product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
PSD-95 Monoclonal Antibody (7E3-1B8)
catalog :
MA1-046
quantity :
100 µL
price :
US 449.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
7E3-1B8
reactivity :
African green monkey, western clawed frog, human, mouse, rat, bovine, zebrafish , domestic rabbit, roundworm
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, chromatin immunoprecipitation, immunohistochemistry - frozen section, immunohistochemistry - free floating section, blocking or activating experiments
more info or order :
citations: 266
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; 1:50; loading ...; fig 5a
Aoto K, Kato M, Akita T, Nakashima M, Mutoh H, Akasaka N, et al. ATP6V0A1 encoding the a1-subunit of the V0 domain of vacuolar H+-ATPases is essential for brain development in humans and mice. Nat Commun. 2021;12:2107 pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig 1e
  • western blot; mouse; loading ...; fig s3c
Fukata Y, Chen X, Chiken S, Hirano Y, Yamagata A, Inahashi H, et al. LGI1-ADAM22-MAGUK configures transsynaptic nanoalignment for synaptic transmission and epilepsy prevention. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher
  • immunocytochemistry; mouse; 1:1000; loading ...; fig s3c
Iwata S, Morikawa M, Takei Y, Hirokawa N. An activity-dependent local transport regulation via degradation and synthesis of KIF17 underlying cognitive flexibility. Sci Adv. 2020;6: pubmed publisher
  • western blot; rat; 1:2000; loading ...; fig 2b
Gulyassy P, Puska G, Györffy B, Todorov Völgyi K, Juhasz G, Drahos L, et al. Proteomic comparison of different synaptosome preparation procedures. Amino Acids. 2020;52:1529-1543 pubmed publisher
  • immunohistochemistry; mouse; 1:500; loading ...; fig s18a
Suzuki K, Elegheert J, Song I, Sasakura H, Senkov O, Matsuda K, et al. A synthetic synaptic organizer protein restores glutamatergic neuronal circuits. Science. 2020;369: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 4c
Lackie R, Marques Lopes J, Ostapchenko V, Good S, Choy W, van Oosten Hawle P, et al. Increased levels of Stress-inducible phosphoprotein-1 accelerates amyloid-β deposition in a mouse model of Alzheimer's disease. Acta Neuropathol Commun. 2020;8:143 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:500; loading ...; fig 3c
Yu K, Lin C, Hatcher A, Lozzi B, Kong K, Huang Hobbs E, et al. PIK3CA variants selectively initiate brain hyperactivity during gliomagenesis. Nature. 2020;578:166-171 pubmed publisher
  • immunocytochemistry; human; loading ...; fig s1d
Patzke C, Brockmann M, Dai J, Gan K, Grauel M, Fenske P, et al. Neuromodulator Signaling Bidirectionally Controls Vesicle Numbers in Human Synapses. Cell. 2019;179:498-513.e22 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:500; loading ...; fig 2a
Andoh M, Shibata K, Okamoto K, Onodera J, Morishita K, Miura Y, et al. Exercise Reverses Behavioral and Synaptic Abnormalities after Maternal Inflammation. Cell Rep. 2019;27:2817-2825.e5 pubmed publisher
  • western blot; mouse; loading ...; fig 1a
Schaffer T, Smith J, Cook E, Phan T, Margolis S. PKCε Inhibits Neuronal Dendritic Spine Development through Dual Phosphorylation of Ephexin5. Cell Rep. 2018;25:2470-2483.e8 pubmed publisher
  • western blot; rat; fig 1a
Ahmad F, Salahuddin M, Alsamman K, Herzallah H, Al Otaibi S. Neonatal maternal deprivation impairs localized de novo activity-induced protein translation at the synapse in the rat hippocampus. Biosci Rep. 2018;38: pubmed publisher
  • western blot; rat; loading ...; fig 1b
  • immunoprecipitation; mouse; loading ...; fig 3a
  • immunocytochemistry; mouse; fig s1a
  • western blot; mouse; loading ...; fig 1a
Huang H, Lin X, Liang Z, Zhao T, Du S, Loy M, et al. Cdk5-dependent phosphorylation of liprin?1 mediates neuronal activity-dependent synapse development. Proc Natl Acad Sci U S A. 2017;114:E6992-E7001 pubmed publisher
  • immunocytochemistry; rat; 1:200; loading ...; fig 6f
Fowke T, Karunasinghe R, Bai J, Jordan S, Gunn A, Dean J. Hyaluronan synthesis by developing cortical neurons in vitro. Sci Rep. 2017;7:44135 pubmed publisher
  • immunohistochemistry; rat; 1:200; loading ...; fig 1d
Joe I, Kim J, Kim H, Hong J, Kim M, Park M. Cyclin Y-mediated transcript profiling reveals several important functional pathways regulated by Cyclin Y in hippocampal neurons. PLoS ONE. 2017;12:e0172547 pubmed publisher
  • immunoprecipitation; mouse; loading ...; fig s3
  • western blot; human; loading ...; fig s3
Xu J, Marshall J, Fernandes H, Nomura T, Copits B, Procissi D, et al. Complete Disruption of the Kainate Receptor Gene Family Results in Corticostriatal Dysfunction in Mice. Cell Rep. 2017;18:1848-1857 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:200; loading ...; fig 4a
  • western blot; mouse; 1:1000; loading ...; fig 4b
Song L, Yu A, Murray K, Cortopassi G. Bipolar cell reduction precedes retinal ganglion neuron loss in a complex 1 knockout mouse model. Brain Res. 2017;1657:232-244 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig s6c
Rue L, Bañez Coronel M, Creus Muncunill J, Giralt A, Alcalá Vida R, Mentxaka G, et al. Targeting CAG repeat RNAs reduces Huntington's disease phenotype independently of huntingtin levels. J Clin Invest. 2016;126:4319-4330 pubmed publisher
  • western blot; mouse; 1:10,000; fig 11
Walkup W, Mastro T, Schenker L, Vielmetter J, Hu R, Iancu A, et al. A model for regulation by SynGAP-?1 of binding of synaptic proteins to PDZ-domain 'Slots' in the postsynaptic density. elife. 2016;5: pubmed publisher
  • western blot; mouse; 1:4000; loading ...; fig 3a
Chen Y, Kuo H, Bornschein U, Takahashi H, Chen S, Lu K, et al. Foxp2 controls synaptic wiring of corticostriatal circuits and vocal communication by opposing Mef2c. Nat Neurosci. 2016;19:1513-1522 pubmed publisher
  • western blot; mouse; loading ...; fig 7a
Fukada M, Nakayama A, Mamiya T, Yao T, Kawaguchi Y. Dopaminergic abnormalities in Hdac6-deficient mice. Neuropharmacology. 2016;110:470-479 pubmed publisher
  • western blot; rat; 1:500; fig 1
Heintz T, Eva R, Fawcett J. Regional Regulation of Purkinje Cell Dendritic Spines by Integrins and Eph/Ephrins. PLoS ONE. 2016;11:e0158558 pubmed publisher
  • immunocytochemistry; mouse; 1:200; loading ...; fig 4a
Kumar A, Paeger L, Kosmas K, Kloppenburg P, Noegel A, Peche V. Neuronal Actin Dynamics, Spine Density and Neuronal Dendritic Complexity Are Regulated by CAP2. Front Cell Neurosci. 2016;10:180 pubmed publisher
  • western blot; mouse; 1:2000; fig 3
Choi M, Ahn S, Yang E, Kim H, Chong Y, Kim H. Hippocampus-based contextual memory alters the morphological characteristics of astrocytes in the dentate gyrus. Mol Brain. 2016;9:72 pubmed publisher
  • immunocytochemistry; rat; fig 3
  • western blot; rat; fig 3
Yokoi N, Fukata Y, Sekiya A, Murakami T, Kobayashi K, Fukata M. Identification of PSD-95 Depalmitoylating Enzymes. J Neurosci. 2016;36:6431-44 pubmed publisher
  • immunocytochemistry; mouse; 1:500; fig s2
Fujiwara K, Fujita Y, Kasai A, Onaka Y, Hashimoto H, Okada H, et al. Deletion of JMJD2B in neurons leads to defective spine maturation, hyperactive behavior and memory deficits in mouse. Transl Psychiatry. 2016;6:e766 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 1f
Ryu J, Hong B, Kim Y, Yang E, Choi M, Kim H, et al. Neuregulin-1 attenuates cognitive function impairments in a transgenic mouse model of Alzheimer's disease. Cell Death Dis. 2016;7:e2117 pubmed publisher
  • western blot; mouse; fig 4
  • western blot; human; fig 4
Ogawa F, Murphy L, Malavasi E, O Sullivan S, Torrance H, Porteous D, et al. NDE1 and GSK3? Associate with TRAK1 and Regulate Axonal Mitochondrial Motility: Identification of Cyclic AMP as a Novel Modulator of Axonal Mitochondrial Trafficking. ACS Chem Neurosci. 2016;7:553-64 pubmed publisher
  • immunoprecipitation; human; fig 5
  • western blot; human; fig 5
Wee K, Tan F, Cheong Y, Khanna S, Low C. Ontogenic Profile and Synaptic Distribution of GluN3 Proteins in the Rat Brain and Hippocampal Neurons. Neurochem Res. 2016;41:290-7 pubmed publisher
  • immunohistochemistry; mouse; 1:500; fig 8
Pak J, Lee E, CRAFT C. The retinal phenotype of Grk1-/- is compromised by a Crb1 rd8 mutation. Mol Vis. 2015;21:1281-94 pubmed
  • western blot; mouse; 1:1000
Zhang P, Fu W, Fu A, Ip N. S-nitrosylation-dependent proteasomal degradation restrains Cdk5 activity to regulate hippocampal synaptic strength. Nat Commun. 2015;6:8665 pubmed publisher
  • western blot; rat; 1:2000; fig 5
Briz V, Liu Y, Zhu G, Bi X, Baudry M. A novel form of synaptic plasticity in field CA3 of hippocampus requires GPER1 activation and BDNF release. J Cell Biol. 2015;210:1225-37 pubmed publisher
  • western blot; rat; fig 1
Cho E, Kim D, Hur Y, Whitcomb D, Regan P, Hong J, et al. Cyclin Y inhibits plasticity-induced AMPA receptor exocytosis and LTP. Sci Rep. 2015;5:12624 pubmed publisher
  • western blot; rat; 1:1000
Farley M, Swulius M, Waxham M. Electron tomographic structure and protein composition of isolated rat cerebellar, hippocampal and cortical postsynaptic densities. Neuroscience. 2015;304:286-301 pubmed publisher
  • immunocytochemistry; rat; 1:200; fig 7
Gainey M, Tatavarty V, Nahmani M, Lin H, Turrigiano G. Activity-dependent synaptic GRIP1 accumulation drives synaptic scaling up in response to action potential blockade. Proc Natl Acad Sci U S A. 2015;112:E3590-9 pubmed publisher
  • immunocytochemistry; mouse; 1:500
  • western blot; mouse; 1:500
Ferreira J, Schmidt J, Rio P, Águas R, Rooyakkers A, Li K, et al. GluN2B-Containing NMDA Receptors Regulate AMPA Receptor Traffic through Anchoring of the Synaptic Proteasome. J Neurosci. 2015;35:8462-79 pubmed publisher
  • immunohistochemistry; rat
Calafate S, Buist A, Miskiewicz K, Vijayan V, Daneels G, De Strooper B, et al. Synaptic Contacts Enhance Cell-to-Cell Tau Pathology Propagation. Cell Rep. 2015;11:1176-83 pubmed publisher
  • immunohistochemistry; mouse
Bacaj T, Ahmad M, Jurado S, Malenka R, Südhof T. Synaptic Function of Rab11Fip5: Selective Requirement for Hippocampal Long-Term Depression. J Neurosci. 2015;35:7460-74 pubmed publisher
  • western blot; human; fig 9
Russwurm C, Koesling D, Russwurm M. Phosphodiesterase 10A Is Tethered to a Synaptic Signaling Complex in Striatum. J Biol Chem. 2015;290:11936-47 pubmed publisher
  • western blot; rat; 1:2500; fig 2
Jadhav S, Katina S, Kovac A, Kazmerova Z, Novak M, Zilka N. Truncated tau deregulates synaptic markers in rat model for human tauopathy. Front Cell Neurosci. 2015;9:24 pubmed publisher
  • western blot; mouse; 1:1000
Walkup W, Washburn L, Sweredoski M, Carlisle H, Graham R, Hess S, et al. Phosphorylation of synaptic GTPase-activating protein (synGAP) by Ca2+/calmodulin-dependent protein kinase II (CaMKII) and cyclin-dependent kinase 5 (CDK5) alters the ratio of its GAP activity toward Ras and Rap GTPases. J Biol Chem. 2015;290:4908-27 pubmed publisher
  • western blot; mouse; fig 5
Fitzgerald P, Pinard C, Camp M, Feyder M, Sah A, Bergstrom H, et al. Durable fear memories require PSD-95. Mol Psychiatry. 2015;20:901-12 pubmed publisher
  • western blot; mouse; 1:500; fig 3b
Yokoi N, Fukata Y, Kase D, Miyazaki T, Jaegle M, Ohkawa T, et al. Chemical corrector treatment ameliorates increased seizure susceptibility in a mouse model of familial epilepsy. Nat Med. 2015;21:19-26 pubmed publisher
  • immunocytochemistry; rat; 2 ug/ml; fig s5
Chazeau A, Mehidi A, Nair D, Gautier J, Leduc C, Chamma I, et al. Nanoscale segregation of actin nucleation and elongation factors determines dendritic spine protrusion. EMBO J. 2014;33:2745-64 pubmed publisher
  • western blot; mouse; 1:5000
Ho T, Vessey K, Fletcher E. Immunolocalization of the P2X4 receptor on neurons and glia in the mammalian retina. Neuroscience. 2014;277:55-71 pubmed publisher
  • immunocytochemistry; human
Ohkawa T, Satake S, Yokoi N, Miyazaki Y, Ohshita T, Sobue G, et al. Identification and characterization of GABA(A) receptor autoantibodies in autoimmune encephalitis. J Neurosci. 2014;34:8151-63 pubmed publisher
  • western blot; mouse; fig 6
Lee S, Sharma M, S dhof T, Shen J. Synaptic function of nicastrin in hippocampal neurons. Proc Natl Acad Sci U S A. 2014;111:8973-8 pubmed publisher
  • immunohistochemistry; mouse; 1:500
  • western blot; mouse; 1:2000
Nikitczuk J, Patil S, Matikainen Ankney B, Scarpa J, Shapiro M, Benson D, et al. N-cadherin regulates molecular organization of excitatory and inhibitory synaptic circuits in adult hippocampus in vivo. Hippocampus. 2014;24:943-962 pubmed publisher
  • immunocytochemistry; rat; 1:4000
Andres A, Gong X, Di K, Bota D. Low-doses of cisplatin injure hippocampal synapses: a mechanism for 'chemo' brain?. Exp Neurol. 2014;255:137-44 pubmed publisher
  • western blot; mouse
Mellstrom B, Sahún I, Ruiz Nuño A, Murtra P, Gomez Villafuertes R, Savignac M, et al. DREAM controls the on/off switch of specific activity-dependent transcription pathways. Mol Cell Biol. 2014;34:877-87 pubmed publisher
  • immunocytochemistry; mouse
Dai X, Iwasaki H, Watanabe M, Okabe S. Dlx1 transcription factor regulates dendritic growth and postsynaptic differentiation through inhibition of neuropilin-2 and PAK3 expression. Eur J Neurosci. 2014;39:531-47 pubmed publisher
  • immunohistochemistry; rat
Ohkawa T, Fukata Y, Yamasaki M, Miyazaki T, Yokoi N, Takashima H, et al. Autoantibodies to epilepsy-related LGI1 in limbic encephalitis neutralize LGI1-ADAM22 interaction and reduce synaptic AMPA receptors. J Neurosci. 2013;33:18161-74 pubmed publisher
  • immunohistochemistry; rat
  • western blot; rat
Yamazaki H, Kojima N, Kato K, Hirose E, Iwasaki T, Mizui T, et al. Spikar, a novel drebrin-binding protein, regulates the formation and stabilization of dendritic spines. J Neurochem. 2014;128:507-22 pubmed publisher
  • immunocytochemistry; rat
Schwechter B, Rosenmund C, Tolias K. RasGRF2 Rac-GEF activity couples NMDA receptor calcium flux to enhanced synaptic transmission. Proc Natl Acad Sci U S A. 2013;110:14462-7 pubmed publisher
  • immunocytochemistry; rat
Nair D, Hosy E, Petersen J, Constals A, Giannone G, Choquet D, et al. Super-resolution imaging reveals that AMPA receptors inside synapses are dynamically organized in nanodomains regulated by PSD95. J Neurosci. 2013;33:13204-24 pubmed publisher
  • immunohistochemistry; mouse; 1:400
Xu D, Shen W, Guo R, Xue Y, Peng W, Sima J, et al. Top3β is an RNA topoisomerase that works with fragile X syndrome protein to promote synapse formation. Nat Neurosci. 2013;16:1238-47 pubmed publisher
  • western blot; mouse; 1:500
Kawahara A, Kurauchi S, Fukata Y, Martínez Hernández J, Yagihashi T, Itadani Y, et al. Neuronal major histocompatibility complex class I molecules are implicated in the generation of asymmetries in hippocampal circuitry. J Physiol. 2013;591:4777-91 pubmed publisher
  • immunocytochemistry; rat; fig 1
  • western blot; rat; fig 3
  • western blot; human; fig 1
  • immunohistochemistry - frozen section; mouse; fig 1
Fukata Y, Dimitrov A, Boncompain G, Vielemeyer O, Perez F, Fukata M. Local palmitoylation cycles define activity-regulated postsynaptic subdomains. J Cell Biol. 2013;202:145-61 pubmed publisher
  • immunohistochemistry; rat; 1:400
  • western blot; rat; 1:400
Aira Z, Buesa I, Garcia del Caño G, Bilbao J, Doñate F, Zimmermann M, et al. Transient, 5-HT2B receptor-mediated facilitation in neuropathic pain: Up-regulation of PKC? and engagement of the NMDA receptor in dorsal horn neurons. Pain. 2013;154:1865-77 pubmed publisher
  • immunohistochemistry; rat
  • western blot; rat
Oku S, Takahashi N, Fukata Y, Fukata M. In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes. J Biol Chem. 2013;288:19816-29 pubmed publisher
  • immunocytochemistry; rat; 1:200
Roppongi R, Kojima N, Hanamura K, Yamazaki H, Shirao T. Selective reduction of drebrin and actin in dendritic spines of hippocampal neurons by activation of 5-HT(2A) receptors. Neurosci Lett. 2013;547:76-81 pubmed publisher
  • western blot; mouse
Bosman E, Estabel J, Ismail O, Podrini C, White J, Steel K. Omi, a recessive mutation on chromosome 10, is a novel allele of Ostm1. Mamm Genome. 2013;24:44-53 pubmed publisher
  • western blot; mouse; 1:1000
Lai K, Wong A, Cheung M, Xu P, Liang Z, Lok K, et al. TrkB phosphorylation by Cdk5 is required for activity-dependent structural plasticity and spatial memory. Nat Neurosci. 2012;15:1506-15 pubmed publisher
  • immunohistochemistry; mouse
Sharma M, Burré J, Sudhof T. Proteasome inhibition alleviates SNARE-dependent neurodegeneration. Sci Transl Med. 2012;4:147ra113 pubmed publisher
  • western blot; mouse; 1:2000
Grünewald E, Tew K, Porteous D, Thomson P. Developmental expression of orphan G protein-coupled receptor 50 in the mouse brain. ACS Chem Neurosci. 2012;3:459-72 pubmed publisher
  • immunohistochemistry; mouse; 1:250
Danglot L, Freret T, Le Roux N, Narboux Nême N, Burgo A, Hyenne V, et al. Vezatin is essential for dendritic spine morphogenesis and functional synaptic maturation. J Neurosci. 2012;32:9007-22 pubmed publisher
  • immunohistochemistry; rat
Mo J, Lee D, Hong S, Han S, Yeo H, Sun W, et al. Preso regulation of dendritic outgrowth through PI(4,5)P2-dependent PDZ interaction with ?Pix. Eur J Neurosci. 2012;36:1960-70 pubmed publisher
  • immunocytochemistry; rat
Gomez Varela D, Schmidt M, Schoellerman J, Peters E, Berg D. PMCA2 via PSD-95 controls calcium signaling by ?7-containing nicotinic acetylcholine receptors on aspiny interneurons. J Neurosci. 2012;32:6894-905 pubmed publisher
  • immunocytochemistry; rat
Seebohm G, Neumann S, Theiss C, Novkovic T, Hill E, Tavare J, et al. Identification of a novel signaling pathway and its relevance for GluA1 recycling. PLoS ONE. 2012;7:e33889 pubmed publisher
  • immunohistochemistry - free floating section; rat; 1:2,000
  • immunohistochemistry; rat; 1:2000
Noam Y, Phan L, McClelland S, Manders E, Ehrengruber M, Wadman W, et al. Distinct regional and subcellular localization of the actin-binding protein filamin A in the mature rat brain. J Comp Neurol. 2012;520:3013-34 pubmed publisher
  • immunohistochemistry; mouse
Irie F, Badie Mahdavi H, Yamaguchi Y. Autism-like socio-communicative deficits and stereotypies in mice lacking heparan sulfate. Proc Natl Acad Sci U S A. 2012;109:5052-6 pubmed publisher
  • immunocytochemistry; mouse; 1:100
Mori Y, Matsui T, Furutani Y, Yoshihara Y, Fukuda M. Small GTPase Rab17 regulates dendritic morphogenesis and postsynaptic development of hippocampal neurons. J Biol Chem. 2012;287:8963-73 pubmed publisher
  • immunohistochemistry; mouse
Prasad T, Weiner J. Direct and Indirect Regulation of Spinal Cord Ia Afferent Terminal Formation by the ?-Protocadherins. Front Mol Neurosci. 2011;4:54 pubmed publisher
  • western blot; rat; 1:2000
Pichardo Casas I, Goff L, Swerdel M, Athie A, Davila J, Ramos Brossier M, et al. Expression profiling of synaptic microRNAs from the adult rat brain identifies regional differences and seizure-induced dynamic modulation. Brain Res. 2012;1436:20-33 pubmed publisher
  • immunohistochemistry; mouse; 1:2000
Cichon J, Sun C, Chen B, Jiang M, Chen X, Sun Y, et al. Cofilin aggregation blocks intracellular trafficking and induces synaptic loss in hippocampal neurons. J Biol Chem. 2012;287:3919-29 pubmed publisher
  • western blot; mouse; 1:500
Briz V, Parkash J, Sánchez Redondo S, Prevot V, Suñol C. Allopregnanolone prevents dieldrin-induced NMDA receptor internalization and neurotoxicity by preserving GABA(A) receptor function. Endocrinology. 2012;153:847-60 pubmed publisher
  • western blot; rat; 1:2000
Alder J, Kramer B, Hoskin C, Thakker Varia S. Brain-derived neurotrophic factor produced by human umbilical tissue-derived cells is required for its effect on hippocampal dendritic differentiation. Dev Neurobiol. 2012;72:755-65 pubmed publisher
  • immunohistochemistry; mouse
  • western blot; mouse
Hagihara H, Ohira K, Toyama K, Miyakawa T. Expression of the AMPA Receptor Subunits GluR1 and GluR2 is Associated with Granule Cell Maturation in the Dentate Gyrus. Front Neurosci. 2011;5:100 pubmed publisher
  • immunohistochemistry; rat
Tapia L, Milnerwood A, Guo A, Mills F, Yoshida E, Vasuta C, et al. Progranulin deficiency decreases gross neural connectivity but enhances transmission at individual synapses. J Neurosci. 2011;31:11126-32 pubmed publisher
  • immunocytochemistry; mouse; 1:500
Ko J, Soler Llavina G, Fuccillo M, Malenka R, Sudhof T. Neuroligins/LRRTMs prevent activity- and Ca2+/calmodulin-dependent synapse elimination in cultured neurons. J Cell Biol. 2011;194:323-34 pubmed publisher
  • immunocytochemistry; mouse; 1:200
Ho G, Selvakumar B, Mukai J, Hester L, Wang Y, Gogos J, et al. S-nitrosylation and S-palmitoylation reciprocally regulate synaptic targeting of PSD-95. Neuron. 2011;71:131-41 pubmed publisher
  • immunocytochemistry; rat; 1:500
Yuen E, Yan Z. Cellular mechanisms for dopamine D4 receptor-induced homeostatic regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. J Biol Chem. 2011;286:24957-65 pubmed publisher
  • immunocytochemistry; rat; 1:500
Sun Q, Turrigiano G. PSD-95 and PSD-93 play critical but distinct roles in synaptic scaling up and down. J Neurosci. 2011;31:6800-8 pubmed publisher
  • immunohistochemistry; mouse; 1:250
Billig G, Pál B, Fidzinski P, Jentsch T. Ca2+-activated Cl? currents are dispensable for olfaction. Nat Neurosci. 2011;14:763-9 pubmed publisher
  • immunocytochemistry; mouse
Bolliger M, Martinelli D, Sudhof T. The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins. Proc Natl Acad Sci U S A. 2011;108:2534-9 pubmed publisher
  • immunocytochemistry; rat; 1:200
Sweet E, Previtera M, Fernandez J, Charych E, Tseng C, Kwon M, et al. PSD-95 alters microtubule dynamics via an association with EB3. J Neurosci. 2011;31:1038-47 pubmed publisher
  • immunohistochemistry; rat; 1:250
  • western blot; rat; 1:1000
Ting A, Chen Y, Wen L, Yin D, Shen C, Tao Y, et al. Neuregulin 1 promotes excitatory synapse development and function in GABAergic interneurons. J Neurosci. 2011;31:15-25 pubmed publisher
  • immunohistochemistry; rat; 1:5000
Puller C, Haverkamp S. Cell-type-specific localization of protocadherin ?16 at AMPA and AMPA/Kainate receptor-containing synapses in the primate retina. J Comp Neurol. 2011;519:467-79 pubmed publisher
  • western blot; mouse; 1:100
  • western blot; rat; 1:100
Kato A, Gill M, Ho M, Yu H, Tu Y, Siuda E, et al. Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins. Neuron. 2010;68:1082-96 pubmed publisher
  • immunohistochemistry; rat
Aiga M, Levinson J, Bamji S. N-cadherin and neuroligins cooperate to regulate synapse formation in hippocampal cultures. J Biol Chem. 2011;286:851-8 pubmed publisher
  • immunohistochemistry; mouse; 1:500
Yang H, Yang X, Cao J, Li S, Liu Y, Suo Z, et al. cAMP-dependent protein kinase activated Fyn in spinal dorsal horn to regulate NMDA receptor function during inflammatory pain. J Neurochem. 2011;116:93-104 pubmed publisher
  • immunocytochemistry; rat
Steinmetz C, Turrigiano G. Tumor necrosis factor-? signaling maintains the ability of cortical synapses to express synaptic scaling. J Neurosci. 2010;30:14685-90 pubmed publisher
  • immunoprecipitation; rat
  • western blot; rat; 1:2000
Paille V, Picconi B, Bagetta V, Ghiglieri V, Sgobio C, Di Filippo M, et al. Distinct levels of dopamine denervation differentially alter striatal synaptic plasticity and NMDA receptor subunit composition. J Neurosci. 2010;30:14182-93 pubmed publisher
  • immunocytochemistry; rat; 1:20
  • western blot; rat; 1:1000
  • western blot; mouse
Swulius M, Kubota Y, Forest A, Waxham M. Structure and composition of the postsynaptic density during development. J Comp Neurol. 2010;518:4243-60 pubmed publisher
  • immunohistochemistry; rat; 1:20000
Poglia L, Muller D, Nikonenko I. Ultrastructural modifications of spine and synapse morphology by SAP97. Hippocampus. 2011;21:990-8 pubmed publisher
  • immunocytochemistry; human
  • western blot; human
Burré J, Sharma M, Tsetsenis T, Buchman V, Etherton M, Südhof T. Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro. Science. 2010;329:1663-7 pubmed publisher
  • immunocytochemistry; mouse; 1:500
Chang M, Park J, Pelkey K, Grabenstatter H, Xu D, Linden D, et al. Narp regulates homeostatic scaling of excitatory synapses on parvalbumin-expressing interneurons. Nat Neurosci. 2010;13:1090-7 pubmed publisher
  • immunohistochemistry; mouse; 1:1000
Chen L, Rex C, Babayan A, Kramar E, Lynch G, Gall C, et al. Physiological activation of synaptic Rac>PAK (p-21 activated kinase) signaling is defective in a mouse model of fragile X syndrome. J Neurosci. 2010;30:10977-84 pubmed publisher
  • immunocytochemistry; mouse
Hanamura K, Mizui T, Kakizaki T, Roppongi R, Yamazaki H, Yanagawa Y, et al. Low accumulation of drebrin at glutamatergic postsynaptic sites on GABAergic neurons. Neuroscience. 2010;169:1489-500 pubmed publisher
  • immunocytochemistry; mouse
  • western blot; mouse
Poore C, Sundaram J, Pareek T, Fu A, Amin N, Mohamed N, et al. Cdk5-mediated phosphorylation of delta-catenin regulates its localization and GluR2-mediated synaptic activity. J Neurosci. 2010;30:8457-67 pubmed publisher
  • immunohistochemistry; rat; 1:100
Henny P, Brischoux F, Mainville L, Stroh T, Jones B. Immunohistochemical evidence for synaptic release of glutamate from orexin terminals in the locus coeruleus. Neuroscience. 2010;169:1150-7 pubmed publisher
  • immunohistochemistry; roundworm ; 1:200
Achilleos A, Wehman A, Nance J. PAR-3 mediates the initial clustering and apical localization of junction and polarity proteins during C. elegans intestinal epithelial cell polarization. Development. 2010;137:1833-42 pubmed publisher
  • western blot; mouse
Weisenhaus M, Allen M, Yang L, Lu Y, Nichols C, Su T, et al. Mutations in AKAP5 disrupt dendritic signaling complexes and lead to electrophysiological and behavioral phenotypes in mice. PLoS ONE. 2010;5:e10325 pubmed publisher
  • immunocytochemistry; rat; 1:250
McClelland A, Hruska M, Coenen A, Henkemeyer M, Dalva M. Trans-synaptic EphB2-ephrin-B3 interaction regulates excitatory synapse density by inhibition of postsynaptic MAPK signaling. Proc Natl Acad Sci U S A. 2010;107:8830-5 pubmed publisher
  • immunocytochemistry; rat; 1:500
Mah W, Ko J, Nam J, Han K, Chung W, Kim E. Selected SALM (synaptic adhesion-like molecule) family proteins regulate synapse formation. J Neurosci. 2010;30:5559-68 pubmed publisher
  • western blot; mouse; 1:2,000
Bartoi T, Rigbolt K, Du D, Köhr G, Blagoev B, Kornau H. GABAB receptor constituents revealed by tandem affinity purification from transgenic mice. J Biol Chem. 2010;285:20625-33 pubmed publisher
  • immunocytochemistry; rat; 1:300
  • immunohistochemistry - frozen section; mouse; 1:300
Lepousez G, Csaba Z, Bernard V, Loudes C, Videau C, Lacombe J, et al. Somatostatin interneurons delineate the inner part of the external plexiform layer in the mouse main olfactory bulb. J Comp Neurol. 2010;518:1976-94 pubmed publisher
  • immunoprecipitation; rat; 1 ug/750 ul
  • western blot; rat; 1:500
Parkash J, d Anglemont de Tassigny X, Bellefontaine N, Campagne C, Mazure D, Buee Scherrer V, et al. Phosphorylation of N-methyl-D-aspartic acid receptor-associated neuronal nitric oxide synthase depends on estrogens and modulates hypothalamic nitric oxide production during the ovarian cycle. Endocrinology. 2010;151:2723-35 pubmed publisher
  • immunocytochemistry; rat; 1:200
  • immunocytochemistry; mouse; 1:200
Greer P, Hanayama R, Bloodgood B, Mardinly A, Lipton D, Flavell S, et al. The Angelman Syndrome protein Ube3A regulates synapse development by ubiquitinating arc. Cell. 2010;140:704-16 pubmed publisher
  • immunoprecipitation; mouse; 1:2000
Wu L, Mellstrom B, Wang H, Ren M, Domingo S, Kim S, et al. DREAM (downstream regulatory element antagonist modulator) contributes to synaptic depression and contextual fear memory. Mol Brain. 2010;3:3 pubmed publisher
  • immunocytochemistry; mouse; 1:200
Tian X, Kai L, Hockberger P, Wokosin D, Surmeier D. MEF-2 regulates activity-dependent spine loss in striatopallidal medium spiny neurons. Mol Cell Neurosci. 2010;44:94-108 pubmed publisher
  • immunocytochemistry; rat
Dean C, Scheiffele P. Imaging synaptogenesis by measuring accumulation of synaptic proteins. Cold Spring Harb Protoc. 2009;2009:pdb.prot5315 pubmed publisher
  • immunocytochemistry; mouse; 1:100
  • western blot; mouse; 1:2000
Pavlowsky A, Gianfelice A, Pallotto M, Zanchi A, Vara H, Khelfaoui M, et al. A postsynaptic signaling pathway that may account for the cognitive defect due to IL1RAPL1 mutation. Curr Biol. 2010;20:103-15 pubmed publisher
  • immunocytochemistry; rat
Petralia R, Wang Y, Hua F, Yi Z, Zhou A, Ge L, et al. Organization of NMDA receptors at extrasynaptic locations. Neuroscience. 2010;167:68-87 pubmed publisher
  • western blot; rat; 1:3000
Su J, Gorse K, Ramirez F, Fox M. Collagen XIX is expressed by interneurons and contributes to the formation of hippocampal synapses. J Comp Neurol. 2010;518:229-53 pubmed publisher
  • immunohistochemistry; rat; 1:200
Lui L, Levinson J, Noel G, Handrigan G, Richman J, El Husseini A, et al. Synaptic localization of neuroligin 2 in the rodent retina: comparative study with the dystroglycan-containing complex. J Neurosci Res. 2010;88:837-49 pubmed publisher
  • western blot; mouse
Kojima N, Hanamura K, Yamazaki H, Ikeda T, Itohara S, Shirao T. Genetic disruption of the alternative splicing of drebrin gene impairs context-dependent fear learning in adulthood. Neuroscience. 2010;165:138-50 pubmed publisher
  • western blot; mouse; 1:500
Lim Y, Kehm V, Li C, Trojanowski J, Lee V. Forebrain overexpression of alpha-synuclein leads to early postnatal hippocampal neuron loss and synaptic disruption. Exp Neurol. 2010;221:86-97 pubmed publisher
  • immunocytochemistry; rat; 1:200
Nguyen V, McQuillen P. AMPA and metabotropic excitoxicity explain subplate neuron vulnerability. Neurobiol Dis. 2010;37:195-207 pubmed publisher
  • western blot; human; 1:2000
Grünewald E, Kinnell H, Porteous D, Thomson P. GPR50 interacts with neuronal NOGO-A and affects neurite outgrowth. Mol Cell Neurosci. 2009;42:363-71 pubmed publisher
  • immunoprecipitation; mouse
  • western blot; mouse
Chaudhury A, He X, Goyal R. Role of PSD95 in membrane association and catalytic activity of nNOSalpha in nitrergic varicosities in mice gut. Am J Physiol Gastrointest Liver Physiol. 2009;297:G806-13 pubmed publisher
  • immunocytochemistry; rat
Zhao P, Leonoudakis D, Abood M, Beattie E. Cannabinoid receptor activation reduces TNFalpha-induced surface localization of AMPAR-type glutamate receptors and excitotoxicity. Neuropharmacology. 2010;58:551-8 pubmed publisher
  • immunocytochemistry; rat; 1:500
  • western blot; rat; 1:1,000
Siegel G, Obernosterer G, Fiore R, Oehmen M, Bicker S, Christensen M, et al. A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis. Nat Cell Biol. 2009;11:705-16 pubmed publisher
  • immunocytochemistry; rat; 1:200
  • western blot; rat; 1:100
Zhang J, Diamond J. Subunit- and pathway-specific localization of NMDA receptors and scaffolding proteins at ganglion cell synapses in rat retina. J Neurosci. 2009;29:4274-86 pubmed publisher
  • immunocytochemistry; rat
Takahashi H, Yamazaki H, Hanamura K, Sekino Y, Shirao T. Activity of the AMPA receptor regulates drebrin stabilization in dendritic spine morphogenesis. J Cell Sci. 2009;122:1211-9 pubmed publisher
  • western blot; African green monkey; 1:1000
Huang K, Sanders S, Singaraja R, Orban P, Cijsouw T, Arstikaitis P, et al. Neuronal palmitoyl acyl transferases exhibit distinct substrate specificity. FASEB J. 2009;23:2605-15 pubmed publisher
  • chromatin immunoprecipitation; rat
  • western blot; rat; 1:500
d Anglemont de Tassigny X, Campagne C, Steculorum S, Prevot V. Estradiol induces physical association of neuronal nitric oxide synthase with NMDA receptor and promotes nitric oxide formation via estrogen receptor activation in primary neuronal cultures. J Neurochem. 2009;109:214-24 pubmed publisher
  • immunoprecipitation; mouse; 1 ug/ml
  • immunocytochemistry; mouse; 1:100
  • western blot; mouse; 1:1000
Mukai J, Dhilla A, Drew L, Stark K, Cao L, Macdermott A, et al. Palmitoylation-dependent neurodevelopmental deficits in a mouse model of 22q11 microdeletion. Nat Neurosci. 2008;11:1302-10 pubmed publisher
  • immunohistochemistry; rat; 1:100
Ward M, Puthussery T, Fletcher E. Localization and possible function of P2Y(4) receptors in the rodent retina. Neuroscience. 2008;155:1262-74 pubmed publisher
  • immunohistochemistry; rat; 1:200
Kropf M, Rey G, Glauser L, Kulangara K, Johnsson K, Hirling H. Subunit-specific surface mobility of differentially labeled AMPA receptor subunits. Eur J Cell Biol. 2008;87:763-78 pubmed publisher
  • immunocytochemistry; rat; 1:50
  • western blot; rat; 1:1000
DeGiorgis J, Galbraith J, Dosemeci A, Chen X, Reese T. Distribution of the scaffolding proteins PSD-95, PSD-93, and SAP97 in isolated PSDs. Brain Cell Biol. 2006;35:239-50 pubmed publisher
  • immunohistochemistry; mouse; 1:200
Goldshmit Y, Lythgo N, Galea M, Turnley A. Treadmill training after spinal cord hemisection in mice promotes axonal sprouting and synapse formation and improves motor recovery. J Neurotrauma. 2008;25:449-65 pubmed publisher
  • immunocytochemistry; rat
Longart M, Chatani Hinze M, Gonzalez C, Vullhorst D, Buonanno A. Regulation of ErbB-4 endocytosis by neuregulin in GABAergic hippocampal interneurons. Brain Res Bull. 2007;73:210-9 pubmed
  • immunohistochemistry - free floating section; mouse
  • western blot; mouse; 1:2,000
Kobayashi C, Aoki C, Kojima N, Yamazaki H, Shirao T. Drebrin a content correlates with spine head size in the adult mouse cerebral cortex. J Comp Neurol. 2007;503:618-26 pubmed
  • immunohistochemistry; domestic rabbit; 1:50
Dmitrieva N, Strang C, Keyser K. Expression of alpha 7 nicotinic acetylcholine receptors by bipolar, amacrine, and ganglion cells of the rabbit retina. J Histochem Cytochem. 2007;55:461-76 pubmed
  • western blot; mouse
Offenhauser N, Castelletti D, Mapelli L, Soppo B, Regondi M, Rossi P, et al. Increased ethanol resistance and consumption in Eps8 knockout mice correlates with altered actin dynamics. Cell. 2006;127:213-26 pubmed
  • immunohistochemistry; zebrafish ; 1:200
Bahadori R, Biehlmaier O, Zeitz C, Labhart T, Makhankov Y, Forster U, et al. Nyctalopin is essential for synaptic transmission in the cone dominated zebrafish retina. Eur J Neurosci. 2006;24:1664-74 pubmed
  • immunohistochemistry; rat; 1:100
Puthussery T, Yee P, Vingrys A, Fletcher E. Evidence for the involvement of purinergic P2X receptors in outer retinal processing. Eur J Neurosci. 2006;24:7-19 pubmed
  • immunohistochemistry; mouse; 1:100
Johnson D, Donovan S, Dyer M. Mosaic deletion of Rb arrests rod differentiation and stimulates ectopic synaptogenesis in the mouse retina. J Comp Neurol. 2006;498:112-28 pubmed
  • immunocytochemistry; mouse; 1:100
Matsuno H, Okabe S, Mishina M, Yanagida T, Mori K, Yoshihara Y. Telencephalin slows spine maturation. J Neurosci. 2006;26:1776-86 pubmed
  • immunohistochemistry - frozen section; mouse; 1:500
  • immunocytochemistry; mouse; 1:500
Lee E, Mann L, Rickman D, Lim E, Chun M, Grzywacz N. AII amacrine cells in the distal inner nuclear layer of the mouse retina. J Comp Neurol. 2006;494:651-62 pubmed
  • immunocytochemistry; rat; 1:100
Gu Z, Jiang Q, Yuen E, Yan Z. Activation of dopamine D4 receptors induces synaptic translocation of Ca2+/calmodulin-dependent protein kinase II in cultured prefrontal cortical neurons. Mol Pharmacol. 2006;69:813-22 pubmed
  • blocking or activating experiments; rat
Dosemeci A, Tao Cheng J, Vinade L, Jaffe H. Preparation of postsynaptic density fraction from hippocampal slices and proteomic analysis. Biochem Biophys Res Commun. 2006;339:687-94 pubmed
  • immunohistochemistry; rat; 1:250
Huang Z, Zang K, Reichardt L. The origin recognition core complex regulates dendrite and spine development in postmitotic neurons. J Cell Biol. 2005;170:527-35 pubmed
  • western blot; rat; 1:3000
Chen S, Bawa D, Besshoh S, Gurd J, Brown I. Association of heat shock proteins and neuronal membrane components with lipid rafts from the rat brain. J Neurosci Res. 2005;81:522-9 pubmed
  • immunohistochemistry; bovine; 1:500
Claudepierre T, Manglapus M, Marengi N, Radner S, Champliaud M, Tasanen K, et al. Collagen XVII and BPAG1 expression in the retina: evidence for an anchoring complex in the central nervous system. J Comp Neurol. 2005;487:190-203 pubmed
  • western blot; rat
Besshoh S, Bawa D, Teves L, Wallace M, Gurd J. Increased phosphorylation and redistribution of NMDA receptors between synaptic lipid rafts and post-synaptic densities following transient global ischemia in the rat brain. J Neurochem. 2005;93:186-94 pubmed
  • immunohistochemistry; mouse
Amparan D, Avram D, Thomas C, Lindahl M, Yang J, Bajaj G, et al. Direct interaction of myosin regulatory light chain with the NMDA receptor. J Neurochem. 2005;92:349-61 pubmed
  • immunohistochemistry; rat
Neuhoff H, Sassoè Pognetto M, Panzanelli P, Maas C, Witke W, Kneussel M. The actin-binding protein profilin I is localized at synaptic sites in an activity-regulated manner. Eur J Neurosci. 2005;21:15-25 pubmed
Wakatsuki S, Ohno M, Araki T. Human vault RNA1-1, but not vault RNA2-1, modulates synaptogenesis. Commun Integr Biol. 2021;14:61-65 pubmed publisher
Jin C, Kang H, Yoo T, Ryu J, Yoo Y, Ma R, et al. The Neomycin Resistance Cassette in the Targeted Allele of Shank3B Knock-Out Mice Has Potential Off-Target Effects to Produce an Unusual Shank3 Isoform. Front Mol Neurosci. 2020;13:614435 pubmed publisher
Huang Y, Huang J, Zhou Q, Yang C, Yang C, Mei W, et al. ZFP804A mutant mice display sex-dependent schizophrenia-like behaviors. Mol Psychiatry. 2020;: pubmed publisher
Hassani Nia F, Woike D, Martens V, Klüssendorf M, Honck H, Harder S, et al. Targeting of δ-catenin to postsynaptic sites through interaction with the Shank3 N-terminus. Mol Autism. 2020;11:85 pubmed publisher
Sieveritz B, Arbuthnott G. Prelimbic cortical targets of ventromedial thalamic projections include inhibitory interneurons and corticostriatal pyramidal neurons in the rat. Brain Struct Funct. 2020;: pubmed publisher
Vevea J, Chapman E. Acute disruption of the synaptic vesicle membrane protein synaptotagmin 1 using knockoff in mouse hippocampal neurons. elife. 2020;9: pubmed publisher
Venkatesan S, Subramaniam S, Rajeev P, Chopra Y, Jose M, Nair D. Differential Scaling of Synaptic Molecules within Functional Zones of an Excitatory Synapse during Homeostatic Plasticity. Eneuro. 2020;7: pubmed publisher
Weinert S, Gimber N, Deuschel D, Stuhlmann T, Puchkov D, Farsi Z, et al. Uncoupling endosomal CLC chloride/proton exchange causes severe neurodegeneration. EMBO J. 2020;39:e103358 pubmed publisher
Lomeli N, Di K, Pearre D, Chung T, Bota D. Mitochondrial-associated impairments of temozolomide on neural stem/progenitor cells and hippocampal neurons. Mitochondrion. 2020;52:56-66 pubmed publisher
Alsabban A, Morikawa M, Tanaka Y, Takei Y, Hirokawa N. Kinesin Kif3b mutation reduces NMDAR subunit NR2A trafficking and causes schizophrenia-like phenotypes in mice. EMBO J. 2020;39:e101090 pubmed publisher
Tanaka H, Sakaguchi D, Hirano T. Amyloid-β oligomers suppress subunit-specific glutamate receptor increase during LTP. Alzheimers Dement (N Y). 2019;5:797-808 pubmed publisher
Norrie J, Lupo M, Xu B, Al Diri I, Valentine M, Putnam D, et al. Nucleome Dynamics during Retinal Development. Neuron. 2019;104:512-528.e11 pubmed publisher
Holz A, Mülsch F, Schwarz M, Hollmann M, Dobrossy M, Coenen V, et al. Enhanced mGlu5 Signaling in Excitatory Neurons Promotes Rapid Antidepressant Effects via AMPA Receptor Activation. Neuron. 2019;104:338-352.e7 pubmed publisher
Subramanian J, Michel K, Benoit M, Nedivi E. CPG15/Neuritin Mimics Experience in Selecting Excitatory Synapses for Stabilization by Facilitating PSD95 Recruitment. Cell Rep. 2019;28:1584-1595.e5 pubmed publisher
Marro S, Chanda S, Yang N, Janas J, Valperga G, Trotter J, et al. Neuroligin-4 Regulates Excitatory Synaptic Transmission in Human Neurons. Neuron. 2019;: pubmed publisher
Verschuuren M, Verstraelen P, Garcia Díaz Barriga G, Cilissen I, Coninx E, Verslegers M, et al. High-throughput microscopy exposes a pharmacological window in which dual leucine zipper kinase inhibition preserves neuronal network connectivity. Acta Neuropathol Commun. 2019;7:6 pubmed publisher
Zhang W, Chuang Y, Na Y, Ye Z, Yang L, Lin R, et al. Arc Oligomerization Is Regulated by CaMKII Phosphorylation of the GAG Domain: An Essential Mechanism for Plasticity and Memory Formation. Mol Cell. 2019;: pubmed publisher
Paul A, Nawalpuri B, Shah D, Sateesh S, Muddashetty R, Clement J. Differential Regulation of Syngap1 Translation by FMRP Modulates eEF2 Mediated Response on NMDAR Activity. Front Mol Neurosci. 2019;12:97 pubmed publisher
Rivell A, Petralia R, Wang Y, Clawson E, Moehl K, Mattson M, et al. Sonic hedgehog expression in the postnatal brain. Biol Open. 2019;: pubmed publisher
Zamzow D, Elias V, Acosta V, Escobedo E, Magnusson K. Higher Levels of Protein Palmitoylation in the Frontal Cortex across Aging Were Associated with Reference Memory and Executive Function Declines. Eneuro. 2019;6: pubmed publisher
Milesi C, Alberici P, Pozzi B, Oldani A, Beznoussenko G, Raimondi A, et al. Redundant and nonredundant organismal functions of EPS15 and EPS15L1. Life Sci Alliance. 2019;2: pubmed publisher
Furumai R, Tamada K, Liu X, Takumi T. UBE3A regulates the transcription of IRF, an antiviral immunity. Hum Mol Genet. 2019;28:1947-1958 pubmed publisher
Spence E, Dube S, Uezu A, Locke M, Soderblom E, Soderling S. In vivo proximity proteomics of nascent synapses reveals a novel regulator of cytoskeleton-mediated synaptic maturation. Nat Commun. 2019;10:386 pubmed publisher
Shu L, Chen B, Chen B, Xu H, Wang G, Huang Y, et al. Brain ischemic insult induces cofilin rod formation leading to synaptic dysfunction in neurons. J Cereb Blood Flow Metab. 2019;39:2181-2195 pubmed publisher
Ahmad F, Salahuddin M, Alsamman K, AlMulla A, Salama K. Developmental lead (Pb)-induced deficits in hippocampal protein translation at the synapses are ameliorated by ascorbate supplementation. Neuropsychiatr Dis Treat. 2018;14:3289-3298 pubmed publisher
Kang S, Ha S, Park H, Nam E, Suh W, Suh Y, et al. Effects of a Dehydroevodiamine-Derivative on Synaptic Destabilization and Memory Impairment in the 5xFAD, Alzheimer's Disease Mouse Model. Front Behav Neurosci. 2018;12:273 pubmed publisher
Zhang H, Zhang C, Vincent J, Zala D, Benstaali C, Sainlos M, et al. Modulation of AMPA receptor surface diffusion restores hippocampal plasticity and memory in Huntington's disease models. Nat Commun. 2018;9:4272 pubmed publisher
Omotade O, Rui Y, Lei W, Yu K, Hartzell H, Fowler V, et al. Tropomodulin Isoform-Specific Regulation of Dendrite Development and Synapse Formation. J Neurosci. 2018;38:10271-10285 pubmed publisher
Condomitti G, Wierda K, Schroeder A, Rubio S, Vennekens K, Orlandi C, et al. An Input-Specific Orphan Receptor GPR158-HSPG Interaction Organizes Hippocampal Mossy Fiber-CA3 Synapses. Neuron. 2018;100:201-215.e9 pubmed publisher
Letellier M, Szíber Z, Chamma I, Saphy C, Papasideri I, Tessier B, et al. A unique intracellular tyrosine in neuroligin-1 regulates AMPA receptor recruitment during synapse differentiation and potentiation. Nat Commun. 2018;9:3979 pubmed publisher
Tu Y, Duman J, Tolias K. The Adhesion-GPCR BAI1 Promotes Excitatory Synaptogenesis by Coordinating Bidirectional Trans-synaptic Signaling. J Neurosci. 2018;38:8388-8406 pubmed publisher
Truckenbrodt S, Maidorn M, Crzan D, Wildhagen H, Kabatas S, Rizzoli S. X10 expansion microscopy enables 25-nm resolution on conventional microscopes. EMBO Rep. 2018;19: pubmed publisher
Schroeder A, Vanderlinden J, Vints K, Ribeiro L, Vennekens K, Gounko N, et al. A Modular Organization of LRR Protein-Mediated Synaptic Adhesion Defines Synapse Identity. Neuron. 2018;99:329-344.e7 pubmed publisher
Papadimitriou C, Celikkaya H, Cosacak M, Mashkaryan V, Bray L, Bhattarai P, et al. 3D Culture Method for Alzheimer's Disease Modeling Reveals Interleukin-4 Rescues A?42-Induced Loss of Human Neural Stem Cell Plasticity. Dev Cell. 2018;46:85-101.e8 pubmed publisher
Koga K, Shimoyama S, Yamada A, Furukawa T, Nikaido Y, Furue H, et al. Chronic inflammatory pain induced GABAergic synaptic plasticity in the adult mouse anterior cingulate cortex. Mol Pain. 2018;14:1744806918783478 pubmed publisher
Kerov V, Laird J, Joiner M, Knecht S, Soh D, Hagen J, et al. α2δ-4 Is Required for the Molecular and Structural Organization of Rod and Cone Photoreceptor Synapses. J Neurosci. 2018;38:6145-6160 pubmed publisher
Yamagata M, Duan X, Sanes J. Cadherins Interact With Synaptic Organizers to Promote Synaptic Differentiation. Front Mol Neurosci. 2018;11:142 pubmed publisher
Paradis Isler N, Boehm J. NMDA receptor-dependent dephosphorylation of serine 387 in Argonaute 2 increases its degradation and affects dendritic spine density and maturation. J Biol Chem. 2018;293:9311-9325 pubmed publisher
Klok M, Bugiani M, de Vries S, Gerritsen W, Breur M, van der Sluis S, et al. Axonal abnormalities in vanishing white matter. Ann Clin Transl Neurol. 2018;5:429-444 pubmed publisher
Choi T, Lee S, Kim Y, Bae J, Lee K, Jo Y, et al. Cereblon Maintains Synaptic and Cognitive Function by Regulating BK Channel. J Neurosci. 2018;38:3571-3583 pubmed publisher
Ing Esteves S, Kostadinov D, Marocha J, Sing A, Joseph K, Laboulaye M, et al. Combinatorial Effects of Alpha- and Gamma-Protocadherins on Neuronal Survival and Dendritic Self-Avoidance. J Neurosci. 2018;38:2713-2729 pubmed publisher
Liu J, Sanes J. Cellular and Molecular Analysis of Dendritic Morphogenesis in a Retinal Cell Type That Senses Color Contrast and Ventral Motion. J Neurosci. 2017;37:12247-12262 pubmed publisher
Aloisi E, Le Corf K, Dupuis J, Zhang P, Ginger M, Labrousse V, et al. Altered surface mGluR5 dynamics provoke synaptic NMDAR dysfunction and cognitive defects in Fmr1 knockout mice. Nat Commun. 2017;8:1103 pubmed publisher
Abrahamsson T, Chou C, Li S, Mancino A, Costa R, Brock J, et al. Differential Regulation of Evoked and Spontaneous Release by Presynaptic NMDA Receptors. Neuron. 2017;96:839-855.e5 pubmed publisher
Kozuka T, Chaya T, Tamalu F, Shimada M, Fujimaki Aoba K, Kuwahara R, et al. The TRPM1 Channel Is Required for Development of the Rod ON Bipolar Cell-AII Amacrine Cell Pathway in the Retinal Circuit. J Neurosci. 2017;37:9889-9900 pubmed publisher
Lee Y, Kang H, Lee B, Zhang Y, Kim Y, Kim S, et al. Integrative Analysis of Brain Region-specific Shank3 Interactomes for Understanding the Heterogeneity of Neuronal Pathophysiology Related to SHANK3 Mutations. Front Mol Neurosci. 2017;10:110 pubmed publisher
Xiao M, Xu D, Craig M, Pelkey K, Chien C, Shi Y, et al. NPTX2 and cognitive dysfunction in Alzheimer's Disease. elife. 2017;6: pubmed publisher
Vullhorst D, Ahmad T, Karavanova I, Keating C, Buonanno A. Structural Similarities between Neuregulin 1-3 Isoforms Determine Their Subcellular Distribution and Signaling Mode in Central Neurons. J Neurosci. 2017;37:5232-5249 pubmed publisher
Giers B, Klein D, Mendes Madeira A, Isiegas C, Lorenz B, Haverkamp S, et al. Outer Plexiform Layer Structures Are Not Altered Following AAV-Mediated Gene Transfer in Healthy Rat Retina. Front Neurol. 2017;8:59 pubmed publisher
Brooks S, Dykes A, Schreurs B. A High-Cholesterol Diet Increases 27-Hydroxycholesterol and Modifies Estrogen Receptor Expression and Neurodegeneration in Rabbit Hippocampus. J Alzheimers Dis. 2017;56:185-196 pubmed publisher
Lin Y, Wang H, Huang D, Hsieh P, Lin M, Chou C, et al. Neuronal Splicing Regulator RBFOX3 (NeuN) Regulates Adult Hippocampal Neurogenesis and Synaptogenesis. PLoS ONE. 2016;11:e0164164 pubmed publisher
Uezu A, Kanak D, Bradshaw T, Soderblom E, Catavero C, Burette A, et al. Identification of an elaborate complex mediating postsynaptic inhibition. Science. 2016;353:1123-9 pubmed publisher
Muona M, Fukata Y, Anttonen A, Laari A, Palotie A, Pihko H, et al. Dysfunctional ADAM22 implicated in progressive encephalopathy with cortical atrophy and epilepsy. Neurol Genet. 2016;2:e46 pubmed publisher
Nakazawa T, Hashimoto R, Sakoori K, Sugaya Y, Tanimura A, Hashimotodani Y, et al. Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders. Nat Commun. 2016;7:10594 pubmed publisher
Takei Y, Kikkawa Y, Atapour N, Hensch T, Hirokawa N. Defects in Synaptic Plasticity, Reduced NMDA-Receptor Transport, and Instability of Postsynaptic Density Proteins in Mice Lacking Microtubule-Associated Protein 1A. J Neurosci. 2015;35:15539-54 pubmed publisher
Hruska M, Henderson N, Xia N, Le Marchand S, Dalva M. Anchoring and synaptic stability of PSD-95 is driven by ephrin-B3. Nat Neurosci. 2015;18:1594-605 pubmed publisher
Lovero K, Fukata Y, Granger A, Fukata M, Nicoll R. The LGI1-ADAM22 protein complex directs synapse maturation through regulation of PSD-95 function. Proc Natl Acad Sci U S A. 2015;112:E4129-37 pubmed publisher
Maze I, Wenderski W, Noh K, Bagot R, Tzavaras N, Purushothaman I, et al. Critical Role of Histone Turnover in Neuronal Transcription and Plasticity. Neuron. 2015;87:77-94 pubmed publisher
Song C, Feodorova Y, Guy J, Peichl L, Jost K, Kimura H, et al. DNA methylation reader MECP2: cell type- and differentiation stage-specific protein distribution. Epigenetics Chromatin. 2014;7:17 pubmed publisher
Samuel M, Voinescu P, Lilley B, de Cabo R, Foretz M, Viollet B, et al. LKB1 and AMPK regulate synaptic remodeling in old age. Nat Neurosci. 2014;17:1190-7 pubmed publisher
Liu X, Heidelberger R, Janz R. Phosphorylation of syntaxin 3B by CaMKII regulates the formation of t-SNARE complexes. Mol Cell Neurosci. 2014;60:53-62 pubmed publisher
Zheng Z, Keifer J. Sequential delivery of synaptic GluA1- and GluA4-containing AMPA receptors (AMPARs) by SAP97 anchored protein complexes in classical conditioning. J Biol Chem. 2014;289:10540-50 pubmed publisher
Mitchell N, Petralia R, Currier D, Wang Y, Kim A, Mattson M, et al. Sonic hedgehog regulates presynaptic terminal size, ultrastructure and function in hippocampal neurons. J Cell Sci. 2012;125:4207-13 pubmed publisher
Vessey K, Fletcher E. Rod and cone pathway signalling is altered in the P2X7 receptor knock out mouse. PLoS ONE. 2012;7:e29990 pubmed publisher
Sharma M, Burré J, Bronk P, Zhang Y, Xu W, Sudhof T. CSP? knockout causes neurodegeneration by impairing SNAP-25 function. EMBO J. 2012;31:829-41 pubmed publisher
Saba R, Störchel P, Aksoy Aksel A, Kepura F, Lippi G, Plant T, et al. Dopamine-regulated microRNA MiR-181a controls GluA2 surface expression in hippocampal neurons. Mol Cell Biol. 2012;32:619-32 pubmed publisher
Sun Y, Bamji S. ?-Pix modulates actin-mediated recruitment of synaptic vesicles to synapses. J Neurosci. 2011;31:17123-33 pubmed publisher
Shavit E, Michaelson D, Chapman J. Anatomical localization of protease-activated receptor-1 and protease-mediated neuroglial crosstalk on peri-synaptic astrocytic endfeet. J Neurochem. 2011;119:460-73 pubmed publisher
Pitt J, Roth W, Lacor P, Smith A, Blankenship M, Velasco P, et al. Alzheimer's-associated Abeta oligomers show altered structure, immunoreactivity and synaptotoxicity with low doses of oleocanthal. Toxicol Appl Pharmacol. 2009;240:189-97 pubmed publisher
Puller C, de Sevilla Müller L, Janssen Bienhold U, Haverkamp S. ZO-1 and the spatial organization of gap junctions and glutamate receptors in the outer plexiform layer of the mammalian retina. J Neurosci. 2009;29:6266-75 pubmed publisher
Luikart B, Zhang W, Wayman G, Kwon C, Westbrook G, Parada L. Neurotrophin-dependent dendritic filopodial motility: a convergence on PI3K signaling. J Neurosci. 2008;28:7006-12 pubmed publisher
Chen X, Winters C, Azzam R, Li X, Galbraith J, Leapman R, et al. Organization of the core structure of the postsynaptic density. Proc Natl Acad Sci U S A. 2008;105:4453-8 pubmed publisher
Dosemeci A, Makusky A, Jankowska Stephens E, Yang X, Slotta D, Markey S. Composition of the synaptic PSD-95 complex. Mol Cell Proteomics. 2007;6:1749-60 pubmed
Kato A, Zhou W, Milstein A, Knierman M, Siuda E, Dotzlaf J, et al. New transmembrane AMPA receptor regulatory protein isoform, gamma-7, differentially regulates AMPA receptors. J Neurosci. 2007;27:4969-77 pubmed
Kuriu T, Inoue A, Bito H, Sobue K, Okabe S. Differential control of postsynaptic density scaffolds via actin-dependent and -independent mechanisms. J Neurosci. 2006;26:7693-706 pubmed
Bamji S, Rico B, Kimes N, Reichardt L. BDNF mobilizes synaptic vesicles and enhances synapse formation by disrupting cadherin-beta-catenin interactions. J Cell Biol. 2006;174:289-99 pubmed
Lise M, Wong T, Trinh A, Hines R, Liu L, Kang R, et al. Involvement of myosin Vb in glutamate receptor trafficking. J Biol Chem. 2006;281:3669-78 pubmed
Chen X, Vinade L, Leapman R, Petersen J, Nakagawa T, Phillips T, et al. Mass of the postsynaptic density and enumeration of three key molecules. Proc Natl Acad Sci U S A. 2005;102:11551-6 pubmed
Fukata Y, Tzingounis A, Trinidad J, Fukata M, Burlingame A, Nicoll R, et al. Molecular constituents of neuronal AMPA receptors. J Cell Biol. 2005;169:399-404 pubmed
Nam C, Chen L. Postsynaptic assembly induced by neurexin-neuroligin interaction and neurotransmitter. Proc Natl Acad Sci U S A. 2005;102:6137-42 pubmed
Levinson J, Chery N, Huang K, Wong T, Gerrow K, Kang R, et al. Neuroligins mediate excitatory and inhibitory synapse formation: involvement of PSD-95 and neurexin-1beta in neuroligin-induced synaptic specificity. J Biol Chem. 2005;280:17312-9 pubmed
Vazquez L, Chen H, Sokolova I, Knuesel I, Kennedy M. SynGAP regulates spine formation. J Neurosci. 2004;24:8862-72 pubmed
Prange O, Wong T, Gerrow K, Wang Y, El Husseini A. A balance between excitatory and inhibitory synapses is controlled by PSD-95 and neuroligin. Proc Natl Acad Sci U S A. 2004;101:13915-20 pubmed
Fleisig H, El Din El Husseini A, Vincent S. Regulation of ErbB4 phosphorylation and cleavage by a novel histidine acid phosphatase. Neuroscience. 2004;127:91-100 pubmed
Govek E, Newey S, Akerman C, Cross J, Van der Veken L, Van Aelst L. The X-linked mental retardation protein oligophrenin-1 is required for dendritic spine morphogenesis. Nat Neurosci. 2004;7:364-72 pubmed
Bresler T, Shapira M, Boeckers T, Dresbach T, Futter M, Garner C, et al. Postsynaptic density assembly is fundamentally different from presynaptic active zone assembly. J Neurosci. 2004;24:1507-20 pubmed
Parker M, Zhao S, Bredt D, Sanes J, Feng G. PSD93 regulates synaptic stability at neuronal cholinergic synapses. J Neurosci. 2004;24:378-88 pubmed
Petersen J, Chen X, Vinade L, Dosemeci A, Lisman J, Reese T. Distribution of postsynaptic density (PSD)-95 and Ca2+/calmodulin-dependent protein kinase II at the PSD. J Neurosci. 2003;23:11270-8 pubmed
Colledge M, Snyder E, Crozier R, Soderling J, Jin Y, Langeberg L, et al. Ubiquitination regulates PSD-95 degradation and AMPA receptor surface expression. Neuron. 2003;40:595-607 pubmed
Stohr H, Stojic J, Weber B. Cellular localization of the MPP4 protein in the mammalian retina. Invest Ophthalmol Vis Sci. 2003;44:5067-74 pubmed
Bamji S, Shimazu K, Kimes N, Huelsken J, Birchmeier W, Lu B, et al. Role of beta-catenin in synaptic vesicle localization and presynaptic assembly. Neuron. 2003;40:719-31 pubmed
Vinade L, Chang M, Schlief M, Petersen J, Reese T, Tao Cheng J, et al. Affinity purification of PSD-95-containing postsynaptic complexes. J Neurochem. 2003;87:1255-61 pubmed
Todd P, Mack K, Malter J. The fragile X mental retardation protein is required for type-I metabotropic glutamate receptor-dependent translation of PSD-95. Proc Natl Acad Sci U S A. 2003;100:14374-8 pubmed
Takahashi H, Sekino Y, Tanaka S, Mizui T, Kishi S, Shirao T. Drebrin-dependent actin clustering in dendritic filopodia governs synaptic targeting of postsynaptic density-95 and dendritic spine morphogenesis. J Neurosci. 2003;23:6586-95 pubmed
Christopherson K, Sweeney N, Craven S, Kang R, El Husseini A, Bredt D. Lipid- and protein-mediated multimerization of PSD-95: implications for receptor clustering and assembly of synaptic protein networks. J Cell Sci. 2003;116:3213-9 pubmed
Larsson M, Hjälm G, Sakwe A, Engström Å, Höglund A, Larsson E, et al. Selective interaction of megalin with postsynaptic density-95 (PSD-95)-like membrane-associated guanylate kinase (MAGUK) proteins. Biochem J. 2003;373:381-91 pubmed
Wang X, Weiner J, Levi S, Craig A, Bradley A, Sanes J. Gamma protocadherins are required for survival of spinal interneurons. Neuron. 2002;36:843-54 pubmed
Elgersma Y, Fedorov N, Ikonen S, Choi E, Elgersma M, Carvalho O, et al. Inhibitory autophosphorylation of CaMKII controls PSD association, plasticity, and learning. Neuron. 2002;36:493-505 pubmed
Klocker N, Bunn R, Schnell E, Caruana G, Bernstein A, Nicoll R, et al. Synaptic glutamate receptor clustering in mice lacking the SH3 and GK domains of SAP97. Eur J Neurosci. 2002;16:1517-22 pubmed
Gomez L, Alam S, Smith K, Horne E, Dell Acqua M. Regulation of A-kinase anchoring protein 79/150-cAMP-dependent protein kinase postsynaptic targeting by NMDA receptor activation of calcineurin and remodeling of dendritic actin. J Neurosci. 2002;22:7027-44 pubmed
Chetkovich D, Bunn R, Kuo S, Kawasaki Y, Kohwi M, Bredt D. Postsynaptic targeting of alternative postsynaptic density-95 isoforms by distinct mechanisms. J Neurosci. 2002;22:6415-25 pubmed
Weber B, Schrewe H, Molday L, Gehrig A, White K, Seeliger M, et al. Inactivation of the murine X-linked juvenile retinoschisis gene, Rs1h, suggests a role of retinoschisin in retinal cell layer organization and synaptic structure. Proc Natl Acad Sci U S A. 2002;99:6222-7 pubmed
Imamura F, Maeda S, Doi T, Fujiyoshi Y. Ligand binding of the second PDZ domain regulates clustering of PSD-95 with the Kv1.4 potassium channel. J Biol Chem. 2002;277:3640-6 pubmed
Russwurm M, Wittau N, Koesling D. Guanylyl cyclase/PSD-95 interaction: targeting of the nitric oxide-sensitive alpha2beta1 guanylyl cyclase to synaptic membranes. J Biol Chem. 2001;276:44647-52 pubmed
Sans N, Racca C, Petralia R, Wang Y, McCallum J, Wenthold R. Synapse-associated protein 97 selectively associates with a subset of AMPA receptors early in their biosynthetic pathway. J Neurosci. 2001;21:7506-16 pubmed
Tao Cheng J, Vinade L, Smith C, Winters C, Ward R, Brightman M, et al. Sustained elevation of calcium induces Ca(2+)/calmodulin-dependent protein kinase II clusters in hippocampal neurons. Neuroscience. 2001;106:69-78 pubmed
Dosemeci A, Tao Cheng J, Vinade L, Winters C, Pozzo Miller L, Reese T. Glutamate-induced transient modification of the postsynaptic density. Proc Natl Acad Sci U S A. 2001;98:10428-32 pubmed
Stockklausner C, Ludwig J, Ruppersberg J, Klocker N. A sequence motif responsible for ER export and surface expression of Kir2.0 inward rectifier K(+) channels. FEBS Lett. 2001;493:129-33 pubmed
Chen L, Chetkovich D, Petralia R, Sweeney N, Kawasaki Y, Wenthold R, et al. Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms. Nature. 2000;408:936-43 pubmed
Honjo Y, Nakagawa S, Takeichi M. Blockade of cadherin-6B activity perturbs the distribution of PSD-95 family proteins in retinal neurones. Genes Cells. 2000;5:309-18 pubmed
Dosemeci A, Reese T, Petersen J, Tao Cheng J. A novel particulate form of Ca(2+)/calmodulin-dependent [correction of Ca(2+)/CaMKII-dependent] protein kinase II in neurons. J Neurosci. 2000;20:3076-84 pubmed
Garcia R, Vasudevan K, Buonanno A. The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses. Proc Natl Acad Sci U S A. 2000;97:3596-601 pubmed
Christopherson K, Hillier B, Lim W, Bredt D. PSD-95 assembles a ternary complex with the N-methyl-D-aspartic acid receptor and a bivalent neuronal NO synthase PDZ domain. J Biol Chem. 1999;274:27467-73 pubmed
McGee A, Bredt D. Identification of an intramolecular interaction between the SH3 and guanylate kinase domains of PSD-95. J Biol Chem. 1999;274:17431-6 pubmed
Furuyashiki T, Fujisawa K, Fujita A, Madaule P, Uchino S, Mishina M, et al. Citron, a Rho-target, interacts with PSD-95/SAP-90 at glutamatergic synapses in the thalamus. J Neurosci. 1999;19:109-18 pubmed
Zhang W, Vazquez L, Apperson M, Kennedy M. Citron binds to PSD-95 at glutamatergic synapses on inhibitory neurons in the hippocampus. J Neurosci. 1999;19:96-108 pubmed
Koulen P, Fletcher E, Craven S, Bredt D, Wassle H. Immunocytochemical localization of the postsynaptic density protein PSD-95 in the mammalian retina. J Neurosci. 1998;18:10136-49 pubmed
Kornau H, Schenker L, Kennedy M, Seeburg P. Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95. Science. 1995;269:1737-40 pubmed
image
image 1 :
Invitrogen MA1-046 image 1
Immunofluorescent analysis of PSD95 using Anti-PSD95 Monoclonal Antibody (7E3-1B8) (Product# MA1-046) shows staining in C6 Cells. PSD95 staining (green), F-Actin staining with Phalloidin (red) and nuclei with DAPI (blue) is shown. Cells were grown on chamber slides and fixed with formaldehyde prior to staining. Cells were probed without (control) or with or an antibody recognizing PSD95 (Product# MA1-046) at a dilution of 1:20 over night at 4 ?C, washed with PBS and incubated with a DyLight-488 conjugated secondary antibody (Product# 35503, Goat Anti-Mouse). Images were taken at 60X magnification.
product information
Product Type :
Antibody
Product Name :
PSD-95 Monoclonal Antibody (7E3-1B8)
Catalog # :
MA1-046
Quantity :
100 µL
Price :
US 449.00
Clonality :
Monoclonal
Purity :
protein A
Host :
Mouse
Reactivity :
Human, Mouse, Rat, Xenopus laevis
Applications :
Flow Cytometry: 2 µg/test, Immunocytochemistry: 1:500, Immunohistochemistry (Frozen): Assay-dependent, Immunoprecipitation: Assay-dependent, Western Blot: 1:2,000
Species :
Human, Mouse, Rat, Xenopus laevis
Clone :
7E3-1B8
Isotype :
IgG1, kappa
Storage :
-20° C, Avoid Freeze/Thaw Cycles
Description :
Post Synaptic Density 95 kDa (PSD-95), also known as synapse associated protein 90 kDa (SAP90), is one of a family of membrane-associated proteins found in the postsynaptic density in forebrain neurons and certain presynaptic structures in the cerebellum. Like other members of the family, PSD-95 has three 90 amino acid repeats called PDZ domains followed by an SH3 domain and a yeast guanylate kinase homology (GuK) domain. PSD-95 is believed to participate in the clustering of certain proteins, including NMDA receptors, Shaker-type potassium channels at the synaptic membrane in central nervous system (CNS) neurons. There are two principal modes of interaction between PSD-95 and other proteins. NMDA receptors and shaker-type potassium channels both share C-terminal sequence homology consisting of a threonine/serine-X-valine-COOH (T/SXV) motif. Other neuronal proteins that share this motif (beta 1 adrenergic receptor, some serotonin receptors, some sodium channel subunits, and additional potassium channel subunits), and some of these proteins may interact with PSD-95 by binding to its PDZ domains. Neuronal nitric oxide synthase (nNOS), which lacks the T/SXV motif but which has its own PDZ domain, has been shown to associate with PSD-95 in vitro through a pseudo-homotypic PDZ-PDZ interaction.
Immunogen :
Purified recombinant rat PSD-95.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 2 µg/test, Immunocytochemistry: 1:500, Immunohistochemistry (Frozen): Assay-dependent, Immunoprecipitation: Assay-dependent, Western Blot: 1:2,000
Aliases :
discs large homolog 4; discs large MAGUK scaffold protein 4; discs, large homolog 4; discs, large homolog 4 (Drosophila); disks large homolog 4; Dlg4; Dlgh4; FLJ97752; FLJ98574; post synaptic density; postsynaptic density protein 95; post-synaptic density protein 95; PSD95; PSD-95; PSD-95 alpha 2b; PSD-95 beta; Sap90; SAP-90; SAP90A; Synapse-associated protein 90; synapse-associated protein SAP90; Tax interaction protein 15
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA