Cyclin D2 Monoclonal Antibody (DCS3.1) | Invitrogen MA1-12297 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Cyclin D2 Monoclonal Antibody (DCS3.1)

catalog :

MA1-12297

quantity :

100 µg

price :

US 450.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

DCS3.1

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunoprecipitation

more info or order :

Invitrogen product webpage

citations: 25

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; 1:400	Yang Y, Chang B, Chan L. Sustained expression of the transcription factor GLIS3 is required for normal beta cell function in adults. EMBO Mol Med. 2013;5:92-104 pubmed publisher
immunoprecipitation; mouse western blot; mouse	Zhang Q, Sakamoto K, Liu C, Triplett A, Lin W, Rui H, et al. Cyclin D3 compensates for the loss of cyclin D1 during ErbB2-induced mammary tumor initiation and progression. Cancer Res. 2011;71:7513-24 pubmed publisher
western blot; human	Stein J, Milewski W, Hara M, Steiner D, Dey A. GSK-3 inactivation or depletion promotes β-cell replication via down regulation of the CDK inhibitor, p27 (Kip1). Islets. 2011;3:21-34 pubmed
western blot; human	Zhang Q, Gu J, Li L, Liu J, Luo B, Cheung H, et al. Control of cyclin D1 and breast tumorigenesis by the EglN2 prolyl hydroxylase. Cancer Cell. 2009;16:413-24 pubmed publisher
immunohistochemistry; mouse western blot; mouse	He L, Sartori D, Teta M, Opare Addo L, Rankin M, Long S, et al. Cyclin D2 protein stability is regulated in pancreatic beta-cells. Mol Endocrinol. 2009;23:1865-75 pubmed publisher
western blot; mouse	Rankin M, Kushner J. Adaptive beta-cell proliferation is severely restricted with advanced age. Diabetes. 2009;58:1365-72 pubmed publisher
western blot; mouse	Zheng Y, Bie W, Yang R, Perekatt A, Poole A, Tyner A. Functions of p21 and p27 in the regenerating epithelial linings of the mouse small and large intestine. Cancer Biol Ther. 2008;7:873-9 pubmed
western blot; human; 1:1000	Rubio D, Garcia S, Paz M, de la Cueva T, Lopez Fernandez L, Lloyd A, et al. Molecular characterization of spontaneous mesenchymal stem cell transformation. PLoS ONE. 2008;3:e1398 pubmed publisher
immunohistochemistry; mouse; 1:1000	Glickstein S, Moore H, Slowinska B, Racchumi J, Suh M, Chuhma N, et al. Selective cortical interneuron and GABA deficits in cyclin D2-null mice. Development. 2007;134:4083-93 pubmed
western blot; mouse; 1:500	Andreu Vieyra C, Chen R, Matzuk M. Effects of granulosa cell-specific deletion of Rb in Inha-alpha null female mice. Endocrinology. 2007;148:3837-49 pubmed
immunohistochemistry; mouse; 1:500	Pogoriler J, Millen K, Utset M, Du W. Loss of cyclin D1 impairs cerebellar development and suppresses medulloblastoma formation. Development. 2006;133:3929-37 pubmed
western blot; rat	Fritz M, Mirnics Z, Nylander K, Schor N. p75NTR enhances PC12 cell tumor growth by a non-receptor mechanism involving downregulation of cyclin D2. Exp Cell Res. 2006;312:3287-97 pubmed
western blot; human	Malik A, Afaq F, Sarfaraz S, Adhami V, Syed D, Mukhtar H. Pomegranate fruit juice for chemoprevention and chemotherapy of prostate cancer. Proc Natl Acad Sci U S A. 2005;102:14813-8 pubmed
	Murase M, Seino Y, Maekawa R, Iida A, Hosokawa K, Hayami T, et al. Functional adenosine triphosphate-sensitive potassium channel is required in high-carbohydrate diet-induced increase in β-cell mass. J Diabetes Investig. 2019;10:238-250 pubmed publisher
	Pierozan P, Jernerén F, Karlsson O. Perfluorooctanoic acid (PFOA) exposure promotes proliferation, migration and invasion potential in human breast epithelial cells. Arch Toxicol. 2018;92:1729-1739 pubmed publisher
	Pierozan P, Karlsson O. PFOS induces proliferation, cell-cycle progression, and malignant phenotype in human breast epithelial cells. Arch Toxicol. 2018;92:705-716 pubmed publisher
	Huang X, Xiao F, Wang S, Yin R, Lu C, Li Q, et al. G protein pathway suppressor 2 (GPS2) acts as a tumor suppressor in liposarcoma. Tumour Biol. 2016;37:13333-13343 pubmed
	Yung Y, Walker J, Roberts J, Assoian R. A Skp2 autoinduction loop and restriction point control. J Cell Biol. 2007;178:741-7 pubmed
	Jirawatnotai S, Aziyu A, Osmundson E, Moons D, Zou X, Kineman R, et al. Cdk4 is indispensable for postnatal proliferation of the anterior pituitary. J Biol Chem. 2004;279:51100-6 pubmed
	Chen B, Pollard J. Cyclin D2 compensates for the loss of cyclin D1 in estrogen-induced mouse uterine epithelial cell proliferation. Mol Endocrinol. 2003;17:1368-81 pubmed
	Gupta S, Afaq F, Mukhtar H. Involvement of nuclear factor-kappa B, Bax and Bcl-2 in induction of cell cycle arrest and apoptosis by apigenin in human prostate carcinoma cells. Oncogene. 2002;21:3727-38 pubmed
	Clark W, Black E, MacLaren A, Kruse U, LaThangue N, Vogt P, et al. v-Jun overrides the mitogen dependence of S-phase entry by deregulating retinoblastoma protein phosphorylation and E2F-pocket protein interactions as a consequence of enhanced cyclin E-cdk2 catalytic activity. Mol Cell Biol. 2000;20:2529-42 pubmed
	Servant M, Coulombe P, Turgeon B, Meloche S. Differential regulation of p27(Kip1) expression by mitogenic and hypertrophic factors: Involvement of transcriptional and posttranscriptional mechanisms. J Cell Biol. 2000;148:543-56 pubmed
	Tsutsui T, Hesabi B, Moons D, Pandolfi P, Hansel K, Koff A, et al. Targeted disruption of CDK4 delays cell cycle entry with enhanced p27(Kip1) activity. Mol Cell Biol. 1999;19:7011-9 pubmed
	Ladha M, Lee K, Upton T, Reed M, Ewen M. Regulation of exit from quiescence by p27 and cyclin D1-CDK4. Mol Cell Biol. 1998;18:6605-15 pubmed

product information

Product Type :

Antibody

Product Name :

Cyclin D2 Monoclonal Antibody (DCS3.1)

Catalog # :

MA1-12297

Quantity :

100 µg

Price :

US 450.00

Clonality :

Monoclonal

Purity :

Ammonium sulfate precipitation

Host :

Mouse

Reactivity :

Human, Mouse, Rat

Applications :

Immunoprecipitation: Assay-dependent, Western Blot: Assay-dependent

Species :

Human, Mouse, Rat

Clone :

DCS3.1

Isotype :

IgG2a

Storage :

-20° C, Avoid Freeze/Thaw Cycles

Description :

Cyclin D2 is a G1 cyclin required for G1 phase progression and is a strong candidate for a proto-oncogene. Cyclin D2 can phosphorylate pRB when associated with cdk 4 and / or cdk 6.

Immunogen :

His-tagged recombinant full-length Cyclin D2

Format :

Liquid

Applications w/Dilutions :

Immunoprecipitation: Assay-dependent, Western Blot: Assay-dependent

Aliases :

2600016F06Rik; AI256817; BF642806; C86853; CCND2; cD2; cyclin D2; Cyl-2; G1/S-specific cyclin-D2; KIAK0002; MGC102758; MPPH3; Vin1; Vin-1; Vin-1 proto-oncogene

more info or order :

Invitrogen product webpage