CD28 Monoclonal Antibody (37.51) | Invitrogen MA1-10172 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD28 Monoclonal Antibody (37.51)

catalog :

MA1-10172

quantity :

100 ug

price :

US 207.00

clonality :

monoclonal

host :

Syrian golden hamster

conjugate :

nonconjugated

clone name :

37.51

reactivity :

human, mouse

application :

immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - frozen section, blocking or activating experiments

more info or order :

Invitrogen product webpage

citations: 23

Published Application/Species/Sample/Dilution	Reference
blocking or activating experiments; mouse; loading ...	Akgul A, Maddaloni M, Jun S, Nelson A, Odreman V, Hoffman C, et al. Stimulation of regulatory T cells with Lactococcus lactis expressing enterotoxigenic E. coli colonization factor antigen 1 retains salivary flow in a genetic model of Sjögren's syndrome. Arthritis Res Ther. 2021;23:99 pubmed publisher
flow cytometry; mouse	Zhao L, Hu S, Davila M, Yang J, Lin Y, Albanese J, et al. Coordinated co-migration of CCR10+ antibody-producing B cells with helper T cells for colonic homeostatic regulation. Mucosal Immunol. 2021;14:420-430 pubmed publisher
flow cytometry; human; fig 2e	Pasciuto E, Burton O, Roca C, Lagou V, Rajan W, Theys T, et al. Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition. Cell. 2020;182:625-640.e24 pubmed publisher
flow cytometry; mouse; loading ...; fig 1d	Xing S, Gai K, Li X, Shao P, Zeng Z, Zhao X, et al. Tcf1 and Lef1 are required for the immunosuppressive function of regulatory T cells. J Exp Med. 2019;: pubmed publisher
flow cytometry; human; loading ...; fig 6a	Muscate F, Stetter N, Schramm C, Schulze zur Wiesch J, Bosurgi L, Jacobs T. HVEM and CD160: Regulators of Immunopathology During Malaria Blood-Stage. Front Immunol. 2018;9:2611 pubmed publisher
blocking or activating experiments; mouse; loading ...; fig 7	Hwang I, Kim K, Choi S, Lomunova M. Potentiation of T Cell Stimulatory Activity by Chemical Fixation of a Weak Peptide-MHC Complex. Mol Cells. 2017;40:24-36 pubmed publisher
blocking or activating experiments; mouse; fig 5	Vähätupa M, Aittomaki S, Martinez Cordova Z, May U, Prince S, Uusitalo Jarvinen H, et al. T-cell-expressed proprotein convertase FURIN inhibits DMBA/TPA-induced skin cancer development. Oncoimmunology. 2016;5:e1245266 pubmed publisher
blocking or activating experiments; mouse; loading ...; fig 2f	Blanquiceth Y, Rodríguez Perea A, Tabares Guevara J, Correa L, Sánchez M, Ramirez Pineda J, et al. Increase of Frequency and Modulation of Phenotype of Regulatory T Cells by Atorvastatin Is Associated with Decreased Lung Inflammatory Cell Infiltration in a Murine Model of Acute Allergic Asthma. Front Immunol. 2016;7:620 pubmed publisher
blocking or activating experiments; mouse; 2 ug/ml; loading ...	Araujo L, Khim P, Mkhikian H, Mortales C, Demetriou M. Glycolysis and glutaminolysis cooperatively control T cell function by limiting metabolite supply to N-glycosylation. elife. 2017;6: pubmed publisher
blocking or activating experiments; mouse; loading ...; fig 9a	Massaad M, Zhou J, Tsuchimoto D, Chou J, Jabara H, Janssen E, et al. Deficiency of base excision repair enzyme NEIL3 drives increased predisposition to autoimmunity. J Clin Invest. 2016;126:4219-4236 pubmed publisher
blocking or activating experiments; mouse; loading ...; fig 1e	Eil R, Vodnala S, Clever D, Klebanoff C, Sukumar M, Pan J, et al. Ionic immune suppression within the tumour microenvironment limits T cell effector function. Nature. 2016;537:539-543 pubmed publisher
blocking or activating experiments; mouse; 1 ug/ml; loading ...; fig 5g	Stentzel S, Teufelberger A, Nordengrün M, Kolata J, Schmidt F, Van Crombruggen K, et al. Staphylococcal serine protease-like proteins are pacemakers of allergic airway reactions to Staphylococcus aureus. J Allergy Clin Immunol. 2017;139:492-500.e8 pubmed publisher
blocking or activating experiments; mouse; loading ...; fig s2c	Oudhoff M, Braam M, Freeman S, Wong D, Rattray D, Wang J, et al. SETD7 Controls Intestinal Regeneration and Tumorigenesis by Regulating Wnt/?-Catenin and Hippo/YAP Signaling. Dev Cell. 2016;37:47-57 pubmed publisher
flow cytometry; mouse; 1:1000; loading ...; fig 2c	Martin B, Wang C, Zhang C, Kang Z, Gulen M, Zepp J, et al. T cell-intrinsic ASC critically promotes T(H)17-mediated experimental autoimmune encephalomyelitis. Nat Immunol. 2016;17:583-92 pubmed publisher
blocking or activating experiments; mouse; loading ...; fig 4a	Jabara H, Boyden S, Chou J, Ramesh N, Massaad M, Benson H, et al. A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency. Nat Genet. 2016;48:74-8 pubmed publisher
blocking or activating experiments; mouse; fig 4a	Wei R, Hu Y, Dong F, Xu X, Hu A, Gao G. Hepatoma cell-derived leptin downregulates the immunosuppressive function of regulatory T-cells to enhance the anti-tumor activity of CD8+ T-cells. Immunol Cell Biol. 2016;94:388-99 pubmed publisher
flow cytometry; mouse; tbl s1	Kamachi F, Isshiki T, Harada N, Akiba H, Miyake S. ICOS promotes group 2 innate lymphoid cell activation in lungs. Biochem Biophys Res Commun. 2015;463:739-45 pubmed publisher
blocking or activating experiments; mouse; loading ...; fig 2	Hill E, Ng T, Burton B, Oakley C, Malik K, Wraith D. Glycogen synthase kinase-3 controls IL-10 expression in CD4(+) effector T-cell subsets through epigenetic modification of the IL-10 promoter. Eur J Immunol. 2015;45:1103-15 pubmed publisher
	Siegemund M, Oak P, Hansbauer E, Allersdorfer A, Utschick K, Winter A, et al. Pharmacokinetic Engineering of OX40-Blocking Anticalin Proteins Using Monomeric Plasma Half-Life Extension Domains. Front Pharmacol. 2021;12:759337 pubmed publisher
	He Z, Ma J, Wang R, Zhang J, Huang Z, Wang F, et al. A two-amino-acid substitution in the transcription factor RORγt disrupts its function in TH17 differentiation but not in thymocyte development. Nat Immunol. 2017;18:1128-1138 pubmed publisher
	Britton G, Ambler R, Clark D, Hill E, Tunbridge H, McNally K, et al. PKC? links proximal T cell and Notch signaling through localized regulation of the actin cytoskeleton. elife. 2017;6: pubmed publisher
	Hu H, Wang H, Xiao Y, Jin J, Chang J, Zou Q, et al. Otud7b facilitates T cell activation and inflammatory responses by regulating Zap70 ubiquitination. J Exp Med. 2016;213:399-414 pubmed publisher
	Castillo E, Dekonenko A, Arko Mensah J, Mandell M, Dupont N, Jiang S, et al. Autophagy protects against active tuberculosis by suppressing bacterial burden and inflammation. Proc Natl Acad Sci U S A. 2012;109:E3168-76 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD28 Monoclonal Antibody (37.51)

Catalog # :

MA1-10172

Quantity :

100 ug

Price :

US 207.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Syrian Hamster

Reactivity :

Mouse

Applications :

Flow Cytometry: 6 ug/mL, Functional Assay: Assay-dependent, Immunocytochemistry: 1-4 ug/mL, Immunohistochemistry (Frozen): Assay-dependent, Immunoprecipitation: 1-2 ug/mL

Species :

Mouse

Clone :

37.51

Isotype :

IgG

Storage :

4 C, do not freeze

Description :

CD28 antigen is a 44 kDa disulfide linked homodimeric T cell specific surface glycoprotein. CD28 is a cell adhesion molecule of the immunoglobulin superfamily which is constitutively expressed on most peripheral blood T lymphocytes. Moreover, CD28 is the critical T cell costimulatory receptor that provides the cell the important second activation signal by binding CD80 and CD86 which are expressed by antigen presenting cells. In addition to its co-stimulation role, CD28 functions by preventing T cells from entering an anergic-hyporesponsive state or from undergoing premature apoptotic cell death. In murine peripheral lymphoid organs and in the blood, all CD4+ and CD8+ T cells express CD28. In the thymus, CD28 expression is highest on immature CD3-, CD8+ and CD4+8+ cells, and on CD4-8- cells that express alpha/beta and gamma/delta TCR. The level of CD28 on mature CD4+ and CD8+ alpha/beta TCR+ thymocytes is two- to fourfold lower than on the immature cells. Diseases associated with CD28 dysfunction include mycosis fungiodes and Sezary's Disease.

Immunogen :

Mouse T cell lymphoma EL-4 cells

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 6 ug/mL, Functional Assay: Assay-dependent, Immunocytochemistry: 1-4 ug/mL, Immunohistochemistry (Frozen): Assay-dependent, Immunoprecipitation: 1-2 ug/mL

Aliases :

antigen CD28; CD28; CD28 antigen; CD28 antigen (Tp44); CD28 isoform; CD28 isoform 2; Cd28 molecule; CD28 precursor protein; CD28 protein; CD28 protein precursor; CD28RNA; cell surface protein; CHT28; contains partial extracellular domain; costimulatory molecule B7 receptor CD28; EGK_04709; MGC138290; sCD28; soluble CD28; T44; T-cell costimulatory molecule CD28; T-cell costimulatory molecule Tp44; T-cell-specific surface glycoprotein CD28; T-cell-specific surface glycoprotein CD28 homolog; TP44

more info or order :

Invitrogen product webpage