LIME Monoclonal Antibody (LIME-06), PE | Invitrogen MA1-10398 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

LIME Monoclonal Antibody (LIME-06), PE

catalog :

MA1-10398

quantity :

100 µg

price :

US 437.00

clonality :

monoclonal

host :

mouse

conjugate :

clone name :

LIME-06

reactivity :

human

application :

flow cytometry

product information

Product Type :

Antibody

Product Name :

LIME Monoclonal Antibody (LIME-06), PE

Catalog # :

MA1-10398

Quantity :

100 µg

Price :

US 437.00

Clonality :

Monoclonal

Purity :

Size-exclusion chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 1-5 µg/mL

Species :

Human

Clone :

LIME-06

Isotype :

IgG1, kappa

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

LIME (Lck-interacting molecule) is a 30 kDa double-palmitoylated protein with unusually basic cytoplasmic domain, expressed by T cells. After ligation of CD4 or CD8 T cell coreceptors, LIME is phosphorylated by Src-family kinases and associates with Lck and Fyn kinases and with their negative regulator Csk. Interestingly, Csk-mediated phosphorylation of C-terminal negative-regulatory tyrosine of LIME-associated Lck can result in increase of enzymatic activity compared with the total pool of Lck, thus, LIME serves as a positive regulator of TCR-dependent T cell signaling. However, under some circumstances, LIME may mediate inhibitory signals.

Immunogen :

Bacterially expressed intracellular fragment corresponding to aa 141-295 of human LIME.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1-5 µg/mL

Aliases :

2810038K19Rik; dJ583P15.4; FLJ20406; Lck interacting transmembrane adaptor 1; lck-interacting membrane protein; Lck-interacting molecule; lck-interacting transmembrane adapter 1; Lime; lime 1; LIME1; LP8067; RP4-583P15.5