Collagen I Monoclonal Antibody (5D8-G9) | Invitrogen MA1-141 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Collagen I Monoclonal Antibody (5D8-G9)

catalog :

MA1-141

quantity :

100 µg

price :

US 450.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

5D8-G9

reactivity :

human, bovine, pigs

application :

western blot, ELISA, immunohistochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 3

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:1000; fig 2c	Baik J, Park H, Kataru R, Savetsky I, Ly C, Shin J, et al. TGF-β1 mediates pathologic changes of secondary lymphedema by promoting fibrosis and inflammation. Clin Transl Med. 2022;12:e758 pubmed publisher
western blot; human; loading ...; fig 1c	Li W, Yu X, Zhu C, Wang Z, Zhao Z, Li Y, et al. Notum attenuates HBV-related liver fibrosis through inhibiting Wnt 5a mediated non-canonical pathways. Biol Res. 2019;52:10 pubmed publisher
	Tang L, Heller M, Meng Z, Yu L, Tang Y, Zhou M, et al. Transforming Growth Factor-β (TGF-β) Directly Activates the JAK1-STAT3 Axis to Induce Hepatic Fibrosis in Coordination with the SMAD Pathway. J Biol Chem. 2017;292:4302-4312 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Collagen I Monoclonal Antibody (5D8-G9)

Catalog # :

MA1-141

Quantity :

100 µg

Price :

US 450.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Bovine, Human, Porcine

Applications :

ELISA: 0.4-50 µg/mL, Immunohistochemistry (Frozen): 1:200-1:1,000, Immunohistochemistry (Paraffin): 1:10 - 1:100, Western Blot: 1:500-1:2,000

Species :

Bovine, Human, Porcine

Clone :

5D8-G9

Isotype :

IgG1

Storage :

-20°C

Description :

Collagen I is a Type I collagen with a triple helix structure comprised of two alpha-1 chains and one alpha-2 chain. Collagen I is a member of group I collagen (fibril-forming collagen) found in most connective tissues, and is abundant in bone, cornea, dermis and tendon. Mutations in the COL1A2 gene encoding the alpha-2 chain are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in the COL1A2 gene which codes for the alpha-2 chain, however, tend to be less severe than mutations in the COL1A1 gene, reflecting the different role of alpha-2 chains in matrix integrity. Reciprocal translocations between chromosomes 17 and 22, where Collagen Type 1 genes and the gene for platelet derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified.

Immunogen :

Purified, full-length native human collagen I protein

Format :

Liquid

Applications w/Dilutions :

ELISA: 0.4-50 µg/mL, Immunohistochemistry (Frozen): 1:200-1:1,000, Immunohistochemistry (Paraffin): 1:10 - 1:100, Western Blot: 1:500-1:2,000

Aliases :

AA960264; AI325291; alpha 1 type I collagen; alpha 2 type I collagen; alpha 2 type I procollagen; alpha 2(I) collagen; alpha 2(I) procollagen; alpha 2(I)-collagen; alpha1 chain of type I collagen; alpha-1 collagen (I); alpha-1 type 1 collagen; alpha-1 type I collagen; alpha-1 type-1 collagen; alpha1(I) procollagen; alpha2 chain of type I collagen; alpha-2 type I collagen; alpha-2(1) collagen; alpha2(I) collagen; COL1; Col1a1; Col1a-1; COL1A1; matrix protein; Col1a2; Col1a-2; COLA; Cola1; Cola-1; Cola2; Cola-2; COLIA1; collagen; collagen 1 alpha 2 chain; collagen a2; collagen alpha 1 chain type I; collagen alpha 2(I) chain precursor; collagen alpha-1 chain; collagen alpha-1 chain precursor; collagen alpha-1(I) chain; collagen alpha-1(I) chain preproprotein; collagen alpha-2; collagen alpha-2 chain precursor; collagen alpha-2(I) chain; collagen COL1A2; collagen I alpha-2 polypeptide; collagen I, alpha-2 polypeptide; collagen of skin, tendon and bone, alpha-1 chain; collagen of skin, tendon and bone, alpha-2 chain; collagen type I alpha 1; collagen type I alpha 1 chain; collagen type I alpha 2 chain; collagen, type 1, alpha 1; collagen, type I, alpha 1; collagen, type I, alpha 2; EDSC; Mov13; Mov-13; OI1; OI2; OI3; OI4; oim; osteogenesis imperfecta; precollagen alpha-2; prepro-alpha-1 collagen type I; pro-alpha-1 collagen type 1; procollagen type I, alpha 1; procollagen, type 1, alpha 1; procollagen, type I, alpha 1; procollagen, type I, alpha 2; similar to pro alpha 1(I) collagen; Type I Collagen; type I collagen alpha 1 chain; type I collagen alpha1; type I collagen alpha-2 chain; type I collagen pre-pro-alpha1(I) chain; type I proalpha 1; type I procollagen; type I procollagen alpha 1 chain; type I-alpha 1 collagen

more info or order :

Invitrogen product webpage