PTGER3 Monoclonal Antibody (5F5) | Invitrogen MA1-12647 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

PTGER3 Monoclonal Antibody (5F5)

catalog :

MA1-12647

quantity :

100 ug

price :

US 484.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

5F5

The same clone is also sold as:

Santa Cruz Biotechnology: sc-57105
OriGene: AM05326PU-N

reactivity :

human, rat, bovine

application :

western blot

citations: 1

Reference
Mizoguchi S, Wolf Johnson A, Ni J, Mori K, Suzuki T, Takaoka E, et al. The role of prostaglandin and E series prostaglandin receptor type 4 receptors in the development of bladder overactivity in a rat model of chemically induced prostatic inflammation. BJU Int. 2019;124:883-891 pubmed publisher

product information

Product Type :

Antibody

Product Name :

PTGER3 Monoclonal Antibody (5F5)

Catalog # :

MA1-12647

Quantity :

100 ug

Price :

US 484.00

Clonality :

Monoclonal

Purity :

Protein A/G

Host :

Mouse

Reactivity :

Bovine, Human, Rat

Applications :

Western Blot: 1-5 ug/mL

Species :

Bovine, Human, Rat

Clone :

5F5

Isotype :

IgG2a

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

CD172a, also known as signal-regulatory protein alpha, is a receptor-type transmembrane glycoprotein expressed on cells of myeloid origin, including granulocytes, dendritic cells (DCs), macrophages, mast cells and haematopoietic stem cells. CD172a acts as a substrate for several activated tyrosine kinases, including EGFR, PDGFR, src and insulin receptor and is involved in the negative regulation of receptor tyrosine kinase-coupled signaling pathways. Ligand binding of CD172a to integrin-associated protein CD47, results in tyrosine kinase phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIMs) within the cytoplasmic region of CD172a, mediating the recruitment and activation of the tyrosine phosphatases SHP-1 and SHP-2. These then act as regulators of cellular function, through dephosphorylation of specific substrates. Ligation of CD172a with CD47 has been demonstrated in several regulatory processes, including the inhibition of host cell phagocytosis by macrophages and the bi-directional activation of T cells and DCs.

Immunogen :

Recombinant human EP3 Receptor

Format :

Liquid

Applications w/Dilutions :

Western Blot: 1-5 ug/mL

Aliases :

EP3; Ep3 receptor; EP3A receptor; EP3B receptor; EP3C receptor; EP3D receptor; EP3e; EP3-I; EP3-II; EP3-III; EP3-IV; EP3-VI; MGC141828; MGC141829; MGC27302; PGE receptor EP3 subtype; PGE receptor, EP3 subtype; PGE2 receptor EP3 subtype; PGE2-R; Pgerep3; pr; prostaglandin E receotor EP3 subtype 3 isoform; prostaglandin E receptor 3; prostaglandin E receptor 3 (subtype EP3); prostaglandin E receptor EP3 subtype; prostaglandin E2 receptor EP3 subtype; prostaglandin receptor (PGE-2); prostanoid EP3 receptor; PTGER3; Ptgerep3; Rep3; rEP3a; rEP3b