CD42b Monoclonal Antibody (HIP1), PE | Invitrogen MA1-10223 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD42b Monoclonal Antibody (HIP1), PE

catalog :

MA1-10223

quantity :

100Tests

price :

US 338

clonality :

monoclonal

host :

mouse

conjugate :

clone name :

HIP1

reactivity :

human

application :

flow cytometry

product information

Product Type :

Antibody

Product Name :

CD42b Monoclonal Antibody (HIP1), PE

Catalog # :

MA1-10223

Quantity :

100Tests

Price :

US 338

Clonality :

Monoclonal

Purity :

purified

Host :

Mouse

Reactivity :

Human, Non-human primate

Applications :

Flow Cytometry: 20 µL/1x10^6 cells

Species :

Human, Non-human primate

Clone :

HIP1

Isotype :

IgG1

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

CD42b is a platelet activation marker involved in the process of coagulation as an aggregating factor. It interacts with extracellular matrix as well as with adhesion molecules. CD42b expression and activation seems to be regulated by VEGF and PDGF. CD42b composes together with GPIb beta, GPIX and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular wight kininogen, TSP-1, integrin Mac-1 and P-selectin. The extracellular domain of CD42b by its interactions also contributes to metastasis. Further, CD42b antigen is expressed on platelets and on megakaryocytes in bone marrow. Several polymorphisms and mutations have been described in the CD42b, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease.

Immunogen :

Peripheral blood mononuclear cells of a patient suffering with CLL.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 20 µL/1x10^6 cells

Aliases :

BSS, CD42B, CD42b-alpha, GP1B, MGC34595, GPIB