Pan Ras Monoclonal Antibody (Ras10) | Invitrogen MA1-012 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Pan Ras Monoclonal Antibody (Ras10)

catalog :

MA1-012

quantity :

100 µg

price :

US 452

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

RAS10

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry

more info or order :

Invitrogen product webpage

citations: 16

Published Application/Species/Sample/Dilution	Reference
western blot; human; loading ...; fig 4b	Strazza M, Azoulay Alfaguter I, Peled M, Smrcka A, Skolnik E, Srivastava S, et al. PLCÎµ1 regulates SDF-1Î±-induced lymphocyte adhesion and migration to sites of inflammation. Proc Natl Acad Sci U S A. 2017;114:2693-2698 pubmed publisher
western blot; human; loading ...; fig 1c	Lau H, Tang J, Casey P, Wang M. Isoprenylcysteine carboxylmethyltransferase is critical for malignant transformation and tumor maintenance by all RAS isoforms. Oncogene. 2017;36:3934-3942 pubmed publisher
western blot; human; loading ...; fig 4c	Zhao B, Hu W, Kumar S, Gonyo P, Rana U, Liu Z, et al. The Nogo-B receptor promotes Ras plasma membrane localization and activation. Oncogene. 2017;36:3406-3416 pubmed publisher
western blot; human; loading ...; fig 4a	Raffeiner P, Schraffl A, Schwarz T, RÃ¶ck R, Ledolter K, Hartl M, et al. Calcium-dependent binding of Myc to calmodulin. Oncotarget. 2017;8:3327-3343 pubmed publisher
western blot; human; 1:5000; loading ...; fig 4g	Mitra S, Ghosh B, Gayen N, Roy J, Mandal A. Bipartite Role of Heat Shock Protein 90 (Hsp90) Keeps CRAF Kinase Poised for Activation. J Biol Chem. 2016;291:24579-24593 pubmed
western blot; mouse; fig 3c	Riecken L, Tawamie H, Dornblut C, Buchert R, Ismayel A, Schulz A, et al. Inhibition of RAS activation due to a homozygous ezrin variant in patients with profound intellectual disability. Hum Mutat. 2015;36:270-8 pubmed publisher
western blot; human; fig 1	Lau H, Ramanujulu P, Guo D, Yang T, Wirawan M, Casey P, et al. An improved isoprenylcysteine carboxylmethyltransferase inhibitor induces cancer cell death and attenuates tumor growth in vivo. Cancer Biol Ther. 2014;15:1280-91 pubmed publisher
	Lau H, Tang J, Casey P, Wang M. Evaluating the Epithelial-Mesenchymal Program in Human Breast Epithelial Cells Cultured in Soft Agar Using a Novel Macromolecule Extraction Protocol. Cancers (Basel). 2021;13: pubmed publisher
	Liotti F, Kumar N, Prevete N, Marotta M, Sorriento D, Ierano C, et al. PD-1 blockade delays tumor growth by inhibiting an intrinsic SHP2/Ras/MAPK signalling in thyroid cancer cells. J Exp Clin Cancer Res. 2021;40:22 pubmed publisher
	Jilek J, Tu M, Zhang C, Yu A. Pharmacokinetic and Pharmacodynamic Factors Contribute to Synergism between Let-7c-5p and 5-Fluorouracil in Inhibiting Hepatocellular Carcinoma Cell Viability. Drug Metab Dispos. 2020;48:1257-1263 pubmed publisher
	Beckwitt C, Shiraha K, Wells A. Lipophilic statins limit cancer cell growth and survival, via involvement of Akt signaling. PLoS ONE. 2018;13:e0197422 pubmed publisher
	Umstead M, Xiong J, Qi Q, Du Y, Fu H. Aurora kinase A interacts with H-Ras and potentiates Ras-MAPK signaling. Oncotarget. 2017;8:28359-28372 pubmed publisher
	Shi Q, Li C, Li K, Liu Q. Pallidin protein in neurodevelopment and its relation to the pathogenesis of schizophrenia. Mol Med Rep. 2017;15:665-672 pubmed publisher
	Shi D, Shi G, Xie J, Du X, Yang H. MicroRNA-27a Inhibits Cell Migration and Invasion of Fibroblast-Like Synoviocytes by Targeting Follistatin-Like Protein 1 in Rheumatoid Arthritis. Mol Cells. 2016;39:611-8 pubmed publisher
	Figueras A, Arbos M, Quiles M, Vinals F, Germà J, Capella G. The impact of KRAS mutations on VEGF-A production and tumour vascular network. BMC Cancer. 2013;13:125 pubmed publisher
	Hamer P, Trimpe K, Pullano T, Ng S, LaVecchio J, Petit D, et al. Production and characterization of anti-RAS p21 monoclonal antibodies. Hybridoma. 1990;9:573-87 pubmed

product information

Product Type :

Antibody

Product Name :

Pan Ras Monoclonal Antibody (Ras10)

Catalog # :

MA1-012

Quantity :

100 µg

Pricing :

US 452

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human, Mouse, Non-human primate

Applications :

Flow Cytometry: Assay-dependent, Immunocytochemistry: 1:50-1:200, Immunohistochemistry: 1:100-1:500, Immunoprecipitation: 2 µg, Western Blot: 1:1,000

Species :

Human, Mouse, Non-human primate

Clone :

Ras10

Isotype :

IgG2a

Storage :

-20° C, Avoid Freeze/Thaw Cycles

Description :

This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene.

Immunogen :

Purified recombinant Ras protein

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: Assay-dependent, Immunocytochemistry: 1:50-1:200, Immunohistochemistry: 1:100-1:500, Immunoprecipitation: 2 µg, Western Blot: 1:1,000

Aliases :

AI929937; ALPS4; AV095280; C-BAS/HAS; cellular c-Ki-ras2; cellular c-Ki-ras2 proto-oncogene; CFC2; c-Ha-ras; c-Ha-ras p21 protein; c-Ha-ras transgene; C-HA-RAS1; c-has/bas p21 protein; C-H-RAS; c-Ki-ras; c-Kirsten-ras protein; c-Kirsten-ras proto-oncogene; c-K-ras; c-K-ras2 protein; CMNS; c-rasHa; c-ras-Ki-2 activated oncogene; CTLO; etID18709.8; fa04e08; fc14b12; fc23g10; fj89d12; fj99a10; GTP- and GDP-binding peptide B; GTPase HRas; GTPase HRas, N-terminally processed; GTPase Hras1; GTPase KRas; GTPase KRas, N-terminally processed; GTPase NRas; HAMSV; Ha-ras; Ha-Ras1 proto-oncoprotein; Harvey ras1 protein; Harvey rat sarcoma viral (v-Ha-ras) oncogene homolog; Harvey rat sarcoma viral oncogene homolog; Harvey rat sarcoma viral oncoprotein; Harvey rat sarcoma virus oncogene; Harvey rat sarcoma virus oncogene 1; Harvey-ras; hras; H-ras; H-ras 1 protein; HRas proto-oncogene, GTPase; HRas proto-oncogene, GTPase a; HRAS1; H-Ras-1; Hras-1; hrasa; H-RASIDX; hypothetical protein LOC445289; hypothetical protein LOC550286; K RAS; Ki-ras; Kirsten rat sarcoma oncogene 2, expressed; Kirsten rat sarcoma viral oncogene; Kirsten rat sarcoma viral oncogene homolog; Kirsten rat sarcoma viral oncogene homologue 2 (active); Kras; K-ras; K-Ras 2; K-ras p21 protein; KRAS proto-oncogene, GTPase; KRAS1; KRAS2; Kras-2; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; NCMS; Neuroblastoma RAS; neuroblastoma ras oncogene; neuroblastoma RAS viral (v-ras) oncogene homolog; neuroblastoma RAS viral oncogene homolog; NRAS; N-ras; N-ras oncogene p21; N-ras protein part 4; NRAS proto-oncogene, GTPase; NRAS1; NS; NS3; NS6; oncogene KRAS2; p19 H-RasIDX protein; p21; p21 N-ras oncogene; p21 protein; p21B; p21ras; PR310 c-K-ras oncogene; RALD; ras; Ras family small GTP binding protein H-Ras; RASH1; RASK; RASK2; ras-like protein; RASN; sb:eu826; transformation gene: oncogene HAMSV; transforming protein N-Ras; Transforming protein p21; v-Ha-ras Harvey rat sarcoma viral oncogene homolog; v-Ha-ras Harvey rat sarcoma viral oncogene homolog a; v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog; v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; v-ras neuroblastoma RAS viral oncogene homolog; wu:fa04e08; wu:fc14b12; wu:fc23g10; wu:fj89d12; wu:fj99a10; xRAS1; xRAS2; zgc:100761; zgc:110250; zgc:85725; zras-b1

more info or order :

Invitrogen product webpage