Biochem Biophys Res Commun. 2007;361:1022-6 pubmed
Ricke R, Bielinsky A. A conserved Hsp10-like domain in Mcm10 is required to stabilize the catalytic subunit of DNA polymerase-alpha in budding yeast. J Biol Chem. 2006;281:18414-25 pubmed
Yan H, Yang W, Zhang R, Chen L, Tang L, Zhai B, et al. Protein-tyrosine phosphatase PCP-2 inhibits beta-catenin signaling and increases E-cadherin-dependent cell adhesion. J Biol Chem. 2006;281:15423-33 pubmed
Ricke R, Bielinsky A. Mcm10 regulates the stability and chromatin association of DNA polymerase-alpha. Mol Cell. 2004;16:173-85 pubmed
Tsuchida K, Nakatani M, Yamakawa N, Hashimoto O, Hasegawa Y, Sugino H. Activin isoforms signal through type I receptor serine/threonine kinase ALK7. Mol Cell Endocrinol. 2004;220:59-65 pubmed
Casolari J, Brown C, Komili S, West J, Hieronymus H, Silver P. Genome-wide localization of the nuclear transport machinery couples transcriptional status and nuclear organization. Cell. 2004;117:427-39 pubmed
Hwang C, Su C, Huang S, Huang C, Fang F, Lui C, et al. Low expression levels of p27 correlate with loco-regional recurrence in nasopharyngeal carcinoma. Cancer Lett. 2003;189:231-6 pubmed
Kimura A, Umehara T, Horikoshi M. Chromosomal gradient of histone acetylation established by Sas2p and Sir2p functions as a shield against gene silencing. Nat Genet. 2002;32:370-7 pubmed
product information
Product Type :
Antibody
Product Name :
c-Myc Monoclonal Antibody (9E11)
Catalog # :
MA1-16637
Quantity :
100 uL
Price :
US 469.00
Clonality :
Monoclonal
Purity :
Protein A/G
Host :
Mouse
Reactivity :
Chicken, Human, Mouse, Rat, Yeast
Applications :
ChIP Assay: 2 ug/500 ug extract, ELISA: 1:100-1:2,000, Flow Cytometry: 1:200-1:400, Immunocytochemistry: Assay-Dependent, Immunohistochemistry (Frozen): 1:100, Immunohistochemistry (Paraffin): 1:100, Immunoprecipitation: 2 ug/mg lysate, Western Blot: 1:500-1:1,000
Species :
Chicken, Human, Mouse, Rat, Yeast
Clone :
9.00E+11
Isotype :
IgG2a, kappa
Storage :
Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.
Description :
The c-Myc protein is a 62 kDa transcription factor that is encoded by the c-Myc gene on human chromosome 8q24. c-Myc is commonly activated in a variety of tumor cells and plays an important role in cellular proliferation, differentiation, apoptosis and cell cycle progression. The phosphorylation of c-Myc has been investigated and previous studies have suggested a functional association between phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin dependent kinase, ERK2 and C-Jun N terminal Kinase (JNK) in cell proliferation and cell cycle regulation. Studies have shown that c-Myc is essential for vasculogenesis and angiogenesis in tumor development, which distributes blood throughout the cells. The c-myc oncogene (p62 c-myc) is involved in the control of normal cellular proliferation and differentiation, and the deregulated expression of c-Myc induces apoptosis in different cell types. Antibodies against c-myc epitopes recognize overexpressed proteins containing Myc epitope tag fused to either amino- or carboxy-termini of targeted proteins. c-Myc-, N-Myc- and L-Myc-encoded proteins function in cell proliferation, differentiation and neoplastic disease. Amplification of the c-Myc gene has been found in several types of human tumors including lung, breast and colon carcinomas, while the N-Myc gene has been found amplified in neuroblastomas. Translocation of the c-myc locus on chromosome 8 to the immunoglobulin loci on chromosome 14 (heavy chain); 2 (delta light chain); or 22 (light chain) is described in Burkitts lymphoma and other B-cell lymphoproliferative conditions. An aberrant expression of the c-myc gene occurs in tumors of different origins such as colorectal, gastric, gallbladder, hepatic, mammary, ovarian, endometrial, head and neck, pulmonary, prostatic, thyroidal, oral, ocular, nasopharyngeal, endocrine, as well as hematopoietic neoplasms.
Immunogen :
Synthetic peptide, conjugated to KLH, corresponding to residues A(408) E E Q K L I S E E D L(420) of human c-Myc.
Format :
Liquid
Applications w/Dilutions :
ChIP Assay: 2 ug/500 ug extract, ELISA: 1:100-1:2,000, Flow Cytometry: 1:200-1:400, Immunocytochemistry: Assay-Dependent, Immunohistochemistry (Frozen): 1:100, Immunohistochemistry (Paraffin): 1:100, Immunoprecipitation: 2 ug/mg lysate, Western Blot: 1:500-1:1,000
Aliases :
AU016757; Avian myelocytomatosis viral (v-myc) oncogene homolog; avian myelocytomatosis viral oncogene homolog; bHLHe39; c Myc; class E basic helix-loop-helix protein 39; cmyc; c-Myc; c-myc epitope tag; c-myc proto-oncogene; mMyc; MRTL; Myc; Myc protein; Myc proto-oncogene protein; MYC proto-oncogene, bHLH transcription factor; Myc2; MYCC; myc-related translation/localization regulatory factor; myelocytomatosis oncogene; myelocytomatosis viral oncogene homolog; Niard; Nird; Proto-oncogene c-Myc; RNCMYC; Transcription factor p64; v-myc avian myelocytomatosis viral oncogene homolog; v-myc myelocytomatosis viral oncogene homolog; v-myc myelocytomatosis viral oncogene-like protein
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA