product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD80 Monoclonal Antibody (16-10A1)
catalog :
MA1-10287
quantity :
100 ug
price :
US 207.00
clonality :
monoclonal
host :
hamsters
conjugate :
nonconjugated
clone name :
16-10A1
reactivity :
mouse, dogs
application :
immunohistochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - frozen section, blocking or activating experiments
more info or order :
citations: 45
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; 1:200; loading ...; fig s10c
Stoff M, Ebbecke T, Ciurkiewicz M, Pavasutthipaisit S, Mayer Lambertz S, St xf6 rk T, et al. C-type lectin receptor DCIR contributes to hippocampal injury in acute neurotropic virus infection. Sci Rep. 2021;11:23819 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 4a, 7a
Weng X, Zhao H, Guan Q, Shi G, Feng S, Gleave M, et al. Clusterin regulates macrophage expansion, polarization and phagocytic activity in response to inflammation in the kidneys. Immunol Cell Biol. 2021;99:274-287 pubmed publisher
  • flow cytometry; mouse; 1:300; loading ...; fig 3m
Stebegg M, Bignon A, Hill D, Silva Cayetano A, Krueger C, Vanderleyden I, et al. Rejuvenating conventional dendritic cells and T follicular helper cell formation after vaccination. elife. 2020;9: pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1b
Mizuno R, Sugiura D, Shimizu K, Maruhashi T, Watada M, Okazaki I, et al. PD-1 Primarily Targets TCR Signal in the Inhibition of Functional T Cell Activation. Front Immunol. 2019;10:630 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 6c
Lee Y, Ju J, Shon W, Oh S, Min C, Kang M, et al. Skewed Dendritic Cell Differentiation of MyD88-Deficient Donor Bone Marrow Cells, Instead of Massive Expansion as Myeloid-Derived Suppressor Cells, Aggravates GVHD. Immune Netw. 2018;18:e44 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3h
Düsedau H, Kleveman J, Figueiredo C, Biswas A, Steffen J, Kliche S, et al. p75NTR regulates brain mononuclear cell function and neuronal structure in Toxoplasma infection-induced neuroinflammation. Glia. 2019;67:193-211 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s2
Kaplanov I, Carmi Y, Kornetsky R, Shemesh A, Shurin G, Shurin M, et al. Blocking IL-1β reverses the immunosuppression in mouse breast cancer and synergizes with anti-PD-1 for tumor abrogation. Proc Natl Acad Sci U S A. 2019;116:1361-1369 pubmed publisher
  • flow cytometry; mouse; loading ...; fig e5c
Du X, Wen J, Wang Y, Karmaus P, Khatamian A, Tan H, et al. Hippo/Mst signalling couples metabolic state and immune function of CD8α+ dendritic cells. Nature. 2018;558:141-145 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 5d
Shrestha B, You D, Saravia J, Siefker D, Jaligama S, Lee G, et al. IL-4R? on dendritic cells in neonates and Th2 immunopathology in respiratory syncytial virus infection. J Leukoc Biol. 2017;102:153-161 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 5a
Inoue T, Shinnakasu R, Ise W, Kawai C, Egawa T, Kurosaki T. The transcription factor Foxo1 controls germinal center B cell proliferation in response to T cell help. J Exp Med. 2017;214:1181-1198 pubmed publisher
  • flow cytometry; mouse; 1:400; loading ...; fig s5
Barthels C, Ogrinc A, Steyer V, Meier S, Simon F, Wimmer M, et al. CD40-signalling abrogates induction of RORγt+ Treg cells by intestinal CD103+ DCs and causes fatal colitis. Nat Commun. 2017;8:14715 pubmed publisher
  • blocking or activating experiments; mouse; loading ...; fig 7
Hwang I, Kim K, Choi S, Lomunova M. Potentiation of T Cell Stimulatory Activity by Chemical Fixation of a Weak Peptide-MHC Complex. Mol Cells. 2017;40:24-36 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 5n
van Nieuwenhuijze A, Dooley J, Humblet Baron S, Sreenivasan J, Koenders M, Schlenner S, et al. Defective germinal center B-cell response and reduced arthritic pathology in microRNA-29a-deficient mice. Cell Mol Life Sci. 2017;74:2095-2106 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2b
Tahiri H, Omri S, Yang C, Duhamel F, Samarani S, Ahmad A, et al. Lymphocytic Microparticles Modulate Angiogenic Properties of Macrophages in Laser-induced Choroidal Neovascularization. Sci Rep. 2016;6:37391 pubmed publisher
  • flow cytometry; mouse; fig 4B
Veinotte L, Gebremeskel S, Johnston B. CXCL16-positive dendritic cells enhance invariant natural killer T cell-dependent IFN? production and tumor control. Oncoimmunology. 2016;5:e1160979 pubmed publisher
  • flow cytometry; mouse; fig s2b
Wang S, Xia P, Chen Y, Huang G, Xiong Z, Liu J, et al. Natural Killer-like B Cells Prime Innate Lymphocytes against Microbial Infection. Immunity. 2016;45:131-44 pubmed publisher
  • flow cytometry; mouse; 1:200; loading ...; fig s2b
Jain N, Khullar B, Oswal N, Banoth B, Joshi P, Ravindran B, et al. TLR-mediated albuminuria needs TNF?-mediated cooperativity between TLRs present in hematopoietic tissues and CD80 present on non-hematopoietic tissues in mice. Dis Model Mech. 2016;9:707-17 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 5a
Sei J, Haskett S, Kaminsky L, Lin E, Truckenmiller M, Bellone C, et al. Peptide-MHC-I from Endogenous Antigen Outnumber Those from Exogenous Antigen, Irrespective of APC Phenotype or Activation. PLoS Pathog. 2015;11:e1004941 pubmed publisher
  • flow cytometry; mouse; tbl s1
Kamachi F, Isshiki T, Harada N, Akiba H, Miyake S. ICOS promotes group 2 innate lymphoid cell activation in lungs. Biochem Biophys Res Commun. 2015;463:739-45 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s2b
Jing W, Gershan J, Weber J, Tlomak D, McOlash L, Sabatos Peyton C, et al. Combined immune checkpoint protein blockade and low dose whole body irradiation as immunotherapy for myeloma. J Immunother Cancer. 2015;3:2 pubmed publisher
  • flow cytometry; mouse
Zhang T, He X, Tsang T, Harris D. Transgenic TCR expression: comparison of single chain with full-length receptor constructs for T-cell function. Cancer Gene Ther. 2004;11:487-96 pubmed
  • flow cytometry; mouse
Knobeloch K, Wright M, Ochsenbein A, Liesenfeld O, Lohler J, Zinkernagel R, et al. Targeted inactivation of the tetraspanin CD37 impairs T-cell-dependent B-cell response under suboptimal costimulatory conditions. Mol Cell Biol. 2000;20:5363-9 pubmed
Ten Hoeve A, Hakimi M, Barragan A. Sustained Egr-1 Response via p38 MAP Kinase Signaling Modulates Early Immune Responses of Dendritic Cells Parasitized by Toxoplasma gondii. Front Cell Infect Microbiol. 2019;9:349 pubmed publisher
Faulin T, Kazuma S, Tripodi G, Cavalcante M, Wakasuqui F, Oliveira C, et al. Proinflammatory Action of a New Electronegative Low-Density Lipoprotein Epitope. Biomolecules. 2019;9: pubmed publisher
Lin J, Wang Z, Wang J, Yang Q. Microarray analysis of infectious bronchitis virus infection of chicken primary dendritic cells. BMC Genomics. 2019;20:557 pubmed publisher
Ou P, Wen L, Liu X, HUANG J, Huang X, Su C, et al. Thioesterase PPT1 balances viral resistance and efficient T cell crosspriming in dendritic cells. J Exp Med. 2019;: pubmed publisher
Schrock D, Leddon S, Hughson A, Miller J, Lacy Hulbert A, Fowell D. Pivotal role for αV integrins in sustained Tfh support of the germinal center response for long-lived plasma cell generation. Proc Natl Acad Sci U S A. 2019;: pubmed publisher
Salerno F, Guislain A, Freen van Heeren J, Nicolet B, Young H, Wolkers M. Critical role of post-transcriptional regulation for IFN-γ in tumor-infiltrating T cells. Oncoimmunology. 2019;8:e1532762 pubmed publisher
Ekiz H, Lai S, Gundlapalli H, Haroun F, Williams M, Welm A. Inhibition of RON kinase potentiates anti-CTLA-4 immunotherapy to shrink breast tumors and prevent metastatic outgrowth. Oncoimmunology. 2018;7:e1480286 pubmed publisher
Thomé R, Bonfanti A, Rasouli J, Mari E, Zhang G, Rostami A, et al. Chloroquine-treated dendritic cells require STAT1 signaling for their tolerogenic activity. Eur J Immunol. 2018;48:1228-1234 pubmed publisher
Rodriguez Cetina Biefer H, Heinbokel T, Uehara H, Camacho V, Minami K, Nian Y, et al. Mast cells regulate CD4+ T-cell differentiation in the absence of antigen presentation. J Allergy Clin Immunol. 2018;142:1894-1908.e7 pubmed publisher
Ono Y, Pérez Gutiérrez A, Nakao T, Dai H, Camirand G, Yoshida O, et al. Graft-infiltrating PD-L1hi cross-dressed dendritic cells regulate antidonor T cell responses in mouse liver transplant tolerance. Hepatology. 2018;67:1499-1515 pubmed publisher
Roberts N, Adams B, McCarthy N, Tooze R, Parnell S, Anderson G, et al. Prdm1 Regulates Thymic Epithelial Function To Prevent Autoimmunity. J Immunol. 2017;199:1250-1260 pubmed publisher
White A, Baik S, Parnell S, Holland A, Brombacher F, Jenkinson W, et al. A type 2 cytokine axis for thymus emigration. J Exp Med. 2017;214:2205-2216 pubmed publisher
Thylur R, Wu X, Gowda N, Punnath K, Neelgund S, Febbraio M, et al. CD36 receptor regulates malaria-induced immune responses primarily at early blood stage infection contributing to parasitemia control and resistance to mortality. J Biol Chem. 2017;292:9394-9408 pubmed publisher
Skopova K, Tomalova B, Kanchev I, Rossmann P, Svedova M, Adkins I, et al. Cyclic AMP-Elevating Capacity of Adenylate Cyclase Toxin-Hemolysin Is Sufficient for Lung Infection but Not for Full Virulence of Bordetella pertussis. Infect Immun. 2017;85: pubmed publisher
Zhao T, Bernstein K, Fang J, Shen X. Angiotensin-converting enzyme affects the presentation of MHC class II antigens. Lab Invest. 2017;97:764-771 pubmed publisher
Lehmann C, Baranska A, Heidkamp G, Heger L, Neubert K, Lühr J, et al. DC subset-specific induction of T cell responses upon antigen uptake via Fc? receptors in vivo. J Exp Med. 2017;214:1509-1528 pubmed publisher
Zamarron B, Mergian T, Cho K, Martinez Santibañez G, Luan D, Singer K, et al. Macrophage Proliferation Sustains Adipose Tissue Inflammation in Formerly Obese Mice. Diabetes. 2017;66:392-406 pubmed publisher
Bracamonte Baran W, Florentin J, Zhou Y, Jankowska Gan E, Haynes W, Zhong W, et al. Modification of host dendritic cells by microchimerism-derived extracellular vesicles generates split tolerance. Proc Natl Acad Sci U S A. 2017;114:1099-1104 pubmed publisher
Attridge K, Kenefeck R, Wardzinski L, Qureshi O, Wang C, Manzotti C, et al. IL-21 promotes CD4 T cell responses by phosphatidylinositol 3-kinase-dependent upregulation of CD86 on B cells. J Immunol. 2014;192:2195-201 pubmed publisher
Thomas D, Wong F, Zaccone P, Green E, Wallberg M. Protection of islet grafts through transforming growth factor-?-induced tolerogenic dendritic cells. Diabetes. 2013;62:3132-42 pubmed publisher
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Goodyear C, Silverman G. Death by a B cell superantigen: In vivo VH-targeted apoptotic supraclonal B cell deletion by a Staphylococcal Toxin. J Exp Med. 2003;197:1125-39 pubmed
product information
Product Type :
Antibody
Product Name :
CD80 Monoclonal Antibody (16-10A1)
Catalog # :
MA1-10287
Quantity :
100 ug
Price :
US 207.00
Clonality :
Monoclonal
Purity :
protein A
Host :
Armenian Hamster
Reactivity :
Canine, Mouse
Applications :
Flow Cytometry: 1-4 ug/mL, Immunohistochemistry (Frozen): Assay-Dependent, Immunoprecipitation: Assay-Dependent
Species :
Canine, Mouse
Clone :
16-10A1
Isotype :
IgG2
Storage :
4 C, do not freeze
Description :
CD80 (B7-1) and CD86 (B7-2) are ligands of T cell critical costimulatory molecule CD28, and of an inhibitory receptor CTLA-4 (CD152). Both B7 molecules are expressed on professional antigen-presenting cells and are essential for T cell activation, and both molecules can also substitute for each other in this process. CD80 is rapidly induced on the surface of in vitro activated B cells, with Epstein Barr Virus (EBV) transformed B cell lines, with Burkitts lymphoma cell lines, with freshly isolated follicular B lymphoma cells, T cells, and monocytes. The B-lymphocyte activation antigen B7-1 provides regulatory signals for T lymphocytes as a consequence of binding to the CD28 and CTLA4 ligands of T cells. Diseases associated with CD80 dysfunction include gallbladder squamous cell carcinoma and myocarditis.
Immunogen :
CD80-transfected CHO cell line
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1-4 ug/mL, Immunohistochemistry (Frozen): Assay-Dependent, Immunoprecipitation: Assay-Dependent
Aliases :
Activation B7-1 antigen; B7; B7 protein; B7.1; B71; B7-1; B7-1 protein; B7-1 protein precursor; BB1; B-lymphocyte activation antigen B7; Cd28l; CD28LG; CD28LG1; CD80; Cd80 a rat homolog of the human CD28/CTLA - 4 ligand (B7-1); CD80 anitgen; CD80 antigen; CD80 antigen (CD28 antigen ligand 1, B7-1 antigen); Cd80 molecule; CD80 protein precursor; costimulatory factor CD80; costimulatory molecule variant IgV-CD80; CTLA-4 counter-receptor B7.1; LAB7; Ly53; Ly-53; MIC17; sCD 80; sCD80; secreted B7-1 protein precursor; soluble CD 80; soluble CD80; T-cell costimulatory molecule; T-cell co-stimulatory protein B7-1; T-lymphocyte activation antigen CD80; TS/A-1; TSA1
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA