IL-1 beta Monoclonal Antibody (ILB1-H6), Biotin | Invitrogen M420BB product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

IL-1 beta Monoclonal Antibody (ILB1-H6), Biotin

catalog :

M420BB

quantity :

250 µg

price :

US 514

clonality :

monoclonal

host :

mouse

conjugate :

biotin

clone name :

ILB1-H6

reactivity :

human

application :

ELISA

more info or order :

Invitrogen product webpage

citations: 9

Published Application/Species/Sample/Dilution	Reference
ELISA; human; 2 ug/ml	Loewenbrueck K, Tigno Aranjuez J, Boehm B, Lehmann P, Tary Lehmann M. Th1 responses to beta-amyloid in young humans convert to regulatory IL-10 responses in Down syndrome and Alzheimer's disease. Neurobiol Aging. 2010;31:1732-42 pubmed publisher
ELISA; human	Urbanowska T, Mangialaio S, Zickler C, Cheevapruk S, Hasler P, Regenass S, et al. Protein microarray platform for the multiplex analysis of biomarkers in human sera. J Immunol Methods. 2006;316:1-7 pubmed
ELISA; human	Hugosson E, Montgomery S, Premji Z, Troye Blomberg M, Bjorkman A. Relationship between antipyretic effects and cytokine levels in uncomplicated falciparum malaria during different treatment regimes. Acta Trop. 2006;99:75-82 pubmed
ELISA; human	Zucker B, Scharf P, Kersten C. Determination of the inflammatory potential of bioaerosols from a duck-fattening unit by using a limulus amebocyte lysate assay and human whole blood cytokine response. J Vet Med B Infect Dis Vet Public Health. 2006;53:176-80 pubmed
	Esnault S, Kelly E, Nettenstrom L, Cook E, Seroogy C, Jarjour N. Human eosinophils release IL-1ß and increase expression of IL-17A in activated CD4+ T lymphocytes. Clin Exp Allergy. 2012;42:1756-64 pubmed publisher
	Schotte H, Schluter B, Willeke P, Mickholz E, Schorat M, Domschke W, et al. Long-term treatment with etanercept significantly reduces the number of proinflammatory cytokine-secreting peripheral blood mononuclear cells in patients with rheumatoid arthritis. Rheumatology (Oxford). 2004;43:960-4 pubmed
	Gudipaty L, Munetz J, Verhoef P, Dubyak G. Essential role for Ca2+ in regulation of IL-1beta secretion by P2X7 nucleotide receptor in monocytes, macrophages, and HEK-293 cells. Am J Physiol Cell Physiol. 2003;285:C286-99 pubmed
	Corasaniti M, Bilotta A, Strongoli M, Navarra M, Bagetta G, Di Renzo G. HIV-1 coat protein gp120 stimulates interleukin-1beta secretion from human neuroblastoma cells: evidence for a role in the mechanism of cell death. Br J Pharmacol. 2001;134:1344-50 pubmed
	King C, Marshall J, Alshurafa H, Anderson R. Release of vasoactive cytokines by antibody-enhanced dengue virus infection of a human mast cell/basophil line. J Virol. 2000;74:7146-50 pubmed

product information

Product Type :

Antibody

Product Name :

IL-1 beta Monoclonal Antibody (ILB1-H6), Biotin

Catalog # :

M420BB

Quantity :

250 µg

Price :

US 514

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human

Applications :

ELISA: Assay-dependent

Species :

Human

Clone :

ILB1-H6

Isotype :

IgG1, kappa

Storage :

-20°C

Description :

Interleukin-1 beta (IL-1 beta) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta is synthesized in response to inflammatory stimuli as a 31 kDa inactive pro-form that accumulates in the cytosol. Cleavage of pro-IL-1 beta into the active 17 kDa protein requires the activation of inflammasomes, which are multi-protein complexes that respond to pathogens, stress conditions, and other danger signals. Inflammasome activation triggers the processing of the caspase-1 precursor into its active form, which in turn cleaves pro-IL-1 beta. IL-1 beta lacks a signal sequence peptide for classical ER/Golgi pathway and is secreted alongside caspase-1 via an alternate and incompletely understood mechanism. Although IL-1 beta is most often secreted in its active form, secretion of the uncleaved protein may be detectable under some biological conditions. IL-1 beta signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 alpha. IL-1 beta activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. IL-1 beta play an important role in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses to infection and injury. Elevated levels of IL-1 beta have been associated with many chronic inflammatory conditions IL-1 beta neutralizing antibodies potential therapeutic value.

Immunogen :

Recombinant human IL-1 beta

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent

Aliases :

catabolin; cytokine; Hematopoietin 1 (H1); IFN beta inducing factor; il 1b; IL 1ß; IL-1; IL1 B; IL-1 beta; IL-1 precursor; IL1B; IL-1B; IL1B1; IL1beta; IL-1beta; IL1-BETA; IL1F2; IL1ß; ILN; Interleukin; interleukin 1 beta; Interleukin 1 beta precursor; interleukin 1, beta; interleukin 1, beta 1; interleukin 1-beta; interleukin*1*beta; Interleukin1 beta; interleukin-1 beta; interleukin-1 beta precursor; interleukin-1 beta precursor (AA -113 to 153); interleukin-1 beta proprotein; interleukin-1b; interleukin-1beta; interleukin-beta; LAF; lymphocyte proliferation-potentiating factor; Osteoclast activating factor (OAF); preinterleukin 1 beta; Pro interleukin 1 beta; prointerleukin-1 beta; pro-interleukin-1-beta

more info or order :

Invitrogen product webpage