E-cadherin Monoclonal Antibody (6F9) | Invitrogen MA1-06302 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

E-cadherin Monoclonal Antibody (6F9)

catalog :

MA1-06302

quantity :

100µL

price :

330 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

6F9

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - frozen section

product information

Product Type :

Antibody

Product Name :

E-cadherin Monoclonal Antibody (6F9)

Catalog # :

MA1-06302

Quantity :

100µL

Price :

330 USD

Clonality :

Monoclonal

Purity :

purified

Host :

Mouse

Reactivity :

Human

Applications :

Immunocytochemistry: 1:25-1:100, Immunohistochemistry (Frozen): 1:25-1:100, Western Blot: 1:50-1:500

Species :

Human

Clone :

6F9

Isotype :

IgG1

Storage :

4°C or -20°C if preferred

Description :

E-Cadherin (epithelial cadherin) is a classical cadherin from the cadherin (alcium dependent adhesion protein) superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. E-cadherin plays a central role in the growth and development of cells by controlling tissue architecture, and maintenance of tissue integrity. In humans, E-cadherin is encoded by the CDH1 gene present on chromosome 16. Studies have demonstrated that reduction and/or loss of E-cadherin expression in carcinomas correlates positively with the potential of these tumors for invasion and metastasis.

Immunogen :

E-cadherin derived from human vulva carcinoma cells.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:25-1:100, Immunohistochemistry (Frozen): 1:25-1:100, Western Blot: 1:50-1:500

Aliases :

Arc-1, CD324, CDHE, ECAD, LCAM, UVO, CAM 120/80, E-Cadherin, cadherin 1, E-cadherin epithelial, cadherin-1, calcium-dependent adhesion protein, epithelial, cell-CAM 120/80, epithelial cadherin, uvomorulin, cadherin-E