This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Cyclin D1 Monoclonal Antibody (DCS-6)
catalog :
MA1-12296
quantity :
100µg
price :
US 309.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
DCS-6
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunoprecipitation, ChIP-Seq
citations: 140
Published Application/Species/DilutionReference
  • western blot (knockdown validation); mouse; fig s3
Zampieri A, Champagne J, Auzemery B, Fuentes I, Maurel B, Bienvenu F. Hyper sensitive protein detection by Tandem-HTRF reveals Cyclin D1 dynamics in adult mouse. Sci Rep. 2015;5:15739 pubmed publisher
  • ChIP-Seq; mouse; fig 4
  • western blot; mouse; fig s4
Casimiro M, Di Sante G, Crosariol M, Loro E, Dampier W, Ertel A, et al. Kinase-independent role of cyclin D1 in chromosomal instability and mammary tumorigenesis. Oncotarget. 2015;6:8525-38 pubmed
  • western blot; human; fig 4
Tian L, Wang C, Hagen F, Gormley M, Addya S, Soccio R, et al. Acetylation-defective mutant of Pparγ is associated with decreased lipid synthesis in breast cancer cells. Oncotarget. 2014;5:7303-15 pubmed
  • western blot; human; 1:1000; fig 1e
Ormanns S, Neumann J, Horst D, Kirchner T, Jung A. WNT signaling and distant metastasis in colon cancer through transcriptional activity of nuclear β-Catenin depend on active PI3K signaling. Oncotarget. 2014;5:2999-3011 pubmed
  • western blot; human
Kajanne R, Leppa S, Luukkainen P, Ustinov J, Thiel A, Ristimaki A, et al. Hydrocortisone and indomethacin negatively modulate EGF-R signaling in human fetal intestine. Pediatr Res. 2007;62:570-5 pubmed
  • western blot; human; 1:250; fig 2
Chimploy K, Díaz G, Li Q, Carter O, Dashwood W, Mathews C, et al. E2F4 and ribonucleotide reductase mediate S-phase arrest in colon cancer cells treated with chlorophyllin. Int J Cancer. 2009;125:2086-94 pubmed publisher
  • western blot; human; fig 6
Li C, Fan S, Owonikoko T, Khuri F, Sun S, Li R. Oncogenic role of EAPII in lung cancer development and its activation of the MAPK-ERK pathway. Oncogene. 2011;30:3802-12 pubmed publisher
  • western blot; mouse; fig 1
Chen S, Fu S, Hsu S, Huang Y, Hsu B. Synergistic Effect of Hyperglycemia and p27(kip1) Suppression on Adult Mouse Islet Beta Cell Replication. Int J Endocrinol. 2012;2012:417390 pubmed
  • western blot; rat; 1:200; fig 1b
Friedrichsen B, Richter H, Hansen J, Rhodes C, Nielsen J, Billestrup N, et al. Signal transducer and activator of transcription 5 activation is sufficient to drive transcriptional induction of cyclin D2 gene and proliferation of rat pancreatic beta-cells. Mol Endocrinol. 2003;17:945-58 pubmed
  • western blot; mouse
Mitterberger M, Zwerschke W. Mechanisms of resveratrol-induced inhibition of clonal expansion and terminal adipogenic differentiation in 3T3-L1 preadipocytes. J Gerontol A Biol Sci Med Sci. 2013;68:1356-76 pubmed publisher
  • western blot; human
Tiedemann R, Schmidt J, Keats J, Shi C, Zhu Y, Palmer S, et al. Identification of a potent natural triterpenoid inhibitor of proteosome chymotrypsin-like activity and NF-kappaB with antimyeloma activity in vitro and in vivo. Blood. 2009;113:4027-37 pubmed publisher
  • western blot; human; fig 6
Law B, Chytil A, Dumont N, Hamilton E, Waltner-Law M, Aakre M, et al. Rapamycin potentiates transforming growth factor beta-induced growth arrest in nontransformed, oncogene-transformed, and human cancer cells. Mol Cell Biol. 2002;22:8184-98 pubmed
  • western blot; human; fig s1e
Comstock C, Augello M, Goodwin J, de Leeuw R, Schiewer M, Ostrander W, et al. Targeting cell cycle and hormone receptor pathways in cancer. Oncogene. 2013;32:5481-91 pubmed publisher
  • western blot; human; 1:1000; fig 5
Wei W, Chua M, Grepper S, So S. Soluble Frizzled-7 receptor inhibits Wnt signaling and sensitizes hepatocellular carcinoma cells towards doxorubicin. Mol Cancer. 2011;10:16 pubmed publisher
  • western blot; human; 1:500; fig 6
Gutzman J, Miller K, Schuler L. Endogenous human prolactin and not exogenous human prolactin induces estrogen receptor alpha and prolactin receptor expression and increases estrogen responsiveness in breast cancer cells. J Steroid Biochem Mol Biol. 2004;88:69-77 pubmed
Shukla S, Bhaskaran N, Babcook M, Fu P, MacLennan G, Gupta S. Apigenin inhibits prostate cancer progression in TRAMP mice via targeting PI3K/Akt/FoxO pathway. Carcinogenesis. 2014;35:452-60 pubmed publisher
Elong Edimo W, Schurmans S, Roger P, Erneux C. SHIP2 signaling in normal and pathological situations: Its impact on cell proliferation. Adv Biol Regul. 2014;54:142-51 pubmed publisher
Wang H, Wang H, Makki M, Wen J, Dai Y, Shi Q, et al. Overexpression of β-catenin and cyclinD1 predicts a poor prognosis in ovarian serous carcinomas. Int J Clin Exp Pathol. 2014;7:264-71 pubmed
Do S, Kim K, Lee H, Kim H, Do T, Yun J, et al. Aberrant expression pattern and location of cullin 1 are associated with the development of papillary carcinoma in thyroid and cyclin D1 expression. Endocr Pathol. 2014;25:282-7 pubmed publisher
Cerqueira A, Martin A, Symonds C, Odajima J, Dubus P, Barbacid M, et al. Genetic characterization of the role of the Cip/Kip family of proteins as cyclin-dependent kinase inhibitors and assembly factors. Mol Cell Biol. 2014;34:1452-9 pubmed publisher
Yu D, Petermann A, Kunter U, Rong S, Shankland S, Floege J. Urinary podocyte loss is a more specific marker of ongoing glomerular damage than proteinuria. J Am Soc Nephrol. 2005;16:1733-41 pubmed
Hui A, Li X, Shi Y, Takayama T, Torzilli G, Makuuchi M. Cyclin D1 overexpression is a critical event in gallbladder carcinogenesis and independently predicts decreased survival for patients with gallbladder carcinoma. Clin Cancer Res. 2000;6:4272-7 pubmed
de Leng W, Westerman A, Weterman M, De Rooij F, Dekken Hv H, de Goeij A, et al. Cyclooxygenase 2 expression and molecular alterations in Peutz-Jeghers hamartomas and carcinomas. Clin Cancer Res. 2003;9:3065-72 pubmed
Qi Y, Tu Y, Yang D, Chen Q, Xiao J, Chen Y, et al. Cyclin A but not cyclin D1 is essential for c-myc-modulated cell-cycle progression. J Cell Physiol. 2007;210:63-71 pubmed
Frémin C, Bessard A, Ezan F, Gailhouste L, Régeard M, Le Seyec J, et al. Multiple division cycles and long-term survival of hepatocytes are distinctly regulated by extracellular signal-regulated kinases ERK1 and ERK2. Hepatology. 2009;49:930-9 pubmed publisher
Rozeman L, Hameetman L, Cleton-Jansen A, Taminiau A, Hogendoorn P, Bovee J. Absence of IHH and retention of PTHrP signalling in enchondromas and central chondrosarcomas. J Pathol. 2005;205:476-82 pubmed
Xia W, Nagase S, Montia A, KALACHIKOV S, Keniry M, Su T, et al. BAF180 is a critical regulator of p21 induction and a tumor suppressor mutated in breast cancer. Cancer Res. 2008;68:1667-74 pubmed publisher
Kanungo A, Medeiros L, Abruzzo L, Lin P. Lymphoid neoplasms associated with concurrent t(14;18) and 8q24/c-MYC translocation generally have a poor prognosis. Mod Pathol. 2006;19:25-33 pubmed
Bottino M, Cerliani J, Rojas P, Giulianelli S, Soldati R, Mondillo C, et al. Classical membrane progesterone receptors in murine mammary carcinomas: agonistic effects of progestins and RU-486 mediating rapid non-genomic effects. Breast Cancer Res Treat. 2011;126:621-36 pubmed publisher
Schulze A, Lehmann K, Jefferies H, McMahon M, Downward J. Analysis of the transcriptional program induced by Raf in epithelial cells. Genes Dev. 2001;15:981-94 pubmed
Tong W, Pollard J. Genetic evidence for the interactions of cyclin D1 and p27(Kip1) in mice. Mol Cell Biol. 2001;21:1319-28 pubmed
Soria J, Morat L, Commo F, Dabit D, Perie S, Sabatier L, et al. Telomerase activation cooperates with inactivation of p16 in early head and neck tumorigenesis. Br J Cancer. 2001;84:504-11 pubmed
Wake N, Ricketts C, Morris M, Prigmore E, Gribble S, Skytte A, et al. UBE2QL1 is disrupted by a constitutional translocation associated with renal tumor predisposition and is a novel candidate renal tumor suppressor gene. Hum Mutat. 2013;34:1650-61 pubmed publisher
de Alboran I, O'Hagan R, Gartner F, Malynn B, Davidson L, Rickert R, et al. Analysis of C-MYC function in normal cells via conditional gene-targeted mutation. Immunity. 2001;14:45-55 pubmed
Du Q, Zhang X, Liu Q, Zhang X, Bartels C, Geller D. Nitric oxide production upregulates Wnt/β-catenin signaling by inhibiting Dickkopf-1. Cancer Res. 2013;73:6526-37 pubmed publisher
Giulianelli S, Cerliani J, Lamb C, Fabris V, Bottino M, Gorostiaga M, et al. Carcinoma-associated fibroblasts activate progesterone receptors and induce hormone independent mammary tumor growth: A role for the FGF-2/FGFR-2 axis. Int J Cancer. 2008;123:2518-31 pubmed publisher
Greussing R, Hackl M, Charoentong P, Pauck A, Monteforte R, Cavinato M, et al. Identification of microRNA-mRNA functional interactions in UVB-induced senescence of human diploid fibroblasts. BMC Genomics. 2013;14:224 pubmed publisher
Sarkar R, Hunter I, Rajaganeshan R, Perry S, Guillou P, Jayne D. Expression of cyclin D2 is an independent predictor of the development of hepatic metastasis in colorectal cancer. Colorectal Dis. 2010;12:316-23 pubmed publisher
Friedrichsen B, Neubauer N, Lee Y, Gram V, Blume N, Petersen J, et al. Stimulation of pancreatic beta-cell replication by incretins involves transcriptional induction of cyclin D1 via multiple signalling pathways. J Endocrinol. 2006;188:481-92 pubmed
Wagner M, Hampel B, Pfister G, Krek W, Zwerschke W. Metabolic stabilization of p27 in senescent fibroblasts correlates with reduced expression of the F-box protein Skp2. Exp Gerontol. 2001;37:41-55 pubmed
Liu L, Xu Y, Reiter R. Melatonin inhibits the proliferation of human osteosarcoma cell line MG-63. Bone. 2013;55:432-8 pubmed publisher
Mellai M, Piazzi A, Caldera V, Monzeglio O, Cassoni P, Valente G, et al. IDH1 and IDH2 mutations, immunohistochemistry and associations in a series of brain tumors. J Neurooncol. 2011;105:345-57 pubmed publisher
Fadare O, Shukla P. Another case of mantle cell lymphoma presenting as breast masses. J Clin Pathol. 2002;55:640 pubmed
de Carcer G, Escobar B, Higuero A, Garcia L, Ansón A, Pérez G, et al. Plk5, a polo box domain-only protein with specific roles in neuron differentiation and glioblastoma suppression. Mol Cell Biol. 2011;31:1225-39 pubmed publisher
Ikari A, Okude C, Sawada H, Yamazaki Y, Sugatani J, Miwa M. TRPM6 expression and cell proliferation are up-regulated by phosphorylation of ERK1/2 in renal epithelial cells. Biochem Biophys Res Commun. 2008;369:1129-33 pubmed publisher
Liu L, Zhu Y, Xu Y, Reiter R. Melatonin delays cell proliferation by inducing G1 and G2 /M phase arrest in a human osteoblastic cell line hFOB 1.19. J Pineal Res. 2011;50:222-31 pubmed publisher
Shan Y, Zhou W, Fu X, Yan H, Yang W, Liu S, et al. The role of p28GANK in rat oval cells activation and proliferation. Liver Int. 2006;26:240-7 pubmed
Vogt B, Rossman T. Effects of arsenite on p53, p21 and cyclin D expression in normal human fibroblasts -- a possible mechanism for arsenite's comutagenicity. Mutat Res. 2001;478:159-68 pubmed
Wang X, Sistrunk C, Miliani de Marval P, Kim Y, Rodriguez-Puebla M. Combined effect of cyclin D3 expression and abrogation of cyclin D1 prevent mouse skin tumor development. Cell Cycle. 2012;11:335-42 pubmed publisher
Lewis J, Thomas T, Klinge C, Gallo M, Thomas T. Regulation of cell cycle and cyclins by 16alpha-hydroxyestrone in MCF-7 breast cancer cells. J Mol Endocrinol. 2001;27:293-307 pubmed
Gonzalez-Pardo V, Martin D, Gutkind J, Verstuyf A, Bouillon R, de Boland A, et al. 1 Alpha,25-dihydroxyvitamin D3 and its TX527 analog inhibit the growth of endothelial cells transformed by Kaposi sarcoma-associated herpes virus G protein-coupled receptor in vitro and in vivo. Endocrinology. 2010;151:23-31 pubmed publisher
Gingras B, Rodier G, Giasson E, Coulombe P, Chassagne C, Meloche S. Expression of angiotensin type II receptor downregulates Cdk4 synthesis and inhibits cell-cycle progression. Oncogene. 2003;22:2633-42 pubmed
van den Brink G, Bleuming S, Hardwick J, Schepman B, Offerhaus G, Keller J, et al. Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation. Nat Genet. 2004;36:277-82 pubmed
Hui A, Or Y, Takano H, Tsang R, To K, Guan X, et al. Array-based comparative genomic hybridization analysis identified cyclin D1 as a target oncogene at 11q13.3 in nasopharyngeal carcinoma. Cancer Res. 2005;65:8125-33 pubmed
Arber N, Han E, Sgambato A, Piazza G, Delohery T, Begemann M, et al. A K-ras oncogene increases resistance to sulindac-induced apoptosis in rat enterocytes. Gastroenterology. 1997;113:1892-900 pubmed
Lau C, Koty Z, Nalbantoglu J. Differential response of glioma cells to FOXO1-directed therapy. Cancer Res. 2009;69:5433-40 pubmed publisher
Haven C, van Puijenbroek M, Karperien M, Fleuren G, Morreau H. Differential expression of the calcium sensing receptor and combined loss of chromosomes 1q and 11q in parathyroid carcinoma. J Pathol. 2004;202:86-94 pubmed
Wang J, Thiere M, Henne-Bruns D, Knippschild U, Kornmann M. Inhibition of pancreatic cancer cell growth in vivo using a tetracycline-inducible cyclin D1 antisense expression system. Pancreas. 2013;42:141-8 pubmed publisher
Rodrigues N, Dillon D, Carter D, Parisot N, Haffty B. Differences in the pathologic and molecular features of intraductal breast carcinoma between younger and older women. Cancer. 2003;97:1393-403 pubmed
Ecarnot-Laubriet A, Assem M, Poirson-Bichat F, Moisant M, Bernard C, Lecour S, et al. Stage-dependent activation of cell cycle and apoptosis mechanisms in the right ventricle by pressure overload. Biochim Biophys Acta. 2002;1586:233-42 pubmed
Rafacho A, Quallio S, Ribeiro D, Taboga S, Paula F, Boschero A, et al. The adaptive compensations in endocrine pancreas from glucocorticoid-treated rats are reversible after the interruption of treatment. Acta Physiol (Oxf). 2010;200:223-35 pubmed publisher
Yap T, Walton M, Hunter L, Valenti M, de Haven Brandon A, Eve P, et al. Preclinical pharmacology, antitumor activity, and development of pharmacodynamic markers for the novel, potent AKT inhibitor CCT128930. Mol Cancer Ther. 2011;10:360-71 pubmed publisher
Xuan W, Li Y, Liu G, Ben-David Y, Archer M. Interleukin-24 induces expression of beta4 integrin but suppresses anchorage-independent growth of rat mammary tumor cells by a mechanism that is independent of beta4. Mol Cancer Res. 2009;7:433-42 pubmed publisher
Bearss D, Lee R, Troyer D, Pestell R, Windle J. Differential effects of p21(WAF1/CIP1) deficiency on MMTV-ras and MMTV-myc mammary tumor properties. Cancer Res. 2002;62:2077-84 pubmed
Schmitt-Graeff A, Ertelt-Heitzmann V, Allgaier H, Olschewski M, Nitschke R, Haxelmans S, et al. Coordinated expression of cyclin D1 and LEF-1/TCF transcription factor is restricted to a subset of hepatocellular carcinoma. Liver Int. 2005;25:839-47 pubmed
Vijapurkar U, Kim M, Koland J. Roles of mitogen-activated protein kinase and phosphoinositide 3'-kinase in ErbB2/ErbB3 coreceptor-mediated heregulin signaling. Exp Cell Res. 2003;284:291-302 pubmed
Tian Y, Liu Y, Chen X, Kang Q, Zhang J, Shi Q, et al. AMN082 promotes the proliferation and differentiation of neural progenitor cells with influence on phosphorylation of MAPK signaling pathways. Neurochem Int. 2010;57:8-15 pubmed publisher
Maitra A, Roberts H, Weinberg A, Geradts J. Loss of p16(INK4a) expression correlates with decreased survival in pediatric osteosarcomas. Int J Cancer. 2001;95:34-8 pubmed
Tong W, Pollard J. Progesterone inhibits estrogen-induced cyclin D1 and cdk4 nuclear translocation, cyclin E- and cyclin A-cdk2 kinase activation, and cell proliferation in uterine epithelial cells in mice. Mol Cell Biol. 1999;19:2251-64 pubmed
Rafacho A, Cestari T, Taboga S, Boschero A, Bosqueiro J. High doses of dexamethasone induce increased beta-cell proliferation in pancreatic rat islets. Am J Physiol Endocrinol Metab. 2009;296:E681-9 pubmed publisher
Kirma N, Gill K, Mandava U, Tekmal R. Overexpression of aromatase leads to hyperplasia and changes in the expression of genes involved in apoptosis, cell cycle, growth, and tumor suppressor functions in the mammary glands of transgenic mice. Cancer Res. 2001;61:1910-8 pubmed
Dunphy C, Perkins S. Large cell variants of CD5+, CD23- B-cell lymphoma/leukemia. Arch Pathol Lab Med. 2001;125:513-8 pubmed
Schulze A, Mannhardt B, Zerfass-Thome K, Zwerschke W, Jansen-Durr P. Anchorage-independent transcription of the cyclin A gene induced by the E7 oncoprotein of human papillomavirus type 16. J Virol. 1998;72:2323-34 pubmed
Lai J, Benimetskaya L, Santella R, Wang Q, Miller P, Stein C. G3139 (oblimersen) may inhibit prostate cancer cell growth in a partially bis-CpG-dependent non-antisense manner. Mol Cancer Ther. 2003;2:1031-43 pubmed
Jayasurya R, Francis G, Kannan S, Lekshminarayanan K, Nalinakumari K, Abraham T, et al. p53, p16 and cyclin D1: molecular determinants of radiotherapy treatment response in oral carcinoma. Int J Cancer. 2004;109:710-6 pubmed
Qin X, Zhang H, Zhou X, Wang C, Zhang H, Zhang X, et al. Proliferation and migration mediated by Dkk-1/Wnt/beta-catenin cascade in a model of hepatocellular carcinoma cells. Transl Res. 2007;150:281-94 pubmed
Cerliani J, Guillardoy T, Giulianelli S, Vaque J, Gutkind J, Vanzulli S, et al. Interaction between FGFR-2, STAT5, and progesterone receptors in breast cancer. Cancer Res. 2011;71:3720-31 pubmed publisher
Ko E, Kim Y, Lee B, Han J, Song S, Shim Y, et al. Relationship of phospho-pRb (Ser-807/811) level to exposure to tobacco smoke in primary non-small cell lung cancer. Cancer Lett. 2009;274:225-32 pubmed publisher
Chen B, van den Brekel M, Buschers W, Balm A, van Velthuysen M. Validation of tissue array technology in head and neck squamous cell carcinoma. Head Neck. 2003;25:922-30 pubmed
Naganuma S, Whelan K, Natsuizaka M, Kagawa S, Kinugasa H, Chang S, et al. Notch receptor inhibition reveals the importance of cyclin D1 and Wnt signaling in invasive esophageal squamous cell carcinoma. Am J Cancer Res. 2012;2:459-75 pubmed
Neuman E, Ladha M, Lin N, Upton T, Miller S, DiRenzo J, et al. Cyclin D1 stimulation of estrogen receptor transcriptional activity independent of cdk4. Mol Cell Biol. 1997;17:5338-47 pubmed
Yang Z, Mott S, Rosmarin A. The Ets transcription factor GABP is required for cell-cycle progression. Nat Cell Biol. 2007;9:339-46 pubmed
Papeleu P, Loyer P, Vanhaecke T, Elaut G, Geerts A, Guguen-Guillouzo C, et al. Trichostatin A induces differential cell cycle arrests but does not induce apoptosis in primary cultures of mitogen-stimulated rat hepatocytes. J Hepatol. 2003;39:374-82 pubmed
Wiseman D, Werner S, Crowell P. Cell cycle arrest by the isoprenoids perillyl alcohol, geraniol, and farnesol is mediated by p21(Cip1) and p27(Kip1) in human pancreatic adenocarcinoma cells. J Pharmacol Exp Ther. 2007;320:1163-70 pubmed
Mermelshtein A, Gerson A, Walfisch S, Delgado B, Shechter-Maor G, Delgado J, et al. Expression of D-type cyclins in colon cancer and in cell lines from colon carcinomas. Br J Cancer. 2005;93:338-45 pubmed
Bisteau X, Paternot S, Colleoni B, Ecker K, Coulonval K, De Groote P, et al. CDK4 T172 phosphorylation is central in a CDK7-dependent bidirectional CDK4/CDK2 interplay mediated by p21 phosphorylation at the restriction point. PLoS Genet. 2013;9:e1003546 pubmed publisher
Ramis G, Thomàs-Moyà E, Fernandez De Mattos S, Rodriguez J, Villalonga P. EGFR inhibition in glioma cells modulates Rho signaling to inhibit cell motility and invasion and cooperates with temozolomide to reduce cell growth. PLoS ONE. 2012;7:e38770 pubmed publisher
Tsutsui T, Hesabi B, Moons D, Pandolfi P, Hansel K, Koff A, et al. Targeted disruption of CDK4 delays cell cycle entry with enhanced p27(Kip1) activity. Mol Cell Biol. 1999;19:7011-9 pubmed
Jirawatnotai S, Aziyu A, Osmundson E, Moons D, Zou X, Kineman R, et al. Cdk4 is indispensable for postnatal proliferation of the anterior pituitary. J Biol Chem. 2004;279:51100-6 pubmed
Takeda A, Osaki M, Adachi K, Honjo S, Ito H. Role of the phosphatidylinositol 3'-kinase-Akt signal pathway in the proliferation of human pancreatic ductal carcinoma cell lines. Pancreas. 2004;28:353-8 pubmed
Kirma N, Luthra R, Jones J, Liu Y, Nair H, Mandava U, et al. Overexpression of the colony-stimulating factor (CSF-1) and/or its receptor c-fms in mammary glands of transgenic mice results in hyperplasia and tumor formation. Cancer Res. 2004;64:4162-70 pubmed
Sohn D, Graupner V, Neise D, Essmann F, Schulze-Osthoff K, Jänicke R. Pifithrin-alpha protects against DNA damage-induced apoptosis downstream of mitochondria independent of p53. Cell Death Differ. 2009;16:869-78 pubmed publisher
Lewis J, Thomas T, Pestell R, Albanese C, Gallo M, Thomas T. Differential effects of 16alpha-hydroxyestrone and 2-methoxyestradiol on cyclin D1 involving the transcription factor ATF-2 in MCF-7 breast cancer cells. J Mol Endocrinol. 2005;34:91-105 pubmed
Reynisdottir I, Massague J. The subcellular locations of p15(Ink4b) and p27(Kip1) coordinate their inhibitory interactions with cdk4 and cdk2. Genes Dev. 1997;11:492-503 pubmed
Kornmann M, Arber N, Korc M. Inhibition of basal and mitogen-stimulated pancreatic cancer cell growth by cyclin D1 antisense is associated with loss of tumorigenicity and potentiation of cytotoxicity to cisplatinum. J Clin Invest. 1998;101:344-52 pubmed
Berdiel-Acer M, Bohem M, Lopez-Doriga A, Vidal A, Salazar R, Martínez-Iniesta M, et al. Hepatic carcinoma-associated fibroblasts promote an adaptative response in colorectal cancer cells that inhibit proliferation and apoptosis: nonresistant cells die by nonapoptotic cell death. Neoplasia. 2011;13:931-46 pubmed
Wu J, Raver C, Piao C, Keller A, Faden A. Cell cycle activation contributes to increased neuronal activity in the posterior thalamic nucleus and associated chronic hyperesthesia after rat spinal cord contusion. Neurotherapeutics. 2013;10:520-38 pubmed publisher
Sathyan K, Nalinakumari K, Abraham T, Kannan S. CCND1 polymorphisms (A870G and C1722G) modulate its protein expression and survival in oral carcinoma. Oral Oncol. 2008;44:689-97 pubmed
Heiferman M, Salabat M, Ujiki M, Strouch M, Cheon E, Silverman R, et al. Sansalvamide induces pancreatic cancer growth arrest through changes in the cell cycle. Anticancer Res. 2010;30:73-8 pubmed
Zhang L, Jiang F, Xu L, Wang J, Bai J, Yin R, et al. The role of cyclin D1 expression and patient's survival in non-small-cell lung cancer: a systematic review with meta-analysis. Clin Lung Cancer. 2012;13:188-95 pubmed publisher
Ose R, Yanagawa T, Ikeda S, Ohara O, Koga H. PCDH24-induced contact inhibition involves downregulation of beta-catenin signaling. Mol Oncol. 2009;3:54-66 pubmed publisher
Raynaud F, Whittaker S, Fischer P, McClue S, Walton M, Barrie S, et al. In vitro and in vivo pharmacokinetic-pharmacodynamic relationships for the trisubstituted aminopurine cyclin-dependent kinase inhibitors olomoucine, bohemine and CYC202. Clin Cancer Res. 2005;11:4875-87 pubmed
Casimiro M, Crosariol M, Loro E, Ertel A, Yu Z, Dampier W, et al. ChIP sequencing of cyclin D1 reveals a transcriptional role in chromosomal instability in mice. J Clin Invest. 2012;122:833-43 pubmed publisher
Santamaria D, Barrière C, Cerqueira A, Hunt S, Tardy C, Newton K, et al. Cdk1 is sufficient to drive the mammalian cell cycle. Nature. 2007;448:811-5 pubmed
Paternot S, Dumont J, Roger P. Differential utilization of cyclin D1 and cyclin D3 in the distinct mitogenic stimulations by growth factors and TSH of human thyrocytes in primary culture. Mol Endocrinol. 2006;20:3279-92 pubmed
Faast R, White J, Cartwright P, Crocker L, Sarcevic B, Dalton S. Cdk6-cyclin D3 activity in murine ES cells is resistant to inhibition by p16(INK4a). Oncogene. 2004;23:491-502 pubmed
Khoury T, Alrawi S, Ramnath N, Li Q, Grimm M, Black J, et al. Eukaryotic initiation factor-4E and cyclin D1 expression associated with patient survival in lung cancer. Clin Lung Cancer. 2009;10:58-66 pubmed publisher
Toschi E, Bacigalupo I, Strippoli R, Chiozzini C, Cereseto A, Falchi M, et al. HIV-1 Tat regulates endothelial cell cycle progression via activation of the Ras/ERK MAPK signaling pathway. Mol Biol Cell. 2006;17:1985-94 pubmed
Pich A, Fraire F, Fornari A, Bonino L, Godio L, Bortolin P, et al. Intrasinusoidal bone marrow infiltration and splenic marginal zone lymphoma: a quantitative study. Eur J Haematol. 2006;76:392-8 pubmed
Zwijsen R, Buckle R, Hijmans E, Loomans C, Bernards R. Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin D1. Genes Dev. 1998;12:3488-98 pubmed
Collecchi P, Passoni A, Rocchetta M, Gnesi E, Baldini E, Bevilacqua G. Cyclin-D1 expression in node-positive (N+) and node-negative (N-) infiltrating human mammary carcinomas. Int J Cancer. 1999;84:139-44 pubmed
Pulcrano M, Boukheris H, Talbot M, Caillou B, Dupuy C, Virion A, et al. Poorly differentiated follicular thyroid carcinoma: prognostic factors and relevance of histological classification. Thyroid. 2007;17:639-46 pubmed
Vékony H, Roser K, Löning T, Raaphorst F, Leemans C, Van der Waal I, et al. Deregulated expression of p16INK4a and p53 pathway members in benign and malignant myoepithelial tumours of the salivary glands. Histopathology. 2008;53:658-66 pubmed publisher
Lebe B, Pabuccuoglu U, Ozer E. The significance of Ki-67 proliferative index and cyclin D1 expression of dysplastic nevi in the biologic spectrum of melanocytic lesions. Appl Immunohistochem Mol Morphol. 2007;15:160-4 pubmed
Li Y, Tan X, Dai C, Stolz D, Wang D, Liu Y. Inhibition of integrin-linked kinase attenuates renal interstitial fibrosis. J Am Soc Nephrol. 2009;20:1907-18 pubmed publisher
Chen X, Tian Y, Yao L, Zhang J, Liu Y. Hypoxia stimulates proliferation of rat neural stem cells with influence on the expression of cyclin D1 and c-Jun N-terminal protein kinase signaling pathway in vitro. Neuroscience. 2010;165:705-14 pubmed publisher
Zhao L, Jiao Q, Yang P, Chen X, Zhang J, Zhao B, et al. Metabotropic glutamate receptor 5 promotes proliferation of human neural stem/progenitor cells with activation of mitogen-activated protein kinases signaling pathway in vitro. Neuroscience. 2011;192:185-94 pubmed publisher
Kossatz U, Dietrich N, Zender L, Buer J, Manns M, Malek N. Skp2-dependent degradation of p27kip1 is essential for cell cycle progression. Genes Dev. 2004;18:2602-7 pubmed
Geradts J, Ingram C. Abnormal expression of cell cycle regulatory proteins in ductal and lobular carcinomas of the breast. Mod Pathol. 2000;13:945-53 pubmed
Yang D, Qi Y, Chen Q, Wang Z, Jin X, Gao J, et al. The over-expression of p53 H179Y residue mutation causes the increase of cyclin A1 and Cdk4 expression in HELF cells. Mol Cell Biochem. 2007;304:219-26 pubmed
Chen B, Pollard J. Cyclin D2 compensates for the loss of cyclin D1 in estrogen-induced mouse uterine epithelial cell proliferation. Mol Endocrinol. 2003;17:1368-81 pubmed
Clark W, Black E, MacLaren A, Kruse U, LaThangue N, Vogt P, et al. v-Jun overrides the mitogen dependence of S-phase entry by deregulating retinoblastoma protein phosphorylation and E2F-pocket protein interactions as a consequence of enhanced cyclin E-cdk2 catalytic activity. Mol Cell Biol. 2000;20:2529-42 pubmed
Schnier J, Nishi K, Harley W, Gorin F. An acidic environment changes cyclin D1 localization and alters colony forming ability in gliomas. J Neurooncol. 2008;89:19-26 pubmed publisher
Dong H, Weisberger J, Liu Z, Tugulea S. Immunophenotypic analysis of CD103+ B-lymphoproliferative disorders: hairy cell leukemia and its mimics. Am J Clin Pathol. 2009;131:586-95 pubmed publisher
Cui X, Li S, Shraim A, Kobayashi Y, Hayakawa T, Kanno S, et al. Subchronic exposure to arsenic through drinking water alters expression of cancer-related genes in rat liver. Toxicol Pathol. 2004;32:64-72 pubmed
Wang Z, Qi Y, Chen Q, Yang D, Tang S, Jin X, et al. Cyclin A is essential for the p53-modulated inhibition from benzo(a)pyrene toxicity in A549 cells. Toxicology. 2009;256:1-6 pubmed publisher
Zheng Y, Bie W, Yang R, Perekatt A, Poole A, Tyner A. Functions of p21 and p27 in the regenerating epithelial linings of the mouse small and large intestine. Cancer Biol Ther. 2008;7:873-9 pubmed
Souza C, Gamba C, Campos C, Lopes M, Ferreira M, Andrade S, et al. Carboplatin delays mammary cancer 4T1 growth in mice. Pathol Res Pract. 2013;209:24-9 pubmed publisher
Hawryluk E, Baran J, Gerami P, Sepehr A. 'Monster cell' melanoma with pulmonary metastasis and cyclin D1 amplification. J Cutan Pathol. 2013;40:61-5 pubmed publisher
Obrador-Hevia A, Serra-Sitjar M, Rodriguez J, Villalonga P, Fernandez De Mattos S. The tumour suppressor FOXO3 is a key regulator of mantle cell lymphoma proliferation and survival. Br J Haematol. 2012;156:334-45 pubmed publisher
Gierut J, Zheng Y, Bie W, Carroll R, Ball-Kell S, Haegebarth A, et al. Disruption of the mouse protein tyrosine kinase 6 gene prevents STAT3 activation and confers resistance to azoxymethane. Gastroenterology. 2011;141:1371-80, 1380.e1-2 pubmed publisher
Whittaker S, Walton M, Garrett M, Workman P. The Cyclin-dependent kinase inhibitor CYC202 (R-roscovitine) inhibits retinoblastoma protein phosphorylation, causes loss of Cyclin D1, and activates the mitogen-activated protein kinase pathway. Cancer Res. 2004;64:262-72 pubmed
Beier F, Ali Z, Mok D, Taylor A, Leask T, Albanese C, et al. TGFbeta and PTHrP control chondrocyte proliferation by activating cyclin D1 expression. Mol Biol Cell. 2001;12:3852-63 pubmed
Wu W, Slomovitz B, Soliman P, Schmeler K, Celestino J, Milam M, et al. Correlation of cyclin D1 and cyclin D3 overexpression with the loss of PTEN expression in endometrial carcinoma. Int J Gynecol Cancer. 2006;16:1668-72 pubmed
Xiong W, Pestell R, Rosner M. Role of cyclins in neuronal differentiation of immortalized hippocampal cells. Mol Cell Biol. 1997;17:6585-97 pubmed
Vouret-Craviari V, Boulter E, Grall D, Matthews C, Van Obberghen-Schilling E. ILK is required for the assembly of matrix-forming adhesions and capillary morphogenesis in endothelial cells. J Cell Sci. 2004;117:4559-69 pubmed
LARREA M, Liang J, Da Silva T, Hong F, Shao S, Han K, et al. Phosphorylation of p27Kip1 regulates assembly and activation of cyclin D1-Cdk4. Mol Cell Biol. 2008;28:6462-72 pubmed publisher
Dagvadorj A, Kirken R, Leiby B, Karras J, Nevalainen M. Transcription factor signal transducer and activator of transcription 5 promotes growth of human prostate cancer cells in vivo. Clin Cancer Res. 2008;14:1317-24 pubmed publisher
Reutens A, Fu M, Wang C, Albanese C, McPhaul M, Sun Z, et al. Cyclin D1 binds the androgen receptor and regulates hormone-dependent signaling in a p300/CBP-associated factor (P/CAF)-dependent manner. Mol Endocrinol. 2001;15:797-811 pubmed
Doglioni C, Piccinin S, Demontis S, Cangi M, Pecciarini L, Chiarelli C, et al. Alterations of beta-catenin pathway in non-melanoma skin tumors: loss of alpha-ABC nuclear reactivity correlates with the presence of beta-catenin gene mutation. Am J Pathol. 2003;163:2277-87 pubmed
product information
Product Type :
Antibody
Product Name :
Cyclin D1 Monoclonal Antibody (DCS-6)
Catalog # :
MA1-12296
Quantity :
100µg
Price :
US 309.00
Clonality :
Monoclonal
Purity :
Protein A/G
Host :
Mouse
Reactivity :
Human, Mouse, Non-human primate, Rat
Applications :
Immunohistochemistry: Assay Dependent, Immunoprecipitation: Assay Dependent, Western Blot: 1:1000
Species :
Human, Mouse, Non-human primate, Rat
Clone :
DCS-6
Isotype :
IgG2a
Storage :
-20° C, Avoid Freeze/Thaw Cycles
Description :
Cyclin D1 (Bcl-1 oncogene product), is a member of the Cyclin family that help control transition between phases of the cell cycle by acting as regulatory subunits of the Cdks. The D-type Cyclins are composed of three subtypes, Cyclin D1, D2 and D3. Cyclin D1 is essential for control of the cell cycle at the G1/S transitions and interacts with Cdk4 or Cdk6 protein kinases. On the recent study, Cyclin D1 regulates cellular metabolism, fat cell differentiation and cellular migration. Also Cyclin D1 involves in development and cancer.
Immunogen :
Recombinant Cyclin D1 protein.
Format :
Liquid
Applications w/Dilutions :
Immunohistochemistry: Assay Dependent, Immunoprecipitation: Assay Dependent, Western Blot: 1:1000
Aliases :
PRAD-1, BCL-1
PubMed References :
10022912, 10096245, 10490638, 10713176, 11007034, 11106243, 11158317, 11163229, 11207046, 11241308, 11260626, 11280746, 11316792, 11328859, 11406180, 11719282, 11738146, 11739785, 11929828, 11997075, 12147671, 12417722, 12627502, 12649329, 12651161, 12730677, 12912958, 12927923, 14578468, 14603452, 14633602, 14694525, 14713550, 14724578, 14729633, 14770182, 14999779, 15026085, 15084985, 15205327, 15316070, 15456744, 15520280, 15685701, 15691880, 15829708, 15998435, 16000586, 16012517, 16166286, 16258503, 16436505, 16448463, 16480431, 16522728, 16884382, 16916940, 17013808, 17138864, 17277770, 17525627, 17530187, 17696834, 17700700, 17805209, 17964517, 18061526, 18316550, 18339311, 18339845, 18344686, 18404250, 18710949, 18767044, 18938028, 19027820, 19076682, 19096011, 19158320, 19177593, 19229248, 19258414, 19289374, 19289595, 19383367, 19508551, 19541809, 19549905, 19585502, 19909792, 19915163, 20150619, 20399820, 20456283, 20535544, 21108658, 21191045, 21245385, 21314951, 21464042, 21478903, 21643842, 21723923, 21741923, 22028619, 22107151, 22133292, 22214766, 22307325, 22505890, 22701710, 22860235, 23164716, 23278726, 23470834, 23525482, 23557329, 23708653, 23737759, 23775067, 24000165, 24008318, 24067903, 24091101, 24427347, 24515438, 24819753, 24930890, 25229978, 25940700, 26503526, 9042862, 9271411, 9343422, 9394728, 9435306, 9499093, 9832502
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
www.thermofisher.com
800-678-5599
headquarters: USA