RhoA Monoclonal Antibody (1B8-1C7) | Invitrogen MA1-134 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

RhoA Monoclonal Antibody (1B8-1C7)

catalog :

MA1-134

quantity :

100 ug

price :

US 502.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1B8-1C7

reactivity :

human, mouse, rat

application :

western blot

more info or order :

Invitrogen product webpage

citations: 5

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:500; loading ...; fig 2b	Shah M, Garcia Pak I, Darling E. Influence of Inherent Mechanophenotype on Competitive Cellular Adherence. Ann Biomed Eng. 2017;45:2036-2047 pubmed publisher
	Tritto V, Capitanio D, Gelfi C, Riva P. Changes of RAS Pathway Phosphorylation in Lymphoblastoid Cell Lines from Noonan Syndrome Patients Carrying Hypomorphic Variants in Two NS Genes. Int J Mol Sci. 2023;24: pubmed publisher
	Muneeb M, Mansou S, Saleh S, Mohammed R. Vitamin D and rosuvastatin alleviate type-II diabetes-induced cognitive dysfunction by modulating neuroinflammation and canonical/noncanonical Wnt/β-catenin signaling. PLoS ONE. 2022;17:e0277457 pubmed publisher
	Zhang W, Gunst S. S100A4 is activated by RhoA and catalyses the polymerization of non-muscle myosin, adhesion complex assembly and contraction in airway smooth muscle. J Physiol. 2020;598:4573-4590 pubmed publisher
	Pieuchot L, Marteau J, Guignandon A, Dos Santos T, Brigaud I, Chauvy P, et al. Curvotaxis directs cell migration through cell-scale curvature landscapes. Nat Commun. 2018;9:3995 pubmed publisher

product information

Product Type :

Antibody

Product Name :

RhoA Monoclonal Antibody (1B8-1C7)

Catalog # :

MA1-134

Quantity :

100 ug

Price :

US 502.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human, Mouse, Rat

Applications :

Western Blot: 1:500-1:2,000

Species :

Human, Mouse, Rat

Clone :

1B8-1C7

Isotype :

IgG1

Storage :

-20 C

Description :

RhoA regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. It is involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis, and plays an essential role in cleavage furrow formation. RhoA is required for the apical junction formation of keratinocyte cell-cell adhesion, and serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. RhoA stimulates PKN2 kinase activity and may be an activator of PLCE1. It is activated by ARHGEF2, which promotes the exchange of GDP for GTP. It is essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization.

Immunogen :

Full-length recombinant His-tagged human RhoA

Format :

Liquid

Applications w/Dilutions :

Western Blot: 1:500-1:2,000

Aliases :

Aplysia ras-related homolog 12; Aplysia RAS-related homolog 6; aplysia ras-related homolog A; aplysia ras-related homolog A1; aplysia ras-related homolog A2; ARH12; ARH6; ARH9; ARHA; Arha1; Arha2; ARHB; ARHC; h12; h6; H9; MGC72339; MST081; MSTP081; oncogene RHO H12; oncogene RHO H6; oncogene RHO H9; plysia ras-related homolog A2; Ras family member A; ras homolog A1; ras homolog A2; ras homolog family member A; ras homolog family member B; ras homolog family member C; ras homolog gene family, member A; ras homolog gene family, member A1; ras homolog gene family, member A2; ras homolog gene family, member B; ras homolog gene family, member C; RAS-related homolog 9; Rho; Rho cDNA clone 12; Rho cDNA clone 6; rho cDNA clone 9; Rho family GTPase; RHO12; Rhoa; RHOB; RHOC; rhoC GTPase; RHOH12; RHOH6; RHOH9; rho-related GTP-binding protein RhoB; Rho-related GTP-binding protein RhoC; small GTP binding protein RhoA; small GTP binding protein RhoC; transforming protein RhoA

more info or order :

Invitrogen product webpage