product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
VEGF Monoclonal Antibody (VG1)
catalog :
MA1-16629
quantity :
100 µg
price :
US 450.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
VG1
reactivity :
human, mouse, rat, dogs, pigs , domestic rabbit
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, western blot knockout validation
more info or order :
Invitrogen product webpage
citations: 78
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; human; loading ...; fig 2a
  • immunohistochemistry; human; 1:200; loading ...; fig 9a
Attaai A, Noreldin A, Abdel Maksoud F, Hussein M. An updated investigation on the dromedary camel cerebellum (Camelus dromedarius) with special insight into the distribution of calcium-binding proteins. Sci Rep. 2020;10:21157 pubmed publisher
  • western blot; human; 1:200; loading ...; fig 5a
Loureiro J, Raimundo L, Calheiros J, Carvalho C, Barcherini V, Lima N, et al. Targeting p53 for Melanoma Treatment: Counteracting Tumour Proliferation, Dissemination and Therapeutic Resistance. Cancers (Basel). 2021;13: pubmed publisher
  • immunocytochemistry; mouse; fig 3
Wang Y, Tadjuidje E, Pandey R, Stefater J, Smith L, Lang R, et al. The Eyes Absent Proteins in Developmental and Pathological Angiogenesis. Am J Pathol. 2016;186:568-78 pubmed publisher
  • western blot; rat; 1:200
de Monès E, Schlaubitz S, Oliveira H, d Elbée J, Bareille R, Bourget C, et al. Comparative study of membranes induced by PMMA or silicone in rats, and influence of external radiotherapy. Acta Biomater. 2015;19:119-27 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:50
Gurzu S, Kádár Z, Sugimura H, Bara T, Hălmaciu I, Jung I. Gastric cancer in young vs old Romanian patients: immunoprofile with emphasis on maspin and mena protein reactivity. APMIS. 2015;123:223-33 pubmed publisher
  • immunohistochemistry; human; 1:50
Lattanzio R, La Sorda R, Facciolo F, Sioletic S, Lauriola L, Martucci R, et al. Thymic epithelial tumors express vascular endothelial growth factors and their receptors as potential targets of antiangiogenic therapy: a tissue micro array-based multicenter study. Lung Cancer. 2014;85:191-6 pubmed publisher
  • western blot; mouse
Zhang Q, Zhang Z. Oxygen-induced retinopathy in mice with retinal photoreceptor cell degeneration. Life Sci. 2014;102:28-35 pubmed publisher
  • immunohistochemistry; human; 1:100
Abdelzaher E, El Deeb N, Gowil A, Yehya A. Biological and demographic profile of meningiomas in a cohort of Egyptian patients: impact on tumor recurrence. ScientificWorldJournal. 2013;2013:375139 pubmed publisher
  • immunohistochemistry; human
Tamaki M, Kamio T, Kameoka S, Kojimahara N, Nishikawa T. The relevance of the intrinsic subtype to the clinicopathological features and biomarkers in Japanese breast cancer patients. World J Surg Oncol. 2013;11:293 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200; tbl 2
Qiu S, Wei X, Huang W, Wu M, Qin Y, Li Y, et al. Diagnostic and therapeutic strategy and the most efficient prognostic factors of breast malignant fibrous histiocytoma. Sci Rep. 2013;3:2529 pubmed publisher
  • immunohistochemistry; human; 1:25
Gurzu S, Ciortea D, Munteanu T, Kezdi Zaharia I, Jung I. Mesenchymal-to-endothelial transition in Kaposi sarcoma: a histogenetic hypothesis based on a case series and literature review. PLoS ONE. 2013;8:e71530 pubmed publisher
  • immunohistochemistry; domestic rabbit
Karimian E, Tamm C, Chagin A, Samuelsson K, Kjartansdóttir K, Ohlsson C, et al. Resveratrol treatment delays growth plate fusion and improves bone growth in female rabbits. PLoS ONE. 2013;8:e67859 pubmed publisher
  • immunohistochemistry; human; 1:100
Feng C, Ding G, Song N, Li X, Wu Z, Jiang H, et al. Paraneoplastic hormones: parathyroid hormone-related protein (PTHrP) and erythropoietin (EPO) are related to vascular endothelial growth factor (VEGF) expression in clear cell renal cell carcinoma. Tumour Biol. 2013;34:3471-6 pubmed publisher
  • immunocytochemistry; human; 1:50
Radziwon Balicka A, Moncada de la Rosa C, Zielnik B, Doroszko A, Jurasz P. Temporal and pharmacological characterization of angiostatin release and generation by human platelets: implications for endothelial cell migration. PLoS ONE. 2013;8:e59281 pubmed publisher
  • western blot; mouse
Figueras A, Arbos M, Quiles M, Vinals F, Germà J, Capella G. The impact of KRAS mutations on VEGF-A production and tumour vascular network. BMC Cancer. 2013;13:125 pubmed publisher
  • immunohistochemistry; rat; 1:100
Micili S, Goker A, Sayin O, Akokay P, Ergur B. The effect of lipoic acid on wound healing in a full thickness uterine injury model in rats. J Mol Histol. 2013;44:339-45 pubmed publisher
  • immunohistochemistry; human
Melinte R, Jung I, Georgescu L, Gurzu S. VEGF and CD31 expression in arthritic synovium and cartilage of human knee joints. Rom J Morphol Embryol. 2012;53:911-5 pubmed
  • immunohistochemistry; human
Bohn O, de León E, Lezama O, Rios Luna N, Sanchez Sosa S, Llombart Bosch A. Pulmonary artery sarcoma with angiosarcoma phenotype mimicking pleomorphic malignant fibrous histiocytoma: a case report. Diagn Pathol. 2012;7:154 pubmed publisher
  • immunohistochemistry; rat
Ozer H, Boztosun A, Açmaz G, Atilgan R, Akkar O, Koşar M. The efficacy of bevacizumab, sorafenib, and retinoic acid on rat endometriosis model. Reprod Sci. 2013;20:26-32 pubmed publisher
  • immunohistochemistry; human
Kasai M, Ichimura T, Kawamura N, Sumikura T, Matsuda M, Asano C, et al. Prediction of the shrinking rate of uterine leiomyoma nodules using needle biopsy specimens. Fertil Steril. 2012;98:440-3 pubmed publisher
  • immunohistochemistry; human; 1:100
Ding G, Feng C, Song N, Fang Z, Xia G, Jiang H, et al. Paraneoplastic symptoms: cachexia, polycythemia, and hypercalcemia are, respectively, related to vascular endothelial growth factor (VEGF) expression in renal clear cell carcinoma. Urol Oncol. 2013;31:1820-5 pubmed publisher
  • immunohistochemistry; human; 1:20
Moshkin O, Rotondo F, Scheithauer B, Soares M, Coire C, Smyth H, et al. Bronchial carcinoid tumors metastatic to the sella turcica and review of the literature. Pituitary. 2012;15:160-5 pubmed publisher
  • immunocytochemistry; human
Nylander M, Osman A, Ramstrom S, Aklint E, Larsson A, Lindahl T. The role of thrombin receptors PAR1 and PAR4 for PAI-1 storage, synthesis and secretion by human platelets. Thromb Res. 2012;129:e51-8 pubmed publisher
  • immunohistochemistry; mouse; 1:200
Xu Z, Zhao F, Lin F, Chen J, Huang Y. Lipoxin A4 inhibits the development of endometriosis in mice: the role of anti-inflammation and anti-angiogenesis. Am J Reprod Immunol. 2012;67:491-7 pubmed publisher
  • western blot; mouse
Shukla S, MacLennan G, Fu P, Gupta S. Apigenin attenuates insulin-like growth factor-I signaling in an autochthonous mouse prostate cancer model. Pharm Res. 2012;29:1506-17 pubmed publisher
  • immunohistochemistry; rat; 1:100
Soyer T, Ayva S, Aliefendioglu D, Aktuna Z, Aslan M, Senyücel M, et al. Effect of phototherapy on growth factor levels in neonatal rat skin. J Pediatr Surg. 2011;46:2128-31 pubmed publisher
  • immunohistochemistry; human
Tolunay I, Tunaoglu S, Akyurek N, Halid V, Olgunturk R, Kula S. Serum and pulmonary vascular endothelial growth factor/receptors and haemodynamic measurements in cyanotic congenital heart disease with decreased pulmonary blood flow. Cardiol Young. 2011;21:608-15 pubmed publisher
  • immunohistochemistry; rat
Basbug M, Bulbuller N, Camci C, Ayten R, Aygen E, Ozercan I, et al. The effect of antivascular endothelial growth factor on the development of adhesion formation in laparotomized rats: experimental study. Gastroenterol Res Pract. 2011;2011:578691 pubmed publisher
  • immunohistochemistry; mouse; 1:100
Yadav V, Prasad S, Sung B, Gelovani J, Guha S, Krishnan S, et al. Boswellic acid inhibits growth and metastasis of human colorectal cancer in orthotopic mouse model by downregulating inflammatory, proliferative, invasive and angiogenic biomarkers. Int J Cancer. 2012;130:2176-84 pubmed publisher
  • immunohistochemistry; human; 1:50
Kafousi M, Vrekoussis T, Tsentelierou E, Pavlakis K, Navrozoglou I, Dousias V, et al. Immunohistochemical study of the angiogenetic network of VEGF, HIF1?, VEGFR-2 and endothelial nitric oxide synthase (eNOS) in human breast cancer. Pathol Oncol Res. 2012;18:33-41 pubmed publisher
  • immunohistochemistry; human
Karaca Z, Tanriverdi F, Unluhizarci K, Ozturk F, Gokahmetoglu S, Elbuken G, et al. VEGFR1 expression is related to lymph node metastasis and serum VEGF may be a marker of progression in the follow-up of patients with differentiated thyroid carcinoma. Eur J Endocrinol. 2011;164:277-84 pubmed publisher
  • immunohistochemistry; human
Azamfirei L, Gurzu S, Solomon R, Copotoiu R, Copotoiu S, Jung I, et al. Vascular endothelial growth factor: a possible mediator of endothelial activation in acute respiratory distress syndrome. Minerva Anestesiol. 2010;76:609-16 pubmed
  • immunocytochemistry; mouse
  • western blot; mouse
Long J, Wang Y, Wang W, Chang B, Danesh F. Identification of microRNA-93 as a novel regulator of vascular endothelial growth factor in hyperglycemic conditions. J Biol Chem. 2010;285:23457-65 pubmed publisher
  • immunohistochemistry; rat; 1:50
Saylan A, Arioz D, Koken T, Dilek H, Saylan F, Yilmazer M. Prevention of ovarian hyperstimulation syndrome in a rat model: efficacy comparison between cabergoline and meloxicam. Acta Obstet Gynecol Scand. 2010;89:692-9 pubmed publisher
  • western blot; mouse
Zhang H, Schin M, Saha J, Burke K, Holzman L, Filipiak W, et al. Podocyte-specific overexpression of GLUT1 surprisingly reduces mesangial matrix expansion in diabetic nephropathy in mice. Am J Physiol Renal Physiol. 2010;299:F91-8 pubmed publisher
  • immunohistochemistry; human; 1:100
Bircan A, Bircan S, Kapucuoglu N, Songur N, Ozturk O, Akkaya A. Maspin, VEGF and p53 expression in small biopsies of primary advanced lung cancer and relationship with clinicopathologic parameters. Pathol Oncol Res. 2010;16:553-61 pubmed publisher
  • immunohistochemistry; rat; 1:50
Pereira M, de Pinho C, Medrado A, Andrade Z, Reis S. Influence of 670 nm low-level laser therapy on mast cells and vascular response of cutaneous injuries. J Photochem Photobiol B. 2010;98:188-92 pubmed publisher
  • immunohistochemistry; human; 1:100
Sanci M, Dikis C, Inan S, Turkoz E, Dicle N, Ispahi C. Immunolocalization of VEGF, VEGF receptors, EGF-R and Ki-67 in leiomyoma, cellular leiomyoma and leiomyosarcoma. Acta Histochem. 2011;113:317-25 pubmed publisher
  • immunohistochemistry; human
Yang S. Bevacizumab and breast cancer: current therapeutic progress and future perspectives. Expert Rev Anticancer Ther. 2009;9:1715-25 pubmed publisher
  • immunohistochemistry; human
van der Loos C, Meijer Jorna L, Broekmans M, Ploegmakers H, Teeling P, de Boer O, et al. Anti-human vascular endothelial growth factor (VEGF) antibody selection for immunohistochemical staining of proliferating blood vessels. J Histochem Cytochem. 2010;58:109-18 pubmed publisher
  • immunohistochemistry; human; 1:200
Zhao R, Liu X, Wu X, Liu Y, Zhang Z, Yang G, et al. Vascular endothelial growth factor (VEGF) enhances gastric carcinoma invasiveness via integrin alpha(v)beta6. Cancer Lett. 2010;287:150-6 pubmed publisher
  • immunohistochemistry; human
Deniz H, Karakok M, Yagci F, Guldur M. Evaluation of relationship between HIF-1alpha immunoreactivity and stage, grade, angiogenic profile and proliferative index in bladder urothelial carcinomas. Int Urol Nephrol. 2010;42:103-7 pubmed publisher
  • immunohistochemistry; human; 1:50
Jung I, Gurzu S, Raica M, Cimpean A, Szentirmay Z. The differences between the endothelial area marked with CD31 and CD105 in colorectal carcinomas by computer-assisted morphometrical analysis. Rom J Morphol Embryol. 2009;50:239-43 pubmed
  • immunohistochemistry; human; 1:50
Carpenter P, Chen W, Mendez A, McLaren C, Su M. Angiogenesis in the progression of breast ductal proliferations. Int J Surg Pathol. 2011;19:335-41 pubmed publisher
  • immunohistochemistry - paraffin section; human; fig 1
Dawson M, Opat S, Taouk Y, Donovan M, Zammit M, Monaghan K, et al. Clinical and immunohistochemical features associated with a response to bortezomib in patients with multiple myeloma. Clin Cancer Res. 2009;15:714-22 pubmed publisher
  • immunohistochemistry; human; 1:100
Kim H, Kim W, Park S, Jung C, Choi H, Lee H, et al. Molecular biomarkers for advanced renal cell carcinoma: implications for prognosis and therapy. Urol Oncol. 2010;28:157-63 pubmed publisher
  • immunohistochemistry; human; 1:100
Schneider B, Wang M, Radovich M, Sledge G, Badve S, Thor A, et al. Association of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 genetic polymorphisms with outcome in a trial of paclitaxel compared with paclitaxel plus bevacizumab in advanced breast cancer: ECOG 2100. J Clin Oncol. 2008;26:4672-8 pubmed publisher
  • immunohistochemistry; human
Gurzu S, Jung I, Prantner I, Ember I, Pávai Z, Mezei T. The expression of cytoskeleton regulatory protein Mena in colorectal lesions. Rom J Morphol Embryol. 2008;49:345-9 pubmed
  • immunohistochemistry; human
Sarioglu S, Celik A, Ersen A, Uçer I, Saglam F, Camsari T, et al. Vascular endothelial growth factor expression and vascularity in renal allograft biopsies. Transplant Proc. 2008;40:178-80 pubmed publisher
  • immunohistochemistry; human; 1:250
Timotheadou E, Skarlos D, Samantas E, Papadopoulos S, Murray S, Skrickova J, et al. Evaluation of the prognostic role of a panel of biomarkers in stage IB-IIIA non-small cell lung cancer patients. Anticancer Res. 2007;27:4481-9 pubmed
  • immunohistochemistry; human; 1:300
Ozbudak I, Karaveli S, Simsek T, Erdogan G, Pestereli E. Neoangiogenesis and expression of hypoxia-inducible factor 1alpha, vascular endothelial growth factor, and glucose transporter-1 in endometrioid type endometrium adenocarcinomas. Gynecol Oncol. 2008;108:603-8 pubmed publisher
  • western blot; mouse
Cohen M, Hud E, Shea E, Shearman C. Vitreous fluid of db/db mice exhibits alterations in angiogenic and metabolic factors consistent with early diabetic retinopathy. Ophthalmic Res. 2008;40:5-9 pubmed
  • immunohistochemistry; human
Cabuk D, Basaran G, Celikel C, Dane F, Yumuk P, Iyikesici M, et al. Vascular endothelial growth factor, hypoxia-inducible factor 1 alpha and CD34 expressions in early-stage gastric tumors: relationship with pathological factors and prognostic impact on survival. Oncology. 2007;72:111-7 pubmed
  • immunohistochemistry; human; 1:25
Bangoura G, Liu Z, Qian Q, Jiang C, Yang G, Jing S. Prognostic significance of HIF-2alpha/EPAS1 expression in hepatocellular carcinoma. World J Gastroenterol. 2007;13:3176-82 pubmed
  • immunohistochemistry; rat
Yülek F, Or M, Ozogul C, Isik A, Ari N, Stefek M, et al. Effects of stobadine and vitamin E in diabetes-induced retinal abnormalities: involvement of oxidative stress. Arch Med Res. 2007;38:503-11 pubmed
  • immunohistochemistry; human; 1:250
Phuoc N, Ehara H, Gotoh T, Nakano M, Yokoi S, Deguchi T, et al. Immunohistochemical analysis with multiple antibodies in search of prognostic markers for clear cell renal cell carcinoma. Urology. 2007;69:843-8 pubmed
  • immunohistochemistry; human
Bolat F, Kayaselcuk F, Nursal T, Yagmurdur M, Bal N, Demirhan B. Microvessel density, VEGF expression, and tumor-associated macrophages in breast tumors: correlations with prognostic parameters. J Exp Clin Cancer Res. 2006;25:365-72 pubmed
  • immunohistochemistry; rat; 1:50
Canda A, Mungan M, Yilmaz O, Yorukoglu K, Tuzel E, Kirkali Z. Effects of finasteride on the vascular surface density, number of microvessels and vascular endothelial growth factor expression of the rat prostate. Int Urol Nephrol. 2006;38:275-80 pubmed
  • immunohistochemistry; human
Tzankov A, Heiss S, Ebner S, Sterlacci W, Schaefer G, Augustin F, et al. Angiogenesis in nodal B cell lymphomas: a high throughput study. J Clin Pathol. 2007;60:476-82 pubmed
  • western blot; human; 1:1000
Haider D, Bucek R, Giurgea A, Maurer G, Glogar H, Minar E, et al. PGE1 analog alprostadil induces VEGF and eNOS expression in endothelial cells. Am J Physiol Heart Circ Physiol. 2005;289:H2066-72 pubmed
Feng J, He W, Xia J, Huang Q, Yang J, Gu W, et al. Human umbilical cord mesenchymal stem cells-derived exosomal circDLGAP4 promotes angiogenesis after cerebral ischemia-reperfusion injury by regulating miR-320/KLF5 axis. FASEB J. 2023;37:e22733 pubmed publisher
Elsayed D, Helmy S, Dessouki A, El Nahla A, Abdelrazek H, El Hak H. Influence of genistein and diadizine on regularity of estrous cycle in cyclic female Wistar rat: interaction with estradiol receptors and vascular endothelial growth factor. Open Vet J. 2022;12:639-648 pubmed publisher
Mustafa F. Characterization of giant neuroendocrine cells in the pregnant New Zealand white rabbit vagina demonstrated by histological, histochemical, and immunohistochemical methods. Microsc Res Tech. 2022;85:3309-3315 pubmed publisher
Man A, Zhou Y, Lam U, Reifenberg G, Werner A, Habermeier A, et al. l-Citrulline ameliorates pathophysiology in a rat model of superimposed preeclampsia. Br J Pharmacol. 2022;179:3007-3023 pubmed publisher
Mustafa F, Abdelhafez E, Abd Elhafeez H. Characterization of the primo vascular system in rabbit vagina. Microsc Res Tech. 2022;85:799-806 pubmed publisher
Jiang W, Zhu P, Huang F, Zhao Z, Zhang T, An X, et al. The RNA Methyltransferase METTL3 Promotes Endothelial Progenitor Cell Angiogenesis in Mandibular Distraction Osteogenesis via the PI3K/AKT Pathway. Front Cell Dev Biol. 2021;9:720925 pubmed publisher
Santocildes G, Viscor G, Pag xe8 s T, Ramos Romero S, Torres J, Torrella J. Physiological Effects of Intermittent Passive Exposure to Hypobaric Hypoxia and Cold in Rats. Front Physiol. 2021;12:673095 pubmed publisher
Schoedel K, MILLER V, Osei Hwedieh D, Watters R, Duensing A, John I, et al. Differential expression of angiogenesis markers HSP70, HSP90, VEGF and pERK1/2 in both components of dedifferentiated chondrosarcomas. J Bone Oncol. 2021;29:100370 pubmed publisher
Zhang Q, Long J, Li N, Ma X, Zheng L. Circ_CLASP2 Regulates High Glucose-Induced Dysfunction of Human Endothelial Cells Through Targeting miR-140-5p/FBXW7 Axis. Front Pharmacol. 2021;12:594793 pubmed publisher
Wang Y, Pandey R, Roychoudhury K, Milewski D, Kalin T, Szabo S, et al. Targeting EYA3 in Ewing Sarcoma Retards Tumor Growth and Angiogenesis. Mol Cancer Ther. 2021;20:803-815 pubmed publisher
Shao Z, Lyu C, Teng L, Xie X, Sun J, Zou D, et al. An Injectable Fibrin Scaffold Rich in Growth Factors for Skin Repair. Biomed Res Int. 2021;2021:8094932 pubmed publisher
Jiang W, Zhu P, Zhang T, Liao F, Yu Y, Liu Y, et al. MicroRNA-205 mediates endothelial progenitor functions in distraction osteogenesis by targeting the transcription regulator NOTCH2. Stem Cell Res Ther. 2021;12:101 pubmed publisher
Elsayed D, Abdelrazek H, Eltamany D, Ebaid H, El Nahla A. Effect of soy isoflavones on implantation losses in Wistar rat: implication of progesterone receptors, vascular endothelial growth factor and estradiol receptors alpha. Iran J Vet Res. 2020;21:46-51 pubmed
Reddy S, Prabhakar Y, Kumar C, Reddy P, Reddy G. Effect of vitamin B12 supplementation on retinal lesions in diabetic rats. Mol Vis. 2020;26:311-325 pubmed
Rizo Roca D, Bonet J, Ínal B, Ríos Kristjánsson J, Pages T, Viscor G, et al. Contractile Activity Is Necessary to Trigger Intermittent Hypobaric Hypoxia-Induced Fiber Size and Vascular Adaptations in Skeletal Muscle. Front Physiol. 2018;9:481 pubmed publisher
Hua S, Dias T, Pepperall D, Yang Y. Topical Loperamide-Encapsulated Liposomal Gel Increases the Severity of Inflammation and Accelerates Disease Progression in the Adjuvant-Induced Model of Experimental Rheumatoid Arthritis. Front Pharmacol. 2017;8:503 pubmed publisher
Hafez N, Tahoun N. Expression of cyclooxygenase 2 and vascular endothelial growth factor in gastric carcinoma: Relationship with clinicopathological parameters. J Egypt Natl Canc Inst. 2016;28:149-56 pubmed publisher
Weber D, Tille J, Combescure C, Egger J, Laouiti M, Hammad K, et al. The prognostic value of expression of HIF1?, EGFR and VEGF-A, in localized prostate cancer for intermediate- and high-risk patients treated with radiation therapy with or without androgen deprivation therapy. Radiat Oncol. 2012;7:66 pubmed publisher
image
image 1 :
Invitrogen MA1-16629 image 1
Western blot analysis of VEGF in human kidney protein using MA1-16629.
product information
Product Type :
Antibody
Product Name :
VEGF Monoclonal Antibody (VG1)
Catalog # :
MA1-16629
Quantity :
100 µg
Price :
US 450.00
Clonality :
Monoclonal
Purity :
Protein G
Host :
Mouse
Reactivity :
Canine, Human, Mouse, Porcine, Rat
Applications :
ELISA: Assay-Dependent, Flow Cytometry: Assay-Dependent, Immunocytochemistry: 1:10-1:500, Immunohistochemistry (Frozen): 1:20-1:100, Immunohistochemistry (Paraffin): 1:20-1:100, Western Blot: 1-2 µg/mL
Species :
Canine, Human, Mouse, Porcine, Rat
Clone :
VG1
Isotype :
IgG1, kappa
Storage :
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Description :
VEGF (vascular endothelial growth factor) which is a 45 kDa homodimeric, disulfide-linked glycoprotein involved in angiogenesis which promotes tumor progression and metastasis. VEGF has a variety of effects on vascular endothelium, including the ability to promote endothelial cell viability, mitogenesis, chemotaxis, and vascular permeability. The VEGF family currently includes VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E, and PIGF. VEGF and its receptor system have been shown to be the fundamental regulators in the cell signaling of angiogenesis. Most tumors have the absolute requirement of angiogenesis, and VEGF has been described as the most potent angiogenic cytokine linked to this process. To date 5 different isoforms of VEGF have been described. These isoforms are generated as the result of alternative splicing from a single VEGF gene. These various isoforms have been shown to bind to two tyrosine-kinase receptors flt-1 (VEGFR-1) and flk-1/KDR (VEGFR-2), which have been found to be expressed almost exclusively on endothelial cells. VEGF and its high-affinity binding receptors, the tyrosine kinases FLK1 and FLT1, are thought to be important for the development of embryonic vasculature. Studies have shown that an alternately spliced form of FLT1 produces a soluble protein, termed sFLT1, which binds vascular endothelial growth factor with high affinity, playing an inhibitory role in angiogenesis. Elevated levels of VEGF is linked to POEMS syndrome (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammopathy, Skin changes) also known as Crow-Fukase syndrome which affects multiple organs in the body.
Immunogen :
Recombinant VEGF protein.
Format :
Liquid
Applications w/Dilutions :
ELISA: Assay-Dependent, Flow Cytometry: Assay-Dependent, Immunocytochemistry: 1:10-1:500, Immunohistochemistry (Frozen): 1:20-1:100, Immunohistochemistry (Paraffin): 1:20-1:100, Western Blot: 1-2 µg/mL
Aliases :
angiogenic factor; etID309976.16; eVEGF120; eVEGF164; human VEGF121 homolog; MGC70609; MVCD1; ovine vascular endothelial growth factor; RP1-261G23.1; unnamed protein product; VAS; vascular endothelial growth factor; vascular endothelial growth factor (VEGF) precursor; vascular endothelial growth factor 121 isoform; vascular endothelial growth factor 164; vascular endothelial growth factor 165b; vascular endothelial growth factor 182; vascular endothelial growth factor 182 isoform; vascular endothelial growth factor 188; vascular endothelial growth factor 188 isoform; vascular endothelial growth factor 189; vascular endothelial growth factor A; vascular endothelial growth factor A121; vascular endothelial growth factor A165; vascular endothelial growth factor Aa; Vascular endothelial growth factor A-A; vascular endothelial growth factor isoform 165; vascular permeability factor; Vasculotropin; VEGF; VEGF1; VEGF164; VEGF182; VEGF188; vegfa; VEGF-A; VEGFA165b; vegfaa; VEGF-A-A; VEGFMGC70609; VPF; VPF ant; wu:fj82c06
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA