product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Hepatitis C Virus Core Antigen Monoclonal Antibody (C7-50)
catalog :
MA1-080
quantity :
100 µg
price :
US 399.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
C7-50
reactivity :
Hepacivirus C
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section
more info or order :
citations: 151
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; Hepacivirus C; loading ...; fig 1b
  • immunohistochemistry; Hepacivirus C; loading ...; fig 1a
Joyce M, Berry Wynne K, Dos Santos T, Addison W, McFarlane N, Hobman T, et al. HCV and flaviviruses hijack cellular mechanisms for nuclear STAT2 degradation: Up-regulation of PDLIM2 suppresses the innate immune response. PLoS Pathog. 2019;15:e1007949 pubmed publisher
  • immunocytochemistry; Hepacivirus C; loading ...; fig 5a
Yu D, Zhao M, Dong L, Zhao L, Zou M, Sun H, et al. Design and evaluation of novel interferon lambda analogs with enhanced antiviral activity and improved drug attributes. Drug Des Devel Ther. 2016;10:163-82 pubmed publisher
  • immunohistochemistry - paraffin section; Hepacivirus C; 1:500; fig 4
Uruha A, Noguchi S, Hayashi Y, Tsuburaya R, Yonekawa T, Nonaka I, et al. Hepatitis C virus infection in inclusion body myositis: A case-control study. Neurology. 2016;86:211-7 pubmed publisher
  • western blot; Hepacivirus C; fig 3,4,5
Elgner F, Donnerhak C, Ren H, Medvedev R, Schreiber A, Weber L, et al. Characterization of α-taxilin as a novel factor controlling the release of hepatitis C virus. Biochem J. 2016;473:145-55 pubmed publisher
  • immunocytochemistry; Hepacivirus C; 1:100; fig 1b
Dai B, Chen A, Corkum C, Peroutka R, Landon A, Houng S, et al. Hepatitis C virus upregulates B-cell receptor signaling: a novel mechanism for HCV-associated B-cell lymphoproliferative disorders. Oncogene. 2016;35:2979-90 pubmed publisher
  • immunocytochemistry; Hepacivirus C; 1:300; fig 4
Zhang J, Garrison J, Poluektova L, Bronich T, Osna N. Liver-targeted antiviral peptide nanocomplexes as potential anti-HCV therapeutics. Biomaterials. 2015;70:37-47 pubmed publisher
  • immunocytochemistry; Hepacivirus C; 1:300; fig 7
Ganesan M, Zhang J, BRONICH T, Poluektova L, Donohue T, Tuma D, et al. Acetaldehyde accelerates HCV-induced impairment of innate immunity by suppressing methylation reactions in liver cells. Am J Physiol Gastrointest Liver Physiol. 2015;309:G566-77 pubmed publisher
  • immunocytochemistry; Hepacivirus C; 1:200
Kurt R, Chandra P, Aboulnasr F, Panigrahi R, Ferraris P, Aydin Y, et al. Chaperone-Mediated Autophagy Targets IFNAR1 for Lysosomal Degradation in Free Fatty Acid Treated HCV Cell Culture. PLoS ONE. 2015;10:e0125962 pubmed publisher
  • immunocytochemistry; Hepacivirus C
Pène V, Li Q, Sodroski C, Hsu C, Liang T. Dynamic Interaction of Stress Granules, DDX3X, and IKK-α Mediates Multiple Functions in Hepatitis C Virus Infection. J Virol. 2015;89:5462-77 pubmed publisher
  • western blot; Hepacivirus C; 1:2000
Kim S, Jin B, Choi S, Han K, Ahn S. Casein kinase II inhibitor enhances production of infectious genotype 1a hepatitis C virus (H77S). PLoS ONE. 2014;9:e113938 pubmed publisher
  • western blot; Hepacivirus C; fig 2
Eggert D, Rösch K, Reimer R, Herker E. Visualization and analysis of hepatitis C virus structural proteins at lipid droplets by super-resolution microscopy. PLoS ONE. 2014;9:e102511 pubmed publisher
  • flow cytometry; Hepacivirus C
Sung P, Murayama A, Kang W, Kim M, Yoon S, Fukasawa M, et al. Hepatitis C virus entry is impaired by claudin-1 downregulation in diacylglycerol acyltransferase-1-deficient cells. J Virol. 2014;88:9233-44 pubmed publisher
  • ELISA; Hepacivirus C
Bilello J, Lallos L, McCarville J, La Colla M, Serra I, Chapron C, et al. In vitro activity and resistance profile of samatasvir, a novel NS5A replication inhibitor of hepatitis C virus. Antimicrob Agents Chemother. 2014;58:4431-42 pubmed publisher
  • immunocytochemistry; Hepacivirus C
Boyer A, Dumans A, Beaumont E, Etienne L, Roingeard P, Meunier J. The association of hepatitis C virus glycoproteins with apolipoproteins E and B early in assembly is conserved in lipoviral particles. J Biol Chem. 2014;289:18904-13 pubmed publisher
  • immunocytochemistry; Hepacivirus C
Liu Z, Zhao F, He J. Hepatitis C virus (HCV) interaction with astrocytes: nonproductive infection and induction of IL-18. J Neurovirol. 2014;20:278-93 pubmed publisher
