ABRA1 Monoclonal Antibody (ABRA1-01) | Invitrogen MA1-10045 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

ABRA1 Monoclonal Antibody (ABRA1-01)

catalog :

MA1-10045

quantity :

100 ug

price :

US 414.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

ABRA1-01

The same clone is also sold as:

Exbio: 11-619-C025, 11-619-C100
OriGene: AM12137PU-N

reactivity :

human

application :

western blot, immunoprecipitation, flow cytometry

product information

Product Type :

Antibody

Product Name :

ABRA1 Monoclonal Antibody (ABRA1-01)

Catalog # :

MA1-10045

Quantity :

100 ug

Price :

US 414.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 1-2 ug/mL, Immunoprecipitation: Assay-dependent, Western Blot: Assay-dependent

Species :

Human

Clone :

ABRA1-01

Isotype :

IgG2a, kappa

Storage :

4 C, do not freeze

Description :

CCDC98, also known as Abraxas 1, was identified through protein binding studies using the breast and ovarian predisposition protein BRCA1 as the binding target. CCDC98 recruits RAP80, a ubiquitin-binding protein, to BRCA1, allowing the formation of BRCA1 foci in response to DNA damage caused by ionizing radiation. Both CCDC98 and RAP80 are required for DNA damage resistance, G2-M checkpoint control, and DNA repair. Cells depleted of either CCDC98 or RAP80 exhibited increased sensitivity to ionizing radiation, although not as much as in BRCA1-depleted cells, suggesting that CCDC98 and RAP80 control only part of the DNA damage response role of BRCA1. At least two isoforms of CCDC98 are known to exist.

Immunogen :

Recombinant protein corresponding to amino acids 1-313 of ABRA1 with N-terminal His6 tag

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1-2 ug/mL, Immunoprecipitation: Assay-dependent, Western Blot: Assay-dependent

Aliases :

3830405G04Rik; 5630400M01Rik; ABRA1; abraxas protein; Abraxas1; AI506069; AL024423; AV118690; BRCA1-A complex subunit Abraxas; BRCA1-A complex subunit Abraxas 1; Ccdc98; coiled-coil domain containing 98; coiled-coil domain-containing protein 98; FAM175A; family with sequence similarity 175 member A; family with sequence similarity 175, member A; FLJ11520; FLJ12642; FLJ13614; Protein FAM175A; RGD1305287; UNQ496/PRO1013