product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD62L Monoclonal Antibody (DREG56)
catalog :
MA1-10259
quantity :
100 ug
price :
US 242.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
DREG56
reactivity :
human
application :
western blot, immunohistochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, blocking or activating experiments
more info or order :
Invitrogen product webpage
citations: 39
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; loading ...; fig 3c
Tong A, Hashem H, Eid S, Allen F, Kingsley D, Huang A. Adoptive natural killer cell therapy is effective in reducing pulmonary metastasis of Ewing sarcoma. Oncoimmunology. 2017;6:e1303586 pubmed publisher
  • western blot; human; loading ...; fig 3d
Mytych J, Romerowicz Misielak M, Koziorowski M. Long-term culture with lipopolysaccharide induces dose-dependent cytostatic and cytotoxic effects in THP-1 monocytes. Toxicol In Vitro. 2017;42:1-9 pubmed publisher
  • flow cytometry; human; loading ...; fig s2
Su S, Zou Z, Chen F, Ding N, Du J, Shao J, et al. CRISPR-Cas9-mediated disruption of PD-1 on human T cells for adoptive cellular therapies of EBV positive gastric cancer. Oncoimmunology. 2017;6:e1249558 pubmed publisher
  • flow cytometry; human; loading ...
Ryan P, Sumaria N, Holland C, Bradford C, Izotova N, Grandjean C, et al. Heterogeneous yet stable Vδ2(+) T-cell profiles define distinct cytotoxic effector potentials in healthy human individuals. Proc Natl Acad Sci U S A. 2016;113:14378-14383 pubmed
  • flow cytometry; human; loading ...; fig s5c
Tomic A, Varanasi P, Golemac M, Malic S, Riese P, Borst E, et al. Activation of Innate and Adaptive Immunity by a Recombinant Human Cytomegalovirus Strain Expressing an NKG2D Ligand. PLoS Pathog. 2016;12:e1006015 pubmed publisher
  • flow cytometry; human; loading ...
Wahid R, Fresnay S, Levine M, Sztein M. Cross-reactive multifunctional CD4+ T cell responses against Salmonella enterica serovars Typhi, Paratyphi A and Paratyphi B in humans following immunization with live oral typhoid vaccine Ty21a. Clin Immunol. 2016;173:87-95 pubmed publisher
  • flow cytometry; human; fig 1h
Boddupalli C, Nair S, Gray S, Nowyhed H, Verma R, Gibson J, et al. ABC transporters and NR4A1 identify a quiescent subset of tissue-resident memory T cells. J Clin Invest. 2016;126:3905-3916 pubmed publisher
  • flow cytometry; human; loading ...; fig s1
Graves S, Kouriba B, Diarra I, Daou M, Niangaly A, Coulibaly D, et al. Strain-specific Plasmodium falciparum multifunctional CD4(+) T cell cytokine expression in Malian children immunized with the FMP2.1/AS02A vaccine candidate. Vaccine. 2016;34:2546-55 pubmed publisher
  • flow cytometry; human; loading ...; fig 1c
Rombout A, Lust S, Offner F, Naessens E, Verhasselt B, Philippé J. Mimicking the tumour microenvironment of chronic lymphocytic leukaemia in vitro critically depends on the type of B-cell receptor stimulation. Br J Cancer. 2016;114:704-12 pubmed publisher
  • flow cytometry; human; fig 2
Arriaga Pizano L, Ferat Osorio E, Rodríguez Abrego G, Mancilla Herrera I, Domínguez Cerezo E, Valero Pacheco N, et al. Differential Immune Profiles in Two Pandemic Influenza A(H1N1)pdm09 Virus Waves at Pandemic Epicenter. Arch Med Res. 2015;46:651-8 pubmed publisher
  • flow cytometry; human; loading ...; fig e4a
Mitson Salazar A, Yin Y, Wansley D, Young M, Bolan H, Arceo S, et al. Hematopoietic prostaglandin D synthase defines a proeosinophilic pathogenic effector human T(H)2 cell subpopulation with enhanced function. J Allergy Clin Immunol. 2016;137:907-18.e9 pubmed publisher
  • immunohistochemistry; human; 1:100
  • western blot; human; 1:500
Vassena L, Giuliani E, Koppensteiner H, Bolduan S, Schindler M, Doria M. HIV-1 Nef and Vpu Interfere with L-Selectin (CD62L) Cell Surface Expression To Inhibit Adhesion and Signaling in Infected CD4+ T Lymphocytes. J Virol. 2015;89:5687-700 pubmed publisher
  • flow cytometry; human
