FANCD2 Monoclonal Antibody (FI-17) | Invitrogen MA1-16570 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

FANCD2 Monoclonal Antibody (FI-17)

catalog :

MA1-16570

quantity :

100 µL

price :

US 446.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

FI-17

reactivity :

human

application :

western blot, immunocytochemistry, immunoprecipitation

more info or order :

Invitrogen product webpage

citations: 3

Published Application/Species/Sample/Dilution	Reference
western blot; human; loading ...; fig 1a	Spriggs C, Laimins L. FANCD2 Binds Human Papillomavirus Genomes and Associates with a Distinct Set of DNA Repair Proteins to Regulate Viral Replication. MBio. 2017;8: pubmed publisher
	Virts E, Jankowska A, MacKay C, Glaas M, Wiek C, Kelich S, et al. AluY-mediated germline deletion, duplication and somatic stem cell reversion in UBE2T defines a new subtype of Fanconi anemia. Hum Mol Genet. 2015;24:5093-108 pubmed publisher
	Liang C, Zhan B, Yoshikawa Y, Haas W, Gygi S, Cohn M. UHRF1 is a sensor for DNA interstrand crosslinks and recruits FANCD2 to initiate the Fanconi anemia pathway. Cell Rep. 2015;10:1947-56 pubmed publisher

image

image 1 :

Expression of FancD2 (mAb) in different cell lines. Proliferating cells were treated with 10-Gy IR. Fifty microgram protein was loaded each lane. Working dilution - 1:1000 LCL 6% SDS-PAGE.

image 2 :

Western blot of FANCD2 on MCF7 cell line (lane 1) and HeLa whole cell extract (lane 2) using MA1-16570.

product information

Product Type :

Antibody

Product Name :

FANCD2 Monoclonal Antibody (FI-17)

Catalog # :

MA1-16570

Quantity :

100 µL

Price :

US 446.00

Clonality :

Monoclonal

Host :

Mouse

Reactivity :

Human

Applications :

ChIP Assay: 1:10-1:500, Immunocytochemistry: 1:10-1:500, Immunoprecipitation: Assay-Dependent, Western Blot: 1:1,000-1:2,000

Species :

Human

Clone :

FI-17

Isotype :

IgG1

Storage :

-20° C, Avoid Freeze/Thaw Cycles

Description :

FANCD2 (Fanconi anemia group D2 protein) is required for maintenance of chromosomal stability. It promotes accurate and efficient pairing of homologs during meiosis. FANCD2 is involved in the repair of DNA double-stranded breaks, both by homologous recombination and single-stranded annealing. It is required for the targeting/stabilization of BLM to non-centromeric abnormal structures induced by replicative stress. FANCD2 promotes BRCA2/FANCD1 loading onto damaged chromatin. Defects in the FANCD2 gene result in Fanconi anemia complementation group D2. This disorder affects all bone marrow elements resulting in anemia, leukopenia, and thrombopenia.

Immunogen :

FANCD2 fusion protein

Format :

Liquid

Applications w/Dilutions :

ChIP Assay: 1:10-1:500, Immunocytochemistry: 1:10-1:500, Immunoprecipitation: Assay-Dependent, Western Blot: 1:1,000-1:2,000

Aliases :

2410150O07Rik; AU015151; BB137857; DKFZp762A223; FA4; FACD; FACD2; FAD; FAD2; FA-D2; FANCD; FANCD2; Fanconi anemia complementation group D2; Fanconi anemia D2 protein; Fanconi anemia group D2 protein; Fanconi anemia group D2 protein homolog; Fanconi anemia, complementation group D2; FLJ23826; Protein FACD2

more info or order :

Invitrogen product webpage