CD19 Monoclonal Antibody (4G7) | Invitrogen MA1-10126 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD19 Monoclonal Antibody (4G7)

catalog :

MA1-10126

quantity :

100 ug

price :

US 246.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4G7

reactivity :

human

application :

immunocytochemistry, flow cytometry

more info or order :

Invitrogen product webpage

citations: 4

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; fig 4	Sathler Avelar R, Vitelli Avelar D, Massara R, de Lana M, Pinto Dias J, Teixeira Carvalho A, et al. Etiological treatment during early chronic indeterminate Chagas disease incites an activated status on innate and adaptive immunity associated with a type 1-modulated cytokine pattern. Microbes Infect. 2008;10:103-13 pubmed publisher
flow cytometry; human; fig 1	Martins M, Silva M, Marciano A, Peruhype Magalhães V, Eloi Santos S, Ribeiro J, et al. Activation/modulation of adaptive immunity emerges simultaneously after 17DD yellow fever first-time vaccination: is this the key to prevent severe adverse reactions following immunization?. Clin Exp Immunol. 2007;148:90-100 pubmed
flow cytometry; human	Muench M, Roncarolo M, Menon S, Xu Y, Kastelein R, Zurawski S, et al. FLK-2/FLT-3 ligand regulates the growth of early myeloid progenitors isolated from human fetal liver. Blood. 1995;85:963-72 pubmed
	Dieu Nosjean M, Massacrier C, Homey B, Vanbervliet B, Pin J, Vicari A, et al. Macrophage inflammatory protein 3alpha is expressed at inflamed epithelial surfaces and is the most potent chemokine known in attracting Langerhans cell precursors. J Exp Med. 2000;192:705-18 pubmed

product information

Product Type :

Antibody

Product Name :

CD19 Monoclonal Antibody (4G7)

Catalog # :

MA1-10126

Quantity :

100 ug

Price :

US 246.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 1 ug/mL, Immunocytochemistry: Assay-dependent

Species :

Human

Clone :

4G7

Isotype :

IgG1, kappa

Storage :

4 C, do not freeze

Description :

CD19 is a member of the immunoglobulin superfamily and has two Ig like domains. The CD19 molecule is expressed on 100% of the peripheral B cells as defined by expression of kappa or lambda light chains. CD19 appears to be expressed on myeloid leukemia cells, particularly those of monocytic lineage. Leukemia phenotype studies have demonstrated that the earliest and broadest B cell restricted antigen is the CD19 antigen. The receptor for CD19 is an important functional regulator of normal and malignant B cell proliferation, and is expressed in all B cell precursor leukemias. Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. CD19 is a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. Besides being a signal-amplifying coreceptor for the B cell receptor (BCR), CD19 can also signal independently of BCR co-ligation and is a central regulatory component upon which multiple signaling pathways converge. Mutation of the CD19 gene results in hypogammaglobulinemia, whereas CD19 overexpression causes B cell hyperactivity.

Immunogen :

Human CCL (chronic lymphocytic leukemia) cells

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1 ug/mL, Immunocytochemistry: Assay-dependent

Aliases :

AW495831; B4; B-lymphocyte antigen CD19; B-lymphocyte surface antigen B4; Cd19; CD19 antigen; CD19 molecule; CVID3; differentiation antigen CD19; Leu-12; T-cell surface antigen Leu-12

more info or order :

Invitrogen product webpage