Pegram H, Purdon T, van Leeuwen D, Curran K, Giralt S, Barker J, et al. IL-12-secreting CD19-targeted cord blood-derived T cells for the immunotherapy of B-cell acute lymphoblastic leukemia. Leukemia. 2015;29:415-22 pubmed publisher
  • flow cytometry; human; fig 1
Cernea S, Herold K. Monitoring of antigen-specific CD8 T cells in patients with type 1 diabetes treated with antiCD3 monoclonal antibodies. Clin Immunol. 2010;134:121-9 pubmed publisher
  • immunohistochemistry - frozen section; human; fig 2
Prakobphol A, Genbacev O, Gormley M, Kapidzic M, Fisher S. A role for the L-selectin adhesion system in mediating cytotrophoblast emigration from the placenta. Dev Biol. 2006;298:107-17 pubmed
  • immunohistochemistry - paraffin section; human; fig 1
Zdravkovic T, Genbacev O, Prakobphol A, Cvetkovic M, Schanz A, McMaster M, et al. Nicotine downregulates the l-selectin system that mediates cytotrophoblast emigration from cell columns and attachment to the uterine wall. Reprod Toxicol. 2006;22:69-76 pubmed
  • flow cytometry; human; tbl 2
Bratke K, Kuepper M, Bade B, Virchow J, Luttmann W. Differential expression of human granzymes A, B, and K in natural killer cells and during CD8+ T cell differentiation in peripheral blood. Eur J Immunol. 2005;35:2608-16 pubmed
  • flow cytometry; human
Crough T, Burrows J, Fazou C, Walker S, Davenport M, Khanna R. Contemporaneous fluctuations in T cell responses to persistent herpes virus infections. Eur J Immunol. 2005;35:139-49 pubmed
  • flow cytometry; human; fig 3
Biancone L, Cantaluppi V, Duò D, Deregibus M, Torre C, Camussi G. Role of L-selectin in the vascular homing of peripheral blood-derived endothelial progenitor cells. J Immunol. 2004;173:5268-74 pubmed
  • flow cytometry; human; tbl 1
Tan P, Chan C, Xue S, Dong R, Ananthesayanan B, Manunta M, et al. Phenotypic and functional differences between human saphenous vein (HSVEC) and umbilical vein (HUVEC) endothelial cells. Atherosclerosis. 2004;173:171-83 pubmed
  • flow cytometry; human; fig 7c
Lester E, Babensee J. Proinflammatory phenotype of endothelial cells after coculture with biomaterial-treated blood cells. J Biomed Mater Res A. 2003;64:397-410 pubmed
  • flow cytometry; human
Greco N, Lee W, Kurtz J, Seetharaman S, Moroff G. Characterization of multiple CD34+ cell populations in cord blood. J Hematother Stem Cell Res. 2003;12:199-213 pubmed
  • flow cytometry; human
Ku C, Padilla J, Grose C, Butcher E, Arvin A. Tropism of varicella-zoster virus for human tonsillar CD4(+) T lymphocytes that express activation, memory, and skin homing markers. J Virol. 2002;76:11425-33 pubmed
  • flow cytometry; human; fig 2
Rutella S, Pierelli L, Bonanno G, Sica S, Ameglio F, Capoluongo E, et al. Role for granulocyte colony-stimulating factor in the generation of human T regulatory type 1 cells. Blood. 2002;100:2562-71 pubmed
  • flow cytometry; human; fig 2
Sharron M, Pohlmann S, Price K, Lolis E, Tsang M, Kirchhoff F, et al. Expression and coreceptor activity of STRL33/Bonzo on primary peripheral blood lymphocytes. Blood. 2000;96:41-9 pubmed
  • blocking or activating experiments; human
Greenberg A, Kerr W, Hammer D. Relationship between selectin-mediated rolling of hematopoietic stem and progenitor cells and progression in hematopoietic development. Blood. 2000;95:478-86 pubmed
  • flow cytometry; human
Lee B, Sharron M, Montaner L, Weissman D, Doms R. Quantification of CD4, CCR5, and CXCR4 levels on lymphocyte subsets, dendritic cells, and differentially conditioned monocyte-derived macrophages. Proc Natl Acad Sci U S A. 1999;96:5215-20 pubmed
Algorri M, Wong Beringer A. Differential effects of antibiotics on neutrophils exposed to lipoteichoic acid derived from Staphylococcus aureus. Ann Clin Microbiol Antimicrob. 2020;19:50 pubmed publisher
Kim Y, Lee S, Kim S, Jang H, Hwang I, Jin S, et al. Toll-like receptor mediated inflammation requires FASN-dependent MYD88 palmitoylation. Nat Chem Biol. 2019;15:907-916 pubmed publisher
Kononchik J, Ireland J, Zou Z, Segura J, Holzapfel G, Chastain A, et al. HIV-1 targets L-selectin for adhesion and induces its shedding for viral release. Nat Commun. 2018;9:2825 pubmed publisher
Tsai S, McOlash L, Palen K, Johnson B, Duris C, Yang Q, et al. Development of primary human pancreatic cancer organoids, matched stromal and immune cells and 3D tumor microenvironment models. BMC Cancer. 2018;18:335 pubmed publisher
Kyoizumi S, Kubo Y, Kajimura J, Yoshida K, Hayashi T, Nakachi K, et al. Fate Decision Between Group 3 Innate Lymphoid and Conventional NK Cell Lineages by Notch Signaling in Human Circulating Hematopoietic Progenitors. J Immunol. 2017;199:2777-2793 pubmed publisher
Radley G, Pieper I, Thornton C. The effect of ventricular assist device-associated biomaterials on human blood leukocytes. J Biomed Mater Res B Appl Biomater. 2018;106:1730-1738 pubmed publisher
Nouri Shirazi M, Bible B, Zeng M, Tamjidi S, Bossart G. Phenotyping and comparing the immune cell populations of free-ranging Atlantic bottlenose dolphins (Tursiops truncatus) and dolphins under human care. BMC Vet Res. 2017;13:78 pubmed publisher
Aw Yeang H, Piersma S, Lin Y, Yang L, Malkova O, Miner C, et al. Cutting Edge: Human CD49e- NK Cells Are Tissue Resident in the Liver. J Immunol. 2017;198:1417-1422 pubmed publisher
Baldan V, Griffiths R, Hawkins R, Gilham D. Efficient and reproducible generation of tumour-infiltrating lymphocytes for renal cell carcinoma. Br J Cancer. 2015;112:1510-8 pubmed publisher
Algra S, Groeneveld K, Schadenberg A, Haas F, Evens F, Meerding J, et al. Cerebral ischemia initiates an immediate innate immune response in neonates during cardiac surgery. J Neuroinflammation. 2013;10:24 pubmed publisher
Salerno Goncalves R, Wahid R, Sztein M. Ex Vivo kinetics of early and long-term multifunctional human leukocyte antigen E-specific CD8+ cells in volunteers immunized with the Ty21a typhoid vaccine. Clin Vaccine Immunol. 2010;17:1305-14 pubmed publisher
van Zante A, Gauguet J, Bistrup A, Tsay D, von Andrian U, Rosen S. Lymphocyte-HEV interactions in lymph nodes of a sulfotransferase-deficient mouse. J Exp Med. 2003;198:1289-300 pubmed
product information
Product Type :
Antibody
Product Name :
CD62L Monoclonal Antibody (DREG56)
Catalog # :
MA1-10259
Quantity :
100 ug
Price :
US 242.00
Clonality :
Monoclonal
Purity :
protein A
Host :
Mouse
Reactivity :
Human
Applications :
Flow Cytometry: 2 ug/mL, Immunohistochemistry (Frozen): Assay-Dependent, Immunoprecipitation: Assay-Dependent, Western Blot: Assay-dependent
Species :
Human
Clone :
DREG56
Isotype :
IgG1
Storage :
4 C, do not freeze
Description :
The human CD62L is a 74-95 kDa glycoprotein member of the selectin family of adhesion receptors. L-Selectin is comprised of an aminoterminal C-type lectin binding domain, an epidermal growth factor-like domain, two short consensus repeat (SCR) sequences homologous to those found in complement binding proteins, a short spacer region, a transmembrane region and a short cytoplasmic region. Human CD62L (L-Selectin) is constitutively expressed on all classes of leukocytes including lymphocytes (except a substantial population of memory T cells), monocytes and polymorphonuclear cells.
Immunogen :
PMA-activated human peripheral blood leukocytes
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 2 ug/mL, Immunohistochemistry (Frozen): Assay-Dependent, Immunoprecipitation: Assay-Dependent, Western Blot: Assay-dependent
Aliases :
A.11; AI528707; CD62 antigen-like family member L; CD62L; gp90-MEL; hLHRc; LAM1; LAM-1; LECAM1; LECAM-1; LEU8; Leu-8; Leukocyte adhesion molecule 1; leukocyte surface antigen Leu-8; Leukocyte-endothelial cell adhesion molecule 1; LNHR; LSEL; L-selectin; Ly22; Ly-22; LYAM1; Lyam-1; Ly-m22; Lymph node homing receptor; lymphocyte adhesion molecule 1; lymphocyte antigen 22; Lymphocyte surface MEL-14 antigen; pln homing receptor; PLNHR; SELE; selectin E (endothelial adhesion molecule 1); selectin L; selectin L (lymphocyte adhesion molecule 1); selectin, lymphocyte; Sell; TQ1
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA