PKC alpha Monoclonal Antibody (MC5) | Invitrogen MA1-157 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

PKC alpha Monoclonal Antibody (MC5)

catalog :

MA1-157

quantity :

100 µg

price :

US 471.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

MC5

reactivity :

hamsters, human, mouse, rat, dogs, bovine, domestic rabbit

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 6

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; dogs; 1:100; fig 2 immunohistochemistry; hamsters; 1:100; fig 2 immunohistochemistry; domestic rabbit; 1:100; fig 2 immunohistochemistry; mouse; 1:100; fig 2	Huh Y, Choi J, Jeon C. Localization of Rod Bipolar Cells in the Mammalian Retina Using an Antibody Against the Î±1c L-type Ca(2+) Channel. Acta Histochem Cytochem. 2015;48:47-52 pubmed publisher
	Tay H, André H, Chrysostomou V, Adusumalli S, Guo J, Ren X, et al. Photoreceptor laminin drives differentiation of human pluripotent stem cells to photoreceptor progenitors that partially restore retina function. Mol Ther. 2023;31:825-846 pubmed publisher
	Wang Z, Feng C, Yang R, Liu T, Chen Y, Chen A, et al. Large-Area Photoreceptor Degeneration Model in Rabbits by Photocoagulation and Oxidative Stress in the Retina. Front Neurosci. 2021;15:617175 pubmed publisher
	Striebel J, Race B, Leung J, Schwartz C, Chesebro B. Prion-induced photoreceptor degeneration begins with misfolded prion protein accumulation in cones at two distinct sites: cilia and ribbon synapses. Acta Neuropathol Commun. 2021;9:17 pubmed publisher
	Maddox J, Randall K, Yadav R, Williams B, Hagen J, Derr P, et al. A dual role for Cav1.4 Ca2+ channels in the molecular and structural organization of the rod photoreceptor synapse. elife. 2020;9: pubmed publisher
	Yang Y, Liu W, Sun K, Jiang L, Zhu X. Tmem30a deficiency leads to retinal rod bipolar cell degeneration. J Neurochem. 2019;148:400-412 pubmed publisher

product information

Product Type :

Antibody

Product Name :

PKC alpha Monoclonal Antibody (MC5)

Catalog # :

MA1-157

Quantity :

100 µg

Price :

US 471.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Bovine, Canine, Human, Mouse, Non-human primate, Rabbit, Rat

Applications :

Immunocytochemistry: 1:50-1:100, Immunohistochemistry (Paraffin): 1:10-1:100, Immunoprecipitation: 5 µg, Western Blot: 1:1,000

Species :

Bovine, Canine, Human, Mouse, Non-human primate, Rabbit, Rat

Clone :

MC5

Isotype :

IgG2a

Storage :

-20°C

Description :

The PKC family of serine/threonine kinases, including PRKCA (PKC alpha), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity. PKC alpha, beta I, beta II, and gamma form the conventional family; their activities are Ca2+- and phospholipid-dependent. Protein kinase C (PKC) can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes.

Immunogen :

Purified bovine brain Protein Kinase C alpha.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:50-1:100, Immunohistochemistry (Paraffin): 1:10-1:100, Immunoprecipitation: 5 µg, Western Blot: 1:1,000

Aliases :

AAG6; aging-associated gene 6; AI875142; EC 2.7.11.13; FHC; FTH; FTHL6; im:7139045; kinase PKC-alpha; KPCA; MGC104426; PIG15; PKC III; Pkca; PKC-A; PKC-alpha; PKC-III; PKRCA; PLIF; PRKACA; Prkca; prkcaa; protein kinase C; protein kinase C alpha; protein kinase C alpha type; protein kinase C alpha type; protein kinase C, alpha, a; protein kinase C, alpha; protein kinase C, alpha, a; protein kinase c-alpha; si:dkey-8l19.1; Unknown (protein for IMAGE:7139045); unnamed protein product

more info or order :

Invitrogen product webpage