This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
BUBR1 Monoclonal Antibody (8G1)
catalog :
MA1-16577
quantity :
100 uL
price :
US 538.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
8G1

The same clone is also sold as:
reactivity :
human, mouse, rat
application :
western blot, immunocytochemistry, immunoprecipitation, flow cytometry
product information
Product Type :
Antibody
Product Name :
BUBR1 Monoclonal Antibody (8G1)
Catalog # :
MA1-16577
Quantity :
100 uL
Price :
US 538.00
Clonality :
Monoclonal
Purity :
Protein G
Host :
Mouse
Reactivity :
Human, Mouse, Rat
Applications :
Flow Cytometry: 1 ug/1 million cells, Immunocytochemistry: 1:100, Immunoprecipitation: 1:10-1:500, Western Blot: 1:2,000-1:5,000
Species :
Human, Mouse, Rat
Clone :
8G1
Isotype :
IgG1, kappa
Storage :
-20 C, Avoid Freeze/Thaw Cycles
Description :
BUBR1 is a member of the Ser/Thr protein kinase family. It is a component of the mitotic checkpoint that delays anaphase until all chromosome are properly attached to the mitotic spindle. Compromised spindle checkpoints are thought to play an important role in genetic instability that predisposes cells to malignant transformations. Human cells contain two related checkpoint protein kinases, evolved from the BUB1 gene; hBUBR1 and hBUB1. They are important components of the spindle checkpoint Both kinases monitor mitotic kinetochore-microtubule interactions. hBUBR1 is essential for normal mitotic progression as it prevents cells from entering into anaphase too early. BUBR1 has been detected in human cancers. It has been identified as a novel binding partner of BCSG1 (Breast Cancer-Specific Gene 1), which has been suggested to accelerate the progression of breast cancer by compromising the mitotic checkpoint control through inactivation of BUBR1.
Immunogen :
Residues 1-350 of human BUBR1, tagged at the N-terminus with pMAL.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1 ug/1 million cells, Immunocytochemistry: 1:100, Immunoprecipitation: 1:10-1:500, Western Blot: 1:2,000-1:5,000
Aliases :
AU045529; BUB1 budding uninhibited by benzimidazoles 1 homolog beta; BUB1 mitotic checkpoint serine/threonine kinase B; Bub1A; Bub1b; BUB1B, mitotic checkpoint serine/threonine kinase; BUB1beta; BUBR1; budding uninhibited by benzimidazoles 1 beta; budding uninhibited by benzimidazoles 1 homolog beta; budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae); hBub1; hBUBR1; MAD3/BUB1-related protein kinase; MAD3L; Mitotic checkpoint kinase MAD3L; mitotic checkpoint serine/threonine-protein kinase BUB1 beta; MVA1; Protein SSK1; SSK1
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA