Androgen Receptor Monoclonal Antibody (AN1-15) | Invitrogen MA1-150 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Androgen Receptor Monoclonal Antibody (AN1-15)

catalog :

MA1-150

quantity :

50 ug

price :

US 451.00

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

AN1-15

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 25

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; rat; loading ...; fig 2a	Abdelrazek H, Helmy S, Elsayed D, Ebaid H, Mohamed R. Ameliorating effects of green tea extract on cadmium induced reproductive injury in male Wistar rats with respect to androgen receptors and caspase- 3. Reprod Biol. 2016;16:300-308 pubmed publisher
	Seo E, Jee B, Chung J, Song W, Sung H, Jeon H, et al. Repression of SLC22A3 by the AR-V7/YAP1/TAZ axis in enzalutamide-resistant castration-resistant prostate cancer. FEBS J. 2023;290:1645-1662 pubmed publisher
	Salah M, Ismail K, Khadrawy S. Nobiletin protects against diabetes-induced testicular injury via hypophysis-gonadal axis upregulation and amelioration of oxidative stress. Mol Biol Rep. 2022;49:189-203 pubmed publisher
	Kamel S, Tag H, Ebeid H, Khaled H, Almallah A, El Naggar M. Adverse effect of rheumatoid arthritis on male Wistar rat's fertility: protective role of Costus extract. Environ Sci Pollut Res Int. 2022;29:4193-4205 pubmed publisher
	Brinks J, van Dijk E, Kiełbasa S, Mei H, van der Veen I, Peters H, et al. The Cortisol Response of Male and Female Choroidal Endothelial Cells: Implications for Central Serous Chorioretinopathy. J Clin Endocrinol Metab. 2021;: pubmed publisher
	Ibrahim I, Shalaby A, Abd Elaziz R, Bahr H. Chlorella vulgaris or Spirulina platensis mitigate lead acetate-induced testicular oxidative stress and apoptosis with regard to androgen receptor expression in rats. Environ Sci Pollut Res Int. 2021;28:39126-39138 pubmed publisher
	Liu Z, Murphy S, Huang J, Zhao L, Hall C, Schaeffer A, et al. A novel immunocompetent model of metastatic prostate cancer-induced bone pain. Prostate. 2020;80:782-794 pubmed publisher
	Stojic L, Lun A, Mascalchi P, Ernst C, Redmond A, Mangei J, et al. A high-content RNAi screen reveals multiple roles for long noncoding RNAs in cell division. Nat Commun. 2020;11:1851 pubmed publisher
	Selakovic D, Joksimovic J, Jovicic N, Mitrović S, Mihailović V, Katanić J, et al. The Impact of Hippocampal Sex Hormones Receptors in Modulation of Depressive-Like Behavior Following Chronic Anabolic Androgenic Steroids and Exercise Protocols in Rats. Front Behav Neurosci. 2019;13:19 pubmed publisher
	Elgawish R, Abdelrazek H. Effects of lead acetate on testicular function and caspase-3 expression with respect to the protective effect of cinnamon in albino rats. Toxicol Rep. 2014;1:795-801 pubmed publisher
	Shakil T, Hoque A, Husain M, Belsham D. Differential regulation of gonadotropin-releasing hormone secretion and gene expression by androgen: membrane versus nuclear receptor activation. Mol Endocrinol. 2002;16:2592-602 pubmed
	Yamamoto A, Hashimoto Y, Kohri K, Ogata E, Kato S, Ikeda K, et al. Cyclin E as a coactivator of the androgen receptor. J Cell Biol. 2000;150:873-80 pubmed
	Zhang M, Magit D, Sager R. Expression of maspin in prostate cells is regulated by a positive ets element and a negative hormonal responsive element site recognized by androgen receptor. Proc Natl Acad Sci U S A. 1997;94:5673-8 pubmed
	Nakada S, di Sant Agnese P, Moynes R, Hiipakka R, Liao S, Cockett A, et al. The androgen receptor status of neuroendocrine cells in human benign and malignant prostatic tissue. Cancer Res. 1993;53:1967-70 pubmed
	Morvillo V, Luthy I, Bravo A, Capurro M, Donaldson M, Quintans C, et al. Atypical androgen receptor in the human melanoma cell line IIB-MEL-J. Pigment Cell Res. 1995;8:135-41 pubmed
	Luke M, Coffey D. Human androgen receptor binding to the androgen response element of prostate specific antigen. J Androl. 1994;15:41-51 pubmed
	Puy L, MacLusky N, Becker L, Karsan N, Trachtenberg J, Brown T. Immunocytochemical detection of androgen receptor in human temporal cortex characterization and application of polyclonal androgen receptor antibodies in frozen and paraffin-embedded tissues. J Steroid Biochem Mol Biol. 1995;55:197-209 pubmed
	Chang C, Whelan C, Popovich T, Kokontis J, Liao S. Fusion proteins containing androgen receptor sequences and their use in the production of poly- and monoclonal anti-androgen receptor antibodies. Endocrinology. 1989;125:1097-9 pubmed
	Chang C, Chodak G, Sarac E, Takeda H, Liao S. Prostate androgen receptor: immunohistological localization and mRNA characterization. J Steroid Biochem. 1989;34:311-3 pubmed
	West N, Chang C, Liao S, Brenner R. Localization and regulation of estrogen, progestin and androgen receptors in the seminal vesicle of the rhesus monkey. J Steroid Biochem Mol Biol. 1990;37:11-21 pubmed
	Takeda H, Chodak G, Mutchnik S, Nakamoto T, Chang C. Immunohistochemical localization of androgen receptors with mono- and polyclonal antibodies to androgen receptor. J Endocrinol. 1990;126:17-25 pubmed
	Roselli C, West N, Brenner R. Androgen receptor and 5 alpha-reductase activity in the ductuli efferentes and epididymis of adult rhesus macaques. Biol Reprod. 1991;44:739-45 pubmed
	Takeda H, Nakamoto T, Kokontis J, Chodak G, Chang C. Autoregulation of androgen receptor expression in rodent prostate: immunohistochemical and in situ hybridization analysis. Biochem Biophys Res Commun. 1991;177:488-96 pubmed
	Cutolo M, Accardo S, Villaggio B, Clerico P, Indiveri F, Carruba G, et al. Evidence for the presence of androgen receptors in the synovial tissue of rheumatoid arthritis patients and healthy controls. Arthritis Rheum. 1992;35:1007-15 pubmed
	Brolin J, Skoog L, Ekman P. Immunohistochemistry and biochemistry in detection of androgen, progesterone, and estrogen receptors in benign and malignant human prostatic tissue. Prostate. 1992;20:281-95 pubmed

product information

Product Type :

Antibody

Product Name :

Androgen Receptor Monoclonal Antibody (AN1-15)

Catalog # :

MA1-150

Quantity :

50 ug

Price :

US 451.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Rat

Reactivity :

Human, Mouse, Non-human primate, Rat

Applications :

Gel Shift: Assay-dependent, Immunocytochemistry: 5 ug/mL, Immunohistochemistry (Frozen): 2-4 ug/mL, Immunohistochemistry (Paraffin): 2-4 ug/mL, Immunoprecipitation: Assay-dependent, Western Blot: 1:50-1:500

Species :

Human, Mouse, Non-human primate, Rat

Clone :

AN1-15

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors. The receptor is more than 90 kDa and has three major functional domains: the N-terminal domain, DNA-binding domain, and the androgen-binding domain. The androgen receptor is a ligand-activated transcription factor that binds active testosterone (T) and dihydrotestosterone (DHT). Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. The AR signaling pathway plays a key role in development and function of male reproductive organs, including the prostate and epididymis.AR also plays a role in nonreproductive organs, such as muscle, hair follicles, and brain.Androgen Receptor is a phosphoprotein, and also regulates mitogen-activated protein kinase (MAP kinase). The inhibition of the MEK1/2 pathway correlates directly with a change in phosphorylation state of the androgen receptor. Abnormalities in the AR signaling pathway have been linked to a number of diseases, including prostate cancer, Kennedy's disease, and male infertility. Mutations in this gene are associated with complete androgen insensitivity (CAIS).

Immunogen :

A fusion protein corresponding to residues 331-572 of human androgen receptor.

Format :

Lyophilized

Applications w/Dilutions :

Aliases :

AIS; Andr; androgen nuclear receptor variant 2; androgen receptor; androgen receptor (Testicular feminization), same as Tfm; androgen receptor splice variant 4b; Ar; AR8; AR-A; AW320017; DHTR; dihydrotestosterone receptor; HUMARA; HYSP1; KD; NR3C4; Nuclear receptor subfamily 3 group C member 4; RP11-383C12.1; SBMA; SMAX1; TFM; Variant AR45

more info or order :

Invitrogen product webpage