Perlecan Monoclonal Antibody (A7L6) | Invitrogen MA1-06821 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Perlecan Monoclonal Antibody (A7L6)

catalog :

MA1-06821

quantity :

100 µL

price :

US 399.00

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

A7L6

reactivity :

human, mouse, rat, dogs, bovine

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 10

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; mouse; 1:250; loading ...; fig 1b	Han C, Kang I, Harten I, Gebe J, Chan C, Omer M, et al. Adipocyte-Derived Versican and Macrophage-Derived Biglycan Control Adipose Tissue Inflammation in Obesity. Cell Rep. 2020;31:107818 pubmed publisher
immunohistochemistry; dogs; 1:1000; loading ...; fig s6a	Amoasii L, Hildyard J, Li H, Sanchez Ortiz E, Mireault A, Caballero D, et al. Gene editing restores dystrophin expression in a canine model of Duchenne muscular dystrophy. Science. 2018;362:86-91 pubmed publisher
immunohistochemistry - paraffin section; human; 1:100; loading ...; fig 3a	Chajra H, Auriol D, Joly F, Pagnon A, Rodrigues M, Allart S, et al. Reactivating the extracellular matrix synthesis of sulfated glycosaminoglycans and proteoglycans to improve the human skin aspect and its mechanical properties. Clin Cosmet Investig Dermatol. 2016;9:461-472 pubmed
immunohistochemistry; mouse; 1:100; fig S1G	Fantauzzo K, Soriano P. PDGFR? regulates craniofacial development through homodimers and functional heterodimers with PDGFR?. Genes Dev. 2016;30:2443-2458 pubmed
immunohistochemistry; mouse; 1:200	Cogger V, Svistounov D, Warren A, Zykova S, Melvin R, Solon Biet S, et al. Liver aging and pseudocapillarization in a Werner syndrome mouse model. J Gerontol A Biol Sci Med Sci. 2014;69:1076-86 pubmed publisher
immunohistochemistry; human	Goddeeris M, Wu B, Venzke D, Yoshida Moriguchi T, Saito F, Matsumura K, et al. LARGE glycans on dystroglycan function as a tunable matrix scaffold to prevent dystrophy. Nature. 2013;503:136-40 pubmed publisher
immunohistochemistry; mouse	Nguyen A, Xiao B, Neppl R, Kallin E, Li J, Chen T, et al. DOT1L regulates dystrophin expression and is critical for cardiac function. Genes Dev. 2011;25:263-74 pubmed publisher
immunohistochemistry; bovine	Nigro J, White J, Ramshaw J, Haylock D, Nilsson S, Werkmeister J. The effect of bovine endosteum-derived particles on the proliferation of human mesenchymal stem cells. Biomaterials. 2010;31:5689-99 pubmed publisher
immunohistochemistry; mouse	Beiting D, Park P, Appleton J. Synthesis of syndecan-1 by skeletal muscle cells is an early response to infection with Trichinella spiralis but is not essential for nurse cell development. Infect Immun. 2006;74:1941-3 pubmed
	de Greef J, Hamlyn R, Jensen B, O Campo Landa R, Levy J, Kobuke K, et al. Collagen VI deficiency reduces muscle pathology, but does not improve muscle function, in the Î³-sarcoglycan-null mouse. Hum Mol Genet. 2016;25:1357-69 pubmed publisher

image

image 1 :

product information

Product Type :

Antibody

Product Name :

Perlecan Monoclonal Antibody (A7L6)

Catalog # :

MA1-06821

Quantity :

100 µL

Price :

US 399.00

Clonality :

Monoclonal

Purity :

purified

Host :

Rat

Reactivity :

Bovine, Fish, Human, Mouse, Rat

Applications :

Immunocytochemistry: 1:25-1:200, Immunohistochemistry (Frozen): 1:25-1:200, Immunohistochemistry (Paraffin): 1:25-1:200, Immunoprecipitation: Assay-dependent, Western Blot: 1:100-1:1,000

Species :

Bovine, Fish, Human, Mouse, Rat

Clone :

A7L6

Isotype :

IgG2a

Storage :

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Description :

Perlecan is a major heparan-sulfate proteoglycan (HSPG) found within all basement membranes and cell surfaces. Because of its strategic location and ability to store and protect growth factors, perlecan has been strongly implicated in the control of tumor cell growth and metastatic behavior. Perlecan possesses angiogenic and growth-promoting attributes primarily by acting as a coreceptor for basic fibroblast growth factor (FGF-2). Suppression of perlecan causes substantial inhibition of neoplastic growth and neovascularization. Thus, perlecan is a potent inducer of neoplasm growth and angiogenesis in vivo and therapeutic interventions targeting this key modulator of tumor progression may improve neoplastic treatment.

Immunogen :

High molecular mass material derived from the Engelbreth-Holm-Swarm (EHS) tumor matrix containing laminin, entactin and HSPG.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:25-1:200, Immunohistochemistry (Frozen): 1:25-1:200, Immunohistochemistry (Paraffin): 1:25-1:200, Immunoprecipitation: Assay-dependent, Western Blot: 1:100-1:1,000

Aliases :

AI852380; Basement membrane-specific heparan sulfate proteoglycan core protein; Endorepellin; endorepellin (domain V region); heparan sulfate proteoglycan 2; HSPG; Hspg2; LG3 peptide; LOC313641; Pcn; per; perlecan; perlecan (heparan sulfate proteoglycan 2); perlecan proteoglycan; PLC; PRCAN; RP11-132G19.2; SJA; SJS; SJS1

more info or order :

Invitrogen product webpage