This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
alpha Synuclein Monoclonal Antibody (Syn 211)
catalog :
MA1-12874
quantity :
100µg
price :
405 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
Syn 211
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - free floating section, western blot knockout validation
citations: 22
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; human; 1:1000; loading ...; fig 6a
  • immunocytochemistry; human; 1:400; loading ...; fig 5b, 8
Zhang S, Eitan E, Wu T, Mattson M. Intercellular transfer of pathogenic α-synuclein by extracellular vesicles is induced by the lipid peroxidation product 4-hydroxynonenal. Neurobiol Aging. 2018;61:52-65 pubmed publisher
  • immunocytochemistry; human; 1:100; fig 2c
López de Maturana R, Lang V, Zubiarrain A, Sousa A, Vázquez N, Gorostidi A, et al. Mutations in LRRK2 impair NF-κB pathway in iPSC-derived neurons. J Neuroinflammation. 2016;13:295 pubmed
  • western blot; human; fig 2
Caviness J, Lue L, Hentz J, Schmitz C, Adler C, Shill H, et al. Cortical phosphorylated α-Synuclein levels correlate with brain wave spectra in Parkinson's disease. Mov Disord. 2016;31:1012-9 pubmed publisher
  • immunohistochemistry; mouse; fig 1
Kim C, Ojo Amaize E, Spencer B, Rockenstein E, Mante M, Desplats P, et al. Hypoestoxide reduces neuroinflammation and α-synuclein accumulation in a mouse model of Parkinson's disease. J Neuroinflammation. 2015;12:236 pubmed publisher
  • western blot; human; fig 4
Spencer B, Valera E, Rockenstein E, Trejo Morales M, Adame A, Masliah E. A brain-targeted, modified neurosin (kallikrein-6) reduces α-synuclein accumulation in a mouse model of multiple system atrophy. Mol Neurodegener. 2015;10:48 pubmed publisher
  • immunohistochemistry; human; 1:1000; fig 1
Bourdenx M, Dovero S, Engeln M, Bido S, Bastide M, Dutheil N, et al. Lack of additive role of ageing in nigrostriatal neurodegeneration triggered by α-synuclein overexpression. Acta Neuropathol Commun. 2015;3:46 pubmed publisher
  • western blot; human; 1:500; fig 5
Ettle B, Reiprich S, Deusser J, Schlachetzki J, Xiang W, Prots I, et al. Intracellular alpha-synuclein affects early maturation of primary oligodendrocyte progenitor cells. Mol Cell Neurosci. 2014;62:68-78 pubmed publisher
  • immunohistochemistry - free floating section; human; 1:250
  • immunohistochemistry; human; 1:250
May V, Ettle B, Poehler A, Nuber S, Ubhi K, Rockenstein E, et al. ?-Synuclein impairs oligodendrocyte progenitor maturation in multiple system atrophy. Neurobiol Aging. 2014;35:2357-68 pubmed publisher
  • immunocytochemistry; human
Taguchi K, Watanabe Y, Tsujimura A, Tatebe H, Miyata S, Tokuda T, et al. Differential expression of alpha-synuclein in hippocampal neurons. PLoS ONE. 2014;9:e89327 pubmed publisher
  • immunohistochemistry - free floating section; rat; 1:1000
Reyes J, Rey N, Bousset L, Melki R, Brundin P, Angot E. Alpha-synuclein transfers from neurons to oligodendrocytes. Glia. 2014;62:387-98 pubmed publisher
  • western blot; human; 1:1000
Chen R, Wislet Gendebien S, Samuel F, Visanji N, Zhang G, Marsilio D, et al. ?-Synuclein membrane association is regulated by the Rab3a recycling machinery and presynaptic activity. J Biol Chem. 2013;288:7438-49 pubmed publisher
  • western blot; human
Muntane G, Ferrer I, Martinez Vicente M. ?-synuclein phosphorylation and truncation are normal events in the adult human brain. Neuroscience. 2012;200:106-19 pubmed publisher
  • immunohistochemistry; human
Verhagen M, Martin J, van Deuren M, Ceuterick de Groote C, Weemaes C, Kremer B, et al. Neuropathology in classical and variant ataxia-telangiectasia. Neuropathology. 2012;32:234-44 pubmed publisher
  • western blot; human
Rieker C, Dev K, Lehnhoff K, Barbieri S, Ksiazek I, Kauffmann S, et al. Neuropathology in mice expressing mouse alpha-synuclein. PLoS ONE. 2011;6:e24834 pubmed publisher
  • immunohistochemistry; human; 1:50
Holm I, Englund E, Mackenzie I, Johannsen P, Isaacs A. A reassessment of the neuropathology of frontotemporal dementia linked to chromosome 3. J Neuropathol Exp Neurol. 2007;66:884-91 pubmed
  • western blot; human; 1:1000
Dalfo E, Martinez A, Muntane G, Ferrer I. Abnormal alpha-synuclein solubility, aggregation and nitration in the frontal cortex in Pick's disease. Neurosci Lett. 2006;400:125-9 pubmed
Murakami H, Tokuda T, El Agnaf O, Ohmichi T, Miki A, Ohashi H, et al. Correlated levels of cerebrospinal fluid pathogenic proteins in drug-naïve Parkinson's disease. BMC Neurol. 2019;19:113 pubmed publisher
Li X, Koudstaal W, Fletcher L, Costa M, Van Winsen M, Siregar B, et al. Naturally occurring antibodies isolated from PD patients inhibit synuclein seeding in vitro and recognize Lewy pathology. Acta Neuropathol. 2019;137:825-836 pubmed publisher
Recasens A, Carballo Carbajal I, Parent A, Bove J, Gelpi E, Tolosa E, et al. Lack of pathogenic potential of peripheral ?-synuclein aggregates from Parkinson's disease patients. Acta Neuropathol Commun. 2018;6:8 pubmed publisher
Zunke F, Moise A, Belur N, Gelyana E, Stojkovska I, Dzaferbegovic H, et al. Reversible Conformational Conversion of α-Synuclein into Toxic Assemblies by Glucosylceramide. Neuron. 2018;97:92-107.e10 pubmed publisher
Rockenstein E, Ostroff G, Dikengil F, Rus F, Mante M, Florio J, et al. Combined Active Humoral and Cellular Immunization Approaches for the Treatment of Synucleinopathies. J Neurosci. 2018;38:1000-1014 pubmed publisher
Spencer B, Valera E, Rockenstein E, OVERK C, Mante M, Adame A, et al. Anti-α-synuclein immunotherapy reduces α-synuclein propagation in the axon and degeneration in a combined viral vector and transgenic model of synucleinopathy. Acta Neuropathol Commun. 2017;5:7 pubmed publisher
product information
Product Type :
Antibody
Product Name :
alpha Synuclein Monoclonal Antibody (Syn 211)
Catalog # :
MA1-12874
Quantity :
100µg
Price :
405 USD
Clonality :
Monoclonal
Purity :
Protein A/G
Host :
Mouse
Reactivity :
Human
Applications :
ELISA: Assay Dependent, Immunohistochemistry (Paraffin): Assay Dependent, Western Blot: 0.5-1.0 µg/mL
Species :
Human
Clone :
Syn 211
Isotype :
IgG1
Storage :
Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Description :
Alpha-Synuclein belongs to the Synuclein family, which includes beta and gamma Synuclein, and is predominantly expressed in neurons, and concentrated at synaptic terminals. Synucleins may be involved in the regulation of dopamine release and transport and the modulation of synaptic vesicle function. Alpha-Synuclein is a small, presynaptic protein that is the major nonamyloid component of the pathological inclusions characteristic of a wide range of neurodegenerative disorders, collectively known as synucleinopathies. Alpha-Synuclein is involved in the formation of SNARE complexes, and most significantly, aggregated alpha-synuclein is one of the major components found in the Lewy bodies that occur in Parkinson's disease (PD) and other neurodegenerative disorders. Mutation of the alpha-synuclein gene is associated with familial forms of PD. Alpha-Synuclein is known to reduce the fibrillization of the microtubule-associated protein, tau, to bind various targets such as 14-3-3, protein kinase C, synphilin-1, Elk and Tat-binding protein 1. The alpha and beta synucleins are found primarily in brain tissue where they are seen mainly in neuronal cytosol and presynaptic terminals. The antibody specific for alpha-synuclein does not cross react with beta-synuclein and will be useful for the confirmation of Parkinson's disease and Lewy body dementia and other studies for the localization and detection of alpha-synuclein. Four alternatively spliced transcripts that encode two different isoforms of the alpha-synuclein protein have been identified.
Immunogen :
Recombinant human alpha-synuclein
Format :
Liquid
Applications w/Dilutions :
ELISA: Assay Dependent, Immunohistochemistry (Paraffin): Assay Dependent, Western Blot: 0.5-1.0 µg/mL
Aliases :
Non-A beta component of AD amyloid
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA