STAT3 Monoclonal Antibody (9D8) | Invitrogen MA1-13042 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

STAT3 Monoclonal Antibody (9D8)

catalog :

MA1-13042

quantity :

100 uL

price :

US 520.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

9D8

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, chromatin immunoprecipitation, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 22

Published Application/Species/Sample/Dilution	Reference
chromatin immunoprecipitation; human; loading ...; fig 4e	Muller A, Dickmanns A, Resch C, Schakel K, Hailfinger S, Dobbelstein M, et al. The CDK4/6-EZH2 pathway is a potential therapeutic target for psoriasis. J Clin Invest. 2020;: pubmed publisher
western blot; human; fig 5g	McGirt L, Jia P, Baerenwald D, Duszynski R, Dahlman K, Zic J, et al. Whole-genome sequencing reveals oncogenic mutations in mycosis fungoides. Blood. 2015;126:508-19 pubmed publisher
western blot; human; 1:5000; fig 4	Campia I, Buondonno I, Castella B, Rolando B, Kopecka J, Gazzano E, et al. An Autocrine Cytokine/JAK/STAT-Signaling Induces Kynurenine Synthesis in Multidrug Resistant Human Cancer Cells. PLoS ONE. 2015;10:e0126159 pubmed publisher
western blot; human	Liu F, Cao J, Wu J, Sullivan K, Shen J, Ryu B, et al. Stat3-targeted therapies overcome the acquired resistance to vemurafenib in melanomas. J Invest Dermatol. 2013;133:2041-9 pubmed publisher
western blot; human; fig 3d	Dong L, Li Y, Cao J, Liu F, Pier E, Chen J, et al. FGF2 regulates melanocytes viability through the STAT3-transactivated PAX3 transcription. Cell Death Differ. 2012;19:616-22 pubmed publisher
	Shin J, Cho B, Park J, Kang E, Kim Y, Jang S. Diospyros lotus leaf extract and its main component myricitrin regulate pruritus through the inhibition of astrocyte activation. Exp Ther Med. 2023;26:323 pubmed publisher
	Chang J, Zhang W. Remifentanil modulates the TLR4‑mediated MMP‑9/TIMP1 balance and NF‑κB/STAT3 signaling in LPS‑induced A549 cells. Exp Ther Med. 2023;25:79 pubmed publisher
	Ninomiya I, Yamatoya K, Mashimo K, Matsuda A, Usui Ouchi A, Araki Y, et al. Role of Oncostatin M in the Pathogenesis of Vernal Keratoconjunctivitis: Focus on the Barrier Function of the Epithelium and Interleukin-33 Production by Fibroblasts. Invest Ophthalmol Vis Sci. 2022;63:26 pubmed publisher
	Sorger H, Dey S, Vieyra Garcia P, P xf6 l xf6 ske D, Teufelberger A, de Araujo E, et al. Blocking STAT3/5 through direct or upstream kinase targeting in leukemic cutaneous T-cell lymphoma. EMBO Mol Med. 2022;14:e15200 pubmed publisher
	Deland L, Keane S, Bontell T, Fagman H, Sj xf6 gren H, Lind A, et al. Novel TPR::ROS1 Fusion Gene Activates MAPK, PI3K and JAK/STAT Signaling in an Infant-type Pediatric Glioma. Cancer Genomics Proteomics. 2022;19:711-726 pubmed publisher
	Afsar T, Razak S, Trembley J, Khan K, Shabbir M, Almajwal A, et al. Prevention of Testicular Damage by Indole Derivative MMINA via Upregulated StAR and CatSper Channels with Coincident Suppression of Oxidative Stress and Inflammation: In Silico and In Vivo Validation. Antioxidants (Basel). 2022;11: pubmed publisher
	Silva Oliveira Junior M, Schira Heinen J, Reiche L, Han S, de Amorim V, Lewen I, et al. Myelin repair is fostered by the corticosteroid medrysone specifically acting on astroglial subpopulations. EBioMedicine. 2022;83:104204 pubmed publisher
	Balkrishna A, Mulay V, Verma S, Srivastava J, Lochab S, Varshney A. Penta-O-Galloyl-β-D-Glucose in Pistacia integerrima Targets AMPK-ULK1 and ERK/STAT3 Signaling Axes to Induce ROS-Independent Autophagic Cell Death in Human Lung Cancer Cells. Front Pharmacol. 2022;13:889335 pubmed publisher
	Wang R, Wang Y, Liao G, Chen B, Panettieri R, Penn R, et al. Abi1 mediates airway smooth muscle cell proliferation and airway remodeling via Jak2/STAT3 signaling. iScience. 2022;25:103833 pubmed publisher
	Rashid M, Ali R, Almuzzaini B, Song H, Alhallaj A, Abdulkarim A, et al. Discovery of a novel potentially transforming somatic mutation in CSF2RB gene in breast cancer. Cancer Med. 2021;10:8138-8150 pubmed publisher
	Porritt R, Chase Huizar C, Dick E, Kumar S, Escalona R, Gomez A, et al. Inhibition of IL-6 in the LCWE Mouse Model of Kawasaki Disease Inhibits Acute Phase Reactant Serum Amyloid A but Fails to Attenuate Vasculitis. Front Immunol. 2021;12:630196 pubmed publisher
	Bozzini S, Pandolfi L, Rossi E, Inghilleri S, Zorzetto M, Ferrario G, et al. miRNAs Potentially Involved in Post Lung Transplant-Obliterative Bronchiolitis: The Role of miR-21-5p. Cells. 2021;10: pubmed publisher
	Fu B, Xue W, Zhang H, Zhang R, Feldman K, Zhao Q, et al. MicroRNA-325-3p Facilitates Immune Escape of Mycobacterium tuberculosis through Targeting LNX1 via NEK6 Accumulation to Promote Anti-Apoptotic STAT3 Signaling. MBio. 2020;11: pubmed publisher
	Mishra S, Wheeler J, Pitake S, Ding H, Jiang C, Fukuyama T, et al. Periostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch. Cell Rep. 2020;31:107472 pubmed publisher
	Niu J, Sun Y, Chen B, Zheng B, Jarugumilli G, Walker S, et al. Fatty acids and cancer-amplified ZDHHC19 promote STAT3 activation through S-palmitoylation. Nature. 2019;573:139-143 pubmed publisher
	Kaminska K, Czarnecka A, Khan M, Fendler W, Klemba A, Krasowski P, et al. Effects of cell-cell crosstalk on gene expression patterns in a cell model of renal cell carcinoma lung metastasis. Int J Oncol. 2018;52:768-786 pubmed publisher
	Fuchs S, Rensing Ehl A, Erlacher M, Vraetz T, Hartjes L, Janda A, et al. Patients with T⁺/low NK⁺ IL-2 receptor γ chain deficiency have differentially-impaired cytokine signaling resulting in severe combined immunodeficiency. Eur J Immunol. 2014;44:3129-40 pubmed publisher

product information

Product Type :

Antibody

Product Name :

STAT3 Monoclonal Antibody (9D8)

Catalog # :

MA1-13042

Quantity :

100 uL

Price :

US 520.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human, Mouse, Non-human primate, Rat

Applications :

ChIP Assay: 1-3 uL, Immunocytochemistry: 1:100, Immunohistochemistry (Paraffin): 1:1,600, Immunoprecipitation: 2 ug, Western Blot: 1:5000-1:10,000

Species :

Human, Mouse, Non-human primate, Rat

Clone :

9D8

Isotype :

IgG2a

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

STAT3 belongs to the family of STAT (signal transducers and activators of transcription) proteins which are phosphorylated by receptor associated kinases, translocate to the nucleus, and act as transcription factors in response to cytokines and growth factors. Coactivators such as CREB-binding protein are required for the transcriptional activation by STAT3. STAT3 can also be activated by Interferon-alpha, Interferon-gamma, EGF, PDGF and IL6. Phosphorylation on tyrosine 705 by JAK1 and JAK2 is essential for STAT3 dimer formation, nuclear translocation, and DNA binding activity. In humans, the STAT3 gene is located on the q arm of chromosome 17. STAT3 has been shown to be activated by IFN-alpha but not IFN-beta. The transcription factors associated with STAT3 are c-Jun and cyclic AMP-responsive enhancer binding protein (CREB). STAT3 mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of STAT3 while the PIAS3 protein is a specific inhibitor of STAT3. Three alternatively spliced transcript variants encoding distinct isoforms of STAT3 have been described. Deletion of the STAT3 gene in knock-out mice was lethal at the early embryonic stage.

Immunogen :

Residues 655-770 from human recombinant protein expressed in bacteria

Format :

Liquid

Applications w/Dilutions :

ChIP Assay: 1-3 uL, Immunocytochemistry: 1:100, Immunohistochemistry (Paraffin): 1:1,600, Immunoprecipitation: 2 ug, Western Blot: 1:5000-1:10,000

Aliases :

1110034C02Rik; acute phase response factor; acute-phase response factor; ADMIO; ADMIO1; APRF; AW109958; DNA-binding protein APRF; FLJ20882; HIES; MGC16063; signal transducer and activator of transcription 3; signal transducer and activator of transcription 3 (acute-phase response factor); signal transducer; activator of transcription; acute-phase response factor; signal transduction and activation of transcription 3; STAT; STAT3; STAT-3; stat3 protein; STAT3b1; STAT3b2; transcription factor; Unknown (protein for MGC:128731); wu:fc15d02; wu:fl59g06; z-Stat3

more info or order :

Invitrogen product webpage