IL-1 beta Monoclonal Antibody (ILB1-H67) | Invitrogen M421B product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

IL-1 beta Monoclonal Antibody (ILB1-H67)

catalog :

M421B

quantity :

500 µg

price :

US 446

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

ILB1-H67

reactivity :

human, mouse

application :

western blot, ELISA, immunocytochemistry

more info or order :

Invitrogen product webpage

citations: 19

Published Application/Species/Sample/Dilution	Reference
ELISA; human; 1.5 ug/ml	Loewenbrueck K, Tigno Aranjuez J, Boehm B, Lehmann P, Tary Lehmann M. Th1 responses to beta-amyloid in young humans convert to regulatory IL-10 responses in Down syndrome and Alzheimer's disease. Neurobiol Aging. 2010;31:1732-42 pubmed publisher
ELISA; human; 200 ug/ml	Urbanowska T, Mangialaio S, Zickler C, Cheevapruk S, Hasler P, Regenass S, et al. Protein microarray platform for the multiplex analysis of biomarkers in human sera. J Immunol Methods. 2006;316:1-7 pubmed
ELISA; human	Hugosson E, Montgomery S, Premji Z, Troye Blomberg M, Bjorkman A. Relationship between antipyretic effects and cytokine levels in uncomplicated falciparum malaria during different treatment regimes. Acta Trop. 2006;99:75-82 pubmed
immunocytochemistry; human; tbl 6	Pietschmann P, Grisar J, Thien R, Willheim M, Kerschan Schindl K, Preisinger E, et al. Immune phenotype and intracellular cytokine production of peripheral blood mononuclear cells from postmenopausal patients with osteoporotic fractures. Exp Gerontol. 2001;36:1749-59 pubmed
	Li T, Bou Dargham M, Fultang N, Li X, Pear W, Sun H, et al. c-Rel-dependent monocytes are potent immune suppressor cells in cancer. J Leukoc Biol. 2022;112:845-859 pubmed publisher
	Wei Y, Li W, Yang S, Zhong P, Bi Y, Tang Y. Noise exposure and its relationship with postinfarction cardiac remodeling: implications for NLRP3 inflammasome activation. Bioengineered. 2022;13:12127-12140 pubmed publisher
	Li J, Bai J, Tuerdi N, Liu K. Long non-coding RNA MEG3 promotes tumor necrosis factor-alpha induced oxidative stress and apoptosis in interstitial cells of cajal via targeting the microRNA-21 /I-kappa-B-kinase beta axis. Bioengineered. 2022;13:8676-8688 pubmed publisher
	Liang B, Liao S, Huang W, Huang C, Liu H, Shen W. Intermittent fasting therapy promotes insulin sensitivity by inhibiting NLRP3 inflammasome in rat model. Ann Palliat Med. 2021;10:5299-5309 pubmed publisher
	Ullah M, Liu D, Rai S, Concepcion W, Thakor A. HSP70-Mediated NLRP3 Inflammasome Suppression Underlies Reversal of Acute Kidney Injury Following Extracellular Vesicle and Focused Ultrasound Combination Therapy. Int J Mol Sci. 2020;21: pubmed publisher
	Song Y, Li Y, Xiao Y, Hu W, Wang X, Wang P, et al. Neutralization of interleukin-17A alleviates burn-induced intestinal barrier disruption via reducing pro-inflammatory cytokines in a mouse model. Burns Trauma. 2019;7:37 pubmed publisher
	Yakimchuk K, Roura Mir C, Magalhaes K, de Jong A, Kasmar A, Granter S, et al. Borrelia burgdorferi infection regulates CD1 expression in human cells and tissues via IL1-?. Eur J Immunol. 2011;41:694-705 pubmed publisher
	Hetherington V, Kawalec J, Dockery D, Targoni O, Lehmann P, Nadler D. Immunologic testing of xeno-derived osteochondral grafts using peripheral blood mononuclear cells from healthy human donors. BMC Musculoskelet Disord. 2005;6:36 pubmed
	Kahlenberg J, Dubyak G. Differing caspase-1 activation states in monocyte versus macrophage models of IL-1beta processing and release. J Leukoc Biol. 2004;76:676-84 pubmed
	Schotte H, Schluter B, Willeke P, Mickholz E, Schorat M, Domschke W, et al. Long-term treatment with etanercept significantly reduces the number of proinflammatory cytokine-secreting peripheral blood mononuclear cells in patients with rheumatoid arthritis. Rheumatology (Oxford). 2004;43:960-4 pubmed
	Corasaniti M, Bilotta A, Strongoli M, Navarra M, Bagetta G, Di Renzo G. HIV-1 coat protein gp120 stimulates interleukin-1beta secretion from human neuroblastoma cells: evidence for a role in the mechanism of cell death. Br J Pharmacol. 2001;134:1344-50 pubmed
	Dumoulin F, Leifeld L, Honecker U, Sauerbruch T, Spengler U. Intrahepatic expression of interleukin-1beta and tumor necrosis factor-alpha in chronic hepatitis C. J Infect Dis. 1999;180:1704-8 pubmed
	Kalinski P, Schuitemaker J, Hilkens C, Kapsenberg M. Prostaglandin E2 induces the final maturation of IL-12-deficient CD1a+CD83+ dendritic cells: the levels of IL-12 are determined during the final dendritic cell maturation and are resistant to further modulation. J Immunol. 1998;161:2804-9 pubmed
	Kalinski P, Hilkens C, Snijders A, Snijdewint F, Kapsenberg M. IL-12-deficient dendritic cells, generated in the presence of prostaglandin E2, promote type 2 cytokine production in maturing human naive T helper cells. J Immunol. 1997;159:28-35 pubmed
	Marth T, Kelsall B. Regulation of interleukin-12 by complement receptor 3 signaling. J Exp Med. 1997;185:1987-95 pubmed

product information

Product Type :

Antibody

Product Name :

IL-1 beta Monoclonal Antibody (ILB1-H67)

Catalog # :

M421B

Quantity :

500 µg

Price :

US 446

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human, Mouse

Applications :

ELISA: Assay-dependent, Western Blot: 1 µg/mL

Species :

Human, Mouse

Clone :

ILB1-H67

Isotype :

IgG2b

Storage :

-20°C

Description :

Interleukin-1 beta (IL-1 beta) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta is synthesized in response to inflammatory stimuli as a 31 kDa inactive pro-form that accumulates in the cytosol. Cleavage of pro-IL-1 beta into the active 17 kDa protein requires the activation of inflammasomes, which are multi-protein complexes that respond to pathogens, stress conditions, and other danger signals. Inflammasome activation triggers the processing of the caspase-1 precursor into its active form, which in turn cleaves pro-IL-1 beta. IL-1 beta lacks a signal sequence peptide for classical ER/Golgi pathway and is secreted alongside caspase-1 via an alternate and incompletely understood mechanism. Although IL-1 beta is most often secreted in its active form, secretion of the uncleaved protein may be detectable under some biological conditions. IL-1 beta signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 alpha. IL-1 beta activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. IL-1 beta play an important role in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses to infection and injury. Elevated levels of IL-1 beta have been associated with many chronic inflammatory conditions IL-1 beta neutralizing antibodies potential therapeutic value.

Immunogen :

Recombinant human IL-1 beta

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Western Blot: 1 µg/mL

Aliases :

catabolin; cytokine; Hematopoietin 1 (H1); IFN beta inducing factor; il 1b; IL 1ß; IL-1; IL1 B; IL-1 beta; IL-1 precursor; IL1B; IL-1B; IL1B1; IL1beta; IL-1beta; IL1-BETA; IL1F2; IL1ß; ILN; Interleukin; interleukin 1 beta; Interleukin 1 beta precursor; interleukin 1, beta; interleukin 1, beta 1; interleukin 1-beta; interleukin*1*beta; Interleukin1 beta; interleukin-1 beta; interleukin-1 beta precursor; interleukin-1 beta precursor (AA -113 to 153); interleukin-1 beta proprotein; interleukin-1b; interleukin-1beta; interleukin-beta; LAF; lymphocyte proliferation-potentiating factor; Osteoclast activating factor (OAF); preinterleukin 1 beta; Pro interleukin 1 beta; prointerleukin-1 beta; pro-interleukin-1-beta

more info or order :

Invitrogen product webpage