product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD11b Monoclonal Antibody (M1/70), PE
catalog :
MA1-10082
quantity :
100 ug
price :
US 363.00
clonality :
monoclonal
host :
rat
conjugate :
PE
clone name :
M1/70
reactivity :
human, mouse
application :
immunohistochemistry, flow cytometry
more info or order :
Invitrogen product webpage
citations: 17
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; 1:100; loading ...; fig 4d
Stewart B, Ferdinand J, Young M, Mitchell T, Loudon K, Riding A, et al. Spatiotemporal immune zonation of the human kidney. Science. 2019;365:1461-1466 pubmed publisher
  • flow cytometry; mouse; 1:100; loading ...; fig s1c
He Z, Zhang J, Huang Z, Du Q, Li N, Zhang Q, et al. Sumoylation of RORγt regulates TH17 differentiation and thymocyte development. Nat Commun. 2018;9:4870 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 4a
Cole C, Russler Germain D, Ketkar S, Verdoni A, Smith A, Bangert C, et al. Haploinsufficiency for DNA methyltransferase 3A predisposes hematopoietic cells to myeloid malignancies. J Clin Invest. 2017;127:3657-3674 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 4b
Gittens B, Bodkin J, Nourshargh S, Perretti M, Cooper D. Galectin-3: A Positive Regulator of Leukocyte Recruitment in the Inflamed Microcirculation. J Immunol. 2017;198:4458-4469 pubmed publisher
  • flow cytometry; mouse; fig 7a
Mangum L, CROW J, Stokes J, HOWELL G, Ross M, Pruett S, et al. Exposure to p,p'-DDE Alters Macrophage Reactivity and Increases Macrophage Numbers in Adipose Stromal Vascular Fraction. Toxicol Sci. 2016;150:169-77 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2a
Andzinski L, Kasnitz N, Stahnke S, Wu C, Gereke M, von Köckritz Blickwede M, et al. Type I IFNs induce anti-tumor polarization of tumor associated neutrophils in mice and human. Int J Cancer. 2016;138:1982-93 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1f
Cole C, Verdoni A, Ketkar S, Leight E, Russler Germain D, Lamprecht T, et al. PML-RARA requires DNA methyltransferase 3A to initiate acute promyelocytic leukemia. J Clin Invest. 2016;126:85-98 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s2c
Lal G, Nakayama Y, Sethi A, Singh A, Burrell B, Kulkarni N, et al. Interleukin-10 From Marginal Zone Precursor B-Cell Subset Is Required for Costimulatory Blockade-Induced Transplantation Tolerance. Transplantation. 2015;99:1817-28 pubmed publisher
  • flow cytometry; mouse
Reese T, Liang H, Tager A, Luster A, Van Rooijen N, Voehringer D, et al. Chitin induces accumulation in tissue of innate immune cells associated with allergy. Nature. 2007;447:92-6 pubmed
  • flow cytometry; mouse
Egan P, Lawlor K, Alexander W, Wicks I. Suppressor of cytokine signaling-1 regulates acute inflammatory arthritis and T cell activation. J Clin Invest. 2003;111:915-24 pubmed
  • flow cytometry; mouse; fig 5
Leite de Moraes M, Lisbonne M, Arnould A, Machavoine F, Herbelin A, Dy M, et al. Ligand-activated natural killer T lymphocytes promptly produce IL-3 and GM-CSF in vivo: relevance to peripheral myeloid recruitment. Eur J Immunol. 2002;32:1897-904 pubmed
  • flow cytometry; mouse
Sandré C, Gleizes A, Forestier F, Gorges Kergot R, Chilmonczyk S, Léonil J, et al. A peptide derived from bovine beta-casein modulates functional properties of bone marrow-derived macrophages from germfree and human flora-associated mice. J Nutr. 2001;131:2936-42 pubmed
  • flow cytometry; mouse; fig 1
Ohmura K, Kawamoto H, Lu M, Ikawa T, Ozaki S, Nakao K, et al. Immature multipotent hemopoietic progenitors lacking long-term bone marrow-reconstituting activity in the aorta-gonad-mesonephros region of murine day 10 fetuses. J Immunol. 2001;166:3290-6 pubmed
