INSR Monoclonal Antibody (18-44) | Invitrogen MA1-10865 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

INSR Monoclonal Antibody (18-44)

catalog :

MA1-10865

quantity :

100 ug

price :

US 592.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

18-44

The same clone is also sold as:

Abcam: ab983

reactivity :

human

application :

western blot, immunoprecipitation

citations: 4

Reference
Scarpa E, Giordani C, Antonelli A, Petrelli M, Balercia G, Silvetti F, et al. The Combination of Natural Molecules Naringenin, Hesperetin, Curcumin, Polydatin and Quercetin Synergistically Decreases SEMA3E Expression Levels and DPPIV Activity in In Vitro Models of Insulin Resistance. Int J Mol Sci. 2023;24: pubmed publisher
Kowalczuk A, Bourebaba N, Kornicka Garbowska K, Turlej E, Marycz K, Bourebaba L. Hyoscyamus albus nortropane alkaloids reduce hyperglycemia and hyperinsulinemia induced in HepG2 cells through the regulation of SIRT1/NF-kB/JNK pathway. Cell Commun Signal. 2021;19:61 pubmed publisher
Meakin P, Mezzapesa A, Benabou E, Haas M, Bonardo B, Grino M, et al. The beta secretase BACE1 regulates the expression of insulin receptor in the liver. Nat Commun. 2018;9:1306 pubmed publisher
Burtrum D, Zhu Z, Lu D, Anderson D, Prewett M, Pereira D, et al. A fully human monoclonal antibody to the insulin-like growth factor I receptor blocks ligand-dependent signaling and inhibits human tumor growth in vivo. Cancer Res. 2003;63:8912-21 pubmed

product information

Product Type :

Antibody

Product Name :

INSR Monoclonal Antibody (18-44)

Catalog # :

MA1-10865

Quantity :

100 ug

Price :

US 592.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human

Applications :

Immunoprecipitation: 1-10 ug/mL, Western Blot: 1-10 ug/mL

Species :

Human

Clone :

18-44

Isotype :

IgG2b

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

INSR is a receptor tyrosine kinase. Binding of insulin to the extracellular domain of INSR stimulates glucose uptake. INSR and IGF-1 receptors share major structural and functional similarity. The earliest cellular response to insulin stimulation is autophosphorylation of tyrosine in INSR. In humans, the INSR gene is located on chromosome 19. Defects in INSR are the cause of various insulin resistance syndromes and IGF-1R defects may also cause some forms of growth retardation.

Immunogen :

human placental insulin receptor.

Format :

Liquid

Applications w/Dilutions :

Immunoprecipitation: 1-10 ug/mL, Western Blot: 1-10 ug/mL

Aliases :

4932439J01Rik; CD 220; CD220; CD220 antigen; CD220 beta; CD221; D630014A15Rik; HHF 5; HHF5; IGF-I receptor; INSR; Insulin receptor; insulin receptor preproprotein; Insulin receptor subunit alpha; Insulin receptor subunit beta; IR; IR 1; IR beta; IR1; IR-1; IR-A; IR-B