  • western blot; Hepacivirus C
Li H, Yang X, Yang G, Hong Z, Zhou L, Yin P, et al. Hepatitis C virus NS5A hijacks ARFGAP1 to maintain a phosphatidylinositol 4-phosphate-enriched microenvironment. J Virol. 2014;88:5956-66 pubmed publisher
  • western blot; Hepacivirus C
Gawlik K, BAUGH J, Chatterji U, Lim P, Bobardt M, Gallay P. HCV core residues critical for infectivity are also involved in core-NS5A complex formation. PLoS ONE. 2014;9:e88866 pubmed publisher
  • flow cytometry; Hepacivirus C
Kang W, Sung P, Park S, Yoon S, Chang D, Kim S, et al. Hepatitis C virus attenuates interferon-induced major histocompatibility complex class I expression and decreases CD8+ T cell effector functions. Gastroenterology. 2014;146:1351-60.e1-4 pubmed publisher
  • immunocytochemistry; Hepacivirus C
  • western blot; Hepacivirus C
Ploen D, Hafirassou M, Himmelsbach K, Schille S, Biniossek M, Baumert T, et al. TIP47 is associated with the hepatitis C virus and its interaction with Rab9 is required for release of viral particles. Eur J Cell Biol. 2013;92:374-82 pubmed publisher
  • immunocytochemistry; Hepacivirus C; 1:200
Eyre N, Fiches G, Aloia A, Helbig K, McCartney E, McErlean C, et al. Dynamic imaging of the hepatitis C virus NS5A protein during a productive infection. J Virol. 2014;88:3636-52 pubmed publisher
  • immunocytochemistry; Hepacivirus C
Syed G, Tang H, Khan M, Hassanein T, Liu J, Siddiqui A. Hepatitis C virus stimulates low-density lipoprotein receptor expression to facilitate viral propagation. J Virol. 2014;88:2519-29 pubmed publisher
  • immunocytochemistry; Hepacivirus C
Tumurbaatar B, Tikhanovich I, Li Z, Ren J, Ralston R, Kuravi S, et al. Hepatitis C and alcohol exacerbate liver injury by suppression of FOXO3. Am J Pathol. 2013;183:1803-1814 pubmed publisher
  • immunocytochemistry; Hepacivirus C; 1:200
Chandra P, Bao L, Song K, Aboulnasr F, Baker D, Shores N, et al. HCV infection selectively impairs type I but not type III IFN signaling. Am J Pathol. 2014;184:214-29 pubmed publisher
  • immunocytochemistry; Hepacivirus C; 1:200
Germain M, Chatel Chaix L, Gagné B, Bonneil E, Thibault P, Pradezynski F, et al. Elucidating novel hepatitis C virus-host interactions using combined mass spectrometry and functional genomics approaches. Mol Cell Proteomics. 2014;13:184-203 pubmed publisher
  • immunohistochemistry; Hepacivirus C; 1:200
Panigrahi R, Hazari S, Chandra S, Chandra P, Datta S, Kurt R, et al. Interferon and ribavirin combination treatment synergistically inhibit HCV internal ribosome entry site mediated translation at the level of polyribosome formation. PLoS ONE. 2013;8:e72791 pubmed publisher
  • immunohistochemistry; Hepacivirus C; 1:600
  • western blot; Hepacivirus C; 1:2000
Shanmugam S, Yi M. Efficiency of E2-p7 processing modulates production of infectious hepatitis C virus. J Virol. 2013;87:11255-66 pubmed publisher
  • immunocytochemistry; Hepacivirus C
  • western blot; Hepacivirus C
Shanker V, Trincucci G, Heim H, Duong H. Protein phosphatase 2A impairs IFN?-induced antiviral activity against the hepatitis C virus through the inhibition of STAT1 tyrosine phosphorylation. J Viral Hepat. 2013;20:612-21 pubmed publisher
  • western blot; Hepacivirus C
Duong F, Dill M, Matter M, Makowska Z, Calabrese D, Dietsche T, et al. Protein phosphatase 2A promotes hepatocellular carcinogenesis in the diethylnitrosamine mouse model through inhibition of p53. Carcinogenesis. 2014;35:114-22 pubmed publisher
  • immunocytochemistry; Hepacivirus C
Ramakrishnaiah V, Thumann C, Fofana I, Habersetzer F, Pan Q, De Ruiter P, et al. Exosome-mediated transmission of hepatitis C virus between human hepatoma Huh7.5 cells. Proc Natl Acad Sci U S A. 2013;110:13109-13 pubmed publisher
  • immunocytochemistry; Hepacivirus C
  • western blot; Hepacivirus C
Cheng M, Si Y, Niu Y, Liu X, Li X, Zhao J, et al. High-throughput profiling of alpha interferon- and interleukin-28B-regulated microRNAs and identification of let-7s with anti-hepatitis C virus activity by targeting IGF2BP1. J Virol. 2013;87:9707-18 pubmed publisher
  • immunocytochemistry; Hepacivirus C; 1:1000
  • western blot; Hepacivirus C; 1:1000
Atoom A, Jones D, Russell R. Evidence suggesting that HCV p7 protects E2 glycoprotein from premature degradation during virus production. Virus Res. 2013;176:199-210 pubmed publisher
  • western blot; Hepacivirus C; 1 ug/ml
Liu Z, He J. Cell-cell contact-mediated hepatitis C virus (HCV) transfer, productive infection, and replication and their requirement for HCV receptors. J Virol. 2013;87:8545-58 pubmed publisher
  • western blot; Hepacivirus C; 1:50
Takebe Y, Saucedo C, Lund G, Uenishi R, Hase S, Tsuchiura T, et al. Antiviral lectins from red and blue-green algae show potent in vitro and in vivo activity against hepatitis C virus. PLoS ONE. 2013;8:e64449 pubmed publisher
  • flow cytometry; Hepacivirus C; 1:100
Mazumdar B, Kim H, Meyer K, Bose S, Di Bisceglie A, Ray R, et al. Hepatitis C virus infection upregulates CD55 expression on the hepatocyte surface and promotes association with virus particles. J Virol. 2013;87:7902-10 pubmed publisher
  • western blot; Hepacivirus C
Lee C, Lee Y, Kim J, Lim J, Kim J, Han W, et al. Inhibition of hepatitis C virus (HCV) replication by specific RNA aptamers against HCV NS5B RNA replicase. J Virol. 2013;87:7064-74 pubmed publisher
  • immunocytochemistry; Hepacivirus C
Wang Y, Li J, Wang X, Ye L, Zhou Y, Thomas R, et al. Hepatitis C virus impairs TLR3 signaling and inhibits IFN-? 1 expression in human hepatoma cell line. Innate Immun. 2014;20:3-11 pubmed publisher
  • western blot; Hepacivirus C
Lupberger J, Duong F, Fofana I, Zona L, Xiao F, Thumann C, et al. Epidermal growth factor receptor signaling impairs the antiviral activity of interferon-alpha. Hepatology. 2013;58:1225-35 pubmed publisher
  • immunocytochemistry; Hepacivirus C
  • western blot; Hepacivirus C
Shirasaki T, Honda M, Shimakami T, Horii R, Yamashita T, Sakai Y, et al. MicroRNA-27a regulates lipid metabolism and inhibits hepatitis C virus replication in human hepatoma cells. J Virol. 2013;87:5270-86 pubmed publisher
  • immunoprecipitation; Hepacivirus C
  • immunocytochemistry; Hepacivirus C
  • western blot; Hepacivirus C
Camus G, Herker E, Modi A, Haas J, Ramage H, Farese R, et al. Diacylglycerol acyltransferase-1 localizes hepatitis C virus NS5A protein to lipid droplets and enhances NS5A interaction with the viral capsid core. J Biol Chem. 2013;288:9915-23 pubmed publisher
  • immunocytochemistry; Hepacivirus C
Zhang J, Mulvenon A, Makarov E, Wagoner J, Knibbe J, Kim J, et al. Antiviral peptide nanocomplexes as a potential therapeutic modality for HIV/HCV co-infection. Biomaterials. 2013;34:3846-57 pubmed publisher
  • immunocytochemistry; Hepacivirus C; 1:300
Colpitts C, Ustinov A, Epand R, Epand R, Korshun V, Schang L. 5-(Perylen-3-yl)ethynyl-arabino-uridine (aUY11), an arabino-based rigid amphipathic fusion inhibitor, targets virion envelope lipids to inhibit fusion of influenza virus, hepatitis C virus, and other enveloped viruses. J Virol. 2013;87:3640-54 pubmed publisher
  • immunocytochemistry; Hepacivirus C
  • western blot; Hepacivirus C
Himmelsbach K, Hildt E. The kinase inhibitor Sorafenib impairs the antiviral effect of interferon ? on hepatitis C virus replication. Eur J Cell Biol. 2013;92:12-20 pubmed publisher
  • immunocytochemistry; Hepacivirus C; 1:500
Wang Y, Ye L, Wang X, Li J, Song L, Ho W. Retinoic acid inducible gene-I (RIG-I) signaling of hepatic stellate cells inhibits hepatitis C virus replication in hepatocytes. Innate Immun. 2013;19:193-202 pubmed publisher
  • immunocytochemistry; Hepacivirus C
Florentin J, Aouar B, Dental C, Thumann C, Firaguay G, Gondois Rey F, et al. HCV glycoprotein E2 is a novel BDCA-2 ligand and acts as an inhibitor of IFN production by plasmacytoid dendritic cells. Blood. 2012;120:4544-51 pubmed publisher
  • western blot; Hepacivirus C
Herzer K, Carbow A, Sydor S, Sowa J, Biesterfeld S, Hofmann T, et al. Deficiency of the promyelocytic leukemia protein fosters hepatitis C-associated hepatocarcinogenesis in mice. PLoS ONE. 2012;7:e44474 pubmed publisher
  • immunocytochemistry; Hepacivirus C
  • western blot; Hepacivirus C
Alisi A, Arciello M, Petrini S, Conti B, Missale G, Balsano C. Focal adhesion kinase (FAK) mediates the induction of pro-oncogenic and fibrogenic phenotypes in hepatitis C virus (HCV)-infected cells. PLoS ONE. 2012;7:e44147 pubmed publisher
  • immunocytochemistry; Hepacivirus C; 1:300
Kang W, Shin E. Colorimetric focus-forming assay with automated focus counting by image analysis for quantification of infectious hepatitis C virions. PLoS ONE. 2012;7:e43960 pubmed publisher
  • immunocytochemistry; Hepacivirus C
Da Costa D, Turek M, Felmlee D, Girardi E, Pfeffer S, Long G, et al. Reconstitution of the entire hepatitis C virus life cycle in nonhepatic cells. J Virol. 2012;86:11919-25 pubmed publisher
  • western blot; Hepacivirus C
Reyes del Valle J, de La Fuente C, Turner M, Springfeld C, Apte Sengupta S, Frenzke M, et al. Broadly neutralizing immune responses against hepatitis C virus induced by vectored measles viruses and a recombinant envelope protein booster. J Virol. 2012;86:11558-66 pubmed publisher
  • immunocytochemistry; Hepacivirus C; 3 ug/ml
Wichroski M, Fang J, Eggers B, Rose R, Mazzucco C, Pokornowski K, et al. High-throughput screening and rapid inhibitor triage using an infectious chimeric Hepatitis C virus. PLoS ONE. 2012;7:e42609 pubmed publisher
  • immunohistochemistry; Hepacivirus C; 1:200
Gunduz F, Aboulnasr F, Chandra P, Hazari S, Poat B, Baker D, et al. Free fatty acids induce ER stress and block antiviral activity of interferon alpha against hepatitis C virus in cell culture. Virol J. 2012;9:143 pubmed publisher
  • immunocytochemistry; Hepacivirus C
Bishe B, Syed G, Field S, Siddiqui A. Role of phosphatidylinositol 4-phosphate (PI4P) and its binding protein GOLPH3 in hepatitis C virus secretion. J Biol Chem. 2012;287:27637-47 pubmed publisher
  • immunohistochemistry; Hepacivirus C
Pérez Vilaró G, Scheller N, Saludes V, Diez J. Hepatitis C virus infection alters P-body composition but is independent of P-body granules. J Virol. 2012;86:8740-9 pubmed publisher
  • western blot; Hepacivirus C; 1:2000
Kumthip K, Chusri P, Jilg N, Zhao L, Fusco D, Zhao H, et al. Hepatitis C virus NS5A disrupts STAT1 phosphorylation and suppresses type I interferon signaling. J Virol. 2012;86:8581-91 pubmed publisher
  • immunoprecipitation; Hepacivirus C
  • immunocytochemistry; Hepacivirus C
  • western blot; Hepacivirus C
Garcia Mediavilla M, Pisonero Vaquero S, Lima Cabello E, Benedicto I, Majano P, Jorquera F, et al. Liver X receptor ?-mediated regulation of lipogenesis by core and NS5A proteins contributes to HCV-induced liver steatosis and HCV replication. Lab Invest. 2012;92:1191-202 pubmed publisher
  • western blot; Hepacivirus C
Lagaye S, Shen H, Saunier B, Nascimbeni M, Gaston J, Bourdoncle P, et al. Efficient replication of primary or culture hepatitis C virus isolates in human liver slices: a relevant ex vivo model of liver infection. Hepatology. 2012;56:861-72 pubmed publisher
  • western blot; Hepacivirus C
Cheng J, Yeh Y, Tseng C, Hsu S, Chang Y, Sakamoto N, et al. Let-7b is a novel regulator of hepatitis C virus replication. Cell Mol Life Sci. 2012;69:2621-33 pubmed publisher
  • immunocytochemistry; Hepacivirus C
Kota S, Takahashi V, Ni F, Snyder J, Strosberg A. Direct binding of a hepatitis C virus inhibitor to the viral capsid protein. PLoS ONE. 2012;7:e32207 pubmed publisher
  • immunocytochemistry; Hepacivirus C; 1:300
Shapira A, Shapira S, Gal Tanamy M, Zemel R, Tur Kaspa R, Benhar I. Removal of hepatitis C virus-infected cells by a zymogenized bacterial toxin. PLoS ONE. 2012;7:e32320 pubmed publisher
  • western blot; Hepacivirus C
Zhang L, Hong Z, Lin W, Shao R, Goto K, Hsu V, et al. ARF1 and GBF1 generate a PI4P-enriched environment supportive of hepatitis C virus replication. PLoS ONE. 2012;7:e32135 pubmed publisher
  • immunocytochemistry; Hepacivirus C
Molina Jiménez F, Benedicto I, Dao Thi V, Gondar V, Lavillette D, Marin J, et al. Matrigel-embedded 3D culture of Huh-7 cells as a hepatocyte-like polarized system to study hepatitis C virus cycle. Virology. 2012;425:31-9 pubmed publisher
  • immunocytochemistry; Hepacivirus C; 1:300
Zhu H, Wong Staal F, Lee H, SYDER A, McKelvy J, Schooley R, et al. Evaluation of ITX 5061, a scavenger receptor B1 antagonist: resistance selection and activity in combination with other hepatitis C virus antivirals. J Infect Dis. 2012;205:656-62 pubmed publisher
  • immunocytochemistry; Hepacivirus C; 1:300
Welsch C, Schweizer S, Shimakami T, Domingues F, Kim S, Lemon S, et al. Ketoamide resistance and hepatitis C virus fitness in val55 variants of the NS3 serine protease. Antimicrob Agents Chemother. 2012;56:1907-15 pubmed publisher
  • immunocytochemistry; Hepacivirus C; 1:1000; tbl 1
Chu V, Bhattacharya S, Nomoto A, Lin J, Zaidi S, Oberley T, et al. Persistent expression of hepatitis C virus non-structural proteins leads to increased autophagy and mitochondrial injury in human hepatoma cells. PLoS ONE. 2011;6:e28551 pubmed publisher
  • immunocytochemistry; Hepacivirus C
  • western blot; Hepacivirus C
Counihan N, Rawlinson S, Lindenbach B. Trafficking of hepatitis C virus core protein during virus particle assembly. PLoS Pathog. 2011;7:e1002302 pubmed publisher
  • immunocytochemistry; Hepacivirus C; 1:1000
Jones D, Atoom A, Zhang X, Kottilil S, Russell R. A genetic interaction between the core and NS3 proteins of hepatitis C virus is essential for production of infectious virus. J Virol. 2011;85:12351-61 pubmed publisher
  • immunocytochemistry; Hepacivirus C
Merquiol E, Uzi D, Mueller T, Goldenberg D, Nahmias Y, Xavier R, et al. HCV causes chronic endoplasmic reticulum stress leading to adaptation and interference with the unfolded protein response. PLoS ONE. 2011;6:e24660 pubmed publisher
  • immunocytochemistry; Hepacivirus C
Ye L, Wang X, Li J, Liu J, Ramirez S, Wu J, et al. Tetherin has negligible activity in restricting hepatitis C virus in hepatocytes. Innate Immun. 2012;18:398-405 pubmed publisher
  • immunocytochemistry; Hepacivirus C; 1:500
Amet T, Ghabril M, Chalasani N, Byrd D, Hu N, Grantham A, et al. CD59 incorporation protects hepatitis C virus against complement-mediated destruction. Hepatology. 2012;55:354-63 pubmed publisher
  • immunocytochemistry; Hepacivirus C
  • western blot; Hepacivirus C
Nakashima K, Takeuchi K, Chihara K, Hotta H, Sada K. Inhibition of hepatitis C virus replication through adenosine monophosphate-activated protein kinase-dependent and -independent pathways. Microbiol Immunol. 2011;55:774-82 pubmed publisher
  • western blot; Hepacivirus C
Zhao H, Lin W, Kumthip K, Cheng D, Fusco D, Hofmann O, et al. A functional genomic screen reveals novel host genes that mediate interferon-alpha's effects against hepatitis C virus. J Hepatol. 2012;56:326-33 pubmed publisher
  • immunocytochemistry; Hepacivirus C
  • western blot; Hepacivirus C
Su W, Chao T, Huang Y, Weng S, Jeng K, Lai M. Rab5 and class III phosphoinositide 3-kinase Vps34 are involved in hepatitis C virus NS4B-induced autophagy. J Virol. 2011;85:10561-71 pubmed publisher
  • immunocytochemistry; Hepacivirus C
Kim C, Keum S, Jang S. Generation of a cell culture-adapted hepatitis C virus with longer half life at physiological temperature. PLoS ONE. 2011;6:e22808 pubmed publisher
  • immunocytochemistry; Hepacivirus C
Hötzel I, Chiang V, Diao J, Pantua H, Maun H, Kapadia S. Efficient production of antibodies against a mammalian integral membrane protein by phage display. Protein Eng Des Sel. 2011;24:679-89 pubmed publisher
  • western blot; Hepacivirus C
Ishida H, Tatsumi T, Hosui A, Nawa T, Kodama T, Shimizu S, et al. Alterations in microRNA expression profile in HCV-infected hepatoma cells: involvement of miR-491 in regulation of HCV replication via the PI3 kinase/Akt pathway. Biochem Biophys Res Commun. 2011;412:92-7 pubmed publisher
  • western blot; Hepacivirus C; 1:300
Gal Tanamy M, Bachmetov L, Ravid A, Koren R, Erman A, Tur Kaspa R, et al. Vitamin D: an innate antiviral agent suppressing hepatitis C virus in human hepatocytes. Hepatology. 2011;54:1570-9 pubmed publisher
  • western blot; Hepacivirus C
Kannan R, Hensley L, Evers L, Lemon S, McGivern D. Hepatitis C virus infection causes cell cycle arrest at the level of initiation of mitosis. J Virol. 2011;85:7989-8001 pubmed publisher
  • western blot; Hepacivirus C
Triyatni M, Berger E, Saunier B. A new model to produce infectious hepatitis C virus without the replication requirement. PLoS Pathog. 2011;7:e1001333 pubmed publisher
  • western blot; Hepacivirus C; 1:2000
Kim S, Welsch C, Yi M, Lemon S. Regulation of the production of infectious genotype 1a hepatitis C virus by NS5A domain III. J Virol. 2011;85:6645-56 pubmed publisher
  • immunocytochemistry; Hepacivirus C
Pascarella S, Clement S, Guilloux K, Conzelmann S, Penin F, Negro F. Effects of hepatitis C virus on suppressor of cytokine signaling mRNA levels: comparison between different genotypes and core protein sequence analysis. J Med Virol. 2011;83:1005-15 pubmed publisher
  • immunocytochemistry; Hepacivirus C
Lam A, Espiritu C, Murakami E, Zennou V, Bansal S, Micolochick Steuer H, et al. Inhibition of hepatitis C virus replicon RNA synthesis by PSI-352938, a cyclic phosphate prodrug of ?-D-2'-deoxy-2'-?-fluoro-2'-?-C-methylguanosine. Antimicrob Agents Chemother. 2011;55:2566-75 pubmed publisher
  • western blot; Hepacivirus C; 1:2500
Amako Y, Syed G, Siddiqui A. Protein kinase D negatively regulates hepatitis C virus secretion through phosphorylation of oxysterol-binding protein and ceramide transfer protein. J Biol Chem. 2011;286:11265-74 pubmed publisher
  • immunoprecipitation; Hepacivirus C
  • immunocytochemistry; Hepacivirus C; 1:300
Shapira A, Gal Tanamy M, Nahary L, Litvak Greenfeld D, Zemel R, Tur Kaspa R, et al. Engineered toxins "zymoxins" are activated by the HCV NS3 protease by removal of an inhibitory protein domain. PLoS ONE. 2011;6:e15916 pubmed publisher
  • immunocytochemistry; Hepacivirus C
Oshiumi H, Ikeda M, Matsumoto M, Watanabe A, Takeuchi O, Akira S, et al. Hepatitis C virus core protein abrogates the DDX3 function that enhances IPS-1-mediated IFN-beta induction. PLoS ONE. 2010;5:e14258 pubmed publisher
  • western blot; Hepacivirus C
Stapleford K, Lindenbach B. Hepatitis C virus NS2 coordinates virus particle assembly through physical interactions with the E1-E2 glycoprotein and NS3-NS4A enzyme complexes. J Virol. 2011;85:1706-17 pubmed publisher
  • western blot; Hepacivirus C
Zhang L, Jilg N, Shao R, Lin W, Fusco D, Zhao H, et al. IL28B inhibits hepatitis C virus replication through the JAK-STAT pathway. J Hepatol. 2011;55:289-98 pubmed publisher
  • western blot; Hepacivirus C
Jang J, Shao R, Lin W, Weinberg E, Chung W, Tsai W, et al. HIV infection increases HCV-induced hepatocyte apoptosis. J Hepatol. 2011;54:612-20 pubmed publisher
  • immunoprecipitation; Hepacivirus C
  • western blot; Hepacivirus C
Alisi A, Ghidinelli M, Zerbini A, Missale G, Balsano C. Hepatitis C virus and alcohol: same mitotic targets but different signaling pathways. J Hepatol. 2011;54:956-63 pubmed publisher
  • western blot; Hepacivirus C
Phan T, Kohlway A, Dimberu P, Pyle A, Lindenbach B. The acidic domain of hepatitis C virus NS4A contributes to RNA replication and virus particle assembly. J Virol. 2011;85:1193-204 pubmed publisher
  • immunocytochemistry; Hepacivirus C; 1:600
  • western blot; Hepacivirus C; 1:30000
Ma Y, Anantpadma M, Timpe J, Shanmugam S, Singh S, Lemon S, et al. Hepatitis C virus NS2 protein serves as a scaffold for virus assembly by interacting with both structural and nonstructural proteins. J Virol. 2011;85:86-97 pubmed publisher
  • western blot; Hepacivirus C
Mousseau G, Kota S, Takahashi V, Frick D, Strosberg A. Dimerization-driven interaction of hepatitis C virus core protein with NS3 helicase. J Gen Virol. 2011;92:101-11 pubmed publisher
  • immunocytochemistry; Hepacivirus C
Pollock S, Nichita N, Böhmer A, Radulescu C, Dwek R, Zitzmann N. Polyunsaturated liposomes are antiviral against hepatitis B and C viruses and HIV by decreasing cholesterol levels in infected cells. Proc Natl Acad Sci U S A. 2010;107:17176-81 pubmed publisher
  • immunocytochemistry; Hepacivirus C; 3 ug/ml
Baldick C, Wichroski M, Pendri A, Walsh A, Fang J, Mazzucco C, et al. A novel small molecule inhibitor of hepatitis C virus entry. PLoS Pathog. 2010;6:e1001086 pubmed publisher
  • western blot; Hepacivirus C
Malathi K, Saito T, Crochet N, Barton D, Gale M, Silverman R. RNase L releases a small RNA from HCV RNA that refolds into a potent PAMP. RNA. 2010;16:2108-19 pubmed publisher
  • immunocytochemistry; Hepacivirus C; 1:300
  • western blot; Hepacivirus C; 1:1000
Wozniak A, Griffin S, Rowlands D, Harris M, Yi M, Lemon S, et al. Intracellular proton conductance of the hepatitis C virus p7 protein and its contribution to infectious virus production. PLoS Pathog. 2010;6:e1001087 pubmed publisher
  • western blot; Hepacivirus C; 1:1000
Fillebeen C, Pantopoulos K. Iron inhibits replication of infectious hepatitis C virus in permissive Huh7.5.1 cells. J Hepatol. 2010;53:995-9 pubmed publisher
  • ELISA; Hepacivirus C
Yu X, Uprichard S. Cell-based hepatitis C virus infection fluorescence resonance energy transfer (FRET) assay for antiviral compound screening. Curr Protoc Microbiol. 2010;Chapter 17:Unit 17.5. pubmed publisher
  • immunocytochemistry; Hepacivirus C
Silberstein E, Mihalik K, Ulitzky L, Plant E, Puig M, Gagneten S, et al. Persistent growth of a human plasma-derived hepatitis C virus genotype 1b isolate in cell culture. PLoS Pathog. 2010;6:e1000910 pubmed publisher
  • immunocytochemistry; Hepacivirus C
  • western blot; Hepacivirus C
Shirasaki T, Honda M, Mizuno H, Shimakami T, Okada H, Sakai Y, et al. La protein required for internal ribosome entry site-directed translation is a potential therapeutic target for hepatitis C virus replication. J Infect Dis. 2010;202:75-85 pubmed publisher
  • western blot; Hepacivirus C
Jangra R, Yi M, Lemon S. Regulation of hepatitis C virus translation and infectious virus production by the microRNA miR-122. J Virol. 2010;84:6615-25 pubmed publisher
  • immunoprecipitation; Hepacivirus C; 1:100
  • immunocytochemistry; Hepacivirus C; 1:600
Jangra R, Yi M, Lemon S. DDX6 (Rck/p54) is required for efficient hepatitis C virus replication but not for internal ribosome entry site-directed translation. J Virol. 2010;84:6810-24 pubmed publisher
  • western blot; Hepacivirus C
Shao R, Zhang L, Peng L, Sun E, Chung W, Jang J, et al. Suppressor of cytokine signaling 3 suppresses hepatitis C virus replication in an mTOR-dependent manner. J Virol. 2010;84:6060-9 pubmed publisher
  • western blot; Hepacivirus C
Polyak S, Morishima C, Lohmann V, Pal S, Lee D, Liu Y, et al. Identification of hepatoprotective flavonolignans from silymarin. Proc Natl Acad Sci U S A. 2010;107:5995-9 pubmed publisher
  • western blot; Hepacivirus C
Lin W, Tsai W, Shao R, Wu G, Peng L, Barlow L, et al. Hepatitis C virus regulates transforming growth factor beta1 production through the generation of reactive oxygen species in a nuclear factor kappaB-dependent manner. Gastroenterology. 2010;138:2509-18, 2518.e1 pubmed publisher
  • immunocytochemistry; Hepacivirus C
Liu R, Tewari M, Kong R, Zhang R, Ingravallo P, Ralston R. A peptide derived from hepatitis C virus E2 envelope protein inhibits a post-binding step in HCV entry. Antiviral Res. 2010;86:172-9 pubmed publisher
  • immunocytochemistry; Hepacivirus C
Duong F, Christen V, Lin S, Heim M. Hepatitis C virus-induced up-regulation of protein phosphatase 2A inhibits histone modification and DNA damage repair. Hepatology. 2010;51:741-51 pubmed publisher
  • western blot; Hepacivirus C
Wang T, Campbell R, Yi M, Lemon S, Weinman S. Role of Hepatitis C virus core protein in viral-induced mitochondrial dysfunction. J Viral Hepat. 2010;17:784-93 pubmed publisher
  • western blot; Hepacivirus C; 1:1000
Yu X, Sainz B, Uprichard S. Development of a cell-based hepatitis C virus infection fluorescent resonance energy transfer assay for high-throughput antiviral compound screening. Antimicrob Agents Chemother. 2009;53:4311-9 pubmed publisher
  • immunocytochemistry; Hepacivirus C
Benedicto I, Molina Jiménez F, Bartosch B, Cosset F, Lavillette D, Prieto J, et al. The tight junction-associated protein occludin is required for a postbinding step in hepatitis C virus entry and infection. J Virol. 2009;83:8012-20 pubmed publisher
  • western blot; Hepacivirus C
Phan T, Beran R, Peters C, Lorenz I, Lindenbach B. Hepatitis C virus NS2 protein contributes to virus particle assembly via opposing epistatic interactions with the E1-E2 glycoprotein and NS3-NS4A enzyme complexes. J Virol. 2009;83:8379-95 pubmed publisher
  • immunocytochemistry; Hepacivirus C; 1:300, 1:400
  • western blot; Hepacivirus C; 1:30000
Yi M, Ma Y, Yates J, Lemon S. Trans-complementation of an NS2 defect in a late step in hepatitis C virus (HCV) particle assembly and maturation. PLoS Pathog. 2009;5:e1000403 pubmed publisher
  • immunocytochemistry; Hepacivirus C; 1:500-1:1000
Kang J, Kim J, Wakita T, Ahn B. Cell culture-adaptive mutations in the NS5B gene of hepatitis C virus with delayed replication and reduced cytotoxicity. Virus Res. 2009;144:107-16 pubmed publisher
  • western blot; Hepacivirus C
Ebihara T, Masuda H, Akazawa T, Shingai M, Kikuta H, Ariga T, et al. Induction of NKG2D ligands on human dendritic cells by TLR ligand stimulation and RNA virus infection. Int Immunol. 2007;19:1145-55 pubmed
  • immunoprecipitation; Hepacivirus C
  • western blot; Hepacivirus C
Ernst E, Schonig K, Bugert J, Blaker H, Pfaff E, Stremmel W, et al. Generation of inducible hepatitis C virus transgenic mouse lines. J Med Virol. 2007;79:1103-12 pubmed
  • immunocytochemistry; Hepacivirus C; 1:300
Kato T, Date T, Murayama A, Morikawa K, Akazawa D, Wakita T. Cell culture and infection system for hepatitis C virus. Nat Protoc. 2006;1:2334-9 pubmed
  • immunocytochemistry; Hepacivirus C; 1:300
  • western blot; Hepacivirus C; 1:30000
Yi M, Villanueva R, Thomas D, Wakita T, Lemon S. Production of infectious genotype 1a hepatitis C virus (Hutchinson strain) in cultured human hepatoma cells. Proc Natl Acad Sci U S A. 2006;103:2310-5 pubmed
  • immunocytochemistry; Hepacivirus C
  • western blot; Hepacivirus C
Herzer K, Weyer S, Krammer P, Galle P, Hofmann T. Hepatitis C virus core protein inhibits tumor suppressor protein promyelocytic leukemia function in human hepatoma cells. Cancer Res. 2005;65:10830-7 pubmed
Tai C, Jassey A, Liu C, Tai C, Richardson C, Wong S, et al. Targeting Autophagy Augments BBR-Mediated Cell Death in Human Hepatoma Cells Harboring Hepatitis C Virus RNA. Cells. 2020;9: pubmed publisher
Xu H, Xu S, Xie S, Zhang Y, Yang J, Zhang W, et al. MicroRNA-122 supports robust innate immunity in hepatocytes by targeting the RTKs/STAT3 signaling pathway. elife. 2019;8: pubmed publisher
Akil A, Endsley M, Shanmugam S, Saldarriaga O, Somasunderam A, Spratt H, et al. Fibrogenic Gene Expression in Hepatic Stellate Cells Induced by HCV and HIV Replication in a Three Cell Co-Culture Model System. Sci Rep. 2019;9:568 pubmed publisher
Murai K, Shimakami T, Welsch C, Shirasaki T, Liu F, Kitabayashi J, et al. Unexpected Replication Boost by Simeprevir for Simeprevir-Resistant Variants in Genotype 1a Hepatitis C Virus. Antimicrob Agents Chemother. 2018;62: pubmed publisher
Cheng M, Niu Y, Fan J, Chi X, Liu X, Yang W. Interferon down-regulation of miR-1225-3p as an antiviral mechanism through modulating Grb2-associated binding protein 3 expression. J Biol Chem. 2018;293:5975-5986 pubmed publisher
Wang Z, Gao Y, Zhang C, Hu H, Guo D, Xu Y, et al. Quinolinate Phosphoribosyltransferase is an Antiviral Host Factor Against Hepatitis C Virus Infection. Sci Rep. 2017;7:5876 pubmed publisher
Wang S, Lai K, Li C, Chiang C, Yu G, Sakamoto N, et al. The Paradoxical Effects of Different Hepatitis C Viral Loads on Host DNA Damage and Repair Abilities. PLoS ONE. 2017;12:e0164281 pubmed publisher
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Piver E, Boyer A, Gaillard J, Bull A, Beaumont E, Roingeard P, et al. Ultrastructural organisation of HCV from the bloodstream of infected patients revealed by electron microscopy after specific immunocapture. Gut. 2017;66:1487-1495 pubmed publisher
Elgner F, Ren H, Medvedev R, Ploen D, Himmelsbach K, Boller K, et al. The Intracellular Cholesterol Transport Inhibitor U18666A Inhibits the Exosome-Dependent Release of Mature Hepatitis C Virus. J Virol. 2016;90:11181-11196 pubmed
Ren H, Elgner F, Jiang B, Himmelsbach K, Medvedev R, Ploen D, et al. The Autophagosomal SNARE Protein Syntaxin 17 Is an Essential Factor for the Hepatitis C Virus Life Cycle. J Virol. 2016;90:5989-6000 pubmed publisher
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product information
Product Type :
Antibody
Product Name :
Hepatitis C Virus Core Antigen Monoclonal Antibody (C7-50)
Catalog # :
MA1-080
Quantity :
100 µg
Price :
US 399.00
Clonality :
Monoclonal
Purity :
protein A
Host :
Mouse
Reactivity :
Virus
Applications :
ELISA: Assay-dependent, Flow Cytometry: 1/100, Immunocytochemistry: Assay-dependent, Immunoprecipitation: Assay-dependent, Western Blot: 1 µg/mL
Species :
Virus
Clone :
C7-50
Isotype :
IgG1
Storage :
-20° C, Avoid Freeze/Thaw Cycles
Description :
HCV is a positive, single-stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. The polyprotein is processed by host cell and viral proteases into three major structural proteins and several non-structural protein necessary for viral replication. Several different genotypes of HCV with slightly different genomic sequences have since been identified that correlate with differences in response to treatment with interferon alpha.
Immunogen :
Purified HCV core-GST fusion protein (genotype 1b).
Format :
Liquid
Applications w/Dilutions :
ELISA: Assay-dependent, Flow Cytometry: 1/100, Immunocytochemistry: Assay-dependent, Immunoprecipitation: Assay-dependent, Western Blot: 1 µg/mL
Aliases :
HCV core; HCVgp1; HepC; HepC core; polyprotein
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA