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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD2 Monoclonal Antibody (TS2/18)
catalog :
MA0200
quantity :
200 µg
price :
US 466
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
TS2/18
reactivity :
human
application :
western blot, immunoprecipitation, flow cytometry, blocking or activating experiments
more info or order :
citations: 7
Published Application/Species/Sample/DilutionReference
  • blocking or activating experiments; human
Peiser M, Becht A, Wanner R. Antibody blocking of MHC II on human activated regulatory T cells abrogates their suppressive potential. Allergy. 2007;62:773-80 pubmed
  • blocking or activating experiments; human
Zhu D, Dustin M, Cairo C, Thatte H, Golan D. Mechanisms of Cellular Avidity Regulation in CD2-CD58-Mediated T Cell Adhesion. ACS Chem Biol. 2006;1:649-58 pubmed
Wang P, Malkovsky M. Different roles of the CD2 and LFA-1 T-cell co-receptors for regulating cytotoxic, proliferative, and cytokine responses of human V gamma 9/V delta 2 T cells. Mol Med. 2000;6:196-207 pubmed
Branco L, Barren P, Mao S, Pfarr D, Kaplan R, Postema C, et al. Selective deletion of antigen-specific, activated T cells by a humanized MAB to CD2 (MEDI-507) is mediated by NK cells. Transplantation. 1999;68:1588-96 pubmed
Lamphear J, Stevens K, Rich R. Intercellular adhesion molecule-1 and leukocyte function-associated antigen-3 provide costimulation for superantigen-induced T lymphocyte proliferation in the absence of a specific presenting molecule. J Immunol. 1998;160:615-23 pubmed
Zell T, Hunt S, Mobley J, Finkelstein L, Shimizu Y. CD28-mediated up-regulation of beta 1-integrin adhesion involves phosphatidylinositol 3-kinase. J Immunol. 1996;156:883-6 pubmed
Selvaraj P, Plunkett M, Dustin M, Sanders M, Shaw S, Springer T. The T lymphocyte glycoprotein CD2 binds the cell surface ligand LFA-3. Nature. 1987;326:400-3 pubmed
product information
Product Type :
Antibody
Product Name :
CD2 Monoclonal Antibody (TS2/18)
Catalog # :
MA0200
Quantity :
200 µg
Price :
US 466
Clonality :
Monoclonal
Purity :
protein A
Host :
Mouse
Reactivity :
Human
Applications :
Flow Cytometry: 3-5 µg/1x10^6 cells, Immunoprecipitation: Assay-dependent, Inhibition Assays: 0.5 µg/test, Western Blot: 0.5-2 µg/mL
Species :
Human
Clone :
TS2/18
Isotype :
IgG1
Storage :
-20°C
Description :
CD2 (LFA-2) is a monomeric surface antigen (MW range 45-58 kDa) of the human T-lymphocyte lineage that is expressed on all peripheral blood T cells. CD2 is one of the earliest T-cell markers, being present on more than 95% of thymocytes and it is also found on some natural killer cells, but not on B lymphocytes. Monoclonal antibodies directed against CD2 inhibit the formation of rosettes with sheep erythrocytes, indicating that CD2 is the erythrocyte receptor or is closely associated with it. The interaction between CD2 and CD58 stabilizes adhesion between T cells and antigen presenting or target cells. Relatively low affinity of CD2 to CD58 (as measured in solution) is compensated within the two-dimensional cell-cell interface to provide tight adhesion. Moreover, T cell activation induces increased CD2 expression and its lateral mobility, making easier contact between CD2 and CD58. Subsequently, T cell activation causes fixation of CD58-CD2 at sites of cell-cell contact, thereby strengthening intercellular adhesion. CD2 deficiency reduces intestinal inflammation and helps to control infection. Diseases associated with CD2 dysfunction include penis squamous cell carcinoma and immune deficiency due to the absence of the thymus.
Immunogen :
Human LFA-2 (CD2)
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 3-5 µg/1x10^6 cells, Immunoprecipitation: Assay-dependent, Inhibition Assays: 0.5 µg/test, Western Blot: 0.5-2 µg/mL
Aliases :
Cd2; CD2 antigen; CD2 antigen (p50), sheep red blood cell receptor; CD2 molecule; CD2R; cluster of differentiation 2; Erythrocyte receptor; FLJ46032; LFA2; LFA-2; LFA-3 receptor; Ly37; Ly-37; lymphocyte antigen 37; OX34; OX-34; OX-34 antigen; OX-45 surface antigen homolog to human T lymphocyte CD2 antigen; Rosette receptor; SRBC; surface immunoglobulin superfamily molecule; T11; T-cell surface antigen CD2; T-cell surface antigen T11/Leu-5
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA