LAMP1 Monoclonal Antibody (LY1C6) | Invitrogen MA1-164 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

LAMP1 Monoclonal Antibody (LY1C6)

catalog :

MA1-164

quantity :

100 µg

price :

US 478

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

Ly1C6

reactivity :

Chinese hamsters, human, mouse, rat

application :

western blot, immunocytochemistry

more info or order :

Invitrogen product webpage

citations: 10

Published Application/Species/Sample/Dilution	Reference
western blot; human; fig 2	Smith G, Howell G, Phillips C, Muench S, Ponnambalam S, Harrison M. Extracellular and Luminal pH Regulation by Vacuolar H+-ATPase Isoform Expression and Targeting to the Plasma Membrane and Endosomes. J Biol Chem. 2016;291:8500-15 pubmed publisher
	Zhao S, Liu Y, Wang J, Wen Y, Wu B, Yang D, et al. ADSCs increase the autophagy of chondrocytes through decreasing miR-7-5p in Osteoarthritis rats by targeting ATG4A. Int Immunopharmacol. 2023;120:110390 pubmed publisher
	Dhar V, Gandhi S, Sakharwade S, Chawla A, Mukhopadhaya A. Vibrio cholerae Porin OmpU Activates Dendritic Cells via TLR2 and the NLRP3 Inflammasome. Infect Immun. 2023;91:e0033222 pubmed publisher
	Li M, Feng F, Feng H, Hu P, Xue Y, Xu T, et al. VAMP4 regulates insulin levels by targeting secretory granules to lysosomes. J Cell Biol. 2022;221: pubmed publisher
	Wang S, Liu H, Roberts J, Wiley A, Marayati B, Adams K, et al. Prolonged ethanol exposure modulates constitutive internalization and recycling of 5-HT1A receptors. J Neurochem. 2022;160:469-481 pubmed publisher
	Liu J, Zhu S, Zeng L, Li J, Klionsky D, Kroemer G, et al. DCN released from ferroptotic cells ignites AGER-dependent immune responses. Autophagy. 2021;:1-14 pubmed publisher
	Dankovich T, Kaushik R, Olsthoorn L, Petersen G, Giro P, Kluever V, et al. Extracellular matrix remodeling through endocytosis and resurfacing of Tenascin-R. Nat Commun. 2021;12:7129 pubmed publisher
	Yu H, Xie M, Meng Z, Lo C, Chan F, Jiang L, et al. Endolysosomal ion channel MCOLN2 (Mucolipin-2) promotes prostate cancer progression via IL-1β/NF-κB pathway. Br J Cancer. 2021;125:1420-1431 pubmed publisher
	Puthenveetil R, Lun C, Murphy R, Healy L, Vilmen G, Christenson E, et al. S-acylation of SARS-CoV-2 spike protein: Mechanistic dissection, in vitro reconstitution and role in viral infectivity. J Biol Chem. 2021;297:101112 pubmed publisher
	Liu M, Pi H, Xi Y, Wang L, Tian L, Chen M, et al. KIF5A-dependent axonal transport deficiency disrupts autophagic flux in trimethyltin chloride-induced neurotoxicity. Autophagy. 2021;17:903-924 pubmed publisher

product information

Product Type :

Antibody

Product Name :

LAMP1 Monoclonal Antibody (LY1C6)

Catalog # :

MA1-164

Quantity :

100 µg

Price :

US 478

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Hamster, Human, Mouse, Rat

Applications :

Immunocytochemistry: 10 µg/mL, Western Blot: 1:100-1:500

Species :

Hamster, Human, Mouse, Rat

Clone :

LY1C6

Isotype :

IgG1

Storage :

-20°C

Description :

LAMP1 (CD107a, lysosome-associated membrane protein-1) together with LAMP-2, is a major constituent of lysosomal membrane, 1-2% of total CD107a is found also on the plasma membrane. LAMP1 is a heavily glycosylated membrane protein which contains a putative signal peptide, 18 sites for N-linked glycosylation, a single membrane-spanning segment and a short (11 amino acid) cytosolic tail. The LAMP proteins are involved in lysosome biogenesis and are required for fusion of lysosomes with phagosomes. LAMP1 is a type 1 integral membrane protein that is transported from trans-Golgi network to endosomes and then lysosomes. Upon cell activation, LAMP1 transfer to the plasma membrane is dependent on a carboyxl-terminal tyrosine based motif (YXXI). Perturbation in the spacing between the tyrosine based motif relative to the membrane abolishes lysosome localization of LAMP1, and this mutant protein then cycles between the plasma membrane and the endosome. Cell surface LAMP1 (and LAMP2) have been shown to promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, therefore, they are possibly involved in the adhesion of PBMC to the site of inflammation. Increased LAMP1 immunoreactivity is observed in neurons and glial cells surrounding senile plaques in Alzheimer’s Disease (AD) cases, and is localized in medullary epithelial cells, single macrophages and lymphocytes in acute thymic involution. LAMP1 is a good marker of mast cell activation.

Immunogen :

Rat liver lysosomal membrane preparations

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 10 µg/mL, Western Blot: 1:100-1:500

Aliases :

120 kDa lysosomal membrane glycoprotein; AI196048; CD107 antigen-like family member A; CD107a; I79_011073; Lamp I; LAMP1; LAMP-1; LAMPA; LGP120; LGP-120; LGPA; LGP-A; lysosomal associated membrane protein 1; Lysosomal associated membrane protein 1 (120 kDa); lysosomal membrane glycoprotein 1; lysosomal membrane glycoprotein A; lysosomal-associated membrane protein 1; lysosome-associated membrane glycoprotein 1; LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN 1 PRECURSOR (LAMP-1) (LGP-A) (LGP-120) (CD107A) (P2B); lysosome-associated membrane protein 1; P2B

more info or order :

Invitrogen product webpage