product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
SOX2 Monoclonal Antibody (20G5)
catalog :
MA1-014
quantity :
100 ug
price :
US 414.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
20G5
reactivity :
human, mouse, dogs
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 35
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - paraffin section; human; 1:600; loading ...; fig 2c
Audesse A, Karashchuk G, Gardell Z, Lakis N, Maybury Lewis S, Brown A, et al. FOXO3 regulates a common genomic program in aging and glioblastoma stem cells. Aging Cancer. 2021;2:137-159 pubmed publisher
  • immunocytochemistry; human; 1:200; loading ...; fig 1b
Modafferi S, Zhong X, Kleensang A, Murata Y, Fagiani F, Pamies D, et al. Gene-Environment Interactions in Developmental Neurotoxicity: a Case Study of Synergy between Chlorpyrifos and CHD8 Knockout in Human BrainSpheres. Environ Health Perspect. 2021;129:77001 pubmed publisher
  • immunohistochemistry; human; 1:50; fig 4
Gerashchenko B, Salmina K, Eglitis J, Huna A, Grjunberga V, Erenpreisa J. Disentangling the aneuploidy and senescence paradoxes: a study of triploid breast cancers non-responsive to neoadjuvant therapy. Histochem Cell Biol. 2016;145:497-508 pubmed publisher
  • western blot; human; 1:1000; fig s2
Vijaya Chandra S, Makhija H, Peter S, Myint Wai C, Li J, Zhu J, et al. Conservative site-specific and single-copy transgenesis in human LINE-1 elements. Nucleic Acids Res. 2016;44:e55 pubmed publisher
  • western blot; human; fig 3a
Huna A, Salmina K, Erenpreisa J, Vazquez Martin A, Krigerts J, Inashkina I, et al. Role of stress-activated OCT4A in the cell fate decisions of embryonal carcinoma cells treated with etoposide. Cell Cycle. 2015;14:2969-84 pubmed publisher
Marelli E, Hughes J, Scotting P. SUMO-dependent transcriptional repression by Sox2 inhibits the proliferation of neural stem cells. PLoS ONE. 2024;19:e0298818 pubmed publisher
Mukherjee S, Chakraborty S, Basak U, Pati S, Dutta A, Dutta S, et al. Breast cancer stem cells generate immune-suppressive T regulatory cells by secreting TGFβ to evade immune-elimination. Discov Oncol. 2023;14:220 pubmed publisher
Suresh V, Muralidharan B, Pradhan S, Bose M, D Souza L, Parichha A, et al. Regulation of chromatin accessibility and gene expression in the developing hippocampal primordium by LIM-HD transcription factor LHX2. PLoS Genet. 2023;19:e1010874 pubmed publisher
Steffens Reinhardt L, Groen K, Zhang X, Morten B, Wawruszak A, Avery Kiejda K. p53 isoform expression promotes a stemness phenotype and inhibits doxorubicin sensitivity in breast cancer. Cell Death Dis. 2023;14:509 pubmed publisher
Shin K, Ali G, Ali Moussa H, Gupta V, de la Fuente A, Kim H, et al. Deletion of TRPC6, an Autism Risk Gene, Induces Hyperexcitability in Cortical Neurons Derived from Human Pluripotent Stem Cells. Mol Neurobiol. 2023;60:7297-7308 pubmed publisher
Zayat V, Kuczynska Z, Liput M, Metin E, Rzonca Niewczas S, Smyk M, et al. The Generation of Human iPSC Lines from Three Individuals with Dravet Syndrome and Characterization of Neural Differentiation Markers in iPSC-Derived Ventral Forebrain Organoid Model. Cells. 2023;12: pubmed publisher
Lakis N, Brodsky A, Karashchuk G, Audesse A, Yang D, Sturtevant A, et al. Stem cell phenotype predicts therapeutic response in glioblastomas with MGMT promoter methylation. Acta Neuropathol Commun. 2022;10:159 pubmed publisher
Parichha A, Datta D, Suresh V, Chatterjee M, Holtzman M, Tole S. Dentate gyrus morphogenesis is regulated by β-catenin function in hem-derived fimbrial glia. Development. 2022;149: pubmed publisher
Warrier N, Krishnan R, Prabhu V, Hariharapura R, Agarwal P, Kumar P. Survivin Inhibition by Piperine Sensitizes Glioblastoma Cancer Stem Cells and Leads to Better Drug Response. Int J Mol Sci. 2022;23: pubmed publisher
Ord xf3 xf1 ez Le xf3 n E, Mart xed nez Rodero I, Garc xed a Mart xed nez T, L xf3 pez B xe9 jar M, Yeste M, Mercade E, et al. Exopolysaccharide ID1 Improves Post-Warming Outcomes after Vitrification of In Vitro-Produced Bovine Embryos. Int J Mol Sci. 2022;23: pubmed publisher
Garc xed a Mart xed nez T, Mart xed nez Rodero I, Roncero Carol J, Y xe1 nez Ortiz I, Higgins A, Mogas T. Impact of equilibration duration combined with temperature on the outcome of bovine oocyte vitrification. Theriogenology. 2022;184:110-123 pubmed publisher
Soleas J, Huang L, D Arcangelo E, Nostro M, Waddell T, McGuigan A, et al. Guided Self-Assembly of ES-Derived Lung Progenitors into Biomimetic Tube Structures That Impact Cell Differentiation. Bioengineering (Basel). 2021;8: pubmed publisher
Mei C, Xin L, Liu Y, Lin J, Xian H, Zhang X, et al. Establishment of a New Cell Line of Canine Mammary Tumor CMT-1026. Front Vet Sci. 2021;8:744032 pubmed publisher
Kimura K, Koizumi T, Urasawa T, Ohta Y, Takakura D, Kawasaki N. Glycoproteomic analysis of the changes in protein N-glycosylation during neuronal differentiation in human-induced pluripotent stem cells and derived neuronal cells. Sci Rep. 2021;11:11169 pubmed publisher
Brighi C, Salaris F, Soloperto A, Cordella F, Ghirga S, de Turris V, et al. Novel fragile X syndrome 2D and 3D brain models based on human isogenic FMRP-KO iPSCs. Cell Death Dis. 2021;12:498 pubmed publisher
Zhao W, Dovas A, Spinazzi E, Levitin H, Banu M, Upadhyayula P, et al. Deconvolution of cell type-specific drug responses in human tumor tissue with single-cell RNA-seq. Genome Med. 2021;13:82 pubmed publisher
Bassi G, Panseri S, Dozio S, Sandri M, Campodoni E, Dapporto M, et al. Scaffold-based 3D cellular models mimicking the heterogeneity of osteosarcoma stem cell niche. Sci Rep. 2020;10:22294 pubmed publisher
Zhang L, Jing H, Li H, Chen W, Luo B, Zhang H, et al. Neddylation is critical to cortical development by regulating Wnt/β-catenin signaling. Proc Natl Acad Sci U S A. 2020;117:26448-26459 pubmed publisher
Aramini B, Masciale V, Manfredini B, Bianchi D, Banchelli F, D Amico R, et al. Expression of ALDH and SOX-2 in Pulmonary Sclerosing Pnemocytoma (PSP) of the Lung: Is There a Meaning Behind?. Front Med (Lausanne). 2020;7:497 pubmed publisher
Leibel S, McVicar R, Winquist A, Niles W, Snyder E. Generation of Complete Multi-Cell Type Lung Organoids From Human Embryonic and Patient-Specific Induced Pluripotent Stem Cells for Infectious Disease Modeling and Therapeutics Validation. Curr Protoc Stem Cell Biol. 2020;54:e118 pubmed publisher
Masciale V, Grisendi G, Banchelli F, D Amico R, Maiorana A, Sighinolfi P, et al. Cancer Stem-Like Cells in a Case of an Inflammatory Myofibroblastic Tumor of the Lung. Front Oncol. 2020;10:673 pubmed publisher
Kozlowski M, Rudolf M, Corwin J. EGF and a GSK3 Inhibitor Deplete Junctional E-cadherin and Stimulate Proliferation in the Mature Mammalian Ear. J Neurosci. 2020;40:2618-2632 pubmed publisher
Masciale V, Grisendi G, Banchelli F, D Amico R, Maiorana A, Morandi U, et al. Cancer stem-neuroendocrine cells in an atypical carcinoid case report. Transl Lung Cancer Res. 2019;8:1157-1162 pubmed publisher
Matrone G, Thandavarayan R, Walther B, Meng S, Mojiri A, Cooke J. Dysfunction of iPSC-derived endothelial cells in human Hutchinson-Gilford progeria syndrome. Cell Cycle. 2019;18:2495-2508 pubmed publisher
Rusu P, Shao C, Neuerburg A, Acikgöz A, Wu Y, Zou P, et al. GPD1 Specifically Marks Dormant Glioma Stem Cells with a Distinct Metabolic Profile. Cell Stem Cell. 2019;25:241-257.e8 pubmed publisher
Ren L, Deng B, Saloura V, Park J, Nakamura Y. MELK inhibition targets cancer stem cells through downregulation of SOX2 expression in head and neck cancer cells. Oncol Rep. 2019;41:2540-2548 pubmed publisher
Li H, Saucedo Cuevas L, Yuan L, Ross D, Johansen A, Sands D, et al. Zika Virus Protease Cleavage of Host Protein Septin-2 Mediates Mitotic Defects in Neural Progenitors. Neuron. 2019;101:1089-1098.e4 pubmed publisher
Tandon R, Brändl B, Baryshnikova N, Landshammer A, Steenpaß L, Keminer O, et al. Generation of two human isogenic iPSC lines from fetal dermal fibroblasts. Stem Cell Res. 2018;33:120-124 pubmed publisher
El Battrawy I, Lan H, Cyganek L, Zhao Z, Li X, Buljubasic F, et al. Modeling Short QT Syndrome Using Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes. J Am Heart Assoc. 2018;7: pubmed publisher
Li D, Takeda N, Jain R, Manderfield L, Liu F, Li L, et al. Hopx distinguishes hippocampal from lateral ventricle neural stem cells. Stem Cell Res. 2015;15:522-529 pubmed publisher
product information
Product Type :
Antibody
Product Name :
SOX2 Monoclonal Antibody (20G5)
Catalog # :
MA1-014
Quantity :
100 ug
Price :
US 414.00
Clonality :
Monoclonal
Purity :
protein A
Host :
Mouse
Reactivity :
Canine, Fish, Human, Mouse
Applications :
ChIP Assay: 1-3 uL, Flow Cytometry: 1:100, Immunocytochemistry: 1:200, Immunohistochemistry (Frozen): Assay-dependent, Immunohistochemistry (Paraffin): 1:20-1:200, Immunoprecipitation: 5 ug, Western Blot: 1:1,000-1:2,000
Species :
Canine, Fish, Human, Mouse
Clone :
20G5
Isotype :
IgG1, kappa
Storage :
-20 C
Description :
SOX2 is an intronless gene encoding a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of the SOX2 gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. The SOX2 gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). Further, SOX2 protein may act as a transcriptional activator after forming a protein complex with other proteins. Mutations in the SOX2 gene have been associated with bilateral anophthalmia, a severe form of structural eye malformation, optic nerve hypoplasia and syndromic microphthalmia.
Immunogen :
Full-length human recombinant protein expressed in bacteria
Format :
Liquid
Applications w/Dilutions :
ChIP Assay: 1-3 uL, Flow Cytometry: 1:100, Immunocytochemistry: 1:200, Immunohistochemistry (Frozen): Assay-dependent, Immunohistochemistry (Paraffin): 1:20-1:200, Immunoprecipitation: 5 ug, Western Blot: 1:1,000-1:2,000
Aliases :
ANOP3; cb236; Delta EF2a; lcc; MCOPS3; MCOPS3 (Microphthalmia Syndromic type 3); RGD1565646; sex determining region Y-box 2; SOX 2; SOX2; Sox-2; soxp; SRY (sex determining region Y) box 2; SRY (sex determining region Y)-box 2; SRY box 2; SRY related HMG box 2; SRY-box 2; SRY-box 2; SOX2; SRY-box containing gene 2; SRY-box transcription factor 2; SRY-related HMG-box gene 2; transcription factor SOX2; transcription factor SOX-2; wu:fb83g04; wu:fc14d07; ysb; zgc:65860; zgc:77389
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA