TRAP1 Monoclonal Antibody (TRAP1-6) | Invitrogen MA1-010 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TRAP1 Monoclonal Antibody (TRAP1-6)

catalog :

MA1-010

quantity :

100 ug

price :

US 451.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

Trap1-6

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 6

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:1000	Grogan P, Sleder K, Samadi A, Zhang H, Timmermann B, Cohen M. Cytotoxicity of withaferin A in glioblastomas involves induction of an oxidative stress-mediated heat shock response while altering Akt/mTOR and MAPK signaling pathways. Invest New Drugs. 2013;31:545-57 pubmed publisher
western blot; mouse; 1:1000	Samadi A, Zhang X, Mukerji R, Donnelly A, Blagg B, Cohen M. A novel C-terminal HSP90 inhibitor KU135 induces apoptosis and cell cycle arrest in melanoma cells. Cancer Lett. 2011;312:158-67 pubmed publisher
	K xf6 ritzer J, Blenn C, B xfc rkle A, Beneke S. Mitochondria are devoid of poly(ADP-ribose)polymerase-1, but harbor its product oligo(ADP-ribose). J Cell Biochem. 2021;122:507-523 pubmed publisher
	Masuda Y, Shima G, Aiuchi T, Horie M, Hori K, Nakajo S, et al. Involvement of tumor necrosis factor receptor-associated protein 1 (TRAP1) in apoptosis induced by beta-hydroxyisovalerylshikonin. J Biol Chem. 2004;279:42503-15 pubmed
	Johnson B, Chadli A, Felts S, Bouhouche I, Catelli M, Toft D. Hsp90 chaperone activity requires the full-length protein and interaction among its multiple domains. J Biol Chem. 2000;275:32499-507 pubmed
	Felts S, Owen B, Nguyen P, Trepel J, Donner D, Toft D. The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties. J Biol Chem. 2000;275:3305-12 pubmed

product information

Product Type :

Antibody

Product Name :

TRAP1 Monoclonal Antibody (TRAP1-6)

Catalog # :

MA1-010

Quantity :

100 ug

Price :

US 451.00

Clonality :

Monoclonal

Purity :

purified

Host :

Mouse

Reactivity :

Human

Applications :

Immunocytochemistry: 1:250, Immunohistochemistry (Frozen): 1:20, Immunohistochemistry (Paraffin): 1:10-1:100, Immunoprecipitation: Assay-dependent, Western Blot: 1:2,000

Species :

Human

Clone :

TRAP1-6

Isotype :

IgG2a, kappa

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

The 90 kDa heat shock protein (hsp90) family of molecular chaperones is a highly conserved family of proteins that play an important physiological role. Hsp90 is involved in numerous cellular processes but is best known for its association with signal transduction machinery. A recently cloned homolog of hsp90 is the tumor necrosis factor receptor-associated protein (TRAP1). Like hsp90, TRAP1 is found to be associated with numerous proteins involved in diverse actions. Immunofluorescence data has shown TRAP1 to be localized in the mitochondria of mammalian cells. This observation and the fact that TRAP1 is shown to have a mitochondrial targeting presequence strongly implicates TRAP1 as a mitochondrial matrix protein.

Immunogen :

Purified recombinant TRAP1.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:250, Immunohistochemistry (Frozen): 1:20, Immunohistochemistry (Paraffin): 1:10-1:100, Immunoprecipitation: Assay-dependent, Western Blot: 1:2,000

Aliases :

2410002K23Rik; heat shock protein 75 kDa, mitochondrial; HSP 75; HSP75; HSP90L; testicular tissue protein Li 209; TNF receptor associated protein 1; TNF receptor-associated protein 1; TNFR-associated protein 1; TRAP1; TRAP-1; tumor necrosis factor type 1 receptor associated protein; tumor necrosis factor type 1 receptor-associated protein

more info or order :

Invitrogen product webpage