  • flow cytometry; mouse
Kawamoto H, Ohmura K, Fujimoto S, Katsura Y. Emergence of T cell progenitors without B cell or myeloid differentiation potential at the earliest stage of hematopoiesis in the murine fetal liver. J Immunol. 1999;162:2725-31 pubmed
  • flow cytometry; mouse; fig 1
Godfrey D, Kennedy J, Suda T, Zlotnik A. A developmental pathway involving four phenotypically and functionally distinct subsets of CD3-CD4-CD8- triple-negative adult mouse thymocytes defined by CD44 and CD25 expression. J Immunol. 1993;150:4244-52 pubmed
Liu Y, Zhang X, Hu Y, Kang M, Wu Y, Wang Y, et al. Human placental mesenchymal stem cells regulate inflammation via the NF‑κB signaling pathway. Exp Ther Med. 2022;24:654 pubmed publisher
Tiedje C, Díaz Muñoz M, Trulley P, Ahlfors H, Laaß K, Blackshear P, et al. The RNA-binding protein TTP is a global post-transcriptional regulator of feedback control in inflammation. Nucleic Acids Res. 2016;44:7418-40 pubmed publisher
product information
Product Type :
Antibody
Product Name :
CD11b Monoclonal Antibody (M1/70), PE
Catalog # :
MA1-10082
Quantity :
100 ug
Price :
US 363.00
Clonality :
Monoclonal
Purity :
Size-exclusion chromatography
Host :
Rat
Reactivity :
Human, Mouse, Non-human primate, Rabbit
Applications :
Flow Cytometry: 1-2 ug/mL
Species :
Human, Mouse, Non-human primate, Rabbit
Clone :
M1/70
Isotype :
IgG2b
Storage :
4 C, store in dark, DO NOT FREEZE!
Description :
CD11b (integrin alpha-M, ITGAM, integrin alpha-X, ITGAX) is a 165 kDa adhesion molecule that associates non-covalently with integrin beta-2 (CD18). The CD11b/CD18 heterodimeric complex is also known as integrin alpha-M beta-2, Mac-1, and CR3 (complement receptor 3). CD11b is expressed on the surface of monocytes/macrophages, granulocytes, activated lymphocytes, a subset of NK cells, a subset of dendritic cells, and microglia in the brain. CD11b/CD18 functions as the receptor for ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), CD14, CD50, CD23, heparin, iC3b, fibrinogen, and Factor X -these adhesions are critical for cell-cell and cell-matrix interactions. CD11b is expressed on 8% of spleen cells, 44% of bone marrow cells, and less than 1% of thymocytes, and is commonly used as a microglial marker in nervous tissue. The expression of CD11b increases during monocyte maturation and expression levels vary on tissue macrophages. Further, peritoneal macrophages are reported to express higher levels of CD11b than splenic macrophages. Diseases associated with CD11b dysfunction include systemic lupus erythematosus 6 and ITGAM-related susceptibility to systemic lupus erythematosus.
Immunogen :
B10 mouse spleen cells enriched for T cells
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1-2 ug/mL
Aliases :
antigen CD11b (p170); antigen CD11b (p170); macrophage antigen alpha polypeptide; CD11 antigen-like family member B; CD11b; CD11B (p170); CD11b/CD18; cell surface glycoprotein MAC-1 alpha subunit; cell surface glycoprotein MAC-1 subunit alpha; complement component 3 receptor 3 subunit; complement component receptor 3 alpha-a; complement receptor type 3; CR3; CR-3 alpha chain; CR3A; F730045J24Rik; integrin alpha M; integrin alpha-M; integrin subunit alpha M; integrin, alpha M; integrin, alpha M (complement component 3 receptor 3 subunit); ITGAM; Leukocyte adhesion receptor MO1; leukocyte integrin alpha-M chain; LOC100351865; Ly-40; MAC1; Mac-1; Mac-1 alpha; Mac-1 alpha (Mac1A); MAC-1 alpha subunit; MAC1A; Mac-1a; macrophage antigen alpha; macrophage antigen alpha polypeptide; MGC117044; MO1A; Neutrophil adherence receptor; neutrophil adherence receptor alpha-M subunit; SLEB6; unnamed protein product
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA