Desmin Monoclonal Antibody (RD301) | Invitrogen MA1-12788 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Desmin Monoclonal Antibody (RD301)

catalog :

MA1-12788

quantity :

100µg

price :

US 399.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

RD301

reactivity :

Chinese hamster, human, mouse, rat, dog, chicken, pig, rabbit

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - frozen section

citations: 2

Reference
Lewis C, Jockusch H, Ohlendieck K. Proteomic Profiling of the Dystrophin-Deficient MDX Heart Reveals Drastically Altered Levels of Key Metabolic and Contractile Proteins. J Biomed Biotechnol. 2010;2010:648501 pubmed
Pallero M, Talbert Roden M, Chen Y, Anderson P, Lemons J, Brott B, et al. Stainless steel ions stimulate increased thrombospondin-1-dependent TGF-beta activation by vascular smooth muscle cells: implications for in-stent restenosis. J Vasc Res. 2010;47:309-22 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Desmin Monoclonal Antibody (RD301)

Catalog # :

MA1-12788

Quantity :

100µg

Price :

US 399.00

Clonality :

Monoclonal

Purity :

Protein A/G

Host :

Mouse

Reactivity :

Canine, Chicken, Hamster, Human, Mouse, Porcine, Rabbit, Rat

Applications :

Immunohistochemistry (Frozen): 1:100 - 1:200, Immunohistochemistry: Assay Dependent, Western Blot: 1:100 - 1:1000

Species :

Canine, Chicken, Hamster, Human, Mouse, Porcine, Rabbit, Rat

Clone :

RD301

Isotype :

IgG2b

Storage :

-20° C, Avoid Freeze/Thaw Cycles

Description :

Desmin is a 53 kDa intermediate filament protein expressed in cardiac, skeletal, and smooth muscle cells, as well as lung tissue. In skeletal and cardiac muscle cells, desmin is localized at the Z-disk region and the intercalated disk. In smooth muscle tissue, desmin is expressed throughout the cells. During development, levels of desmin expression vary, being present at low levels in the early stages of myoblast replication and increasing during terminal differentiation. Unlike vimentin, desmin is expressed in both differentiating and mature muscle cells. Inhibiting desmin expression blocks myoblast fusion and myotube formation, suggesting that desmin is crucial during myogenesis.

Immunogen :

A cytoskeletal extract of chicken gizzard.

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Frozen): 1:100 - 1:200, Immunohistochemistry: Assay Dependent, Western Blot: 1:100 - 1:1000

Aliases :

CMD1I, CSM2, DES, FLJ12025

PubMed References :

20016205, 20508850