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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
GATA3 Monoclonal Antibody (1A12-1D9)
catalog :
MA1-028
quantity :
100 ug
price :
US 502.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
1A12-1D9
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, western blot knockout validation
more info or order :
Invitrogen product webpage
citations: 14
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; human; 1:2000; loading ...; fig s1d
  • immunoprecipitation; human; loading ...; fig s4b, s5d
Geng X, Wang C, Gao X, Chowdhury P, Weiss J, Villegas J, et al. GATA-3 is a proto-oncogene in T-cell lymphoproliferative neoplasms. Blood Cancer J. 2022;12:149 pubmed publisher
  • immunocytochemistry; human; 1:100; fig 1
Deglincerti A, Croft G, Pietila L, Zernicka Goetz M, Siggia E, Brivanlou A. Self-organization of the in vitro attached human embryo. Nature. 2016;533:251-4 pubmed publisher
Hosseinzadeh L, Kikhtyak Z, Laven Law G, Pederson S, Puiu C, D Santos C, et al. The androgen receptor interacts with GATA3 to transcriptionally regulate a luminal epithelial cell phenotype in breast cancer. Genome Biol. 2024;25:44 pubmed publisher
Cermakova K, Tao L, Dejmek M, Sála M, Montierth M, Chan Y, et al. Reactivation of the G1 enhancer landscape underlies core circuitry addiction to SWI/SNF. Nucleic Acids Res. 2024;52:4-21 pubmed publisher
Lilao Garz xf3 n J, Brito Casillas Y, Quesada Canales Ó, W xe4 gner A, Mu xf1 oz Descalzo S. Maternal age, obesity and hyperglycaemia are associated with a delay in preimplantation embryo development in mouse. Reproduction. 2023;166:235-245 pubmed publisher
Kalim K, Yang J, Wunderlich M, Modur V, Nguyen P, Li Y, et al. Targeting of Cdc42 GTPase in regulatory T cells unleashes antitumor T-cell immunity. J Immunother Cancer. 2022;10: pubmed publisher
Zheng Y, Yan R, Sun S, Kobayashi M, Xiang L, Yang R, et al. Single-cell analysis of embryoids reveals lineage diversification roadmaps of early human development. Cell Stem Cell. 2022;29:1402-1419.e8 pubmed publisher
Ai Z, Xiang X, Xiang Y, Szczerbinska I, Qian Y, Xu X, et al. Krüppel-like factor 5 rewires NANOG regulatory network to activate human naive pluripotency specific LTR7Ys and promote naive pluripotency. Cell Rep. 2022;40:111240 pubmed publisher
Zhu M, Shahbazi M, Martin A, Zhang C, Sozen B, Borsos M, et al. Human embryo polarization requires PLC signaling to mediate trophectoderm specification. elife. 2021;10: pubmed publisher
Yanagida A, Spindlow D, Nichols J, Dattani A, Smith A, Guo G. Naive stem cell blastocyst model captures human embryo lineage segregation. Cell Stem Cell. 2021;28:1016-1022.e4 pubmed publisher
Rashid R, Gaglia G, Chen Y, Lin J, Du Z, Maliga Z, et al. Highly multiplexed immunofluorescence images and single-cell data of immune markers in tonsil and lung cancer. Sci Data. 2019;6:323 pubmed publisher
Kang Y, Ai Z, Duan K, Si C, Wang Y, Zheng Y, et al. Improving Cell Survival in Injected Embryos Allows Primed Pluripotent Stem Cells to Generate Chimeric Cynomolgus Monkeys. Cell Rep. 2018;25:2563-2576.e9 pubmed publisher
Victor A, Griffin D, Brake A, Tyndall J, Murphy A, Lepkowsky L, et al. Assessment of aneuploidy concordance between clinical trophectoderm biopsy and blastocyst. Hum Reprod. 2019;34:181-192 pubmed publisher
Durbin A, Zimmerman M, Dharia N, Abraham B, Iniguez A, Weichert Leahey N, et al. Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry. Nat Genet. 2018;50:1240-1246 pubmed publisher
product information
Product Type :
Antibody
Product Name :
GATA3 Monoclonal Antibody (1A12-1D9)
Catalog # :
MA1-028
Quantity :
100 ug
Price :
US 502.00
Clonality :
Monoclonal
Purity :
protein A
Host :
Mouse
Reactivity :
Human, Mouse, Rat
Applications :
ChIP Assay: 2.5 ug/10^6 cells, Immunocytochemistry: 1:50-1:100, Immunohistochemistry (Paraffin): 1:200-1:2,000, Immunoprecipitation: 5 ug, Western Blot: 1:1,000
Species :
Human, Mouse, Rat
Clone :
1A12-1D9
Isotype :
IgG1
Storage :
-20 C
Description :
The genes for all 4 subunits of the T-cell antigen receptor (alpha, beta, gamma and delta) are controlled by distinct enhancers and their enhancer-binding proteins. Marine and Winoto (1991) identified a common TCR regulatory element by demonstrating binding of the enhancer-binding protein GATA3 to the enhancer elements of all 4 TCR genes. GATA3 had been shown in the chicken to be an enhancer-binding protein containing a zinc finger domain. GATA3 mRNA was demonstrated by Northern blot analysis in T cells but not in B cells or macrophages. GATA3 is abundantly expressed in the T-lymphocyte lineage and is thought to participate in T-cell receptor gene activation through binding to enhancers. Labastie et al. (1994) cloned the human gene and the 5-prime end of the mouse gene. The human gene comprises 6 exons distributed over 17 kb of DNA. Its 2 zinc fingers are encoded by 2 separate exons highly conserved with those of GATA1, but no other structural homologies between the 2 genes could be found.
Immunogen :
Purified partial recombinant human GATA3 protein expressed in E. coli.
Format :
Liquid
Applications w/Dilutions :
ChIP Assay: 2.5 ug/10^6 cells, Immunocytochemistry: 1:50-1:100, Immunohistochemistry (Paraffin): 1:200-1:2,000, Immunoprecipitation: 5 ug, Western Blot: 1:1,000
Aliases :
EGK_19445; GATA binding factor-3; GATA binding protein 3; GATA binding protein-3; GATA3; Gata-3; GATA-binding factor 3; GATA-binding protein 3; HDR; HDRS; jal; MGC2346; MGC5199; MGC5445; Trans-acting T-cell-specific transcription factor GATA-3; Transacting T-cell-specific transcription factor GATA-3
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA