product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CaMKII alpha Monoclonal Antibody (6G9)
catalog :
MA1-048
quantity :
100 µL
price :
US 482
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
6G9
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - frozen section
more info or order :
citations: 103
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - frozen section; mouse; loading ...; fig s2b
Hauser D, Behr K, Konno K, Schreiner D, Schmidt A, Watanabe M, et al. Targeted proteoform mapping uncovers specific Neurexin-3 variants required for dendritic inhibition. Neuron. 2022;: pubmed publisher
  • immunocytochemistry; mouse; 1:1000; loading ...; fig e6c
Yang N, Isensee J, Neel D, Quadros A, Zhang H, Lauzadis J, et al. Anthrax toxins regulate pain signaling and can deliver molecular cargoes into ANTXR2+ DRG sensory neurons. Nat Neurosci. 2022;25:168-179 pubmed publisher
  • immunocytochemistry; mouse; loading ...; fig 2a
  • immunohistochemistry; mouse; loading ...; fig 3a
Tran B, Valek L, Wilken Schmitz A, Fuhrmann D, Namgaladze D, Wittig I, et al. Reduced exploratory behavior in neuronal nucleoredoxin knockout mice. Redox Biol. 2021;45:102054 pubmed publisher
  • immunohistochemistry - frozen section; rat; 1:100; loading ...; fig 4a
Nihonmatsu I, Ohkawa N, Saitoh Y, Okubo Suzuki R, Inokuchi K. Selective targeting of mRNA and the following protein synthesis of CaMKIIα at the long-term potentiation-induced site. Biol Open. 2020;9: pubmed publisher
  • western blot; mouse; 1:5000; loading ...; fig 2b
Marks C, Shonesy B, Wang X, Stephenson J, Niswender C, Colbran R. Activated CaMKIIα Binds to the mGlu5 Metabotropic Glutamate Receptor and Modulates Calcium Mobilization. Mol Pharmacol. 2018;94:1352-1362 pubmed publisher
  • western blot; human; 1:5000; loading ...; fig 2d
Stephenson J, Wang X, Perfitt T, Parrish W, Shonesy B, Marks C, et al. A Novel Human CAMK2A Mutation Disrupts Dendritic Morphology and Synaptic Transmission, and Causes ASD-Related Behaviors. J Neurosci. 2017;37:2216-2233 pubmed publisher
  • immunohistochemistry; rat; 1:500; loading ...; fig 3c
Biró L, Toth M, Sipos E, Bruzsik B, Tulogdi A, Bendahan S, et al. Structural and functional alterations in the prefrontal cortex after post-weaning social isolation: relationship with species-typical and deviant aggression. Brain Struct Funct. 2017;222:1861-1875 pubmed publisher
  • western blot; rat; loading ...; fig 7g
Bramini M, Sacchetti S, Armirotti A, Rocchi A, Vazquez E, León Castellanos V, et al. Graphene Oxide Nanosheets Disrupt Lipid Composition, Ca(2+) Homeostasis, and Synaptic Transmission in Primary Cortical Neurons. ACS Nano. 2016;10:7154-71 pubmed publisher
  • western blot; mouse; 1:2000; fig s3
Bosch C, Muhaisen A, Pujadas L, Soriano E, MARTINEZ A. Reelin Exerts Structural, Biochemical and Transcriptional Regulation Over Presynaptic and Postsynaptic Elements in the Adult Hippocampus. Front Cell Neurosci. 2016;10:138 pubmed publisher
  • immunohistochemistry; rat; 1:200; fig 5
  • western blot; rat; 1:2000; fig 5
Györffy B, Gulyassy P, Gellén B, Völgyi K, Madarasi D, Kis V, et al. Widespread alterations in the synaptic proteome of the adolescent cerebral cortex following prenatal immune activation in rats. Brain Behav Immun. 2016;56:289-309 pubmed publisher
  • immunohistochemistry; human; 1:100; fig 3
Mantoan Ritter L, Macdonald D, Ritter G, Escors D, Chiara F, Cariboni A, et al. Lentiviral expression of GAD67 and CCK promoter-driven opsins to target interneurons in vitro and in vivo. J Gene Med. 2016;18:27-37 pubmed publisher
  • immunocytochemistry; rat; fig 6
Cisternas P, Louveau A, Bueno S, Kalergis A, Boudin H, Riedel C. Gestational Hypothyroxinemia Affects Glutamatergic Synaptic Protein Distribution and Neuronal Plasticity Through Neuron-Astrocyte Interplay. Mol Neurobiol. 2016;53:7158-7169 pubmed
  • immunohistochemistry - frozen section; mouse; 1:100; fig 8
Giordano C, Vinet J, Curia G, Biagini G. Repeated 6-Hz Corneal Stimulation Progressively Increases FosB/ΔFosB Levels in the Lateral Amygdala and Induces Seizure Generalization to the Hippocampus. PLoS ONE. 2015;10:e0141221 pubmed publisher
  • western blot; mouse; 1:2000; fig 8
Tajerian M, Leu D, Yang P, Huang T, Kingery W, Clark J. Differential Efficacy of Ketamine in the Acute versus Chronic Stages of Complex Regional Pain Syndrome in Mice. Anesthesiology. 2015;123:1435-47 pubmed publisher
  • western blot; mouse; 1:2000; fig 1
Tom Dieck S, Kochen L, Hanus C, Heumüller M, Bartnik I, Nassim Assir B, et al. Direct visualization of newly synthesized target proteins in situ. Nat Methods. 2015;12:411-4 pubmed publisher
  • western blot; mouse; fig 2c
Baucum A, Shonesy B, Rose K, Colbran R. Quantitative proteomics analysis of CaMKII phosphorylation and the CaMKII interactome in the mouse forebrain. ACS Chem Neurosci. 2015;6:615-31 pubmed publisher
  • immunocytochemistry; rat; 1:500; fig 4
Isensee J, Wenzel C, Buschow R, Weissmann R, Kuss A, Hucho T. Subgroup-elimination transcriptomics identifies signaling proteins that define subclasses of TRPV1-positive neurons and a novel paracrine circuit. PLoS ONE. 2014;9:e115731 pubmed publisher
  • immunocytochemistry; mouse; 1:200
  • immunohistochemistry; mouse; 1:200
  • western blot; mouse
Cooper M, Koleske A. Ablation of ErbB4 from excitatory neurons leads to reduced dendritic spine density in mouse prefrontal cortex. J Comp Neurol. 2014;522:3351-62 pubmed publisher
  • immunocytochemistry; mouse
Dai X, Iwasaki H, Watanabe M, Okabe S. Dlx1 transcription factor regulates dendritic growth and postsynaptic differentiation through inhibition of neuropilin-2 and PAK3 expression. Eur J Neurosci. 2014;39:531-47 pubmed publisher
  • western blot; human; 1:3000; fig 2
Shonesy B, Wang X, Rose K, Ramikie T, Cavener V, Rentz T, et al. CaMKII regulates diacylglycerol lipase-? and striatal endocannabinoid signaling. Nat Neurosci. 2013;16:456-63 pubmed publisher
  • western blot; human
Sanz Clemente A, Gray J, Ogilvie K, Nicoll R, Roche K. Activated CaMKII couples GluN2B and casein kinase 2 to control synaptic NMDA receptors. Cell Rep. 2013;3:607-14 pubmed publisher
  • immunohistochemistry - frozen section; rat; 1:1000
  • immunohistochemistry; rat; 1:1000
Calu D, Kawa A, Marchant N, Navarre B, Henderson M, Chen B, et al. Optogenetic inhibition of dorsal medial prefrontal cortex attenuates stress-induced reinstatement of palatable food seeking in female rats. J Neurosci. 2013;33:214-26 pubmed publisher
  • immunohistochemistry; rat; 1:100
Fanous S, Goldart E, Theberge F, Bossert J, Shaham Y, Hope B. Role of orbitofrontal cortex neuronal ensembles in the expression of incubation of heroin craving. J Neurosci. 2012;32:11600-9 pubmed publisher
  • western blot; rat; 1:1000
Hodas J, Nehring A, Höche N, Sweredoski M, Pielot R, Hess S, et al. Dopaminergic modulation of the hippocampal neuropil proteome identified by bioorthogonal noncanonical amino acid tagging (BONCAT). Proteomics. 2012;12:2464-76 pubmed publisher
  • western blot; human; 1:5000
Sakrikar D, Mazei Robison M, MERGY M, Richtand N, Han Q, Hamilton P, et al. Attention deficit/hyperactivity disorder-derived coding variation in the dopamine transporter disrupts microdomain targeting and trafficking regulation. J Neurosci. 2012;32:5385-97 pubmed publisher
  • western blot; mouse
Wills T, Klug J, Silberman Y, Baucum A, Weitlauf C, Colbran R, et al. GluN2B subunit deletion reveals key role in acute and chronic ethanol sensitivity of glutamate synapses in bed nucleus of the stria terminalis. Proc Natl Acad Sci U S A. 2012;109:E278-87 pubmed publisher
  • western blot; mouse
Pronsato L, Boland R, Milanesi L. Testosterone exerts antiapoptotic effects against H2O2 in C2C12 skeletal muscle cells through the apoptotic intrinsic pathway. J Endocrinol. 2012;212:371-81 pubmed publisher
  • immunocytochemistry; rat; 1:400
  • western blot; rat; 1:400
Otmakhov N, Lisman J. Measuring CaMKII concentration in dendritic spines. J Neurosci Methods. 2012;203:106-14 pubmed publisher
  • western blot; human
Jiao Y, Jalan Sakrikar N, Robison A, Baucum A, Bass M, Colbran R. Characterization of a central Ca2+/calmodulin-dependent protein kinase IIalpha/beta binding domain in densin that selectively modulates glutamate receptor subunit phosphorylation. J Biol Chem. 2011;286:24806-18 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:200
  • immunohistochemistry; mouse; 1:200
  • western blot; mouse; 1:2000
Mouton Liger F, Thomas S, Rattenbach R, Magnol L, Larigaldie V, Ledru A, et al. PCP4 (PEP19) overexpression induces premature neuronal differentiation associated with Ca(2+) /calmodulin-dependent kinase II-? activation in mouse models of Down syndrome. J Comp Neurol. 2011;519:2779-802 pubmed publisher
  • western blot; human; 1:2,000
Bowton E, Saunders C, Erreger K, Sakrikar D, Matthies H, Sen N, et al. Dysregulation of dopamine transporters via dopamine D2 autoreceptors triggers anomalous dopamine efflux associated with attention-deficit hyperactivity disorder. J Neurosci. 2010;30:6048-57 pubmed publisher
  • western blot; mouse; 1:4,000
Brigman J, Wright T, Talani G, Prasad Mulcare S, Jinde S, Seabold G, et al. Loss of GluN2B-containing NMDA receptors in CA1 hippocampus and cortex impairs long-term depression, reduces dendritic spine density, and disrupts learning. J Neurosci. 2010;30:4590-600 pubmed publisher
  • western blot; mouse
Baucum A, Jalan Sakrikar N, Jiao Y, Gustin R, Carmody L, Tabb D, et al. Identification and validation of novel spinophilin-associated proteins in rodent striatum using an enhanced ex vivo shotgun proteomics approach. Mol Cell Proteomics. 2010;9:1243-59 pubmed publisher
  • western blot; mouse
Kojima N, Hanamura K, Yamazaki H, Ikeda T, Itohara S, Shirao T. Genetic disruption of the alternative splicing of drebrin gene impairs context-dependent fear learning in adulthood. Neuroscience. 2010;165:138-50 pubmed publisher
  • western blot; rat; 1:2,000
Soule J, Penke Z, Kanhema T, Alme M, Laroche S, Bramham C. Object-place recognition learning triggers rapid induction of plasticity-related immediate early genes and synaptic proteins in the rat dentate gyrus. Neural Plast. 2008;2008:269097 pubmed publisher
  • western blot; mouse
Lee T, Karl R, Moosmang S, Lenhardt P, Klugbauer N, Hofmann F, et al. Calmodulin kinase II is involved in voltage-dependent facilitation of the L-type Cav1.2 calcium channel: Identification of the phosphorylation sites. J Biol Chem. 2006;281:25560-7 pubmed
  • immunohistochemistry; rat; 1:400
Nyffeler M, Zhang W, Feldon J, Knuesel I. Differential expression of PSD proteins in age-related spatial learning impairments. Neurobiol Aging. 2007;28:143-55 pubmed
  • immunocytochemistry; human
Herrmann T, Morita C, Lee K, Kusner D. Calmodulin kinase II regulates the maturation and antigen presentation of human dendritic cells. J Leukoc Biol. 2005;78:1397-407 pubmed
  • immunocytochemistry; rat
Harms K, Craig A. Synapse composition and organization following chronic activity blockade in cultured hippocampal neurons. J Comp Neurol. 2005;490:72-84 pubmed
  • immunohistochemistry; rat; 1:700
Kalita K, Szymczak S, Kaczmarek L. Non-nuclear estrogen receptor beta and alpha in the hippocampus of male and female rats. Hippocampus. 2005;15:404-12 pubmed
Soli xe9 C, Contestabile A, Espinosa P, Musardo S, Bariselli S, Huber C, et al. Superior Colliculus to VTA pathway controls orienting response and influences social interaction in mice. Nat Commun. 2022;13:817 pubmed publisher
Lautz J, Tsegay K, Zhu Z, Gniffke E, Welsh J, Smith S. Synaptic protein interaction networks encode experience by assuming stimulus-specific and brain-region-specific states. Cell Rep. 2021;37:110076 pubmed publisher
Hu S, Zhang Q, Xia S, Zhao W, Li Q, Yang J, et al. Contralateral Projection of Anterior Cingulate Cortex Contributes to Mirror-Image Pain. J Neurosci. 2021;41:9988-10003 pubmed publisher
GRIGGS R, Nguyen D, Yermakov L, Jaber J, Shelby J, Steinbrunner J, et al. The Type 2 Diabetes Factor Methylglyoxal Mediates Axon Initial Segment Shortening and Alters Neuronal Function at the Cellular and Network Levels. Eneuro. 2021;8: pubmed publisher
Pan Y, He X, Li C, Li Y, Li W, Zhang H, et al. Neuronal activity recruits the CRTC1/CREB axis to drive transcription-dependent autophagy for maintaining late-phase LTD. Cell Rep. 2021;36:109398 pubmed publisher
Yang C, Hung Y, Cheng K, Ling P, Hsu K. Loss of CC2D1A in Glutamatergic Neurons Results in Autistic-Like Features in Mice. Neurotherapeutics. 2021;18:2021-2039 pubmed publisher
Garza Carbajal A, Ebersberger A, Thiel A, Ferrari L, Acuna J, Brosig S, et al. Oncostatin M induces hyperalgesic priming and amplifies signaling of cAMP to ERK by RapGEF2 and PKA. J Neurochem. 2021;157:1821-1837 pubmed publisher
Kang J, Shen J. Cell-autonomous role of Presenilin in age-dependent survival of cortical interneurons. Mol Neurodegener. 2020;15:72 pubmed publisher
Stepler K, Mahoney E, Kofler J, Hohman T, Lopez O, Robinson R. Inclusion of African American/Black adults in a pilot brain proteomics study of Alzheimer's disease. Neurobiol Dis. 2020;146:105129 pubmed publisher
Kuiper L, Lucas K, Mai V, Coolen L. Enhancement of Drug Seeking Following Drug Taking in a Sexual Context Requires Anterior Cingulate Cortex Activity in Male Rats. Front Behav Neurosci. 2020;14:87 pubmed publisher
La Montanara P, Hervera A, Baltussen L, Hutson T, Palmisano I, De Virgiliis F, et al. Cyclin-dependent-like kinase 5 is required for pain signaling in human sensory neurons and mouse models. Sci Transl Med. 2020;12: pubmed publisher
Huang S, Zhang Z, Gambeta E, Xu S, Thomas C, Godfrey N, et al. Dopamine Inputs from the Ventral Tegmental Area into the Medial Prefrontal Cortex Modulate Neuropathic Pain-Associated Behaviors in Mice. Cell Rep. 2020;31:107812 pubmed publisher
Gupta N, Jadhav S, Tan K, Saw G, Mallilankaraman K, Dheen S. miR-142-3p Regulates BDNF Expression in Activated Rodent Microglia Through Its Target CAMK2A. Front Cell Neurosci. 2020;14:132 pubmed publisher
Duda P, Wójtowicz T, Janczara J, Krowarsch D, Czyrek A, Gizak A, et al. Fructose 1,6-Bisphosphatase 2 Plays a Crucial Role in the Induction and Maintenance of Long-Term Potentiation. Cells. 2020;9: pubmed publisher
Huang D, Liu H, Zhu A, Zhou Y, Li Y. Forebrain excitatory neuron-specific SENP2 knockout mouse displays hyperactivity, impaired learning and memory, and anxiolytic-like behavior. Mol Brain. 2020;13:59 pubmed publisher
Perfitt T, Wang X, Dickerson M, Stephenson J, Nakagawa T, Jacobson D, et al. Neuronal L-Type Calcium Channel Signaling to the Nucleus Requires a Novel CaMKIIα-Shank3 Interaction. J Neurosci. 2020;40:2000-2014 pubmed publisher
Perfitt T, Stauffer P, Spiess K, Colbran R. CaMKIIα phosphorylation of Shank3 modulates ABI1-Shank3 interaction. Biochem Biophys Res Commun. 2020;524:262-267 pubmed publisher
Djemil S, Chen X, Zhang Z, Lee J, Rauf M, Pak D, et al. Activation of nicotinic acetylcholine receptors induces potentiation and synchronization within in vitro hippocampal networks. J Neurochem. 2020;153:468-484 pubmed publisher
Hamilton S, Polina I, Terentyeva R, Bronk P, Kim T, Roder K, et al. PKA phosphorylation underlies functional recruitment of sarcolemmal SK2 channels in ventricular myocytes from hypertrophic hearts. J Physiol. 2020;598:2847-2873 pubmed publisher
Shrestha A, Sultana R, Lee C, Ogundele O. SK Channel Modulates Synaptic Plasticity by Tuning CaMKIIα/β Dynamics. Front Synaptic Neurosci. 2019;11:18 pubmed publisher
Foote K, Lyman K, Han Y, Michailidis I, Heuermann R, Mandikian D, et al. Phosphorylation of the HCN channel auxiliary subunit TRIP8b is altered in an animal model of temporal lobe epilepsy and modulates channel function. J Biol Chem. 2019;294:15743-15758 pubmed publisher
Alli Oluwafuyi A, Luis P, Nakashima F, Giménez Bastida J, Presley S, Duvernay M, et al. Curcumin induces secretion of glucagon-like peptide-1 through an oxidation-dependent mechanism. Biochimie. 2019;165:250-257 pubmed publisher
Chiu A, Wang J, Fiske M, Hubálková P, Barse L, Gray J, et al. NMDAR-Activated PP1 Dephosphorylates GluN2B to Modulate NMDAR Synaptic Content. Cell Rep. 2019;28:332-341.e5 pubmed publisher
Yang C, Yu T, Wen W, Ling P, Hsu K. Conditional Deletion of CC2D1A Reduces Hippocampal Synaptic Plasticity and Impairs Cognitive Function through Rac1 Hyperactivation. J Neurosci. 2019;39:4959-4975 pubmed publisher
Witte H, Schreiner D, Scheiffele P. A Sam68-dependent alternative splicing program shapes postsynaptic protein complexes. Eur J Neurosci. 2019;49:1436-1453 pubmed publisher
Matos M, Bosson A, Riebe I, Reynell C, Vallée J, Laplante I, et al. Astrocytes detect and upregulate transmission at inhibitory synapses of somatostatin interneurons onto pyramidal cells. Nat Commun. 2018;9:4254 pubmed publisher
Giannotti G, Barry S, Siemsen B, Peters J, McGinty J. Divergent Prelimbic Cortical Pathways Interact with BDNF to Regulate Cocaine-seeking. J Neurosci. 2018;38:8956-8966 pubmed publisher
Yamazaki H, Sasagawa Y, Yamamoto H, Bito H, Shirao T. CaMKIIβ is localized in dendritic spines as both drebrin-dependent and drebrin-independent pools. J Neurochem. 2018;146:145-159 pubmed publisher
Taoro Gonzalez L, Arenas Y, Cabrera Pastor A, Felipo V. Hyperammonemia alters membrane expression of GluA1 and GluA2 subunits of AMPA receptors in hippocampus by enhancing activation of the IL-1 receptor: underlying mechanisms. J Neuroinflammation. 2018;15:36 pubmed publisher
Tetenborg S, Yadav S, Hormuzdi S, Monyer H, Janssen Bienhold U, Dedek K. Differential Distribution of Retinal Ca2+/Calmodulin-Dependent Kinase II (CaMKII) Isoforms Indicates CaMKII-β and -δ as Specific Elements of Electrical Synapses Made of Connexin36 (Cx36). Front Mol Neurosci. 2017;10:425 pubmed publisher
Larsson M. Non-canonical heterogeneous cellular distribution and co-localization of CaMKIIα and CaMKIIβ in the spinal superficial dorsal horn. Brain Struct Funct. 2018;223:1437-1457 pubmed publisher
Wang X, Marks C, Perfitt T, Nakagawa T, Lee A, Jacobson D, et al. A novel mechanism for Ca2+/calmodulin-dependent protein kinase II targeting to L-type Ca2+ channels that initiates long-range signaling to the nucleus. J Biol Chem. 2017;292:17324-17336 pubmed publisher
Ibi D, de la Fuente Revenga M, Kezunovic N, Muguruza C, Saunders J, Gaitonde S, et al. Antipsychotic-induced Hdac2 transcription via NF-?B leads to synaptic and cognitive side effects. Nat Neurosci. 2017;20:1247-1259 pubmed publisher
Wang S, Stanika R, Wang X, Hagen J, Kennedy M, Obermair G, et al. Densin-180 Controls the Trafficking and Signaling of L-Type Voltage-Gated Cav1.2 Ca2+ Channels at Excitatory Synapses. J Neurosci. 2017;37:4679-4691 pubmed publisher
Kuiper L, Frohmader K, Coolen L. Maladaptive Sexual Behavior Following Concurrent Methamphetamine and Sexual Experience in Male Rats is Associated with Altered Neural Activity in Frontal Cortex. Neuropsychopharmacology. 2017;42:2011-2020 pubmed publisher
Kool M, van de Bree J, Bodde H, Elgersma Y, van Woerden G. The molecular, temporal and region-specific requirements of the beta isoform of Calcium/Calmodulin-dependent protein kinase type 2 (CAMK2B) in mouse locomotion. Sci Rep. 2016;6:26989 pubmed publisher
Pfarr S, Meinhardt M, Klee M, Hansson A, Vengeliene V, Schönig K, et al. Losing Control: Excessive Alcohol Seeking after Selective Inactivation of Cue-Responsive Neurons in the Infralimbic Cortex. J Neurosci. 2015;35:10750-61 pubmed publisher
Leão R, Cruz F, Vendruscolo L, de Guglielmo G, Logrip M, Planeta C, et al. Chronic nicotine activates stress/reward-related brain regions and facilitates the transition to compulsive alcohol drinking. J Neurosci. 2015;35:6241-53 pubmed publisher
Sanz Moreno A, Fuhrmann D, Wolf E, von Eyss B, Eilers M, Elsässer H. Miz1 deficiency in the mammary gland causes a lactation defect by attenuated Stat5 expression and phosphorylation. PLoS ONE. 2014;9:e89187 pubmed publisher
Marcora E, Kennedy M. The Huntington's disease mutation impairs Huntingtin's role in the transport of NF-?B from the synapse to the nucleus. Hum Mol Genet. 2010;19:4373-84 pubmed publisher
Messaoudi E, Kanhema T, Soule J, Tiron A, Dagyte G, da Silva B, et al. Sustained Arc/Arg3.1 synthesis controls long-term potentiation consolidation through regulation of local actin polymerization in the dentate gyrus in vivo. J Neurosci. 2007;27:10445-55 pubmed
Gong R, Park C, Abbassi N, Tang S. Roles of glutamate receptors and the mammalian target of rapamycin (mTOR) signaling pathway in activity-dependent dendritic protein synthesis in hippocampal neurons. J Biol Chem. 2006;281:18802-15 pubmed
Schlief M, Craig A, Gitlin J. NMDA receptor activation mediates copper homeostasis in hippocampal neurons. J Neurosci. 2005;25:239-46 pubmed
Silasi G, Diaz Heijtz R, Besplug J, Rodriguez Juarez R, Titov V, Kolb B, et al. Selective brain responses to acute and chronic low-dose X-ray irradiation in males and females. Biochem Biophys Res Commun. 2004;325:1223-35 pubmed
Miller C, Marshall J. Altered prelimbic cortex output during cue-elicited drug seeking. J Neurosci. 2004;24:6889-97 pubmed
Atkins C, Nozaki N, Shigeri Y, Soderling T. Cytoplasmic polyadenylation element binding protein-dependent protein synthesis is regulated by calcium/calmodulin-dependent protein kinase II. J Neurosci. 2004;24:5193-201 pubmed
Dong Y, Rosenberg H. Prolonged changes in Ca2+/calmodulin-dependent protein kinase II after a brief pentylenetetrazol seizure; potential role in kindling. Epilepsy Res. 2004;58:107-17 pubmed
Dong Y, Rosenberg H. Brief seizure activity alters Ca2+/calmodulin dependent protein kinase II dephosphorylation and subcellular distribution in rat brain for several hours. Neurosci Lett. 2004;357:95-8 pubmed
Gerzanich V, Ivanova S, Van Der Heijden M, Zhou H, Simard J. Trans-cellular proliferating cell nuclear antigen gene activation in cerebral vascular smooth muscle by endothelial oxidative injury in vivo. Arterioscler Thromb Vasc Biol. 2003;23:2048-54 pubmed
Yoshii A, Sheng M, Constantine Paton M. Eye opening induces a rapid dendritic localization of PSD-95 in central visual neurons. Proc Natl Acad Sci U S A. 2003;100:1334-9 pubmed
Menegon A, Verderio C, Leoni C, Benfenati F, Czernik A, Greengard P, et al. Spatial and temporal regulation of Ca2+/calmodulin-dependent protein kinase II activity in developing neurons. J Neurosci. 2002;22:7016-26 pubmed
Fong D, Rao A, Crump F, Craig A. Rapid synaptic remodeling by protein kinase C: reciprocal translocation of NMDA receptors and calcium/calmodulin-dependent kinase II. J Neurosci. 2002;22:2153-64 pubmed
Peng X, Jia Z, Zhang Y, Ware J, Trimble W. The septin CDCrel-1 is dispensable for normal development and neurotransmitter release. Mol Cell Biol. 2002;22:378-87 pubmed
Zhang T, Johnson E, Gu Y, Morissette M, Sah V, Gigena M, et al. The cardiac-specific nuclear delta(B) isoform of Ca2+/calmodulin-dependent protein kinase II induces hypertrophy and dilated cardiomyopathy associated with increased protein phosphatase 2A activity. J Biol Chem. 2002;277:1261-7 pubmed
Allison D, Chervin A, Gelfand V, Craig A. Postsynaptic scaffolds of excitatory and inhibitory synapses in hippocampal neurons: maintenance of core components independent of actin filaments and microtubules. J Neurosci. 2000;20:4545-54 pubmed
Ouyang Y, Rosenstein A, Kreiman G, Schuman E, Kennedy M. Tetanic stimulation leads to increased accumulation of Ca(2+)/calmodulin-dependent protein kinase II via dendritic protein synthesis in hippocampal neurons. J Neurosci. 1999;19:7823-33 pubmed
Zhang W, Vazquez L, Apperson M, Kennedy M. Citron binds to PSD-95 at glutamatergic synapses on inhibitory neurons in the hippocampus. J Neurosci. 1999;19:96-108 pubmed
Ochiishi T, Yamauchi T, Terashima T. Regional differences between the immunohistochemical distribution of Ca2+/calmodulin-dependent protein kinase II alpha and beta isoforms in the brainstem of the rat. Brain Res. 1998;790:129-40 pubmed
Barria A, Muller D, Derkach V, Griffith L, Soderling T. Regulatory phosphorylation of AMPA-type glutamate receptors by CaM-KII during long-term potentiation. Science. 1997;276:2042-5 pubmed
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Patton B, Molloy S, Kennedy M. Autophosphorylation of type II CaM kinase in hippocampal neurons: localization of phospho- and dephosphokinase with complementary phosphorylation site-specific antibodies. Mol Biol Cell. 1993;4:159-72 pubmed
Cho K, Hunt C, Kennedy M. The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor protein. Neuron. 1992;9:929-42 pubmed
Chang P, Sculco F, Yates V. An in vivo and in vitro study of infectious laryngotracheitis virus in chicken leukocytes. Avian Dis. 1977;21:492-500 pubmed
image
image 1 :
Invitrogen MA1-048 image 1
product information
Product Type :
Antibody
Product Name :
CaMKII alpha Monoclonal Antibody (6G9)
Catalog # :
MA1-048
Quantity :
100 µL
Price :
US 482
Clonality :
Monoclonal
Purity :
protein A
Host :
Mouse
Reactivity :
Mouse, Rat
Applications :
Immunohistochemistry: Assay-dependent, Immunoprecipitation: Assay-dependent, Western Blot: 0.5-1 µg/mL
Species :
Mouse, Rat
Clone :
6G9
Isotype :
IgG1
Storage :
-20° C, Avoid Freeze/Thaw Cycles
Description :
The Ca2+/calmodulin-dependent protein kinases (CaM kinases) comprise a structurally related subfamily of serine/threonine kinases which include CaMKI, CaMKII and CaMKIV. CaMKII is an ubiquitously expressed serine/threonine protein kinase that is activated by Ca2+/calmodulin (CaM) binding and autophosphorylation and has been implicated in regulation of the cell cycle and transcription. It is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca2+ transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner.
Immunogen :
Partially purified, rat CaM kinase II.
Format :
Liquid
Applications w/Dilutions :
Immunohistochemistry: Assay-dependent, Immunoprecipitation: Assay-dependent, Western Blot: 0.5-1 µg/mL
Aliases :
alpha CaM kinase II; alpha-CaMKII; Ca2+/calmodulin-dependent protein kinase II; Ca2+/calmodulin-dependent protein kinase II alpha; Calci; calcium/calmodulin dependent protein kinase II alpha; calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha; calcium/calmodulin-dependent protein kinase II alpha; calcium/calmodulin-dependent protein kinase II alpha subunit; calcium/calmodulin-dependent protein kinase II alpha-B subunit; calcium/calmodulin-dependent protein kinase type II alpha chain; calcium/calmodulin-dependent protein kinase type II subunit alpha; CaM kinase II alpha subunit; caM kinase II subunit alpha; CaMK II; CAMK2; Camk2a; CAMKA; CaMKII; CaMK-II alpha subunit; caMK-II subunit alpha; CaMKIINalpha; CaM-kinase II alpha chain; EC 2.7.11.17; KIAA0968; mKIAA0968; OTTHUMP00000165787; OTTHUMP00000165788; Phospho-CaMKI; PK2CDD; PKCCD; R74975
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA