product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD56 Monoclonal Antibody (123C3)
catalog :
MA1-06801
quantity :
100 µL
price :
US 425.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
123C3
reactivity :
human
application :
western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
Invitrogen product webpage
citations: 35
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - paraffin section; human; loading ...; fig 1d
Erdogan Durmus S, Ozcan D, Yarikkaya E, Kurt A, Arslan A. CD56, HBME-1 and cytokeratin 19 expressions in papillary thyroid carcinoma and nodular thyroid lesions. J Res Med Sci. 2016;21:49 pubmed
  • immunohistochemistry - paraffin section; human; loading ...
Nakamura A, Mitsuhashi T, Takano Y, Miyoshi H, Kameda H, Nomoto H, et al. Usefulness of the octreotide test in Japanese patients for predicting the presence/absence of somatostatin receptor 2 expression in insulinomas. Endocr J. 2016;63:135-42 pubmed publisher
  • immunohistochemistry - paraffin section; human; fig 1
Marković Lipkovski J, Životić M, Müller C, Tampe B, Ćirović S, Vještica J, et al. Variable Expression of Neural Cell Adhesion Molecule Isoforms in Renal Tissue: Possible Role in Incipient Renal Fibrosis. PLoS ONE. 2015;10:e0137028 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:50-1:100; fig 4
Ceyran A, Şenol S, Şimşek B, Sağıroğlu J, Aydın A. Role of cd56 and e-cadherin expression in the differential diagnosis of papillary thyroid carcinoma and suspected follicular-patterned lesions of the thyroid: the prognostic importance of e-cadherin. Int J Clin Exp Pathol. 2015;8:3670-80 pubmed
  • immunohistochemistry; human; 1:100
Vanoli A, Argenti F, Vinci A, La Rosa S, Viglio A, Riboni R, et al. Hepatoid carcinoma of the pancreas with lymphoid stroma: first description of the clinical, morphological, immunohistochemical, and molecular characteristics of an unusual pancreatic carcinoma. Virchows Arch. 2015;467:237-45 pubmed publisher
  • immunohistochemistry - paraffin section; human
Jeon Y, Kim J, Sung J, Han J, Ko Y. Epstein-Barr virus-positive nodal T/NK-cell lymphoma: an analysis of 15 cases with distinct clinicopathological features. Hum Pathol. 2015;46:981-90 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:25
Kadota K, Nitadori J, Rekhtman N, Jones D, Adusumilli P, Travis W. Reevaluation and reclassification of resected lung carcinomas originally diagnosed as squamous cell carcinoma using immunohistochemical analysis. Am J Surg Pathol. 2015;39:1170-80 pubmed publisher
  • immunohistochemistry; human; 1:300
Choi J, Kang H, Lee J, Ju H, Hong C, Kim H, et al. Very late relapse of bilateral retinoblastoma. J Pediatr Hematol Oncol. 2015;37:e264-7 pubmed publisher
  • immunohistochemistry; human; 1:100
Tomasini D, Niccoli A, Crivelli F. Pagetoid reticulosis tumor cells with double expression of TCRγδ and TCRαβ: an off-target phenomenon or genuine expression?. J Cutan Pathol. 2015;42:427-34 pubmed publisher
  • immunohistochemistry - paraffin section; human; ready-to-use
Sakakura K, Takahashi H, Kaira K, Toyoda M, Oyama T, Chikamatsu K. Immunological significance of the accumulation of autophagy components in oral squamous cell carcinoma. Cancer Sci. 2015;106:1-8 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100
Kasem K, Lam A. Adrenal oncocytic phaeochromocytoma with putative adverse histologic features: a unique case report and review of the literature. Endocr Pathol. 2014;25:416-21 pubmed publisher
  • immunohistochemistry; human
Thompson L, Bauer J, Chiosea S, McHugh J, Seethala R, Miettinen M, et al. Canalicular adenoma: a clinicopathologic and immunohistochemical analysis of 67 cases with a review of the literature. Head Neck Pathol. 2015;9:181-95 pubmed publisher
  • immunohistochemistry - paraffin section; human
Jeon Y, Moon K, Park S, Chung D. Primary pulmonary myxoid sarcomas with EWSR1-CREB1 translocation might originate from primitive peribronchial mesenchymal cells undergoing (myo)fibroblastic differentiation. Virchows Arch. 2014;465:453-61 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100
Yang Y, Li Y, Liu Y, Yang M, Liu K. CD30+ extranodal natural killer/T-cell lymphoma mimicking phlegmonous myositis: A case report. Oncol Lett. 2014;7:1419-1421 pubmed
  • immunohistochemistry - paraffin section; human
Jones H, Gold M, Giannico G, Troutman A, Vnencak Jones C, Schultenover S, et al. Lymphoepithelioma-like carcinoma of the endometrium: immunophenotypic characterization of a rare tumor with microsatellite instability testing. Int J Gynecol Pathol. 2014;33:64-73 pubmed publisher
  • immunohistochemistry; human; 1:50
Karagkounis G, Argyrakos T, Charkiolakis G, Castana O, Rontogianni D. A Case of Distal Epithelioid Sarcoma of the Thumb Expressing Podoplanin, TLE1 and Ca 125. Case Rep Pathol. 2013;2013:312786 pubmed publisher
  • immunohistochemistry - paraffin section; human
Zuo Z, Tang Y, Bi C, Zhang W, Zhao S, Wang X, et al. Extraosseous (extramedullary) plasmacytomas: a clinicopathologic and immunophenotypic study of 32 Chinese cases. Diagn Pathol. 2011;6:123 pubmed publisher
  • flow cytometry; human; 1:100; tbl 3
Su X, Huang J, Jiang Y, Tang Y, Li G, Liu W. Serous effusion cytology of extranodal natural killer/T-cell lymphoma. Cytopathology. 2012;23:96-102 pubmed publisher
  • immunohistochemistry; human; fig 3
Lee D, Yang J, Lee S, Won C, Chang S, Lee M, et al. Subcutaneous panniculitis-like T-cell lymphoma: a clinical and pathologic study of 14 korean patients. Ann Dermatol. 2011;23:329-37 pubmed publisher
  • immunohistochemistry - paraffin section; human
Petrilli G, Lorenzi L, Paracchini R, Ubiali A, Schumacher R, Cabassa P, et al. Epstein-Barr virus-associated adrenal smooth muscle tumors and disseminated diffuse large B-cell lymphoma in a child with common variable immunodeficiency: a case report and review of the literature. Int J Surg Pathol. 2014;22:712-21 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100; fig 1
Yong Jiang -, Huawei Liu -, Hu Long -, Yingying Yang -, Dianying Liao -, Xiuhui Zhang -. Goblet cell carcinoid of the appendix: a clinicopathological and immunohistochemical study of 26 cases from southwest china. Int J Surg Pathol. 2010;18:488-92 pubmed publisher
  • immunohistochemistry; human; 1:600
Gualco G, Wludarski S, Hayashi Silva L, Medeiros Filho P, Veras G, Bacchi C. Primary central nervous system peripheral T-cell lymphoma in a child. Fetal Pediatr Pathol. 2010;29:224-30 pubmed publisher
  • immunohistochemistry; human; 1:200
Schor A, Moraes M, Bisson F, Bisson M, Luiz O, Bacchi C. Primary plasmacytoma of the cervix in a 21-year-old female patient. Int J Gynecol Pathol. 2010;29:290-3 pubmed publisher
  • immunohistochemistry; human; 1:100
Nannini N, Bertolini F, Cavazza A, Casali C, Mengoli M, Rossi G. Atypical carcinoid with prominent mucinous stroma: a hitherto unreported variant of pulmonary neuroendocrine tumor. Endocr Pathol. 2010;21:120-4 pubmed publisher
  • immunohistochemistry; human
Sartori G, Cavazza A, Sgambato A, Marchioni A, Barbieri F, Longo L, et al. EGFR and K-ras mutations along the spectrum of pulmonary epithelial tumors of the lung and elaboration of a combined clinicopathologic and molecular scoring system to predict clinical responsiveness to EGFR inhibitors. Am J Clin Pathol. 2009;131:478-89 pubmed publisher
  • immunohistochemistry; human; 1:150
Gualco G, Chioato L, van den Berg A, Weiss L, Bacchi C. Composite lymphoma: EBV-positive classic Hodgkin lymphoma and peripheral T-cell lymphoma: a case report. Appl Immunohistochem Mol Morphol. 2009;17:72-6 pubmed
Hu X, Liu Y, Zhang X, Kong D, Kong J, Zhao D, et al. The anti-B7-H4 checkpoint synergizes trastuzumab treatment to promote phagocytosis and eradicate breast cancer. Neoplasia. 2020;22:539-553 pubmed publisher
Su S, Zhao J, Xing Y, Zhang X, Liu J, Ouyang Q, et al. Immune Checkpoint Inhibition Overcomes ADCP-Induced Immunosuppression by Macrophages. Cell. 2018;175:442-457.e23 pubmed publisher
Garzia L, Kijima N, Morrissy A, De Antonellis P, Guerreiro Stucklin A, Holgado B, et al. A Hematogenous Route for Medulloblastoma Leptomeningeal Metastases. Cell. 2018;172:1050-1062.e14 pubmed publisher
Celik B, Bulut T. Human epididymis protein 4 may not be a reliable screening biomarker for detecting lung carcinoma patients. Biomed Rep. 2017;7:297-300 pubmed publisher
Weil S, Memmer S, Lechner A, Huppert V, Giannattasio A, Becker T, et al. Natural Killer Group 2D Ligand Depletion Reconstitutes Natural Killer Cell Immunosurveillance of Head and Neck Squamous Cell Carcinoma. Front Immunol. 2017;8:387 pubmed publisher
George J, Saito M, Tsuta K, Iwakawa R, Shiraishi K, Scheel A, et al. Genomic Amplification of CD274 (PD-L1) in Small-Cell Lung Cancer. Clin Cancer Res. 2017;23:1220-1226 pubmed publisher
Rossi G, Marchioni A, Milani M, Scotti R, Foroni M, Cesinaro A, et al. TTF-1, cytokeratin 7, 34betaE12, and CD56/NCAM immunostaining in the subclassification of large cell carcinomas of the lung. Am J Clin Pathol. 2004;122:884-93 pubmed
Casali C, Stefani A, Rossi G, Migaldi M, Bettelli S, Parise A, et al. The prognostic role of c-kit protein expression in resected large cell neuroendocrine carcinoma of the lung. Ann Thorac Surg. 2004;77:247-52; discussion 252-3 pubmed
Huttenbach Y, Prieto V, Reed J. Desmoplastic and spindle cell melanomas express protein markers of the neural crest but not of later committed stages of Schwann cell differentiation. J Cutan Pathol. 2002;29:562-8 pubmed
product information
Product Type :
Antibody
Product Name :
CD56 Monoclonal Antibody (123C3)
Catalog # :
MA1-06801
Quantity :
100 µL
Price :
US 425.00
Clonality :
Monoclonal
Purity :
purified
Host :
Mouse
Reactivity :
Human
Applications :
Immunocytochemistry: 1:100-1:200, Immunohistochemistry (Frozen): 1:100-1:200, Immunohistochemistry (Paraffin): 1:100 - 1:200, Western Blot: 1:100-1:1,000
Species :
Human
Clone :
123C3
Isotype :
IgG1
Storage :
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Description :
CD56 (NCAM, neural cell adhesion molecule) is a transmembrane glycoprotein of the immunoglobulin family that serves as an adhesive molecule and is ubiquitously expressed in the nervous system in isoforms ranging from 120-180 kDa. CD56 is found on T cells and NK cells, and is involved in cell migration, axonal growth, pathfinding and synaptic plasticity. Polysialic modification results in reduction of CD56-mediated cell adhesion. Through its extracellular region, CD56 mediates homophilic and heterophilic interactions by binding extracellular matrix components such as laminin and integrins. CD56 is expressed on most neuroectodermal derived cell lines, tissues and neoplasms such as retinoblastoma, medulloblastoma, astrocytomas and neuroblastoma. Further, CD56 is a widely used neuroendocrine marker with a high sensitivity for neuroendocrine tumors and ovarian granulosa cell tumors. Diseases associated with CD56 dysfunction include rabies and blastic plasmacytoid dendritic cell neoplasms.
Immunogen :
Small cell lung carcinoma.
Format :
Liquid
Applications w/Dilutions :
Immunocytochemistry: 1:100-1:200, Immunohistochemistry (Frozen): 1:100-1:200, Immunohistochemistry (Paraffin): 1:100 - 1:200, Western Blot: 1:100-1:1,000
Aliases :
adhesion molecule; antigen recognized by monoclonal antibody 5.1H11; Cd56; CD-56; CD56 120 kDa GPI-linked isoform; CD56 140 kDa isoform; CD56 140 kDa VASE isoform; E NCAM; E-NCAM; MSK39; N CAM1; NCAM; N-CAM; Ncam1; N-CAM-1; NCAM-1; NCAMC; NCAM-C; neural cell adhesion molecule; Neural cell adhesion molecule 1; neural cell adhesion molecule, NCAM; sCD56; sNCAM; soluble CD56; soluble NCAM
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA