IL-8 (CXCL8) Monoclonal Antibody (3IL8-H10) | Invitrogen M801 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

IL-8 (CXCL8) Monoclonal Antibody (3IL8-H10)

catalog :

M801

quantity :

500 µg

price :

US 486

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3IL8-H10

reactivity :

human, mouse

application :

western blot, ELISA, immunocytochemistry

more info or order :

Invitrogen product webpage

citations: 33

Published Application/Species/Sample/Dilution	Reference
ELISA; human	Salem S, Harris T, Mok J, Li M, Keenan C, Schuliga M, et al. Transforming growth factor-? impairs glucocorticoid activity in the A549 lung adenocarcinoma cell line. Br J Pharmacol. 2012;166:2036-48 pubmed publisher
ELISA; human	Xi X, McMillan D, Lehmann G, Sime P, Libby R, Huxlin K, et al. Ocular fibroblast diversity: implications for inflammation and ocular wound healing. Invest Ophthalmol Vis Sci. 2011;52:4859-65 pubmed publisher
ELISA; human	Page T, Brown A, Timms E, Foxwell B, Ray K. Inhibitors of p38 suppress cytokine production in rheumatoid arthritis synovial membranes: does variable inhibition of interleukin-6 production limit effectiveness in vivo?. Arthritis Rheum. 2010;62:3221-31 pubmed publisher
ELISA; human; 1:2,000	Libetta C, Sepe V, Zucchi M, Pisacco P, Cosmai L, Meloni F, et al. Intermittent haemodiafiltration in refractory congestive heart failure: BNP and balance of inflammatory cytokines. Nephrol Dial Transplant. 2007;22:2013-9 pubmed
ELISA; human	Saffar A, Alphonse M, Shan L, Hayglass K, Simons F, Gounni A. IgE modulates neutrophil survival in asthma: role of mitochondrial pathway. J Immunol. 2007;178:2535-41 pubmed
ELISA; human; 200 ug/ml	Urbanowska T, Mangialaio S, Zickler C, Cheevapruk S, Hasler P, Regenass S, et al. Protein microarray platform for the multiplex analysis of biomarkers in human sera. J Immunol Methods. 2006;316:1-7 pubmed
ELISA; mouse ELISA; human	Jenmalm M, Cherwinski H, Bowman E, Phillips J, Sedgwick J. Regulation of myeloid cell function through the CD200 receptor. J Immunol. 2006;176:191-9 pubmed
ELISA; human; tbl 1	Meloni F, Cascina A, Paschetto E, Marone Bianco A, Morosini M, Pellegrini C, et al. Monocyte chemoattractant protein-1 levels in bronchoalveolar lavage fluid of lung-transplanted patients treated with tacrolimus as rescue treatment for refractory acute rejection. Transplant Proc. 2003;35:1523-6 pubmed
	Marzougui Z, Le Hegarat L, Hogeveen K, Huet S, Kharrat R, Marrouchi R, et al. An Evaluation of the Cytotoxic and Genotoxic Effects of the Marine Toxin C17-SAMT in Human TK6 and HepaRG Cell Lines. Int J Mol Sci. 2023;24: pubmed publisher
	Jalili P, Krause B, Lanceleur R, Burel A, Jungnickel H, Lampen A, et al. Chronic effects of two rutile TiO2 nanomaterials in human intestinal and hepatic cell lines. Part Fibre Toxicol. 2022;19:37 pubmed publisher
	Kantrong N, Chang A, Bamashmous S, Hajjar A, BUCALA R, Darveau R. Macrophage migration inhibitory factor regulates specific innate immune sensor responses in gingival epithelial cells. J Periodontol. 2022;93:1940-1950 pubmed publisher
	Wang W, Prokopec J, Zhang Y, Sukhoplyasova M, Shinglot H, Wang M, et al. Sensing plasma membrane pore formation induces chemokine production in survivors of regulated necrosis. Dev Cell. 2022;57:228-245.e6 pubmed publisher
	Najdi F, Kr xfc ger P, Djabali K. Impact of Progerin Expression on Adipogenesis in Hutchinson-Gilford Progeria Skin-Derived Precursor Cells. Cells. 2021;10: pubmed publisher
	Chen C, Zhang R, Ma L, Li Q, Zhao Y, Zhang G, et al. Neuropilin-1 is up-regulated by cancer-associated fibroblast-secreted IL-8 and associated with cell proliferation of gallbladder cancer. J Cell Mol Med. 2020;24:12608-12618 pubmed publisher
	Zhang K, Fang Y, He Y, Yin H, Guan X, Pu Y, et al. Extravascular gelation shrinkage-derived internal stress enables tumor starvation therapy with suppressed metastasis and recurrence. Nat Commun. 2019;10:5380 pubmed publisher
	Kwak S, Choi Y, Na H, Bae C, Song S, Kim Y. Fipronil upregulates inflammatory cytokines and MUC5AC expression in human nasal epithelial cells. Rhinology. 2020;58:66-73 pubmed publisher
	Alarcan J, Barbé S, Kopp B, Hessel Pras S, Braeuning A, Lampen A, et al. Combined effects of okadaic acid and pectenotoxin-2, 13-desmethylspirolide C or yessotoxin in human intestinal Caco-2 cells. Chemosphere. 2019;228:139-148 pubmed publisher
	Nikolic N, Kienzl P, Tajpara P, Vierhapper M, Matiasek J, Elbe Bürger A. The Antiseptic Octenidine Inhibits Langerhans Cell Activation and Modulates Cytokine Expression upon Superficial Wounding with Tape Stripping. J Immunol Res. 2019;2019:5143635 pubmed publisher
	Croasdell A, Sime P, Phipps R. Resolvin D2 decreases TLR4 expression to mediate resolution in human monocytes. FASEB J. 2016;30:3181-93 pubmed publisher
	Lee S, Jin G, Kim D, Son S, Lee K, Lee C. Indole derivatives inhibit hepatitis C virus replication through induction of pro-inflammatory cytokines. Acta Virol. 2015;59:64-77 pubmed
	Sahler J, Woeller C, Phipps R. Microparticles engineered to highly express peroxisome proliferator-activated receptor-Î³ decreased inflammatory mediator production and increased adhesion of recipient monocytes. PLoS ONE. 2014;9:e113189 pubmed publisher
	Moore H, Ivey R, Voytovich U, Lin C, Stirewalt D, Pogosova Agadjanyan E, et al. The human salivary proteome is radiation responsive. Radiat Res. 2014;181:521-30 pubmed publisher
	McMillan D, Woeller C, Thatcher T, Spinelli S, Maggirwar S, Sime P, et al. Attenuation of inflammatory mediator production by the NF-?B member RelB is mediated by microRNA-146a in lung fibroblasts. Am J Physiol Lung Cell Mol Physiol. 2013;304:L774-81 pubmed publisher
	Takayama H, Soltow L, Chandler W, Vocelka C, Aldea G. Does the type of surgery effect systemic response following cardiopulmonary bypass?. J Card Surg. 2007;22:307-13 pubmed
	Bainbridge B, Coats S, Pham T, Reife R, Darveau R. Expression of a Porphyromonas gingivalis lipid A palmitylacyltransferase in Escherichia coli yields a chimeric lipid A with altered ability to stimulate interleukin-8 secretion. Cell Microbiol. 2006;8:120-9 pubmed
	Beigi R, Kertesy S, Aquilina G, Dubyak G. Oxidized ATP (oATP) attenuates proinflammatory signaling via P2 receptor-independent mechanisms. Br J Pharmacol. 2003;140:507-19 pubmed
	Urbanowska T, Mangialaio S, Hartmann C, Legay F. Development of protein microarray technology to monitor biomarkers of rheumatoid arthritis disease. Cell Biol Toxicol. 2003;19:189-202 pubmed
	Aldea G, Soltow L, Chandler W, Triggs C, Vocelka C, Crockett G, et al. Limitation of thrombin generation, platelet activation, and inflammation by elimination of cardiotomy suction in patients undergoing coronary artery bypass grafting treated with heparin-bonded circuits. J Thorac Cardiovasc Surg. 2002;123:742-55 pubmed
	Singh R, Varney M. Regulation of interleukin 8 expression in human malignant melanoma cells. Cancer Res. 1998;58:1532-7 pubmed
	Ralston D, Marsh C, Lowe M, Wewers M. Antineutrophil cytoplasmic antibodies induce monocyte IL-8 release. Role of surface proteinase-3, alpha1-antitrypsin, and Fcgamma receptors. J Clin Invest. 1997;100:1416-24 pubmed
	Rasmussen S, Eckmann L, Quayle A, Shen L, Zhang Y, Anderson D, et al. Secretion of proinflammatory cytokines by epithelial cells in response to Chlamydia infection suggests a central role for epithelial cells in chlamydial pathogenesis. J Clin Invest. 1997;99:77-87 pubmed
	Wieder K, Hancock W, Schmidbauer G, Corpier C, Wieder I, Kobzik L, et al. Rapamycin treatment depresses intragraft expression of KC/MIP-2, granzyme B, and IFN-gamma in rat recipients of cardiac allografts. J Immunol. 1993;151:1158-66 pubmed
	Marsh C, Gadek J, Kindt G, Moore S, Wewers M. Monocyte Fc gamma receptor cross-linking induces IL-8 production. J Immunol. 1995;155:3161-7 pubmed

product information

Product Type :

Antibody

Product Name :

IL-8 (CXCL8) Monoclonal Antibody (3IL8-H10)

Catalog # :

M801

Quantity :

500 µg

Price :

US 486

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human

Applications :

ELISA: Assay-dependent, Immunocytochemistry: 2 µg/mL, Western Blot: Assay-dependent

Species :

Human

Clone :

3IL8-H10

Isotype :

IgG1

Storage :

-20°C

Description :

Interleukin 8 (IL-8, CXCL8) is a 72 amino acid pro-inflammatory factor which belongs to the CXC subfamily of chemokines, and are bound by the cell surface receptors IL-8RA and IL-8RB. IL-8 functions as a chemoattractant and potent angiogenic factor. The expression and secretion of IL-8 can be induced by diverse inflammatory stimuli in many cells, including macrophages and endothelial cells. In endothelial cells, IL-8 is present in storage vesicles called Weibel-Palade bodies. IL-8, first isolated from osteosarcoma cells, contains the ELR-motif (N-terminal Glu-Leu-Arg amino acid sequence) and signals through the CXCR1 and CXCR2 receptors. Previous nomenclature for IL-8 includes neutrophil activating protein 1 (NAP-1), granulocyte chemotactic protein 1 (GCP-1), monocyte-derived neutrophil-activating peptide (MONAP) and protein 3-10C. IL-8 and ten other members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q. Cancer studies have demonstrated a role for IL-8 in the angiogenesis and growth of tumours, and IL-8 is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection.

Immunogen :

Recombinant human IL-8

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Immunocytochemistry: 2 µg/mL, Western Blot: Assay-dependent

Aliases :

(Ala-IL-8)77; (Ser-IL-8)72; Alveolar macrophage chemotactic factor I; alveolar macrophage-derived chemotactic factor-I; AMCF-I; ANX7; beta endothelial cell-derived neutrophil activating peptide; beta-thromboglobulin-like protein; chemokine (C-X-C motif) ligand 8; C-X-C motif chemokine 8; C-X-C motif chemokine ligand 8; CXCL8; cytokine 8; emoctakin; GCP/IL-8 protein I; GCP/IL-8 protein II; GCP/IL-8 protein III; GCP/IL-8 protein IV; GCP/IL-8 protein V; GCP/IL-8 protein VI; GCP1; GCP-1; Granulocyte chemotactic protein 1; IL8; IL-8; IL-8(1-77); IL-8(5-77); IL-8(6-77); IL-8(7-77); IL-8(8-77); IL-8(9-77); IL8/NAP1 form I; IL8/NAP1 form II; IL8/NAP1 form III; IL8/NAP1 form IV; IL8/NAP1 form V; IL8/NAP1 form VI; ILN; Interleukin; interleukin 8; Interleukin8; interleukin-8; interleuklin-8 precursor; LECT; LUCT; lung giant cell carcinoma-derived chemotactic protein; lymphocyte derived neutrophil activating peptide; Lymphocyte-derived neutrophil-activating factor; LYNAP; MDNCF; MDNCF-a; MDNCF-b; MDNCF-c; MONAP; Monocyte-derived neutrophil chemotactic factor; monocyte-derived neutrophil-activating peptide; NAF; NAP1; NAP-1; neutrophil activating peptide 1; neutrophil and T-lymphocyte chemotactic and activating factor; Neutrophil attractant/activation protein 1; neutrophil attractant/activation protein-1; Neutrophil-activating factor; neutrophil-activating peptide 1; Neutrophil-activating protein 1; Permeability factor 1; PF1; Protein 3-10C; RP11-537A6.8; RPF1; small inducible cytokine subfamily B, member 8; SNX; SYNEXIN; T-cell chemotactic factor; tumor necrosis factor-induced gene 1

more info or order :

Invitrogen product webpage